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RBM3 Gene

protein-coding   GIFtS: 55
GCID: GC0XP048432

RNA Binding Motif (RNP1, RRM) Protein 3

(Previous name: RNA binding motif protein 3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif (RNP1, RRM) Protein 31 2
RNPL2 3
RNA-Binding Motif Protein 32 3
RNA Binding Motif Protein 31
IS1-RNPL2
Putative RNA-Binding Protein 32

External Ids:    HGNC: 99001   Entrez Gene: 59352   Ensembl: ENSG000001023177   OMIM: 3000275   UniProtKB: P981793   

Export aliases for RBM3 gene to outside databases

Previous GC identifers: GC0XP047235 GC0XP046693 GC0XP047478 GC0XP048189 GC0XP048317 GC0XP046097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBM3 Gene:
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA
recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A
pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to
encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay
(NMD) criteria. (provided by RefSeq, Jul 2008)

GeneCards Summary for RBM3 Gene:
RBM3 (RNA binding motif (RNP1, RRM) protein 3) is a protein-coding gene. GO annotations related to this gene include RNA binding and ribosomal large subunit binding. An important paralog of this gene is RBMY1J.

UniProtKB/Swiss-Prot: RBM3_HUMAN, P98179
Function: Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and
mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances
phosphorylation of translation initiation factors and active polysome formation (By similarity)

Gene Wiki entry for RBM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM3 gene promoter:
         E2F-4   E2F-3a   E2F-5   AML1a   E2F-2   E2F   E2F-1   POU2F1   POU2F1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM3 promoter sequence
   Search Chromatin IP Primers for RBM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.2

RBM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048432:  view genomic region     (about GC identifiers)

Start:
48,432,741 bp from pter      End:
48,439,553 bp from pter
Size:
6,813 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBM3_HUMAN, P98179 (See protein sequence)
Recommended Name: Putative RNA-binding protein 3  
Size: 157 amino acids; 17170 Da
Subunit: Interacts with RPL4. Associates with the 60S ribosomal subunits in an RNA-independent manner. Associates
with ribosomes (By similarity)

Explore the universe of human proteins at neXtProt for RBM3: NX_P98179

Explore proteomics data for RBM3 at MOPED

Post-translational modifications: 

  • Arg-105 is dimethylated, probably to asymmetric dimethylarginine1
  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006734.1  
    ENSEMBL proteins: 
     ENSP00000365950   ENSP00000365946   ENSP00000346473   ENSP00000412764  

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    ProSpec Recombinant Protein for RBM3
    Cloud-Clone Corp. Proteins for RBM3

     
    Search eBioscience for Proteins for RBM3 

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    Cloud-Clone Corp. ELISAs for RBM3
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    Search eBioscience for ELISAs for RBM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P98179

    ProtoNet protein and cluster: P98179

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM3_HUMAN, P98179
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with RBM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM3_HUMAN, P98179
    Function: Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and
    mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances
    phosphorylation of translation initiation factors and active polysome formation (By similarity)
    Induction: Up-regulated by hypoxia

         Genatlas biochemistry entry for RBM3:
    Y chromosome RNA recognition motif 3,ubiquitously expressed,with homology to RBM1,RBM2 (see symbols)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS8634703
    GO:0005515protein binding IPI15518812
    GO:0043023ribosomal large subunit binding IEA--
         
    Find genes that share ontologies with RBM3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RBM3:
     Decreased influenza A/WSN/33 r  Increased homologous recombina  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rbm3):
     cellular  embryogenesis  immune system 

    Find genes that share phenotypes with RBM3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rbm3tm1Ttg for RBM3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBM3

    miRNA
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    miRTarBase miRNAs that target RBM3:
    hsa-mir-26b-5p (MIRT029488), hsa-mir-30c-5p (MIRT047926)

    Block miRNA regulation of human, mouse, rat RBM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM3 (see all 28):
    hsa-miR-194* hsa-miR-4254 hsa-miR-502-5p hsa-miR-16-1* hsa-miR-410 hsa-miR-340 hsa-miR-548a-3p hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidRBM3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RBM3

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    GenScript: all cDNA clones in your preferred vector: RBM3 (NM_006743)
    Sino Biological Human cDNA Clone for RBM3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBM3_HUMAN, P98179: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, dendrite (By
    similarity). Note=Localizes in mRNA granules in dentrites (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0015934colocalizes with large ribosomal subunit ISS--
    GO:0030425dendrite ISS--

    Find genes that share ontologies with RBM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RBM3: 
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RBM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for RBM3 (P981791, 2, 3 ENSP000003659464) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPA2B1P226262, 3, ENSP000003466944MINT-6629372 I2D: score=2 STRING: ENSP00000346694
    CHAF1AQ131113, ENSP000003012804I2D: score=1 STRING: ENSP00000301280
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing TAS8634703
    GO:0006412translation IEA--
    GO:0006417regulation of translation ISS--
    GO:0009409response to cold IEA--
    GO:0035196production of miRNAs involved in gene silencing by miRNA IEA--

    Find genes that share ontologies with RBM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM3

    1 Novoseek inferred chemical compound relationship for RBM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    h2o2 22.6 2 14649730 (1), 9245737 (1)



    Find genes that share compounds with RBM3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RBM3 gene (3 alternative transcripts): 
    NM_006743.4  NM_001017430.1  NM_001017431.1  

    Unigene Cluster for RBM3:

    RNA binding motif (RNP1, RRM) protein 3
    Hs.301404  [show with all ESTs]
    Unigene Representative Sequence: NM_006743
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472897 ENST00000488216 ENST00000466764 ENST00000490127 ENST00000491240
    ENST00000489344 ENST00000376759(uc004dkf.2) ENST00000485213 ENST00000376755
    ENST00000491236 ENST00000354480 ENST00000430348
    miRNA
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    Block miRNA regulation of human, mouse, rat RBM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM3 (see all 28):
    hsa-miR-194* hsa-miR-4254 hsa-miR-502-5p hsa-miR-16-1* hsa-miR-410 hsa-miR-340 hsa-miR-548a-3p hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidRBM3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RBM3
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    GenScript: all cDNA clones in your preferred vector: RBM3 (NM_006743)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RBM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM3
      QuantiTect SYBR Green Assays in human, mouse, rat RBM3
      QuantiFast Probe-based Assays in human, mouse, rat RBM3

    Additional mRNA sequence: 

    AK000859.1 AK026664.1 AK129559.1 AK289614.1 AK309137.1 AY203954.1 BC006825.1 

    Selected DOTS entries (see all 46):

    DT.100892698  DT.100892690  DT.449311  DT.92389838  DT.100045139  DT.95275116  DT.100892696  DT.100892700 
    DT.121286130  DT.100892693  DT.101984235  DT.121286025  DT.205601  DT.100045141  DT.100650914  DT.95078581 
    DT.304491  DT.121286021  DT.99954613  DT.121286134  DT.100892679  DT.92461094  DT.100892677  DT.121286132 

    20 AceView cDNA sequences:

    CR626059 CR615516 CR622284 CR601924 CR604888 CR597294 CR620824 CR615558 
    CR591107 CR621948 CR602242 CR615647 CR618991 CR589973 BC006825 AK000859 
    AK026664 AY203954 NM_006743 U28686 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBM3 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a ·
    SP1:                                            -     -     -     -                             -     -     -     -     -     -                                 
    SP2:                                            -     -     -     -                             -                                                               
    SP3:                                            -     -     -     -                 -     -     -                                                               
    SP4:                                                                                            -     -     -     -     -     -                                 
    SP5:                                                                                            -                                                               

    ExUns: 10b ^ 11a · 11b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RBM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATCCAGG
    RBM3 Expression
    About this image


    RBM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RBM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301404
        Pathway & Disease-focused RT2 Profiler PCR Array including RBM3: 
              Cardiotoxicity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RBM3
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    QuantiTect SYBR Green Assays in human, mouse, rat RBM3
    QuantiFast Probe-based Assays in human, mouse, rat RBM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RBM3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm31 , 5 RNA binding motif protein 31, 5 86.8(n)1
    94.16(a)1
      X (3.68 cM)5
    196521  NM_016809.51  NP_058089.21 
     81389755 
    lizard
    (Anolis carolinensis)
    Reptilia RBM36
    RNA binding motif (RNP1, RRM) protein 3
    84(a)
    1 ↔ 1
    GL343252.1(30145-34882)
    fruit fly
    (Drosophila melanogaster)
    Insecta tra26
    transformer 2
    16(a)
    1 → many
    2R(10489509-10491857)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-86
    Protein RSP-8, isoform a
    17(a)
    1 → many
    III(11826215-11831475) WBGene00004705


    ENSEMBL Gene Tree for RBM3 (if available)
    TreeFam Gene Tree for RBM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBM3 gene
    RBMY1J2  RBMY1E2  RBMY1F2  TRA2B2  RBMXL22  RBMXL32  RBMY1B2  RBMXL12  
    RBMY1A12  CIRBP2  RBMX2  TRA2A2  RBMY1D2  
    Selected SIMAP similar genes for RBM3 using alignment to 4 protein entries:     RBM3_HUMAN (see all proteins) (see all similar genes):
    CIRBP    DAZAP1/MEF2D fusion    RBMX    DAZAP1    RBM23    RBMXL3
    RNPC4    RBMY1A1    DKFZp686A11192    DKFZp686C17209    DKFZp781C0423    RBM39
    CSTF2    HNRNPA2B1    RBM38    NCL    RBMXL2    SRSF2

    Find genes that share paralogs with RBM3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RBM3
    PGOHUM00000259596


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBM3 (see all 169)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896038211,2
    --48431016(+) GGGGGA/GAAAAT 1 -- us2k10--------
    rs3761140581,2
    C--48431031(+) ATATCA/GAAATT 1 -- us2k10--------
    rs1913455481,2
    --48431113(+) TTCCAA/GCACCT 1 -- us2k10--------
    rs117989191,2
    H--48431201(+) ATATGC/GATGTA 1 -- us2k10--------
    rs1446270831,2
    C--48431243(+) TGTTGC/GGCAAA 1 -- us2k10--------
    rs1844077701,2
    --48431303(+) CTTCGC/TTGATG 1 -- us2k10--------
    rs594703181,2
    C--48431467(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- us2k10--------
    rs775589591,2
    C--48431851(+) TCCTCC/TTTTGT 1 -- us2k10--------
    rs74728091,2
    A--48432009(+) tttttC/Tttttt 1 -- us2k1 trp30--------
    rs97242361,2
    C--48432019(+) TTTTTC/TTTTTT 1 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for RBM3 (48432741 - 48439553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RBM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740155CNV Deletion23290073
    esv29760CNV Gain19812545
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM3
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300027    OMIM disorders: --


    Find genes that share disorders with RBM3           About GenesLikeMe


    Export disorders for RBM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBM3 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with RBM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain. (PubMed id 8634703)1, 2, 3 Derry J.M.... Francke U. (Hum. Mol. Genet. 1995)
    2. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. (PubMed id 15075239)1, 2, 9 Wellmann S.... Seeger K. (J. Cell Sci. 2004)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress. (PubMed id 9245737)1, 9 Danno S....Fujita J. (Biochem. Biophys. Res. Commun. 1997)
    7. The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements. (PubMed id 12824175)1, 9 Chappell S.A. and Mauro V.P. (J. Biol. Chem. 2003)
    8. The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death. (PubMed id 19770690)1, 9 Wellmann S....BA1hrer C. (Pediatr. Res. 2010)
    9. Down-regulating cold shock protein genes impairs cancer cell survival and enhances chemosensitivity. (PubMed id 19277990)1, 9 Zeng Y....Getzenberg R.H. (J. Cell. Biochem. 2009)
    10. Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer. (PubMed id 23565664)1 Boman K....MalmstrAPm P.U. (BMC Urol 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5935 HGNC: 9900 AceView: RBM3 Ensembl:ENSG00000102317 euGenes: HUgn5935
    ECgene: RBM3 H-InvDB: RBM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBM3 gene:
    Search GeneIP for patents involving RBM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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