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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RBM25 Gene

protein-coding GIFtS: 51
GCID: GC14P073525

RNA Binding Motif Protein 25

(Previous names: RNA-binding region (RNP1, RRM) containing 7)
(Previous symbol: RNPC7)

Alzheimer's & Parkinson's Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
RNA Binding Motif Protein 25¹ ²		NET52²
RNPC7¹ ² ³		S164²
RED120² ³ ⁵		Snu71²
RNA-Binding Region (RNP1, RRM) Containing 7¹ ²		Arg/Glu/Asp-Rich Protein, 120 KDa²
Functional Spliceosome-Associated Protein 94¹ ²		fSAP94²
Arg/Glu/Asp-Rich Protein Of 120 KDa² ³		RNA-Binding Protein 25²
RNA-Binding Motif Protein 25² ³		U1 Small Nuclear Ribonucleoprotein 1SNRP Homolog²
RNA-Binding Region-Containing Protein 7² ³		Protein S164³

External Ids:	HGNC: 23244¹	Entrez Gene: 58517²	Ensembl: ENSG00000119707⁷	OMIM: 612427⁵	UniProtKB: P49756³

Export aliases for RBM25 gene to outside databases

Previous GC identifers: GC14P071517 GC14P072594 GC14P053691

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RBM25 Gene:

RBM25 (RNA binding motif protein 25) is a protein-coding gene. Diseases associated with RBM25 include fainting, and alzheimer's disease, and among its related super-pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include mRNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: RBM25_HUMAN, P49756

Function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic

cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of

proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates

proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of

antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its

association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to

the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA

Gene Wiki entry for RBM25 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NT_026437.12 NC_018925.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RBM25 gene promoter:
CHOP-10 GATA-3 FOXO4 AP-2beta CUTL1 AP-2alpha AP-2gamma GATA-2 GATA-1 AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBM25 promoter sequence

Search SABiosciences Chromatin IP Primers for RBM25

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM25

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.3

RBM25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM25 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P073525: view genomic region (about GC identifiers)

Start:	73,525,144 bp from pter	End:	73,588,122 bp from pter
Size:	62,979 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBM25_HUMAN, P49756 (See protein sequence)

Recommended Name: RNA-binding protein 25

Size: 843 amino acids; 100185 Da

Subunit: Interacts with LUC7L3 and SRRM1. Specifically associates with functional splicing complexes, including Sm

proteins and U1, U2, U4, U5 and U6 snRNAs. Associates with exon junction complex (EJC) proteins, including APEX1,

BAT1, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent

Subcellular location: Nucleus speckle. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing

factors, in nuclear speckles. Cytoplasmic localization is faint

Sequence caution: Sequence=AAH62440.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAH62440.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH83496.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG52915.1;

Type=Erroneous translation; Note=Wrong choice of CDS;

1 PDB 3D structure from and Proteopedia for RBM25:

3V53 (3D)

Secondary accessions: A0PJL9 B2RNA8 B3KT03 Q2TA72 Q5XJ17 Q6P665 Q9H6A1 Q9UEQ5 Q9UIE9

Alternative splicing: 4 isoforms: P49756-1 P49756-2 P49756-3 P49756-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RBM25: NX_P49756

Explore proteomics data for RBM25 at MOPED

Post-translational modifications:

UniProtKB: Sumoylated

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P49756

RBM25 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_067062.1

ENSEMBL proteins:

ENSP00000261973 ENSP00000431150 ENSP00000434333 ENSP00000436868 ENSP00000436225

ENSP00000434004 ENSP00000434444 ENSP00000434950 ENSP00000437934

Human Recombinant Protein Products for RBM25:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0016607	nuclear speck	IDA	18663000

RBM25 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

RBM: RNA binding motif (RRM) containing

3 InterPro protein domains:

IPR002483 PWI_dom

IPR012677 Nucleotide-bd_a/b_plait

IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry P49756

ProtoNet protein and cluster: P49756

UniProtKB/Swiss-Prot: RBM25_HUMAN, P49756

Similarity: Contains 1 PWI domain

Similarity: Contains 1 RRM (RNA recognition motif) domain

RBM25 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RBM25_HUMAN, P49756

Function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic

cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of

proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates

proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of

antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its

association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to

the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003729	mRNA binding	IDA	18663000
GO:0005515	protein binding	IPI	18663000

RBM25 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RBM25:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for RBM25

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RBM25

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBM25

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miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBM25
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		hsa-miR-607 hsa-miR-520e hsa-miR-361-5p hsa-miR-485-3p hsa-miR-219-5p hsa-miR-632 hsa-miR-519a hsa-miR-342-3p

		SwitchGear 3'UTR luciferase reporter plasmid: RBM25 3' UTR sequence

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RBM25
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM25

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RBM25 About

See pathways by source

SuperPath

Contained pathways About

mRNA Splicing - Major Pathway

Spliceosome

0.31

Pathways by source See SuperPaths
Show all pathways

1 Kegg Pathway (Kegg details for RBM25):

Spliceosome

RBM25 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RBM25

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/32 Interacting proteins for RBM25 (P49756^{2, 3} ENSP00000261973⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RBM39	Q14498²^,³, ENSP00000253363⁴	MINT-8333317 I2D: score=1 STRING: ENSP00000253363
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205413 I2D: score=1 STRING: ENSP00000221494
ESR2	Q92731³, ENSP00000343925⁴	I2D: score=1 STRING: ENSP00000343925
SRRM1	Q8IYB3³, ENSP00000326261⁴	I2D: score=1 STRING: ENSP00000326261
SART1	O43290², ENSP00000310448⁴	MINT-8333339 STRING: ENSP00000310448

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA	18663000
GO:0006397	mRNA processing	IEA	--
GO:0008380	RNA splicing	IEA	--
GO:0097194	execution phase of apoptosis	IDA	18663000

RBM25 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBM25

Search CenterWatch for drugs/clinical trials and news about RBM25

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RBM25 gene:

NM_021239.2

Unigene Cluster for RBM25:

RNA binding motif protein 25

Hs.531106 [show with all ESTs]

Unigene Representative Sequence: NM_021239

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261973(uc001xno.3 uc010ttu.2 uc001xnp.3) ENST00000527432

ENST00000531500 ENST00000532683(uc001xnn.4) ENST00000525321 ENST00000526754

ENST00000525161 ENST00000528081 ENST00000532192 ENST00000532483 ENST00000527449

ENST00000530978 ENST00000540173

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBM25
		8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate RBM25 (see all 77):
		hsa-miR-607 hsa-miR-520e hsa-miR-361-5p hsa-miR-485-3p hsa-miR-219-5p hsa-miR-632 hsa-miR-519a hsa-miR-342-3p

		SwitchGear 3'UTR luciferase reporter plasmid: RBM25 3' UTR sequence

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Additional mRNA sequence:

AK026107.1 AK094697.1 AK125513.1 AL833497.1 BC033664.1 BC062440.1 BC083496.1 BC111066.1

BC113389.1 BC113391.1 BC136775.1 BC136776.1 BC144407.1 BX647116.1 L40392.1 Y12017.1

24/25 DOTS entries (see all 25):

DT.100764307 DT.87011249 DT.120764171 DT.95160488 DT.448745 DT.453963 DT.120764199 DT.120764212

DT.95160494 DT.92440705 DT.95230724 DT.97764494 DT.95160497 DT.100868422 DT.120764210 DT.95160501

DT.100675203 DT.120764185 DT.92005317 DT.95101833 DT.95160489 DT.100868417 DT.40294589 DT.95352806

24/418 AceView cDNA sequences (see all 418):

AW008457 AW150014 BX647116 BE466195 CD674722 AW014065 T40389 BE466128

S67071 CR608971 AI536551 AW188842 AA446690 BU166427 AA234317 AA628617

AA147323 BQ686118 AW183617 AA155855 CA312267 BG943432 BE551956 BI019882

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RBM25 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	·	17c	^	18	^
SP1:							-																						-		-
SP2:							-
SP3:
SP4:
SP5:

ExUns:	19a	·	19b	^	20	^	21	^	22a	·	22b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RBM25

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBM25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCTGAGTACT

About this image

See RBM25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM25

SOURCE GeneReport for Unigene cluster: Hs.531106

SABiosciences Custom PCR Arrays for RBM25

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM25 gene from 9/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rbm25^{1 , 5}	RNA binding motif protein 25^{1, 5}	92.24(n)¹ 99.76(a)¹		12 (38.81 cM)⁵ 67039¹ NM_027349.3¹ NP_081625.3¹ 83631236⁵
chicken (Gallus gallus)	Aves	RBM25¹	RNA binding motif protein 25	83.95(n) 96.69(a)		423250 NM_001199684.1 NP_001186613.1
lizard (Anolis carolinensis)	Reptilia	RBM25⁶	Uncharacterized protein	96(a)	1 ↔ 1	1(38904591-38933505)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1918²	Xenopus laevis, clone IMAGE4930521, mRNA, partial cds	78.05(n)		BC045216.1
zebrafish (Danio rerio)	Actinopterygii	BC045992.1²	--	74.49(n)		327336 BC045992.1
fruit fly (Drosophila melanogaster)	Insecta	CG4119¹	CG4119	45.48(n) 39.91(a)		31481 NM_132014.2 NP_572242.1
worm (Caenorhabditis elegans)	Secernentea	W04D2.6¹	Protein W04D2.6	46.7(n) 36.38(a)		259655 NM_073732.5 NP_506133.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G60200¹	RNA-binding protein 25	43.44(n) 31.38(a)		842315 NM_104710.4 NP_176226.3
rice (Oryza sativa)	Liliopsida	Os08g0416400¹	hypothetical protein	45.93(n) 36.28(a)		4345578 NM_001068344.1 NP_001061809.1

ENSEMBL Gene Tree for RBM25 (if available)
TreeFam Gene Tree for RBM25 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188196320^1,2		--	73523224(+)	`AAATAA/GGCACA`	1	--	us2k¹		0	--	--	--	--
rs10135258^1,2	C,F	--	73523308(+)	`gaggtC/Taggag`	1	--	us2k¹ tfbs³		1		WA	118
rs10135445^1,2	C,F	--	73523310(+)	`ggtcaG/Agagtt`	1	--	us2k¹		1		WA	118
rs192958573^1,2		--	73523392(+)	`CCCACA/GCCTAT`	1	--	us2k¹		0	--	--	--	--
rs142871410^1,2	C	--	73523464(+)	`AGTGAA/GCCAAG`	1	--	us2k¹		0	--	--	--	--
rs150803988^1,2		--	73523757(+)	`GTATAC/GAAGGA`	1	--	us2k¹		0	--	--	--	--
rs71109793^1,2	C	--	73523879(-)	`AAAAA-/AAAAG/A AAAGAAAAGAAAAG`	1	--	us2k¹		1		NA	2
rs11159007^1,2	C	--	73523880(+)	`CTTTTC/TTTTTG`	1	--	us2k¹ trp³		0	--	--	--	--
rs12433157^1,2	C,F,A,H	--	73523898(+)	`GTCTCG/ACTTTG`	1	--	us2k¹		4		NA WA	10
rs78815650^1,2	C,F	--	73524193(+)	`ACAAAT/CATTTA`	1	--	us2k¹		3		WA NA EA	358

HapMap Linkage Disequilibrium report for RBM25 (73525144 - 73588122 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for RBM25: About this table

Variant ID	Type	Subtype	PubMed ID
esv2677511	CNV	Deletion	23128226
esv2748862	CNV	Deletion	23290073
esv2748864	CNV	Deletion	23290073
esv2658707	CNV	Deletion	23128226
esv2669446	CNV	Deletion	23128226
esv27604	CNV	Loss	19812545
esv33255	CNV	Loss	17666407
esv27860	CNV	Loss	19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 612427 OMIM disorders: --

3 diseases for RBM25: About MalaCards

fainting alzheimer's disease thyroiditis

RBM25 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Export disorders for RBM25 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RBM25 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with RBM25)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)^{1, 2, 3} Sherrington R....Holman K. (1995)
Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. (PubMed id 18663000)^{1, 2} Zhou A....Huang S.C. (2008)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)^{1, 2} Denis N.J.... Figeys D. (2007)
Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. (PubMed id 17560998)^{1, 2} Fortes P.... Blencowe B.J. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)^{1, 2} Gocke C.B.... Kang J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)
Toward a complete human genome sequence. (PubMed id 9847074)^{1, 3} Wilson R. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 58517	HGNC: 23244	AceView: RBM25	Ensembl:ENSG00000119707	euGenes: HUgn58517
ECgene: RBM25	Kegg: 58517	H-InvDB: RBM25

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RBM25	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RBM25 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RBM25 gene:
Search GeneIP for patents involving RBM25

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RBM25 Gene

RNA Binding Motif Protein 25

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RNA Binding Motif Protein 25

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