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Aliases for RBM27 Gene

Aliases for RBM27 Gene

  • RNA Binding Motif Protein 27 2 3 5
  • Acidic Rich RS Domain Containing 1 2 3
  • RNA-Binding Motif Protein 27 4
  • RNA-Binding Protein 27 3
  • KIAA1311 4
  • ZC3H18 3
  • ZC3H20 3
  • ARRS1 3
  • Psc1 3

External Ids for RBM27 Gene

Previous GeneCards Identifiers for RBM27 Gene

  • GC05P145613
  • GC05P145563
  • GC05U900595
  • GC05P141098

Summaries for RBM27 Gene

GeneCards Summary for RBM27 Gene

RBM27 (RNA Binding Motif Protein 27) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ENSG00000275740.

Additional gene information for RBM27 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM27 Gene

Genomics for RBM27 Gene

GeneHancer (GH) Regulatory Elements for RBM27 Gene

Promoters and enhancers for RBM27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I146202 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 577.4 +0.1 83 2.7 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 IRF4 RBM27 ENSG00000275740 LARS GC05P146208
GH05I146446 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 34.7 +244.3 244276 2.5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 TCERG1 RBM27 LARS GPR151 ENSG00000277568
GH05I146181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.2 -21.1 -21117 2.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 LARS RBM27 TCERG1 GC05M146120
GH05I145974 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -224.3 -224305 9.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 FEZF1 ZNF2 YY1 ZNF213 TCERG1 RBM27 SH3RF2 LARS GRXCR2 GC05P145976 LOC100431175
GH05I146877 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 15.2 +675.0 674968 1.4 MXI1 ZNF449 ZNF223 ZNF2 ZNF335 ZFHX2 GLIS2 POLR2A ZBTB48 PATZ1 PPP2R2B RBM27 TCERG1 GC05P146882 GC05P146800
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM27 gene promoter:

Genomic Locations for RBM27 Gene

Genomic Locations for RBM27 Gene
chr5:146,203,550-146,289,223
(GRCh38/hg38)
Size:
85,674 bases
Orientation:
Plus strand
chr5:145,583,113-145,718,814
(GRCh37/hg19)

Genomic View for RBM27 Gene

Genes around RBM27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM27 Gene

Proteins for RBM27 Gene

  • Protein details for RBM27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2N5-RBM27_HUMAN
    Recommended name:
    RNA-binding protein 27
    Protein Accession:
    Q9P2N5
    Secondary Accessions:
    • Q8IYW9

    Protein attributes for RBM27 Gene

    Size:
    1060 amino acids
    Molecular mass:
    118718 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM27 Gene

Post-translational modifications for RBM27 Gene

Other Protein References for RBM27 Gene

No data available for DME Specific Peptides for RBM27 Gene

Domains & Families for RBM27 Gene

Gene Families for RBM27 Gene

Suggested Antigen Peptide Sequences for RBM27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2N5

UniProtKB/Swiss-Prot:

RBM27_HUMAN :
  • The RRM domain mediates integration into cytospeckles.
Domain:
  • The RRM domain mediates integration into cytospeckles.
genes like me logo Genes that share domains with RBM27: view

Function for RBM27 Gene

Gene Ontology (GO) - Molecular Function for RBM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RBM27: view
genes like me logo Genes that share phenotypes with RBM27: view

Animal Model Products

CRISPR Products

miRNA for RBM27 Gene

miRTarBase miRNAs that target RBM27

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM27 Gene

Localization for RBM27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM27 Gene

Cytoplasm. Nucleus speckle. Note=Incorporated into the nuclear speckles and to speckles proximal to the nuclear periphery. Also localizes to punctate structures in the cytoplasm termed cytospeckles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM27 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with RBM27: view

Pathways & Interactions for RBM27 Gene

SuperPathways for RBM27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with RBM27: view

No data available for Pathways by source and SIGNOR curated interactions for RBM27 Gene

Drugs & Compounds for RBM27 Gene

No Compound Related Data Available

Transcripts for RBM27 Gene

Unigene Clusters for RBM27 Gene

RNA binding motif protein 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM27 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for RBM27 Gene

GeneLoc Exon Structure for
RBM27
ECgene alternative splicing isoforms for
RBM27

Expression for RBM27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM27 Gene

Protein differential expression in normal tissues from HIPED for RBM27 Gene

This gene is overexpressed in Breast (27.2) and Synovial fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM27 Gene



Protein tissue co-expression partners for RBM27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM27 Gene:

RBM27

SOURCE GeneReport for Unigene cluster for RBM27 Gene:

Hs.61441

Evidence on tissue expression from TISSUES for RBM27 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RBM27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM27 Gene

Orthologs for RBM27 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM27 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia RBM27 33 34
  • 93.93 (n)
cow
(Bos Taurus)
Mammalia RBM27 33 34
  • 92.91 (n)
rat
(Rattus norvegicus)
Mammalia Rbm27 33
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Rbm27 33 16 34
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM27 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM27 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM27 33 34
  • 75.66 (n)
lizard
(Anolis carolinensis)
Reptilia RBM27 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm27 33
  • 68.6 (n)
Str.19140 33
zebrafish
(Danio rerio)
Actinopterygii rbm27 33 34
  • 59.02 (n)
Dr.15505 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2616 33
fruit fly
(Drosophila melanogaster)
Insecta swm 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0336.3 34
  • 27 (a)
OneToMany
Species where no ortholog for RBM27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM27 Gene

ENSEMBL:
Gene Tree for RBM27 (if available)
TreeFam:
Gene Tree for RBM27 (if available)

Paralogs for RBM27 Gene

Paralogs for RBM27 Gene

(7) SIMAP similar genes for RBM27 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RBM27: view

Variants for RBM27 Gene

Sequence variations from dbSNP and Humsavar for RBM27 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000025599 -- 146,233,100(+) T/A intron_variant
rs1000031560 -- 146,270,844(+) C/T intron_variant
rs1000045220 -- 146,236,301(+) A/G intron_variant
rs1000200744 -- 146,230,007(+) G/C/T intron_variant
rs1000229725 -- 146,274,804(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM27 Gene

Variant ID Type Subtype PubMed ID
dgv725n27 CNV loss 19166990
esv3890750 CNV loss 25118596
nsv1114740 CNV deletion 24896259
nsv428128 CNV loss 18775914
nsv462478 CNV loss 19166990
nsv517251 CNV loss 19592680
nsv523502 CNV gain 19592680
nsv599935 CNV loss 21841781
nsv599936 CNV loss 21841781
nsv599937 CNV loss 21841781

Variation tolerance for RBM27 Gene

Residual Variation Intolerance Score: 4.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM27 Gene

Disorders for RBM27 Gene

Additional Disease Information for RBM27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RBM27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM27 Gene

Publications for RBM27 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. A family of RS domain proteins with novel subcellular localization and trafficking. (PMID: 15741184) Kavanagh SJ … Rathjen PD (Nucleic acids research 2005) 2 3 58
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for RBM27 Gene

Sources for RBM27 Gene

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