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Aliases for RBM3 Gene

Aliases for RBM3 Gene

  • RNA Binding Motif (RNP1, RRM) Protein 3 2 3
  • RNA-Binding Motif Protein 3 3 4
  • RNPL 3 4
  • Putative RNA-Binding Protein 3 3
  • RNA Binding Motif Protein 3 2
  • RNA-Binding Protein 3 3
  • IS1-RNPL 3

External Ids for RBM3 Gene

Summaries for RBM3 Gene

Entrez Gene Summary for RBM3 Gene

  • This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBM3 Gene

RBM3 (RNA Binding Motif (RNP1, RRM) Protein 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ribosomal large subunit binding. An important paralog of this gene is RBMXL1.

UniProtKB/Swiss-Prot for RBM3 Gene

  • Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).

Gene Wiki entry for RBM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM3 Gene

Genomics for RBM3 Gene

Genomic Location for RBM3 Gene

Start:
48,574,353 bp from pter
End:
48,581,165 bp from pter
Size:
6,813 bases
Orientation:
Plus strand

Genomic View for RBM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM3 Gene

Regulatory Elements for RBM3 Gene

Proteins for RBM3 Gene

  • Protein details for RBM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98179-RBM3_HUMAN
    Recommended name:
    RNA-binding protein 3
    Protein Accession:
    P98179
    Secondary Accessions:

    Protein attributes for RBM3 Gene

    Size:
    157 amino acids
    Molecular mass:
    17170 Da
    Quaternary structure:
    • Interacts with RPL4. Associates with the 60S ribosomal subunits in an RNA-independent manner. Associates with ribosomes (By similarity).

neXtProt entry for RBM3 Gene

Proteomics data for RBM3 Gene at MOPED

Post-translational modifications for RBM3 Gene

Other Protein References for RBM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBM3 Gene

Domains for RBM3 Gene

Gene Families for RBM3 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBM3 Gene

UniProtKB/Swiss-Prot:

RBM3_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • P98179
genes like me logo Genes that share domains with RBM3: view

Function for RBM3 Gene

Molecular function for RBM3 Gene

GENATLAS Biochemistry: Y chromosome RNA recognition motif 3,ubiquitously expressed,with homology to RBM1,RBM2 (see symbols)
UniProtKB/Swiss-Prot Function: Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by hypoxia.

Gene Ontology (GO) - Molecular Function for RBM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 8634703
GO:0005515 protein binding IPI 15518812
GO:0043023 ribosomal large subunit binding IEA --
genes like me logo Genes that share ontologies with RBM3: view
genes like me logo Genes that share phenotypes with RBM3: view

Animal Models for RBM3 Gene

MGI Knock Outs for RBM3:

miRNA for RBM3 Gene

miRTarBase miRNAs that target RBM3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RBM3 Gene

Localization for RBM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM3 Gene

Nucleus. Cytoplasm. Cell projection, dendrite. Note=Localizes in mRNA granules in dentrites. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM3 Gene COMPARTMENTS Subcellular localization image for RBM3 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for RBM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0015934 colocalizes_with large ribosomal subunit ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with RBM3: view

Pathways for RBM3 Gene

SuperPathways for RBM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 8634703
GO:0006412 translation IEA --
GO:0006417 regulation of translation ISS --
GO:0009409 response to cold IEA --
GO:0035196 production of miRNAs involved in gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with RBM3: view

No data available for Pathways by source for RBM3 Gene

Compounds for RBM3 Gene

(1) Novoseek inferred chemical compound relationships for RBM3 Gene

Compound -log(P) Hits PubMed IDs
h2o2 22.6 2
genes like me logo Genes that share compounds with RBM3: view

Transcripts for RBM3 Gene

Unigene Clusters for RBM3 Gene

RNA binding motif (RNP1, RRM) protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a ·
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - -
SP10: -
SP11:
SP12:
SP13: - - - -
SP14:
SP15: - - - - - -

ExUns: 10b ^ 11a · 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for RBM3 Gene

GeneLoc Exon Structure for
RBM3
ECgene alternative splicing isoforms for
RBM3

Expression for RBM3 Gene

mRNA expression in normal human tissues for RBM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM3 Gene

SOURCE GeneReport for Unigene cluster for RBM3 Gene Hs.301404

genes like me logo Genes that share expressions with RBM3: view

Orthologs for RBM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM3 36
  • 99.79 (n)
  • 100 (a)
RBM3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM3 36
  • 86.75 (n)
  • 92.31 (a)
RBM3 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM3 36
  • 92.09 (n)
  • 95.51 (a)
RBM3 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm3 36
  • 86.8 (n)
  • 94.16 (a)
Rbm3 16
Rbm3 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM3 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm3 36
  • 90.6 (n)
  • 97.44 (a)
lizard
(Anolis carolinensis)
Reptilia RBM3 37
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tra2 37
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 37
  • 17 (a)
OneToMany
Species with no ortholog for RBM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RBM3 Gene

ENSEMBL:
Gene Tree for RBM3 (if available)
TreeFam:
Gene Tree for RBM3 (if available)

Paralogs for RBM3 Gene

Paralogs for RBM3 Gene

Pseudogenes.org Pseudogenes for RBM3 Gene

genes like me logo Genes that share paralogs with RBM3: view

Variants for RBM3 Gene

Sequence variations from dbSNP and Humsavar for RBM3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs8893 -- 48,581,039(-) GTAAA(C/T)ACAAA utr-variant-3-prime
rs8931 -- 48,578,119(-) ATACC(C/G)CTGGA utr-variant-3-prime
rs235826 -- 48,579,991(-) CAAAG(C/T)AGGAG utr-variant-3-prime
rs235827 -- 48,578,630(-) TGCCC(A/G)CCCAC utr-variant-3-prime
rs235829 -- 48,577,540(-) GCTTC(A/G)GTGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RBM3 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
esv29760 CNV Gain 19812545
esv2740155 CNV Deletion 23290073

Relevant External Links for RBM3 Gene

HapMap Linkage Disequilibrium report
RBM3

Disorders for RBM3 Gene

No disorders were found for RBM3 Gene.

No data available for UniProtKB/Swiss-Prot for RBM3 Gene

Publications for RBM3 Gene

  1. Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. (PMID: 15075239) Wellmann S. … Seeger K. (J. Cell Sci. 2004) 3 4 23
  2. RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain. (PMID: 8634703) Derry J.M. … Francke U. (Hum. Mol. Genet. 1995) 2 3 4
  3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Down-regulating cold shock protein genes impairs cancer cell survival and enhances chemosensitivity. (PMID: 19277990) Zeng Y. … Getzenberg R.H. (J. Cell. Biochem. 2009) 3 23

Products for RBM3 Gene

Sources for RBM3 Gene

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