Aliases for RBM25 Gene
- RNA Binding Motif Protein 25 2 3
- RED120 3 4 6
- Functional Spliceosome-Associated Protein 94 2 3
- RNA-Binding Region (RNP1, RRM) Containing 7 2 3
- RNA-Binding Region-Containing Protein 7 3 4
- Arg/Glu/Asp-Rich Protein Of 120 KDa 3 4
- RNA-Binding Motif Protein 25 3 4
- RNPC7 3 4
- U1 Small Nuclear Ribonucleoprotein 1SNRP Homolog 3
External Ids for RBM25 Gene
Previous Symbols for RBM25 Gene
GeneCards Summary for RBM25 Gene
RBM25 (RNA Binding Motif Protein 25) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include nucleotide binding and mRNA binding.
UniProtKB/Swiss-Prot for RBM25 Gene
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5-splice site (5-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5-ss usage through the 5-CGGGCA-3 RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5 ss in a 5-CGGGCA-3-dependent manner. Binds to the exonic splicing enhancer 5-CGGGCA-3 RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.