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RBM28 Gene

protein-coding   GIFtS: 55
GCID: GC07M127939

RNA Binding Motif Protein 28

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif Protein 281 2
2810480G15Rik2
RNA-Binding Protein 282
RNA-Binding Motif Protein 283

External Ids:    HGNC: 218631   Entrez Gene: 551312   Ensembl: ENSG000001063447   OMIM: 6120745   UniProtKB: Q9NW133   

Export aliases for RBM28 gene to outside databases

Previous GC identifers: GC07M127505 GC07M127545 GC07M127737 GC07M127951 GC07M122311


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBM28 Gene:
The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear
ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs
(snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia,
progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous
disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Oct 2009)

GeneCards Summary for RBM28 Gene:
RBM28 (RNA binding motif protein 28) is a protein-coding gene. Diseases associated with RBM28 include alopecia, neurologic defects, and endocrinopathy syndrome, and alopecia. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: RBM28_HUMAN, Q9NW13
Function: Nucleolar component of the spliceosomal ribonucleoprotein complexes

Gene Wiki entry for RBM28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM28 gene promoter:
         Egr-2   POU2F1   POU2F1a   HFH-1   Pax-2   Sox9   IRF-7A   Pax-2a   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM28 promoter sequence
   Search Chromatin IP Primers for RBM28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.2

RBM28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM28 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M127939:  view genomic region     (about GC identifiers)

Start:
127,937,738 bp from pter      End:
127,983,962 bp from pter
Size:
46,225 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 127,333,546-127,367,073     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RBM28_HUMAN, Q9NW13 (See protein sequence)
Recommended Name: RNA-binding protein 28  
Size: 759 amino acids; 85738 Da
Subunit: Interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs)
Secondary accessions: A4D100 B4DU52 E9PDD9 Q53H65 Q96CV3
Alternative splicing: 2 isoforms:  Q9NW13-1   Q9NW13-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBM28: NX_Q9NW13

Explore proteomics data for RBM28 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBM28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159607.1  NP_060547.2  

    ENSEMBL proteins: 
     ENSP00000223073   ENSP00000390517   ENSP00000419840   ENSP00000418071   ENSP00000420503  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9NW13

    ProtoNet protein and cluster: Q9NW13

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM28_HUMAN, Q9NW13
    Similarity: Contains 4 RRM (RNA recognition motif) domains


    RBM28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM28_HUMAN, Q9NW13
    Function: Nucleolar component of the spliceosomal ribonucleoprotein complexes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    RBM28 for ontologies           About GeneDecksing


    Animal Models:
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    Block miRNA regulation of human, mouse, rat RBM28 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBM28_HUMAN, Q9NW13: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005681spliceosomal complex IEA--
    GO:0005730nucleolus IDA--
    GO:0005794Golgi apparatus ----

    RBM28 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RBM28 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RBM28):
        Ribosome biogenesis in eukaryotes


    RBM28 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM28
    Interactions:

        Search GeneGlobe Interaction Network for RBM28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBM28 (Q9NW133 ENSP000002230734) via UniProtKB, MINT, STRING, and/or I2D (see all 205)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    RBM28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM28



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RBM28 gene (2 alternative transcripts): 
    NM_001166135.1  NM_018077.2  

    Unigene Cluster for RBM28:

    RNA binding motif protein 28
    Hs.274263  [show with all ESTs]
    Unigene Representative Sequence: NM_018077
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223073(uc003vmp.2 uc011koj.1 uc011kok.1) ENST00000481788
    ENST00000415472 ENST00000495327 ENST00000487602 ENST00000478061 ENST00000488249
    ENST00000459726
    miRNA
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    Additional mRNA sequence: 

    AK001239.1 AK222716.1 AK300500.1 BC013889.2 

    6 DOTS entries:

    DT.213466  DT.100020924  DT.101961087  DT.102828804  DT.100811353  DT.91694955 

    Selected AceView cDNA sequences (see all 102):

    BM758471 BU183334 CA438299 W76513 AV654330 BM766901 BQ646473 AL705640 
    BM690082 BU609187 BQ439480 BQ654136 CR594156 AW801849 BE880277 AI609293 
    BU194429 BM823263 BC013889 AL134936 BQ720067 CR596407 BM747080 AW303557 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBM28 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                                                                                -     -     -               
    SP2:                    -                 -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                                      -                                                                                                                     
    SP5:                    -                 -           -     -                                                                                                   

    ExUns: 19 ^ 20
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RBM28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBM28 expression in normal human tissues (normalized intensities)      RBM28 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTTCTTG
    RBM28 Expression
    About this image


    RBM28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RBM28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274263

    UniProtKB/Swiss-Prot: RBM28_HUMAN, Q9NW13
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM28 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm281 , 5 RNA binding motif protein 281, 5 83.44(n)1
    82.2(a)1
      6 (12.33 cM)5
    682721  NM_133925.21  NP_598686.21 
     291235735 
    lizard
    (Anolis carolinensis)
    Reptilia RBM286
    RNA binding motif protein 28
    52(a)
    1 ↔ 1
    GL343916.1(122-27075)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16812 Xenopus laevis transcribed sequence with weak similarity more 72.15(n)    BU909138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562582 hypothetical protein MGC56258 72.65(n)   393291  BC051781.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48066
    --
    33(a)
    1 ↔ 1
    2R(20553681-20555853)
    worm
    (Caenorhabditis elegans)
    Secernentea rbm-286
    Protein RBM-28 (rbm-28) mRNA, complete cds
    33(a)
    1 ↔ 1
    II(14857190-14866588) WBGene00011043
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP4(YPL043W)4 Nucleolar protein, essential for processing and maturation more   --   16(469939-471996) 856063  NP_015282.1 
    rice
    (Oryza sativa)
    Liliopsida AK067130.12   -- 77.12(n)    AK067130.1 


    ENSEMBL Gene Tree for RBM28 (if available)
    TreeFam Gene Tree for RBM28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBM28 gene
    2 SIMAP similar genes for RBM28 using alignment to 5 protein entries:     RBM28_HUMAN (see all proteins):
    SLIRP    SRSF5

    RBM28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBM28 (see all 822)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0456554
    Alopecia, neurologic defects, and endocrinopathy syndrome (ANES)4--see VAR_0456552 L P mis40--------
    rs360114241,2
    C--127335822(+) ATGTGT/-GGACT 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs679059781,2
    C--127335823(+) TGTGG-/TGACTT 2 -- int10--------
    rs1416582401,2
    --127343410(+) GAAAGA/GAATTA 2 -- int10--------
    rs344072781,2
    C--127349402(+) CGGAGC/-TTGCA 2 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs719912911,2
    C--127349403(+) GGAGT-/CTGCAG 2 -- int10--------
    rs670563021,2
    C--127960289(+) AAAAA-/AA    
       AAG
    /G
    AAAGA
    2 -- int10--------
    rs599693381,2
    C--127960384(+) GGGGGA/-GGGGG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs672645651,2
    C--127960385(+) GGGGG-/AGGGGG 2 -- int10--------
    rs113954601,2
    C--127962100(+) AAAAA-/A/AA  
            
    TTCCC
    2 -- int1 trp31NA 2

    HapMap Linkage Disequilibrium report for RBM28 (127937738 - 127983962 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RBM28:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735136CNV Deletion23290073
    nsv889191CNV Loss21882294
    nsv819317CNV Loss19587683
    nsv831124CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): RBM28
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM28
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612074   
    OMIM disorders: 612079  
    UniProtKB/Swiss-Prot: RBM28_HUMAN, Q9NW13
  • Alopecia, neurologic defects, and endocrinopathy syndrome (ANES) [MIM:612079]: Affected individuals have
    hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body
    hair. All have moderate to severe mental retardation, progressive motor deterioration and central
    hypogonadotropic hypogonadism with delayed or absent puberty and central adrenal insufficiency. Additional
    features included short stature, microcephaly, gynecomastia, pigmentary anomalies, hypodontia, kyphoscoliosis,
    ulnar deviation of the hands, and loss of subcutaneous fat. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 20 diseases for RBM28:    About MalaCards
    alopecia, neurologic defects, and endocrinopathy syndrome    alopecia    combined pituitary hormone deficiency    gynecomastia
    treacher collins syndrome    hypogonadotropism    hypogonadism    microcephaly
    short stature    epididymitis    tonsillitis    mental retardation
    hiv-1    multiple myeloma    myeloma    malaria
    thyroiditis    cerebritis    breast cancer    prostatitis


    RBM28 for disorders           About GeneDecksing


    Export disorders for RBM28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBM28 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with RBM28)
        Utopia: connect your pdf to the dynamic
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    1. Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. (PubMed id 18439547)1, 2 Nousbeck J.... Sprecher E. (Am. J. Hum. Genet. 2008)
    2. Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs. (PubMed id 17081119)1, 2 Damianov A.... Bindereif A. (Biol. Chem. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    8. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55131 HGNC: 21863 AceView: RBM28 Ensembl:ENSG00000106344 euGenes: HUgn55131
    ECgene: RBM28 Kegg: 55131 H-InvDB: RBM28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBM28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBM28 gene:
    Search GeneIP for patents involving RBM28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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