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RBM25 Gene

protein-coding   GIFtS: 52
GCID: GC14P073525

RNA Binding Motif Protein 25

(Previous names: RNA-binding region (RNP1, RRM) containing 7)
(Previous symbol: RNPC7)
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Aliases
for RBM25 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
RNA Binding Motif Protein 251 2     NET522
RNPC71 2 3     S1642
RED1202 3 5     Snu712
RNA-Binding Region (RNP1, RRM) Containing 71 2     Arg/Glu/Asp-Rich Protein, 120 KDa2
Functional Spliceosome-Associated Protein 941 2     fSAP942
Arg/Glu/Asp-Rich Protein Of 120 KDa2 3     RNA-Binding Protein 252
RNA-Binding Motif Protein 252 3     U1 Small Nuclear Ribonucleoprotein 1SNRP Homolog2
RNA-Binding Region-Containing Protein 72 3     Protein S1643

External Ids:    HGNC: 232441   Entrez Gene: 585172   Ensembl: ENSG000001197077   OMIM: 6124275   UniProtKB: P497563   

Export aliases for RBM25 gene to outside databases

Previous GC identifers: GC14P071517 GC14P072594 GC14P053691


Summaries
for RBM25 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for RBM25 Gene:
RBM25 (RNA binding motif protein 25) is a protein-coding gene. GO annotations related to this gene include mRNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: RBM25_HUMAN, P49756
Function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic
cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of
proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates
proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of
antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its
association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to
the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also
involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure

Gene Wiki entry for RBM25 Gene


Genomic Views
for RBM25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM25 gene promoter:
         CHOP-10   GATA-3   FOXO4   AP-2beta   CUTL1   AP-2alpha   AP-2gamma   GATA-2   GATA-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBM25 promoter sequence
   Search Chromatin IP Primers for RBM25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.3

RBM25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM25 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P073525:  view genomic region     (about GC identifiers)

Start:
 73,525,144 bp from pter      End:
 73,588,122 bp from pter
Size:
 62,979 bases      Orientation:
 plus strand

Proteins
for RBM25 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section
UniProtKB/Swiss-Prot: RBM25_HUMAN, P49756 (See protein sequence)
Recommended Name: RNA-binding protein 25  
Size: 843 amino acids; 100185 Da
Subunit: Interacts with LUC7L3 and SRRM1. Specifically associates with functional splicing complexes, including Sm
proteins and U1, U2, U4, U5 and U6 snRNAs. Associates with exon junction complex (EJC) proteins, including APEX1,
BAT1, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent
Sequence caution: Sequence=AAH62440.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH62440.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH83496.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG52915.1;
Type=Erroneous translation; Note=Wrong choice of CDS;
1 PDB 3D structure from and Proteopedia for RBM25:
3V53 (3D)    
Secondary accessions: A0PJL9 B2RNA8 B3KT03 Q2TA72 Q5XJ17 Q6P665 Q9H6A1 Q9UEQ5 Q9UIE9
Alternative splicing: 4 isoforms:  P49756-1   P49756-2   P49756-3   P49756-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RBM25: NX_P49756

Explore proteomics data for RBM25 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys477
  • Modification sites at PhosphoSitePlus

    • See RBM25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067062.1  
    ENSEMBL proteins: 
     ENSP00000261973   ENSP00000431150   ENSP00000434333   ENSP00000436868   ENSP00000436225  
     ENSP00000434004   ENSP00000434444   ENSP00000434950   ENSP00000437934  

    RBM25 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
    OriGene Custom Protein Services for RBM25
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

         		 Search eBioscience for Proteins for RBM25 

         		 Search GeneTex for Proteins for RBM25 

         		 Search antibodies-online for proteins for RBM25 

         		antibodies-online peptides for RBM25

    RBM25 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals RBM25 Antibodies
    Abcam antibodies for RBM25
    Browse Antibodies at Cloud-Clone Corp.
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    antibodies-online antibodies for RBM25 (7 products) 

    RBM25 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RBM25 
    antibodies-online kits for RBM25 (4 products) 

    Domains /
    Families
    for RBM25 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    		 HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR002483 PWI_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P49756

    ProtoNet protein and cluster: P49756

    UniProtKB/Swiss-Prot: RBM25_HUMAN, P49756
    Domain: The PWI domain binds nucleic acids with significant help from its N-terminal flanking basic region. It has
    an equal preference for binding to single- or double-stranded species, and it contributes to RBM25 role in
    modulation of alternative splicing, maybe by mediating RNA-dependent association with LUC7L3
    Similarity: Contains 1 PWI domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with RBM25           About GenesLikeMe


    Function
    for RBM25 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM25_HUMAN, P49756
    Function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic
    cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of
    proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates
    proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of
    antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its
    association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to
    the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also
    involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003729mRNA binding IDA18663000
    GO:0005515protein binding IPI18663000
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RBM25           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RBM25:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RBM25

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat RBM25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM25 (see all 77):
    hsa-miR-607 hsa-miR-520e hsa-miR-361-5p hsa-miR-485-3p hsa-miR-219-5p hsa-miR-632 hsa-miR-519a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RBM25 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for RBM25
    Predesigned siRNA for gene silencing in human, mouse, rat RBM25

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RBM25
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    GenScript: all cDNA clones in your preferred vector: RBM25 (NM_021239)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM25

    Cell Line
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    In Situ Assay
    Products:       
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    Localization
    for RBM25 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section
    Subcellular locations from UniProtKB/Swiss-Prot
    RBM25_HUMAN, P49756: Nucleus speckle. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing
    factors, in nuclear speckles. Cytoplasmic localization is faint
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    chloroplast1
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IBA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IDA18663000

    Find genes that share ontologies with RBM25           About GenesLikeMe


    Pathways & Interactions
    for RBM25 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section





    SuperPaths for RBM25 About    
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Spliceosome
    		Spliceosome


    Find genes that share SuperPaths with RBM25           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RBM25):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM25
    Interactions:

        Search GeneGlobe Interaction Network for RBM25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBM25 (P497562, 3 ENSP000002619734) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM39Q144982, 3, ENSP000002533634MINT-8333317 I2D: score=1 STRING: ENSP00000253363
    SF3A2Q154282, 3, ENSP000002214944MINT-5205413 I2D: score=1 STRING: ENSP00000221494
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    RBM23Q86U062, ENSP000003529564MINT-8333306 STRING: ENSP00000352956
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA18663000
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0042981regulation of apoptotic process IDA18663000

    Find genes that share ontologies with RBM25           About GenesLikeMe



    Drugs & Compounds
    for RBM25 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM25



    Transcripts
    for RBM25 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section
    REFSEQ mRNAs for RBM25 gene: 
    NM_021239.2  

    Unigene Cluster for RBM25:

    RNA binding motif protein 25
    Hs.531106  [show with all ESTs]
    Unigene Representative Sequence: NM_021239
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261973(uc001xno.3 uc010ttu.2 uc001xnp.3) ENST00000527432
    ENST00000531500 ENST00000532683(uc001xnn.4) ENST00000525321 ENST00000526754
    ENST00000525161 ENST00000528081 ENST00000532192 ENST00000532483 ENST00000527449
    ENST00000530978 ENST00000540173
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat RBM25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM25 (see all 77):
    hsa-miR-607 hsa-miR-520e hsa-miR-361-5p hsa-miR-485-3p hsa-miR-219-5p hsa-miR-632 hsa-miR-519a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RBM25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RBM25
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM25
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM25
      QuantiTect SYBR Green Assays in human, mouse, rat RBM25
      QuantiFast Probe-based Assays in human, mouse, rat RBM25

    Additional mRNA sequence: 

    AK026107.1 AK094697.1 AK125513.1 AL833497.1 BC033664.1 BC062440.1 BC083496.1 BC111066.1 
    BC113389.1 BC113391.1 BC136775.1 BC136776.1 BC144407.1 BX647116.1 L40392.1 Y12017.1 

    Selected DOTS entries (see all 25):

    DT.100764307  DT.87011249  DT.120764171  DT.95160488  DT.448745  DT.453963  DT.120764199  DT.120764212 
    DT.95160494  DT.92440705  DT.95230724  DT.97764494  DT.95160497  DT.100868422  DT.120764210  DT.95160501 
    DT.100675203  DT.120764185  DT.92005317  DT.95101833  DT.95160489  DT.100868417  DT.40294589  DT.95352806 

    Selected AceView cDNA sequences (see all 418):

    AA256511 AW150014 BI019882 AA806383 AA436183 BE466128 BM916757 BU686557 
    BX647116 BI496498 BG943432 AI624072 CA312267 AI219472 AA155855 AA628617 
    AA147425 BX103922 AA732593 BM835603 CA941391 AK094697 BG940596 AI636032 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBM25 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^
    SP1:                    -                                                                 -     -                                                               
    SP2:                    -                                                                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RBM25

    Expression
    for RBM25 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBM25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGAGTACT
    RBM25 Expression
    About this image


    RBM25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uterus (Reproductive System)
     
     Spleen (Hematopoietic System)
    RBM25 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    RBM25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531106
        Custom PCR Arrays for RBM25
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for RBM25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM25
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM25

    Orthologs
    for RBM25 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RBM25 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rbm255 RNA binding motif protein 25   --   12 (38.81 cM) 83631236 
    chicken
    (Gallus gallus)    		 Aves RBM251 RNA binding motif protein 25 83.7(n)
    95.71(a)    		   423250  NM_001199684.1  NP_001186613.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RBM256
    		 RNA binding motif protein 25
    		 96(a)
    		 1 ↔ 1
    		 1(38904591-38933505)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.19182 Xenopus laevis, clone IMAGE4930521, mRNA, partial cds 78.05(n)    BC045216.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC045992.12   -- 74.49(n)   327336  BC045992.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG41196
    		 --
    		 34(a)
    		 1 ↔ 1
    		 X(5560127-5564586)
    worm
    (Caenorhabditis elegans)    		 Secernentea W04D2.66
    		 Protein W04D2.6, isoform a (W04D2.6) mRNA, complet...
    		 35(a)
    		 1 ↔ 1
    		 V(12498255-12503744) WBGene00012245


    ENSEMBL Gene Tree for RBM25 (if available)
    TreeFam Gene Tree for RBM25 (if available)

    Paralogs
    for RBM25 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    		  --

    Genomic Variants
    for RBM25 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for RBM25 (see all 1429)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1881963201,2
    		--73523224(+) AAATAA/GGCACA 1 -- us2k10--------
    rs101352581,2
    		C,F--73523308(+) gaggtC/Taggag 1 -- us2k1 tfbs31Minor allele frequency- T:0.06WA 118
    rs101354451,2
    		C,F--73523310(+) ggtcaG/Agagtt 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1929585731,2
    		--73523392(+) CCCACA/GCCTAT 1 -- us2k10--------
    rs1428714101,2
    		C--73523464(+) AGTGAA/GCCAAG 1 -- us2k10--------
    rs1508039881,2
    		--73523757(+) GTATAC/GAAGGA 1 -- us2k10--------
    rs711097931,2
    		C--73523879(-) AAAAA-/AAAAG/A
    AAAGAAAAG    AAAAG     		1 -- us2k11NA 2
    rs111590071,2
    		C--73523880(+) CTTTTC/TTTTTG 1 -- us2k1 trp30--------
    rs124331571,2
    		C,F,A,H--73523898(+) GTCTCG/ACTTTG 1 -- us2k14Minor allele frequency- A:0.50NA WA 10
    rs788156501,2
    		C,F--73524193(+) ACAAAT/CATTTA 1 -- us2k13Minor allele frequency- C:0.10WA NA EA 358

    HapMap Linkage Disequilibrium report for RBM25 (73525144 - 73588122 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RBM25:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677511CNV Deletion23128226
    esv2748862CNV Deletion23290073
    esv2748864CNV Deletion23290073
    esv2658707CNV Deletion23128226
    esv2669446CNV Deletion23128226
    esv27604CNV Loss19812545
    esv33255CNV Loss17666407
    esv27860CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM25
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM25

    Disorders / Diseases
    for RBM25 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    		 OMIM gene information: 612427    OMIM disorders: --


    Find genes that share disorders with RBM25           About GenesLikeMe


    Export disorders for RBM25 gene to outside databases

    Publications
    for RBM25 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for RBM25 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with RBM25)

    1. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2, 3 Sherrington R....St George-Hyslop P.H. (Nature 1995)
    2. Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region. (PubMed id 23190262)1, 2 Gong D....Shi Y. (Biochem. J. 2013)
    3. Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure. (PubMed id 21859973)1, 2 Gao G....Dudley S.C. (Circulation 2011)
    4. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. (PubMed id 18663000)1, 2 Zhou A.... Huang S.C. (Mol. Cell. Biol. 2008)
    5. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    6. Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. (PubMed id 17560998)1, 2 Fortes P.... Blencowe B.J. (FEBS Lett. 2007)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    External Searches for RBM25 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing RBM25 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58517 HGNC: 23244 AceView: RBM25 Ensembl:ENSG00000119707 euGenes: HUgn58517
    ECgene: RBM25 Kegg: 58517 H-InvDB: RBM25

    Other Databases showing RBM25 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RBM25 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBM25 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RBM25 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RBM25 gene:
    Search GeneIP for patents involving RBM25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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