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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBM24 Gene

protein-coding   GIFtS: 48
GCID: GC06P017281

RNA binding motif protein 24

(Previous names: RNA-binding region (RNP1, RRM) containing 6 )
(Previous symbol: RNPC6)
 Explore 1 disease affiliated with
RBM24 via our new
 Human Malady Compendium 
Biological research products
for RBM24
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RNA Binding Motif Protein 241 2     RNA-Binding Motif Protein 242 3
RNPC61 2 3     RNA-Binding Region-Containing Protein 62 3
DJ259A10.11     FLJ308291
RNA-Binding Region (RNP1, RRM) Containing 61 2     RNA-Binding Protein 242

External Ids:    HGNC: 215391   Entrez Gene: 2216622   Ensembl: ENSG000001121837   UniProtKB: Q9BX463   

Export aliases for RBM24 gene to outside databases

Previous GC identifers: GC06P017390 GC06P017391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RBM24_HUMAN, Q9BX46
Function: Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA and
regulates its stability




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBM24 gene promoter:
         NF-AT4   Ik-2   CUTL1   NF-AT1   NF-AT   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM24 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBM24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

RBM24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM24 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P017281:  view genomic region     (about GC identifiers)

Start:
17,281,577 bp from pter      End:
17,294,106 bp from pter
Size:
12,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBM24_HUMAN, Q9BX46 (See protein sequence)
Recommended Name: RNA-binding protein 24  
Size: 236 amino acids; 24776 Da
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)
Sequence caution: Sequence=BAC04474.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: Q6QDA4 Q8N9D3 Q96NI3
Alternative splicing: 2 isoforms:  Q9BX46-1   Q9BX46-2   

Explore the universe of human proteins at neXtProt for RBM24: NX_Q9BX46

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BX46

  • RBM24 Protein expression data from MOPED and PaxDb:    About this image 
    RBM24 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001137413.1  NP_001137414.1  NP_694565.1  

    ENSEMBL proteins: 
     ENSP00000368341   ENSP00000426222   ENSP00000396898   ENSP00000421971   ENSP00000319551  

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    Uscn Proteins for RBM24

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    RBM24 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RBM24 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9BX46

    ProtoNet protein and cluster: Q9BX46

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM24_HUMAN, Q9BX46
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM24_HUMAN, Q9BX46
    Function: Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA and
    regulates its stability

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003730mRNA 3'-UTR binding ISS--
         
    RBM24 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBM24:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RBM24 

    miRNA
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    hsa-miR-124* hsa-miR-323-3p hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidRBM24 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM24


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM24

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RBM24 (Q9BX462, 3 ENSP000003683414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBFOX1Q9NWB12, 3, ENSP000003091174MINT-2879176 I2D: score=3 STRING: ENSP00000309117
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010830regulation of myotube differentiation ISS--
    GO:0030154cell differentiation IEA--
    GO:0043488regulation of mRNA stability ISS--

    RBM24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBM24
    Search CenterWatch for drugs/clinical trials and news about RBM24 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RBM24 gene (3 alternative transcripts): 
    NM_001143941.1  NM_001143942.1  NM_153020.2  

    Unigene Cluster for RBM24:

    RNA binding motif protein 24
    Hs.519904  [show with all ESTs]
    Unigene Representative Sequence: AL832199
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379052(uc003nbz.4 uc003nby.4 uc011dix.2 uc011diy.2 uc011diz.2)
    ENST00000509686 ENST00000425446 ENST00000503965 ENST00000318204(uc003nca.3)
    ENST00000504055 ENST00000510826 ENST00000508508

    miRNA
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    8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate RBM24 (see all 99):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidRBM24 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK055391.1 AK129865.1 AK293052.1 AK300062.1 AK300068.1 AK315856.1 AL832199.1 AL833156.1 
    AY547318.1 BC018674.1 BC040928.1 BC065748.1 BC104808.1 BC104810.1 

    7 DOTS entries:

    DT.100751667  DT.414885  DT.95216905  DT.100021820  DT.102835983  DT.100751668  DT.75178619 

    24/67 AceView cDNA sequences (see all 67):

    AK129865 AL698745 BC040928 AK055391 NM_153020 CB161111 AW085159 CA313161 
    BX089225 BQ005101 BC018674 CD676911 AA349721 BC065748 BU684757 N39066 
    AI218069 AI744574 AI701706 AL832199 BF790525 T19603 BU853754 N56044 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RBM24    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -                 -                     
    SP2:              -                 -     -               
    SP3:                                -     -               
    SP4:                                      -               


    ECgene alternative splicing isoforms for RBM24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBM24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTCTCCTGT
    RBM24 Expression
    About this image

    RBM24 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Mesoderm-like cells (Derivation of cardio...)
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)

    See RBM24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBM24

    SOURCE GeneReport for Unigene cluster: Hs.519904
        SABiosciences Custom PCR Arrays for RBM24
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM24 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RBM246
    RNA binding motif protein 24
    65(a)
    1 ↔ 1
    2(63053768-63064866)
    lizard
    (Anolis carolinensis)
    Reptilia RBM246
    RBM386
    --
    98(a)
    69(a)
    1 ↔ 1
    possible ortholog
    4(58991550-59012234)
    GL343217.1(1133163-1167833)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525302 similar to RNA-binding region (RNP1, RRM) containing more 81.29(n)    BC044956.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rbm24a1 RNA binding motif protein 24a 73.07(n)
    86.46(a)
      405801  NM_212865.1  NP_998030.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    45(a)
    1 → many
    Group10.7(159783-178854)
    worm
    (Caenorhabditis elegans)
    Secernentea sup-121 Protein SUP-12 60.41(n)
    61.33(a)
      180674  NM_076273.3  NP_508674.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G208801 RNA recognition motif-containing protein 46.22(n)
    40.44(a)
      838681  NM_101941.2  NP_564127.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07140001 hypothetical protein 52.59(n)
    46.67(a)
      4330510  NM_001054451.1  NP_001047916.1 


    ENSEMBL Gene Tree for RBM24 (if available)
    TreeFam Gene Tree for RBM24 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBM24 gene
    RBM382  
    2 SIMAP similar genes for RBM24 using alignment to 5 protein entries:     RBM24_HUMAN (see all proteins):
    RBM38    RNPC1

    RBM24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 NCBI SNPs in RBM24 are shown (see all 205    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855340101,2
    --17279849(+) TGTTTC/TGCACA 1 -- us2k10--------
    rs1895311211,2
    --17279862(+) AATATC/TTGCAT 1 -- us2k10--------
    rs1434048151,2
    --17279885(+) TTGCAA/CATGCA 1 -- us2k10--------
    rs1810176791,2
    --17279915(+) GTTGAC/TTGCAA 1 -- us2k10--------
    rs1862169851,2
    --17279947(+) AGTATC/GCACCT 1 -- us2k10--------
    rs1472268381,2
    --17279959(+) TCTAAA/CGGTTA 1 -- us2k10--------
    rs1920710941,2
    --17280033(+) AGACTC/TCCGTA 1 -- us2k10--------
    rs1406359031,2
    --17280110(+) TTTCAC/TCCAAA 1 -- us2k10--------
    rs1835723681,2
    --17280291(+) AATTAC/TACCTT 1 -- us2k10--------
    rs1384206281,2
    C--17280391(+) TAGGG-/AAAAAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RBM24 (17281577 - 17294106 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RBM24: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM24
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RBM24 for disorders           About GeneDecksing

    1 disease for RBM24:    About MalaCards
    ataxia


    Export disorders for RBM24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBM24 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RBM24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470)1 Ovsyannikova I.G....Poland G.A. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiation. (PubMed id 20977548)2 Jin D.... Morisaki T. (2010)
    7. RNA-binding proteins Rbm38 and Rbm24 regulate myogeni c differentiation via p21-dependent and -independent regulatory pathways. (PubMed id 19817877)1 Miyamoto S....Morisaki T. (2009)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221662 HGNC: 21539 AceView: RBM24 Ensembl:ENSG00000112183 euGenes: HUgn221662
    ECgene: RBM24 H-InvDB: RBM24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBM24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RBM24 gene:
    Search GeneIP for patents involving RBM24

    GeneCards and IP:
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