RBM27 Gene
protein-coding GIFtS: 47
GCID: GC05P145563
|
|
RNA binding motif protein 27
| |
Aliases
for RBM27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 271 2 | | KIAA13111 3 | | ARRS11 2 | | RNA-Binding Motif Protein 272 3 | | Psc11 2 | | Acidic Rich RS Domain Containing 12 | | ZC3H181 2 | | RNA-Binding Protein 272 |
Export aliases for RBM27 gene to outside databasesPrevious GC identifers: GC05P145613 GC05U900595 GC05P141098 |
Summaries
for RBM27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RBM27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM27 gene promoter:
c-Fos AP-2rep SRF AP-1 MAZR SRF (504 AA) MZF-1 CP2 LyF-1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32RBM27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P145563: view genomic region
(about GC identifiers)
Start:
|
145,583,113 bp from pter |
End:
|
145,718,814 bp from pter |
Size:
|
135,702 bases |
Orientation:
|
plus strand |
|
Proteins
for RBM27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM27_HUMAN, Q9P2N5 (See
protein sequence)Recommended Name: RNA-binding protein 27 Size: 1060 amino acids; 118718 Da
Subcellular location: Cytoplasm. Nucleus speckle. Note=Incorporated into the nuclear speckles and to speckles proximalto the nuclear periphery. Also localizes to punctate structures in the cytoplasm termed cytospeckles (By similarity)
Secondary accessions: Q8IYW9Explore the universe of human proteins at neXtProt for RBM27: NX_Q9P2N5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2N5
RBM27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061862.1
ENSEMBL proteins: ENSP00000265271
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RBM27 for ontologies About GeneDecksing
RBM27 Antibody Products:
Assay Products for RBM27: |
Protein
Domains /
Families
for RBM27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM27 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P2N5ProtoNet protein and cluster: Q9P2N5 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB000571 Zn-finger
UniProtKB/Swiss-Prot: RBM27_HUMAN, Q9P2N5Domain: The RRM domain mediates integration into cytospeckles (By similarity)Similarity: Contains 1 C3H1-type zinc fingerSimilarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for RBM27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM27 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM27
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM27 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RBM27 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RBM27:
|
Pathways & Interactions
for RBM27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM27
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for RBM27 (Q9P2N53 ENSP000002652714) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006397 | mRNA processing |
IEA | -- |
RBM27 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBM27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM27
Search CenterWatch for drugs/clinical trials and news about RBM27
|
Transcripts
for RBM27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM27 gene: NM_018989.1 Unigene Cluster for RBM27: RNA binding motif protein 27 Hs.61441 [show with all ESTs]Unigene Representative Sequence: NM_0189893 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506502(uc003lny.2) ENST00000265271(uc003lnz.4) ENST00000508019
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM27 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM27
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBM27 (NM_018989) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM27 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBM27 |
Additional cDNA sequence: AB037732.1 AK026358.1 AK074316.1 AK128738.1 AL833706.1 BC009537.1 BC029648.1 BC033524.1 BX647384.1 5 DOTS entries: DT.113725 DT.101980899 DT.95367717 DT.91858442 DT.95357930 24/153 AceView cDNA sequences (see all 153): BC029648 BX097357 AI671019 AK026358 BX280604 AA877636 AW070397 AW467416 AB037732 BM459769 AW206584 BE221791 AI138263 AA046224 AI567164 AW572828 AA315431 AA737401 AA761354 BQ027059 AW086076 BM452783 BF061624 BU678873
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RBM27 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RBM27
|
Expression
for RBM27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGACTTTTG
About this image
See RBM27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM27
SOURCE GeneReport for Unigene cluster: Hs.61441
SABiosciences Custom PCR Arrays for RBM27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBM27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM27 |
Orthologs
for RBM27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBM27 gene from 9/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rbm271 , 5 |
RNA binding motif protein 271, 5 |
90.01(n)1
94.52(a)1 |
|
18 (22.45 cM)5
2254321 NM_172626.21 NP_766214.21
422753535 |
chicken
(Gallus gallus) |
Aves |
RBM271 |
RNA binding motif protein 27 |
76.81(n)
82.46(a) |
|
416348 XM_414664.2 XP_414664.2 |
lizard
(Anolis carolinensis) |
Reptilia |
RBM276 |
-- |
76(a) |
1 ↔ 1 |
GL343234.1(592047-637185) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.191402 |
Transcribed sequence |
74.31(n) |
|
BX774354.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.155052 |
Transcribed sequences |
74.18(n) |
|
AL924657.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
swm6 |
second mitotic wave missing |
24(a) |
1 → many |
2L(19493251-19497978) |
worm
(Caenorhabditis elegans) |
Secernentea |
B0336.36 |
Protein B0336.3 |
27(a) |
1 → many |
III(5711503-5714579) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G277006 |
zinc finger CCCH domain-containing protein 41 |
12(a) |
1 → many |
3(10257117-10261974) |
rice
(Oryza sativa) |
Liliopsida |
-- |
RNA-binding motif protein, putative, expressed |
13(a) |
1 → many |
4(19211410-19219675) |
ENSEMBL Gene Tree for RBM27 (if available)
TreeFam Gene Tree for RBM27 (if available) |
Paralogs
for RBM27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBM27 gene
- RBM262
2 SIMAP similar genes for RBM27 using alignment to 2 protein entries: RBM27_HUMAN (see all proteins):POU4F3 RBM26
RBM27 for paralogs About GeneDecksing
|
Genomic Variants
for RBM27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM27 (145583113 - 145718814 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RBM27
2 CNVs: 53099 51584 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM27 |
|
Disorders
/ Diseases
for RBM27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RBM27 for disorders About MalaCards
RBM27 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RBM27 (1 document)
Export disorders for RBM27 gene to outside databases
|
Publications
for RBM27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM27 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with RBM27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F....Peng X. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- A family of RS domain proteins with novel subcellular localization and trafficking. (PubMed id 15741184)1, 3 Kavanagh S.J....Rathjen P.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for RBM27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM27 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RBM27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM27 gene:
Search GeneIP for patents involving RBM27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | RBM27 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM27 |
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