RBM24 Gene
protein-coding GIFtS : 48
GCID: GC06 P017281
RNA binding motif protein 24 (Previous names: RNA-binding region (RNP1, RRM) containing 6 ) (Previous symbol: RNPC6 )
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Aliasesfor RBM24 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RNA Binding Motif Protein 24 1 2 RNA-Binding Motif Protein 242 3 RNPC61 2 3 RNA-Binding Region-Containing Protein 62 3 DJ259A10.11 FLJ308291 RNA-Binding Region (RNP1, RRM) Containing 61 2 RNA-Binding Protein 242
Export aliases for RBM24 gene to outside databases Previous GC identifers: GC06P017390 GC06P017391
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Summariesfor RBM24 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RBM24_HUMAN, Q9BX46 Function : Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA andregulates its stability
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Genomic Viewsfor RBM24 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RBM24 gene promoter: NF-AT4 Ik-2 CUTL1 NF-AT1 NF-AT Evi-1 Other transcription factors Search SABiosciences Chromatin IP Primers for RBM24 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RBM24
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p22.3 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3 RBM24 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P017281: view genomic region
(about GC identifiers )
Start:
17,281,577 bp from pter
End:
17,294,106 bp from pter
Size:
12,530 bases
Orientation:
plus strand
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Proteinsfor RBM24 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RBM24_HUMAN, Q9BX46 (See
protein sequence )Recommended Name: RNA-binding protein 24 Size : 236 amino acids; 24776 Da
Subcellular location : Nucleus (By similarity). Cytoplasm (By similarity)
Sequence caution : Sequence=BAC04474.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions : Q6QDA4 Q8N9D3 Q96NI3Alternative splicing : 2 isoforms : Q9BX46-1 Q9BX46-2 Explore the universe of human proteins at neXtProt for RBM24: NX_Q9BX46 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BX46 RBM24 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts):
NP_001137413.1 NP_001137414.1 NP_694565.1 ENSEMBL proteins: ENSP00000368341 ENSP00000426222 ENSP00000396898 ENSP00000421971 ENSP00000319551 Human Recombinant Protein Products for RBM24: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
RBM24 for ontologies About GeneDecksing RBM24 Antibody Products: Assay Products for RBM24:
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Protein
Domains / Familiesfor RBM24 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RBM24 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9BX46 ProtoNet protein and cluster: Q9BX46
1 Blocks protein family : IPB000504 RNA-binding region RNP-1 (RNA recognition motif) UniProtKB/Swiss-Prot: RBM24_HUMAN, Q9BX46 Similarity : Contains 1 RRM (RNA recognition motif) domain
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Functionfor RBM24 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: RBM24_HUMAN, Q9BX46 Function : Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA andregulates its stability
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
RBM24 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for RBM24 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RBM24 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RBM24 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): RBM24 (NM_001143942 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM24 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBM24
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM24
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Pathways & Interactionsfor RBM24 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM24 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for RBM24 (Q9BX46 2 , 3 ENSP00000368341 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0010830 regulation of myotube differentiation
ISS -- GO:0030154 cell differentiation
IEA -- GO:0043488 regulation of mRNA stability
ISS --
RBM24 for ontologies About GeneDecksing
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Drugs & Compoundsfor RBM24 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RBM24 Search CenterWatch for drugs/clinical trials and news about RBM24
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Transcriptsfor RBM24 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RBM24 gene (3 alternative transcripts): NM_001143941.1 NM_001143942.1 NM_153020.2 Unigene Cluster for RBM24:
RNA binding motif protein 24 Hs.519904 [show with all ESTs ] Unigene Representative Sequence: AL832199 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000379052 (uc003nbz.4 uc003nby.4 uc011dix.2 uc011diy.2 uc011diz.2 )ENST00000509686 ENST00000425446 ENST00000503965 ENST00000318204 (uc003nca.3 )ENST00000504055 ENST00000510826 ENST00000508508 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RBM24 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RBM24 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): RBM24 (NM_001143942 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM24 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBM24
Additional cDNA sequence: AK055391.1 AK129865.1 AK293052.1 AK300062.1 AK300068.1 AK315856.1 AL832199.1 AL833156.1 AY547318.1 BC018674.1 BC040928.1 BC065748.1 BC104808.1 BC104810.1
7 DOTS entries : DT.100751667 DT.414885
DT.95216905 DT.100021820 DT.102835983 DT.100751668 DT.75178619 24/67 AceView cDNA sequences (see all 67 ):
AK129865 AL698745 BC040928 AK055391 NM_153020 CB161111 AW085159 CA313161 BX089225 BQ005101 BC018674 CD676911 AA349721 BC065748 BU684757 N39066 AI218069 AI744574 AI701706 AL832199 BF790525 T19603 BU853754 N56044 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for RBM24 About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b SP1 :     -       -         SP2 :     -       -   -       SP3 :           -   -       SP4 :             -      
ECgene alternative splicing isoforms for RBM24
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Expression for RBM24 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RBM24 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACTCTCCTGTAbout this image RBM24 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See RBM24 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RBM24 SOURCE GeneReport for Unigene cluster: Hs.519904 SABiosciences Custom PCR Arrays for RBM24 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RBM24Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RBM24 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RBM24 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RBM24 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM24
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Orthologsfor RBM24 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBM24 gene from 8/22 species (see all 22 ) About this table
ENSEMBL Gene Tree for RBM24 (if available)TreeFam Gene Tree for RBM24 (if available)
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Paralogsfor RBM24 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RBM24 gene RBM38 2 2 SIMAP similar genes for RBM24 using alignment to 5 protein entries: RBM24_HUMAN (see all proteins ):RBM38 RNPC1
RBM24 for paralogs About GeneDecksing
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Genomic Variantsfor RBM24 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RBM24 (17281577 - 17294106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RBM24: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RBM24
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Disorders
/ Diseasesfor RBM24 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RBM24 for disorders About GeneDecksing 1 disease for RBM24 : About MalaCards ataxia Export disorders for RBM24 gene to outside databases
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Publicationsfor RBM24 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RBM24 gene integrated from 9 sources : (articles sorted by number of sources associating them with RBM24) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470) 1 Ovsyannikova I.G....Poland G.A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiation. (PubMed id 20977548) 2 Jin D.... Morisaki T. (2010) RNA-binding proteins Rbm38 and Rbm24 regulate myogeni c differentiation via p21-dependent and -independent regulatory pathways. (PubMed id 19817877) 1 Miyamoto S....Morisaki T. (2009) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569) 1 Lim J.... Zoghbi H.Y. (2006) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 1 Suzuki Y.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RBM24 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RBM24 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RBM24 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RBM24 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RBM24 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RBM24 gene: Search GeneIP for patents involving RBM24 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RBM24 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RBM24 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RBM24 OriGene Protein Over-expression Lysate for RBM24 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RBM24 OriGene 3'-UTR Clone for RBM24 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RBM24 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RBM24 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RBM24 OriGene Custom Protein Services for RBM24 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBM24 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RBM24 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RBM24 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RBM24 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RBM24 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RBM24
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RBM24 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM24
ThermoFisher Antibody for RBM24
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBM24
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Aliases for RBM24
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Disorders / Diseases for RBM24
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Expression for RBM24
Function for RBM24
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