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Aliases for RBM24 Gene

Aliases for RBM24 Gene

  • RNA Binding Motif Protein 24 2 3 5
  • RNA-Binding Region (RNP1, RRM) Containing 6 2 3
  • RNA-Binding Region-Containing Protein 6 3 4
  • RNPC6 3 4
  • RNA-Binding Motif Protein 24 4
  • RNA-Binding Protein 24 3
  • DJ259A10.1 3

External Ids for RBM24 Gene

Previous HGNC Symbols for RBM24 Gene

  • RNPC6

Previous GeneCards Identifiers for RBM24 Gene

  • GC06P017390
  • GC06P017391

Summaries for RBM24 Gene

GeneCards Summary for RBM24 Gene

RBM24 (RNA Binding Motif Protein 24) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and mRNA 3-UTR binding. An important paralog of this gene is RBM38.

UniProtKB/Swiss-Prot for RBM24 Gene

  • Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3-UTR of MYOG mRNA and regulates its stability.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM24 Gene

Genomics for RBM24 Gene

Regulatory Elements for RBM24 Gene

Enhancers for RBM24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G017276 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.8 -1.0 -1044 7.6 ZFP64 SIN3A ZNF48 RAD21 ZNF335 GLIS2 SCRT2 FOS CEBPB TGIF2 CAP2 RBM24 STMND1 LOC101928463
GH06G017311 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +30.7 30663 2.0 HNRNPUL1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 PAF1 SP5 RBM24 CAP2 GC06P017304 LOC100421092
GH06G017304 1 ENCODE dbSUPER 11.9 +24.2 24208 1.3 SOX13 TAL1 ZNF644 TCF12 ZNF766 GATA2 ELK1 NCOR1 TRIM24 ZNF584 RBM24 CAP2 GC06P017304 LOC100421092
GH06G017454 0.7 ENCODE dbSUPER 11 +173.4 173354 1.1 NFIC NFIA PRDM4 CAP2 RBM24 LOC101928491
GH06G017211 0.5 Ensembl ENCODE 11 -68.7 -68694 1.5 RBM24 LOC101928463
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM24 on UCSC Golden Path with GeneCards custom track

Promoters for RBM24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000194125 354 2201 ZFP64 SIN3A ZNF48 RAD21 ZNF335 GLIS2 TGIF2 ZNF341 KDM1A ZBTB26

Genomic Location for RBM24 Gene

Chromosome:
6
Start:
17,281,346 bp from pter
End:
17,293,875 bp from pter
Size:
12,530 bases
Orientation:
Plus strand

Genomic View for RBM24 Gene

Genes around RBM24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM24 Gene

Proteins for RBM24 Gene

  • Protein details for RBM24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX46-RBM24_HUMAN
    Recommended name:
    RNA-binding protein 24
    Protein Accession:
    Q9BX46
    Secondary Accessions:
    • E9PAY4
    • Q6QDA4
    • Q8N9D3
    • Q96NI3

    Protein attributes for RBM24 Gene

    Size:
    236 amino acids
    Molecular mass:
    24776 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04474.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM24 Gene

Post-translational modifications for RBM24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM24 Gene

Domains & Families for RBM24 Gene

Gene Families for RBM24 Gene

Protein Domains for RBM24 Gene

Suggested Antigen Peptide Sequences for RBM24 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM24: view

No data available for UniProtKB/Swiss-Prot for RBM24 Gene

Function for RBM24 Gene

Molecular function for RBM24 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3-UTR of MYOG mRNA and regulates its stability.

Gene Ontology (GO) - Molecular Function for RBM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003730 mRNA 3-UTR binding ISS --
genes like me logo Genes that share ontologies with RBM24: view
genes like me logo Genes that share phenotypes with RBM24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM24 Gene

Localization for RBM24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM24 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM24 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RBM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RBM24: view

Pathways & Interactions for RBM24 Gene

SuperPathways for RBM24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010830 regulation of myotube differentiation ISS --
GO:0030154 cell differentiation IEA --
GO:0043488 regulation of mRNA stability ISS --
genes like me logo Genes that share ontologies with RBM24: view

No data available for Pathways by source and SIGNOR curated interactions for RBM24 Gene

Drugs & Compounds for RBM24 Gene

No Compound Related Data Available

Transcripts for RBM24 Gene

Unigene Clusters for RBM24 Gene

RNA binding motif protein 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM24 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for RBM24 Gene

GeneLoc Exon Structure for
RBM24
ECgene alternative splicing isoforms for
RBM24

Expression for RBM24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM24 Gene

mRNA differential expression in normal tissues according to GTEx for RBM24 Gene

This gene is overexpressed in Muscle - Skeletal (x20.0), Heart - Atrial Appendage (x8.6), and Heart - Left Ventricle (x7.7).

Protein differential expression in normal tissues from HIPED for RBM24 Gene

This gene is overexpressed in Bone (44.8) and Heart (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM24 Gene



Protein tissue co-expression partners for RBM24 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM24 Gene:

RBM24

SOURCE GeneReport for Unigene cluster for RBM24 Gene:

Hs.519904

Evidence on tissue expression from TISSUES for RBM24 Gene

  • Nervous system(4.2)
  • Muscle(3.4)
  • Heart(2.9)
genes like me logo Genes that share expression patterns with RBM24: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM24 Gene

Orthologs for RBM24 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM24 34 35
  • 99.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RBM24 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM24 34 35
  • 92.53 (n)
cow
(Bos Taurus)
Mammalia RBM24 34 35
  • 90.68 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM24 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm24 34 16 35
  • 88.7 (n)
rat
(Rattus norvegicus)
Mammalia Rbm24 34
  • 88.14 (n)
chicken
(Gallus gallus)
Aves RBM24 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM24 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm24 34
  • 80.24 (n)
MGC75808 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52530 34
zebrafish
(Danio rerio)
Actinopterygii rbm24a 34 35
  • 71.76 (n)
worm
(Caenorhabditis elegans)
Secernentea sup-12 35
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10652 35
  • 50 (a)
OneToMany
Species where no ortholog for RBM24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM24 Gene

ENSEMBL:
Gene Tree for RBM24 (if available)
TreeFam:
Gene Tree for RBM24 (if available)

Paralogs for RBM24 Gene

Paralogs for RBM24 Gene

(2) SIMAP similar genes for RBM24 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBM24: view

Variants for RBM24 Gene

Sequence variations from dbSNP and Humsavar for RBM24 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000044571 -- 17,282,621(+) CCCCC(A/C)CGCCC intron-variant, upstream-variant-2KB
rs1000099957 -- 17,282,037(+) GGAGG(A/G/T)TTGCG intron-variant, upstream-variant-2KB
rs1000213047 -- 17,285,404(+) TTGCC(A/T)TGGGA intron-variant
rs1000330230 -- 17,288,012(+) TAATG(A/T)TAAGG intron-variant
rs1000532626 -- 17,283,916(+) GGATT(A/T)TTTAC intron-variant, upstream-variant-2KB

Variation tolerance for RBM24 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RBM24 Gene

Disorders for RBM24 Gene

Relevant External Links for RBM24

Genetic Association Database (GAD)
RBM24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM24

No disorders were found for RBM24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM24 Gene

Publications for RBM24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells. (PMID: 26844700) Cardinali B. … Falcone G. (Cell Death Dis 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RBM24 Gene

Sources for RBM24 Gene

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