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RBM23 Gene

protein-coding   GIFtS: 53
GCID: GC14M023369

RNA Binding Motif Protein 23

(Previous names: RNA-binding region (RNP1, RRM) containing 4)
(Previous symbol: RNPC4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif Protein 231 2     RNA-Binding Motif Protein 232 3
RNPC41 2 3     RNA-Binding Region-Containing Protein 42 3
RNA-Binding Region (RNP1, RRM) Containing 41 2     CAPERbeta2
Splicing Factor SF22 3     Probable RNA-Binding Protein 232

External Ids:    HGNC: 201551   Entrez Gene: 551472   Ensembl: ENSG000001004617   UniProtKB: Q86U063   

Export aliases for RBM23 gene to outside databases

Previous GC identifers: GC14M021361 GC14M022439 GC14M003486


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBM23 Gene:
This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some
steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription
of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the
steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RBM23 Gene:
RBM23 (RNA binding motif protein 23) is a protein-coding gene. Diseases associated with RBM23 include hemoglobin e disease. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM39.

UniProtKB/Swiss-Prot: RBM23_HUMAN, Q86U06
Function: Probable RNA-binding protein. May be involved in pre-mRNA splicing process

Gene Wiki entry for RBM23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM23 gene promoter:
         HOXA9   HOXA9B   NRF-2   c-Myb   MyoD   POU3F2   ATF   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM23 promoter sequence
   Search Chromatin IP Primers for RBM23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RBM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM23 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023369:  view genomic region     (about GC identifiers)

Start:
23,369,854 bp from pter      End:
23,388,396 bp from pter
Size:
18,543 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBM23_HUMAN, Q86U06 (See protein sequence)
Recommended Name: Probable RNA-binding protein 23  
Size: 439 amino acids; 48731 Da
2 PDB 3D structures from and Proteopedia for RBM23:
2CQ4 (3D)        2DNZ (3D)    
Secondary accessions: D3DS32 Q8ND16 Q8TB88 Q8WY40 Q9BUJ1 Q9NVV7
Alternative splicing: 5 isoforms:  Q86U06-1   Q86U06-2   Q86U06-3   Q86U06-4   Q86U06-5   

Explore the universe of human proteins at neXtProt for RBM23: NX_Q86U06

Explore proteomics data for RBM23 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys245
  • Modification sites at PhosphoSitePlus

  • See RBM23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070819.1  NP_001070820.1  NP_060577.3  

    ENSEMBL proteins: 
     ENSP00000452602   ENSP00000352956   ENSP00000382806   ENSP00000339220   ENSP00000438504  
     ENSP00000451642   ENSP00000451838   ENSP00000452171   ENSP00000450556   ENSP00000450423  
     ENSP00000452583   ENSP00000450558   ENSP00000451364   ENSP00000452382   ENSP00000452557  
     ENSP00000451403   ENSP00000451448   ENSP00000450672   ENSP00000452538  

    RBM23 Human Recombinant Protein Products:

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    OriGene Purified Protein for RBM23
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    Novus Biologicals RBM23 Protein
    Novus Biologicals RBM23 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RBM23

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    Cloud-Clone Corp. CLIAs for RBM23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR006509 CC1_SF
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q86U06

    ProtoNet protein and cluster: Q86U06

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM23_HUMAN, Q86U06
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    RBM23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM23_HUMAN, Q86U06
    Function: Probable RNA-binding protein. May be involved in pre-mRNA splicing process

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
         
    RBM23 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RBM23:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM23
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBM23
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBM23

    miRNA
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    miRTarBase miRNAs that target RBM23:
    hsa-mir-93-5p (MIRT048779)

    Block miRNA regulation of human, mouse, rat RBM23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM23 (see all 23):
    hsa-miR-1178 hsa-miR-34b* hsa-miR-188-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-650 hsa-miR-133a hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidRBM23 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RBM23
    Predesigned siRNA for gene silencing in human, mouse, rat RBM23

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): RBM23 (NM_001077351)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM23

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RBM23 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBM23_HUMAN, Q86U06: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    RBM23 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM23
    Interactions:

        Search GeneGlobe Interaction Network for RBM23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBM23 (Q86U061, 2, 3 ENSP000003529564) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT5O147441, 2, ENSP000003191694EBI-780319,EBI-351098 MINT-8335275 STRING: ENSP00000319169
    GTF3C1Q127892, 3MINT-64811 I2D: score=4 
    KIAA1377Q9P2H02, 3MINT-64813 I2D: score=4 
    MED31Q9Y3C72, 3MINT-64814 I2D: score=4 
    POLA2Q141812, 3MINT-64812 I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--

    RBM23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM23



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RBM23 gene (3 alternative transcripts): 
    NM_001077351.1  NM_001077352.1  NM_018107.4  

    Unigene Cluster for RBM23:

    RNA binding motif protein 23
    Hs.4997  [show with all ESTs]
    Unigene Representative Sequence: NM_001077351
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000555209 ENST00000359890(uc001whh.3 uc001whg.3 uc001whi.3 uc010tne.2 uc001whj.3)
    ENST00000557667(uc001whk.1) ENST00000399922 ENST00000346528 ENST00000542016
    ENST00000553884 ENST00000556838 ENST00000557245 ENST00000557127 ENST00000307814
    ENST00000556186 ENST00000557403 ENST00000553738 ENST00000555722 ENST00000553920
    ENST00000557227 ENST00000555714
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RBM23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM23 (see all 23):
    hsa-miR-1178 hsa-miR-34b* hsa-miR-188-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-650 hsa-miR-133a hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidRBM23 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RBM23
    Predesigned siRNA for gene silencing in human, mouse, rat RBM23
    Clone
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    OriGene clones in human, mouse for RBM23 (see all 17)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RBM23 (NM_001077351)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM23
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RBM23
    OriGene qSTAR qPCR primer pairs in human, mouse for RBM23
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RBM23
      QuantiTect SYBR Green Assays in human, mouse, rat RBM23
      QuantiFast Probe-based Assays in human, mouse, rat RBM23

    Additional mRNA sequence: 

    AF087905.1 AF275678.1 AK001344.1 AK225792.1 AK295448.1 AK303668.1 AK308055.1 AK315620.1 
    BC002566.2 BC024208.2 BC106012.1 BX161440.1 CR457257.1 

    Selected DOTS entries (see all 44):

    DT.443879  DT.101985380  DT.100807889  DT.120777714  DT.100758647  DT.97770980  DT.92464975  DT.120777811 
    DT.95375569  DT.100887518  DT.100887517  DT.100887519  DT.100887524  DT.100887548  DT.92464976  DT.100031739 
    DT.100887533  DT.102830572  DT.120777863  DT.91984397  DT.100887535  DT.100738150  DT.100887545  DT.92464968 

    Selected AceView cDNA sequences (see all 494):

    BX161440 AI418588 BM684088 BE205911 BU685069 BM929858 T32442 CN483101 
    AI018520 CR594554 AI566649 AI879789 AA449830 AI248796 CF132016 BU846348 
    BE019385 AI189421 BU618908 AI374956 AW583374 AW771177 AW583432 CR602590 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBM23 (see all 23)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^
    SP1:                          -                       -     -     -           -     -     -           -                                                         
    SP2:                          -                       -     -                 -     -     -           -                                                         
    SP3:                          -     -     -     -     -     -     -           -     -     -           -                                                         
    SP4:                                                  -     -     -           -     -     -     -     -                                                         
    SP5:                          -           -     -     -     -     -           -     -     -           -                                                         

    ExUns: 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18
    SP1:        -     -     -                                       
    SP2:                                                            
    SP3:        -     -     -                                       
    SP4:        -     -     -                                       
    SP5:                                                            


    ECgene alternative splicing isoforms for RBM23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBM23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGAGCCCT
    RBM23 Expression
    About this image


    RBM23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    RBM23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4997
        Custom PCR Arrays for RBM23
    Primer
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    OriGene qPCR primer pairs and template standards for RBM23
    OriGene qSTAR qPCR primer pairs in human, mouse for RBM23
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    QuantiTect SYBR Green Assays in human, mouse, rat RBM23
    QuantiFast Probe-based Assays in human, mouse, rat RBM23
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RBM23 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia RBM231 RNA binding motif protein 23 87.02(n)
    90.89(a)
      480241  XM_005623219.1  XP_005623276.1 
    lizard
    (Anolis carolinensis)
    Reptilia RBM236
    RNA binding motif protein 23
    68(a)
    1 ↔ 1
    GL343879.1(38822-52371)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rbm231 RNA binding motif protein 23 65.12(n)
    72.13(a)
      100144745  XM_002941510.2  XP_002941556.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112666
    --
    36(a)
    1 → many
    2L(7032713-7037916)
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3AM.36
    Protein Y55F3AM.3, isoform a
    29(a)
    1 → many
    IV(1012652-1019558) WBGene00021921
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP136
    RNA156
    Nucleolar protein found in preribosomal complexes;...
    Component of the cleavage and polyadenylation fact...
    21(a)
    14(a)
    many ↔ many
    many ↔ many
    XIV(307401-308612) YNL175C
    VII(416146-417036) YGL044C


    ENSEMBL Gene Tree for RBM23 (if available)
    TreeFam Gene Tree for RBM23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBM23 gene
    RBM392  
    13 SIMAP similar genes for RBM23 using alignment to 16 protein entries:     RBM23_HUMAN (see all proteins):
    RNPC4    DKFZp686C17209    DKFZp781I1140    DKFZp781C0423    DKFZp686A11192    RBM39
    CIRBP    RBMY1A1    TIAL1    RBM3    HNRNPD    PABPC4
    HNRNPA1

    RBM23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBM23 (see all 484)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38111851,2
    C,F,A,H--23369378(-) TGTCTA/GCTGTT 3 -- ds500116Minor allele frequency- G:0.24EA NS NA WA CSA 2254
    rs1928365481,2
    --23369399(+) AGAACC/TCTGCT 3 -- ds50010--------
    rs788802821,2
    C,F--23369409(+) TGTTAT/CACAAG 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs341976471,2
    C--23369539(+) CACAA-/C/CC  
            
    CCCCC
    3 -- ds50011CSA 2
    rs668606371,2
    C--23369539(+) CACAA-/CCCCCCC 3 -- ds50012Minor allele frequency- CC:0.25NA 4
    rs2009276131,2
    C--23369549(+) CCCCCC/TCCCCG 3 -- ds50010--------
    rs1838033801,2
    --23369799(+) CCCCAA/CCCAGG 3 -- ds50010--------
    rs783807991,2
    C,F--23369809(+) GTGTGA/TGTTTT 3 -- ds50012Minor allele frequency- T:0.21CSA WA 120
    rs1160364241,2
    F--23369811(+) GTGAGT/CTTTCA 3 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1415230571,2
    C--23369868(+) TAATGC/TTTTAT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RBM23 (23369854 - 23388396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RBM23:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv385e199CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM23
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for RBM23:    
    About MalaCards
    hemoglobin e disease


    RBM23 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: RBM23 (1 document)

    Export disorders for RBM23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBM23 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with RBM23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55147 HGNC: 20155 AceView: RBM23 Ensembl:ENSG00000100461 euGenes: HUgn55147
    ECgene: RBM23 H-InvDB: RBM23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBM23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBM23 gene:
    Search GeneIP for patents involving RBM23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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