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Aliases for RBM22 Gene

Aliases for RBM22 Gene

  • RNA Binding Motif Protein 22 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 16 3 4
  • Functional Spliceosome-Associated Protein 47 2 3
  • RNA-Binding Motif Protein 22 3 4
  • ZC3H16 3 4
  • FSAP47 3
  • Cwc2 3

External Ids for RBM22 Gene

Previous GeneCards Identifiers for RBM22 Gene

  • GC05M150099
  • GC05M150050
  • GC05M145216

Summaries for RBM22 Gene

Entrez Gene Summary for RBM22 Gene

  • This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

GeneCards Summary for RBM22 Gene

RBM22 (RNA Binding Motif Protein 22) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for RBM22 Gene

  • Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.

Gene Wiki entry for RBM22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM22 Gene

Genomics for RBM22 Gene

Regulatory Elements for RBM22 Gene

Promoters for RBM22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM22 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM22 Gene

Chromosome:
5
Start:
150,690,790 bp from pter
End:
150,701,107 bp from pter
Size:
10,318 bases
Orientation:
Minus strand

Genomic View for RBM22 Gene

Genes around RBM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM22 Gene

Proteins for RBM22 Gene

  • Protein details for RBM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW64-RBM22_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor RBM22
    Protein Accession:
    Q9NW64
    Secondary Accessions:
    • A6NDM5
    • B4DLI9
    • O95607

    Protein attributes for RBM22 Gene

    Size:
    420 amino acids
    Molecular mass:
    46896 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm.
    SequenceCaution:
    • Sequence=AAC99998.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM22 Gene

    Alternative splice isoforms for RBM22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM22 Gene

Proteomics data for RBM22 Gene at MOPED

Post-translational modifications for RBM22 Gene

  • Ubiquitination at Lys 78, Lys 114, and Lys 149
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM22 Gene

Antibody Products

No data available for DME Specific Peptides for RBM22 Gene

Domains & Families for RBM22 Gene

Suggested Antigen Peptide Sequences for RBM22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW64

UniProtKB/Swiss-Prot:

RBM22_HUMAN :
  • The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
  • Belongs to the SLT11 family.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the SLT11 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with RBM22: view

Function for RBM22 Gene

Molecular function for RBM22 Gene

UniProtKB/Swiss-Prot Function:
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.

Gene Ontology (GO) - Molecular Function for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0017070 U6 snRNA binding IDA 22246180
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0048306 calcium-dependent protein binding IPI 17045351
genes like me logo Genes that share ontologies with RBM22: view
genes like me logo Genes that share phenotypes with RBM22: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM22 Gene

Localization for RBM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM22 Gene

Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM22 Gene COMPARTMENTS Subcellular localization image for RBM22 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 Prp19 complex IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 21122810
genes like me logo Genes that share ontologies with RBM22: view

Pathways & Interactions for RBM22 Gene

SuperPathways for RBM22 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RBM22: view

Pathways by source for RBM22 Gene

1 KEGG pathway for RBM22 Gene

Gene Ontology (GO) - Biological Process for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033120 positive regulation of RNA splicing IDA 22246180
GO:0035690 cellular response to drug IDA 21122810
GO:0090316 positive regulation of intracellular protein transport IDA 21122810
genes like me logo Genes that share ontologies with RBM22: view

No data available for SIGNOR curated interactions for RBM22 Gene

Drugs & Compounds for RBM22 Gene

No Compound Related Data Available

Transcripts for RBM22 Gene

Unigene Clusters for RBM22 Gene

RNA binding motif protein 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM22 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for RBM22 Gene

GeneLoc Exon Structure for
RBM22
ECgene alternative splicing isoforms for
RBM22

Expression for RBM22 Gene

mRNA expression in normal human tissues for RBM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM22 Gene



SOURCE GeneReport for Unigene cluster for RBM22 Gene Hs.713564

genes like me logo Genes that share expression patterns with RBM22: view

Protein tissue co-expression partners for RBM22 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM22 Gene

Orthologs for RBM22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM22 35
  • 92.7 (n)
  • 99.76 (a)
RBM22 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM22 35
  • 93.73 (n)
  • 100 (a)
RBM22 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm22 35
  • 90 (n)
  • 100 (a)
Rbm22 16
Rbm22 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBM22 35
  • 99.6 (n)
  • 100 (a)
RBM22 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm22 35
  • 89.52 (n)
  • 99.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RBM22 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM22 35
  • 82.94 (n)
  • 97.14 (a)
RBM22 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM22 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76229 35
rbm22 35
  • 76.68 (n)
  • 89.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia cg14641-prov 35
zebrafish
(Danio rerio)
Actinopterygii rbm22 35
  • 75.18 (n)
  • 86.16 (a)
wufc62e03 35
rbm22 36
  • 84 (a)
OneToMany
rbm22 36
  • 84 (a)
OneToMany
RBM22 (3 of 3) 36
  • 84 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004509 35
  • 60.48 (n)
  • 62.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14641 35
  • 60.29 (n)
  • 59.31 (a)
CG14641 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T11G6.8 35
  • 62.17 (n)
  • 59.87 (a)
T11G6.8 36
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM2 36
  • 21 (a)
OneToOne
ECM2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07360 35
  • 57.79 (n)
  • 56.25 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1512 35
barley
(Hordeum vulgare)
Liliopsida Hv.2670 35
rice
(Oryza sativa)
Liliopsida Os.14314 35
Os07g0281000 35
  • 59.57 (n)
  • 59.46 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14515 35
corn
(Zea mays)
Liliopsida Zm.4129 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2969 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8471 36
  • 66 (a)
OneToOne
Species with no ortholog for RBM22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RBM22 Gene

ENSEMBL:
Gene Tree for RBM22 (if available)
TreeFam:
Gene Tree for RBM22 (if available)

Paralogs for RBM22 Gene

genes like me logo Genes that share paralogs with RBM22: view

No data available for Paralogs for RBM22 Gene

Variants for RBM22 Gene

Sequence variations from dbSNP and Humsavar for RBM22 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs11406 -- 150,691,467(+) TTCCA(A/C)TTCAC utr-variant-3-prime
rs33410 -- 150,693,131(-) CATGT(C/T)GCCGC intron-variant
rs252161 -- 150,699,394(+) AGAGA(A/G)AAACA intron-variant
rs384450 -- 150,701,461(-) agaga(C/G)agaga upstream-variant-2KB
rs1128881 -- 150,693,290(-) CAGAG(A/G)AAAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RBM22 Gene

Variant ID Type Subtype PubMed ID
dgv1862e1 CNV Complex 17122850
nsv428129 CNV Loss 18775914
esv33898 CNV Loss 17666407
esv29484 CNV Loss 19812545

Variation tolerance for RBM22 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM22 Gene

HapMap Linkage Disequilibrium report
RBM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM22 Gene

Disorders for RBM22 Gene

Relevant External Links for RBM22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM22

No disorders were found for RBM22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM22 Gene

Publications for RBM22 Gene

  1. The influence of calcium signaling on the regulation of alternative splicing. (PMID: 19133299) Krebs J. (Biochim. Biophys. Acta 2009) 2 3 4 67
  2. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. (PMID: 20013661) He F. … Gou L.T. (Genet. Mol. Res. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RBM22 Gene

Sources for RBM22 Gene

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