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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBM26 Gene

protein-coding   GIFtS: 48
GCID: GC13M079888

RNA binding motif protein 26

(Previous name: chromosome 13 open reading frame 10 )
(Previous symbol: C13orf10)
 Explore 1 disease affiliated with
RBM26 via our new
 Human Malady Compendium 
Biological research products
for RBM26
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RNA Binding Motif Protein 261 2     FLJ209571
C13orf101 2 3     PRO17771
ARRS21 2     Chromosome 13 Open Reading Frame 101
SE70-21 2     RP11-255E21.12
ZC3H171 2     Acidic Rich RS Domain Containing 22
CTCL Tumor Antigen Se70-22 3     Cutaneous T-Cell Lymphoma Tumor Antigen Se70-22
RNA-Binding Motif Protein 262 3     RNA-Binding Protein 262

External Ids:    HGNC: 203271   Entrez Gene: 640622   Ensembl: ENSG000001397467   UniProtKB: Q5T8P63   

Export aliases for RBM26 gene to outside databases

Previous GC identifers: GC13M078783 GC13M060597


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for RBM26


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBM26 gene promoter:
         ER-alpha   USF1   HSF1 (long)   STAT5A   C/EBPalpha   Max   USF-1   HSF1short   ZID   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RBM26 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBM26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

RBM26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM26 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M079888:  view genomic region     (about GC identifiers)

Start:
79,885,962 bp from pter      End:
79,980,612 bp from pter
Size:
94,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBM26_HUMAN, Q5T8P6 (See protein sequence)
Recommended Name: RNA-binding protein 26  
Size: 1007 amino acids; 113597 Da
Sequence caution: Sequence=AAG34912.1; Type=Erroneous initiation; Sequence=BAB14933.1; Type=Erroneous initiation;
Sequence=BAB55125.1; Type=Erroneous initiation; Sequence=CAI12921.2; Type=Erroneous gene model prediction;
Sequence=CAI95136.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DZE0 Q2NKM2 Q2NKQ2 Q5CZH8 Q5T8P5 Q5T8P8 Q5U5P5 Q5W0G7 Q8N3H5 Q96K92 Q96SZ3
Q9H2F8 Q9H7F9 Q9P1G7
Alternative splicing: 6 isoforms:  Q5T8P6-1   Q5T8P6-2   Q5T8P6-3   Q5T8P6-4   Q5T8P6-5   Q5T8P6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBM26: NX_Q5T8P6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T8P6

  • RBM26 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_071401.3  
    ENSEMBL proteins: 
     ENSP00000401474   ENSP00000267229   ENSP00000387531   ENSP00000327080   ENSP00000390222  

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    Uscn Proteins for RBM26


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RBM26 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR002483 PWI_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q5T8P6

    ProtoNet protein and cluster: Q5T8P6

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: RBM26_HUMAN, Q5T8P6
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-323-3p hsa-miR-448 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-485-3p hsa-miR-3133 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRBM26 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM26

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI17577209
    GO:0008270zinc ion binding IEA--


    RBM26 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM26

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for RBM26 (Q5T8P62, 3 ENSP000002672294) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KBTBD7Q8WVZ93, ENSP000003687974I2D: score=3 STRING: ENSP00000368797
    SUMO2ENSP000004059654STRING: ENSP00000405965
    HNRNPA1ENSP000003418264STRING: ENSP00000341826
    PPP1CAENSP000003260314STRING: ENSP00000326031
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0010923negative regulation of phosphatase activity IDA19389623


    RBM26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBM26
    Search CenterWatch for drugs/clinical trials and news about RBM26 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RBM26 gene: 
    NM_022118.3  

    Unigene Cluster for RBM26:

    RNA binding motif protein 26
    Hs.558528  [show with all ESTs]
    Unigene Representative Sequence: BX648672
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449987 ENST00000484573 ENST00000267229(uc001vky.2) ENST00000438737(uc001vkx.2 uc001vkz.2 uc001vla.2 uc010tia.2)
    ENST00000461008 ENST00000472143(uc001vlc.1) ENST00000327303 ENST00000438724(uc001vlb.1)


    miRNA
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    hsa-miR-323-3p hsa-miR-448 hsa-miR-181c hsa-miR-520d-5p hsa-miR-548k hsa-miR-485-3p hsa-miR-3133 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRBM26 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM26

    Additional cDNA sequence: 

    AF273052.1 AK000954.1 AK024610.1 AK027339.1 AK027456.1 AK302871.1 AK302927.1 AL834343.1 
    BC000791.2 BC041655.1 BC065024.1 BC111697.1 BC111739.1 BX648672.1 

    19 DOTS entries:

    DT.447201  DT.70104139  DT.97790437  DT.97824262  DT.120789965  DT.86847574  DT.95146768  DT.91665091 
    DT.95268750  DT.97808695  DT.100822529  DT.101959060  DT.120789972  DT.120790004  DT.95253897  DT.95332833 
    DT.97815640  DT.424754  DT.445923 

    24/289 AceView cDNA sequences (see all 289):

    BF592957 AI092706 CD251807 BI491568 NM_022118 BE221406 AA906275 CA428936 
    AX775883 AI804470 BM453925 BU741748 BC000791 D61584 AF273052 AI824197 
    AI307141 AK027456 AA514263 AI374912 BM462729 BU617687 BM838045 AW236884 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for RBM26 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c ^ 13 ^ 14a ·
    SP1:        -                                                                             -                 -                                                   
    SP2:                                                                                      -                 -                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:  -     -                 -                 -                                                     -                 -               
    SP2:  -                       -                 -                                                     -                 -               
    SP3:                                                                                                  -                 -               
    SP4:                                            -                                                                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for RBM26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBM26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTCCTTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RBM26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBM26

    SOURCE GeneReport for Unigene cluster: Hs.558528
        SABiosciences Custom PCR Arrays for RBM26
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM26 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RBM261 RNA binding motif protein 26 83.57(n)
    91.72(a)
      418804  XM_416998.3  XP_416998.2 
    lizard
    (Anolis carolinensis)
    Reptilia RBM266
    --
    87(a)
    1 ↔ 1
    3(97068522-97124879)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528682 hypothetical protein MGC52868 75.82(n)    BC043744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1097361 zgc:109736 66.46(n)
    71.58(a)
      619195  XM_002662263.2  XP_002662309.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta swm1 second mitotic wave missing 44.84(n)
    36.18(a)
      35235  NM_136132.4  NP_609976.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0336.31 Protein B0336.3 43.59(n)
    36.03(a)
      175800  NM_065833.3  NP_498234.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G277006
    zinc finger CCCH domain-containing protein 41
    14(a)
    1 → many
    3(10257117-10261974)
    rice
    (Oryza sativa)
    Liliopsida --
    RNA-binding motif protein, putative, expressed
    15(a)
    1 → many
    4(19211410-19219675)


    ENSEMBL Gene Tree for RBM26 (if available)
    TreeFam Gene Tree for RBM26 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBM26 gene
    RBM272  
    2 SIMAP similar genes for RBM26 using alignment to 3 protein entries:     RBM26_HUMAN (see all proteins):
    RBM27    POU4F3

    RBM26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1583 NCBI SNPs in RBM26 are shown (see all 1583    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400603101,2
    --79893610(+) AACATC/TAAAGA 1 -- ds50010--------
    rs1433911821,2
    --79893907(+) TTGGAC/TTGTAC 1 -- ds50010--------
    rs1854087821,2
    --79893940(+) CCATTA/GTTATT 1 -- ds50010--------
    rs1881597931,2
    --79894206(+) TCATAC/TACCAT 1 -- ut310--------
    rs96012141,2
    C,F,H,--79894229(+) CCATAT/CGGTAA 1 -- ut315Minor allele frequency- C:0.02NS EA WA 536
    rs1819552471,2
    --79894323(+) GACTTC/TAGTTA 1 -- ut310--------
    rs1864246191,2
    --79894539(+) TAGTGA/TGATGT 1 -- ut310--------
    rs1917421891,2
    --79894542(+) TGTGAA/TGTCTT 1 -- ut310--------
    rs44143671,2
    H--79894721(+) AGGTAG/AAGTTC 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 418
    rs31873381,2
    C,F,A,H,--79894736(-) GATCTG/ACATAT 1 -- ut31 ese324Minor allele frequency- A:0.44MN NS EA NA WA CSA 2529

    HapMap Linkage Disequilibrium report for RBM26 (79885962 - 79980612 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for RBM26
         1 CNV: 4812
         2 Indels: 11686 25304

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RBM26 for disorders           About GeneDecksing

    1 disease for RBM26:    About MalaCards
    cutaneous t cell lymphoma

    Human Genome Epidemiology (HuGE) Navigator: RBM26 (1 document)

    Export disorders for RBM26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBM26 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with RBM26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2, 3 Eichmueller S....Schadendorf D. (2001)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. A family of RS domain proteins with novel subcellular localization and trafficking. (PubMed id 15741184)1, 3 Kavanagh S.J....Rathjen P.D. (2005)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1 Close P.... Svejstrup J.Q. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64062 HGNC: 20327 AceView: C13orf10 Ensembl:ENSG00000139746 euGenes: HUgn64062
    ECgene: RBM26 H-InvDB: RBM26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBM26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RBM26 gene:
    Search GeneIP for patents involving RBM26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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