Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RBM22 Gene

protein-coding   GIFtS: 52
GCID: GC05M150050

RNA Binding Motif Protein 22

  Search for RBM22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RNA Binding Motif Protein 221 2     RNA-Binding Motif Protein 222 3
Functional Spliceosome-Associated Protein 471 2     Cwc22
Zinc Finger CCCH Domain-Containing Protein 162 3     fSAP472
ZC3H162 3     Pre-MRNA-Splicing Factor RBM222

External Ids:    HGNC: 255031   Entrez Gene: 556962   Ensembl: ENSG000000865897   OMIM: 6124305   UniProtKB: Q9NW643   

Export aliases for RBM22 gene to outside databases

Previous GC identifers: GC05M150099 GC05M145216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RBM22 Gene:
This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved
in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. (provided by RefSeq,
Mar 2009)

GeneCards Summary for RBM22 Gene:
RBM22 (RNA binding motif protein 22) is a protein-coding gene. GO annotations related to this gene include nucleocytoplasmic transporter activity and nucleotide binding.

UniProtKB/Swiss-Prot: RBM22_HUMAN, Q9NW64
Function: Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain
of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of
the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic
calcium-binding protein PDCD6 to the nucleus upon cellular stress responses

Gene Wiki entry for RBM22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM22 gene promoter:
         AML1a   Sp1   XBP-1   NF-kappaB   E4BP4   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM22 promoter sequence
   Search Chromatin IP Primers for RBM22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

RBM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM22 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150050:  view genomic region     (about GC identifiers)

Start:
150,070,352 bp from pter      End:
150,080,669 bp from pter
Size:
10,318 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RBM22_HUMAN, Q9NW64 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor RBM22  
Size: 420 amino acids; 46896 Da
Subunit: Identified in the spliceosome C complex. Interacts with PDCD6; the interaction induces translocation of
PDCD6 in the cytoplasm
Sequence caution: Sequence=AAC99998.1; Type=Miscellaneous discrepancy; Note=Chimera;
1 PDB 3D structure from and Proteopedia for RBM22:
2YTC (3D)    
Secondary accessions: A6NDM5 B4DLI9 O95607
Alternative splicing: 2 isoforms:  Q9NW64-1   Q9NW64-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBM22: NX_Q9NW64

Explore proteomics data for RBM22 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys78, Lys114, Lys149
  • Modification sites at PhosphoSitePlus

  • See RBM22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060517.1  
    ENSEMBL proteins: 
     ENSP00000199814   ENSP00000412118   ENSP00000428154   ENSP00000430946   ENSP00000441594  

    RBM22 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RBM22
    OriGene Protein Over-expression Lysate for RBM22
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RBM22
    GenScript Custom Purified and Recombinant Proteins Services for RBM22
    Novus Biologicals RBM22 Protein
    Novus Biologicals RBM22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RBM22

     
    Search eBioscience for Proteins for RBM22 

    RBM22 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RBM22
    Novus Biologicals RBM22 Antibodies
    Abcam antibodies for RBM22
    Cloud-Clone Corp. Antibodies for RBM22
    ThermoFisher Antibodies for RBM22
    LSBio Antibodies in human, mouse, rat for RBM22

    RBM22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RBM22
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RBM22
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RBM22
    Cloud-Clone Corp. CLIAs for RBM22
    Search eBioscience for ELISAs for RBM22 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9NW64

    ProtoNet protein and cluster: Q9NW64

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB000571 Zn-finger


    UniProtKB/Swiss-Prot: RBM22_HUMAN, Q9NW64
    Domain: The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding (By similarity)
    Similarity: Belongs to the SLT11 family
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with RBM22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM22_HUMAN, Q9NW64
    Function: Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain
    of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of
    the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic
    calcium-binding protein PDCD6 to the nucleus upon cellular stress responses

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005487nucleocytoplasmic transporter activity IDA--
    GO:0008270zinc ion binding ----
         
    Find genes that share ontologies with RBM22           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RBM22:
     Decreased Wnt reporter activit  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM22
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RBM22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBM22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBM22

    miRNA
    Products:
        
    miRTarBase miRNAs that target RBM22:
    hsa-let-7b-5p (MIRT052325), hsa-mir-155-5p (MIRT020871)

    Block miRNA regulation of human, mouse, rat RBM22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM22 (see all 23):
    hsa-miR-3164 hsa-miR-181c hsa-miR-522 hsa-miR-134 hsa-miR-944 hsa-miR-10b* hsa-miR-548x hsa-miR-3118
    SwitchGear 3'UTR luciferase reporter plasmidRBM22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RBM22
    Predesigned siRNA for gene silencing in human, mouse, rat RBM22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RBM22

    Clone
    Products:
         
    OriGene clones in human, mouse for RBM22 (see all 7)
    OriGene ORF clones in mouse, rat for RBM22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RBM22 (NM_018047)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM22

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RBM22
    Browse ESI BIO Cell Lines and PureStem Progenitors for RBM22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RBM22_HUMAN, Q9NW64: Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the
    cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with RBM22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RBM22 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome


    Find genes that share SuperPaths with RBM22           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RBM22):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM22
    Interactions:

        Search GeneGlobe Interaction Network for RBM22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBM22 (Q9NW641, 2, 3 ENSP000001998144) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041561, 3EBI-2602260,EBI-977302 I2D: score=1 
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    RBFOX2O432512, ENSP000004130354MINT-8337035 STRING: ENSP00000413035
    HNRNPUL1Q9BUJ22, ENSP000003758634MINT-8337013 STRING: ENSP00000375863
    AQRO603062, ENSP000001564714MINT-8337002 STRING: ENSP00000156471
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA17045351
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0033120positive regulation of RNA splicing IDA--
    GO:0035690cellular response to drug IDA--
    GO:0045292mRNA cis splicing, via spliceosome IDA--

    Find genes that share ontologies with RBM22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM22



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RBM22 gene: 
    NM_018047.2  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520132 ENST00000199814(uc003lst.3) ENST00000447771 ENST00000522469
    ENST00000518917 ENST00000521248 ENST00000521594 ENST00000521464 ENST00000540000

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RBM22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM22 (see all 23):
    hsa-miR-3164 hsa-miR-181c hsa-miR-522 hsa-miR-134 hsa-miR-944 hsa-miR-10b* hsa-miR-548x hsa-miR-3118
    SwitchGear 3'UTR luciferase reporter plasmidRBM22 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RBM22
    Predesigned siRNA for gene silencing in human, mouse, rat RBM22
    Clone
    Products:
         
    OriGene clones in human, mouse for RBM22 (see all 7)
    OriGene ORF clones in mouse, rat for RBM22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RBM22 (NM_018047)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM22
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RBM22
    OriGene qSTAR qPCR primer pairs in human, mouse for RBM22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM22
      QuantiTect SYBR Green Assays in human, mouse, rat RBM22
      QuantiFast Probe-based Assays in human, mouse, rat RBM22

    Selected AceView cDNA sequences (see all 239):

    CR594318 AA740988 CA392137 AA311840 BE045439 BM677554 BX461829 AW189133 
    BU607915 CA312338 BX118278 AK096728 BU631978 CA428134 AI499996 BQ218028 
    BG230629 BM818100 AU135503 CD743109 AA135875 AW135341 C00913 AL538762 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RBM22    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                                  -     -                           
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for RBM22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RBM22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTACTGT
    RBM22 Expression
    About this image


    RBM22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RBM22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM22 Protein Expression
        Custom PCR Arrays for RBM22
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RBM22
    OriGene qSTAR qPCR primer pairs in human, mouse for RBM22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM22
    QuantiTect SYBR Green Assays in human, mouse, rat RBM22
    QuantiFast Probe-based Assays in human, mouse, rat RBM22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM22 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm221 , 5 RNA binding motif protein 221, 5 90(n)1
    100(a)1
      18 (34.36 cM)5
    668101  NM_025776.21  NP_080052.11 
     605607365 
    chicken
    (Gallus gallus)
    Aves RBM221 RNA binding motif protein 22 82.94(n)
    97.14(a)
      416270  NM_001006151.1  NP_001006151.1 
    lizard
    (Anolis carolinensis)
    Reptilia RBM226
    RNA binding motif protein 22
    98(a)
    1 ↔ 1
    2(138447584-138458949)
    African clawed frog
    (Xenopus laevis)
    Amphibia cg14641-prov2 hypothetical protein MGC53757 78.57(n)    BC045067.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc62e032 wufc62e03 79.09(n)   325253  CF265658.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146411 CG14641 60.29(n)
    59.31(a)
      40529  NM_141183.4  NP_649440.3 
    worm
    (Caenorhabditis elegans)
    Secernentea T11G6.81 T11G6.8 62.17(n)
    59.87(a)
      177979  NM_069613.5  NP_502014.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM2(YBR065C)4 Pre-mRNA splicing factor, facilitates the cooperative more   --   2(369678-368584) 852357  NP_009621.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G073601 AT1G07360 57.79(n)
    56.25(a)
      837248  NM_100610.3  NP_563788.1 
    rice
    (Oryza sativa)
    Liliopsida Os.143142 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.98(n)    AK120360.1 


    ENSEMBL Gene Tree for RBM22 (if available)
    TreeFam Gene Tree for RBM22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RBM22 gene

    Find genes that share paralogs with RBM22           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RBM22 (see all 15)
    PGOHUM00000248351 PGOHUM00000249060 PGOHUM00000249066 PGOHUM00000234908 PGOHUM00000243630


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RBM22 (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399274381,2
    --150069854(+) ATAATA/GAATGT 1 -- ds50010--------
    rs798340761,2
    C,F--150069993(+) AGTAGC/TTGGCA 1 -- ds50012Minor allele frequency- T:0.01WA NA 238
    rs1823815511,2
    --150070003(+) ACTATC/TGGCAT 1 -- ds50010--------
    rs1130303531,2
    C--150070127(+) TAAAT-/AACTAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1454483401,2
    --150070185(+) CTGAGA/GTTAAA 1 -- ds50010--------
    rs1890639121,2
    --150070253(+) AAAAAC/TTTACA 1 -- ds50010--------
    rs2008428091,2
    --150070346(+) CCATG-/ACAACATG 1 -- ds50010--------
    rs1452858421,2
    --150070744(+) TCAGAG/TTCCTT 1 -- ut310--------
    rs121871201,2
    H--150070893(+) TTTTTA/TAGATG 1 -- ut311Minor allele frequency- T:0.00NS 120
    rs1477888601,2
    C--150070949(+) TTTTA-/CTGCAGGT 1 -- cds10--------

    HapMap Linkage Disequilibrium report for RBM22 (150070352 - 150080669 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RBM22:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29484CNV Loss19812545
    nsv428129CNV Loss18775914
    esv33898CNV Loss17666407
    dgv1862e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM22
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612430    OMIM disorders: --


    Find genes that share disorders with RBM22           About GenesLikeMe


    Export disorders for RBM22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RBM22 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with RBM22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The influence of calcium signaling on the regulation of alternative splicing. (PubMed id 19133299)1, 2, 3 Krebs J. (Biochim. Biophys. Acta 2009)
    2. Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. (PubMed id 22246180)1, 2 Rasche N....Luhrmann R. (EMBO J. 2012)
    3. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. (PubMed id 20013661)1, 3 He F....Gou L.T. (Genet. Mol. Res. 2009)
    4. Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. (PubMed id 17045351)1, 2 Montaville P.... Krebs J. (Biochim. Biophys. Acta 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Transcriptional map of the Treacher Collins candidate gene region. (PubMed id 8681136)1, 2 Loftus S.K.... Wasmuth J.J. (Genome Res. 1996)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55696 HGNC: 25503 AceView: RBM22 Ensembl:ENSG00000086589 euGenes: HUgn55696
    ECgene: RBM22 Kegg: 55696 H-InvDB: RBM22

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RBM22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RBM22 gene:
    Search GeneIP for patents involving RBM22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RBM22  
     OriGene qPCR primer pairs and template standards for RBM22   OriGene Protein Over-expression Lysate for RBM22  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RBM22  
     OriGene qSTAR qPCR primer pairs in human, mouse for RBM22   OriGene Purified Protein for RBM22  
     OriGene ORF clones in mouse, rat for RBM22   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RBM22   OriGene Custom Protein Services for RBM22  

     
     
     Block miRNA regulation of human, mouse, rat RBM22 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RBM22
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM22 Predesigned siRNA for gene silencing in human, mouse, rat RBM22
     QuantiFast Probe-based Assays in human, mouse, rat RBM22 QuantiTect SYBR Green Assays in human, mouse, rat RBM22
     Custom PCR Arrays for RBM22 Search Chromatin IP Primers for RBM22
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM22  Search GeneGlobe Interaction Network for RBM22
     Regulatory tfbs in RBM22 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RBM22 GenScript cDNA clones with any tag delivered in your preferred vector for RBM22
     GenScript Custom Assay Services for RBM22 GenScript Custom overexpressing Cell Line Services for RBM22
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RBM22
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RBM22 antibodies
     RBM22 proteins
     RBM22 lysates
     Antibodies for RBM22
     See all of Abcam's Antibodies, Kits and Proteins for RBM22
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RBM22
     Antibodies for RBM22
     ELISAs for RBM22
     CLIAs for RBM22



     Browse ESI BIO Cell Lines and PureStem Progenitors for RBM22
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM22
     SwitchGear 3'UTR luciferase reporter plasmids for RBM22
     SwitchGear Promoter luciferase reporter plasmids for RBM22
     ThermoFisher Antibodies for RBM22
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM22
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM22
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RBM22
     LSBio Antibodies in human, mouse, rat for RBM22
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RBM22
      Search eBioscience for proteins for RBM22
      Search eBioscience for elisas for RBM22
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RBM22 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4