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Aliases for RBM22 Gene

Aliases for RBM22 Gene

  • RNA Binding Motif Protein 22 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 16 3 4
  • Functional Spliceosome-Associated Protein 47 2 3
  • ZC3H16 3 4
  • Pre-MRNA-Splicing Factor RBM22 3
  • RNA-Binding Motif Protein 22 4
  • FSAP47 3
  • Cwc2 3

External Ids for RBM22 Gene

Previous GeneCards Identifiers for RBM22 Gene

  • GC05M150099
  • GC05M150050
  • GC05M145216

Summaries for RBM22 Gene

Entrez Gene Summary for RBM22 Gene

  • This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

GeneCards Summary for RBM22 Gene

RBM22 (RNA Binding Motif Protein 22) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for RBM22 Gene

  • Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.

Gene Wiki entry for RBM22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM22 Gene

Genomics for RBM22 Gene

Regulatory Elements for RBM22 Gene

Enhancers for RBM22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F150777 1.5 FANTOM5 ENCODE 13.4 -80.0 -80010 8.1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZNF143 RPL7P1 ZNF300 HMGXB3 RBM22 ZNF300P1 RPS20P4 PDGFRB SMIM3 TIGD6 TNIP1
GH05F150786 1.4 FANTOM5 Ensembl ENCODE 12.6 -88.2 -88248 5.1 BCOR CTCF SUZ12 JUN ZMYM3 SIN3A POLR2A EGR1 EED FOS ZNF300P1 DCTN4 RBM22 RPL7P1 TNIP1 SMIM3 CCDC69 CD74 IRGM
GH05F149745 1.2 Ensembl ENCODE 13.1 +952.7 952732 5.2 PKNOX1 KLF17 ZNF2 RAD21 YY1 ZNF143 FOS RCOR1 EGR2 SMARCA5 RBM22 RNU6-588P PPARGC1B GC05P149733 GC05P149853
GH05F150460 1.3 FANTOM5 Ensembl ENCODE 10.2 +239.7 239707 1.6 HDGF TBP PKNOX1 MAX ZIC2 ZBTB48 POLR2A ZNF366 EED CHD2 NDST1 SYNPO RPS14 NDST1-AS1 SMIM3 RBM22 ENSG00000253852 ZNF300 GC05P150482
GH05F150447 1.2 ENCODE 10.4 +252.2 252155 3.4 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D HMGXB3 RPL7P1 PDGFRB RPS14 ZNF300 SMIM3 ZNF300P1 GPX3 RPS20P4 RBM22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM22 on UCSC Golden Path with GeneCards custom track

Promoters for RBM22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001415310 207 2200 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for RBM22 Gene

Chromosome:
5
Start:
150,690,790 bp from pter
End:
150,701,107 bp from pter
Size:
10,318 bases
Orientation:
Minus strand

Genomic View for RBM22 Gene

Genes around RBM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM22 Gene

Proteins for RBM22 Gene

  • Protein details for RBM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW64-RBM22_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor RBM22
    Protein Accession:
    Q9NW64
    Secondary Accessions:
    • A6NDM5
    • B4DLI9
    • O95607

    Protein attributes for RBM22 Gene

    Size:
    420 amino acids
    Molecular mass:
    46896 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm.
    SequenceCaution:
    • Sequence=AAC99998.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM22 Gene

    Alternative splice isoforms for RBM22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM22 Gene

Post-translational modifications for RBM22 Gene

  • Ubiquitination at Lys 78, Lys 114, and Lys 149
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM22 Gene

No data available for DME Specific Peptides for RBM22 Gene

Domains & Families for RBM22 Gene

Suggested Antigen Peptide Sequences for RBM22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW64

UniProtKB/Swiss-Prot:

RBM22_HUMAN :
  • The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
  • Belongs to the SLT11 family.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the SLT11 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with RBM22: view

Function for RBM22 Gene

Molecular function for RBM22 Gene

UniProtKB/Swiss-Prot Function:
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.

Gene Ontology (GO) - Molecular Function for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005487 nucleocytoplasmic transporter activity IDA 21122810
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBM22: view
genes like me logo Genes that share phenotypes with RBM22: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM22 Gene

Localization for RBM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM22 Gene

Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM22 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 Prp19 complex IBA --
GO:0005634 nucleus IEA,IDA 11278427
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA,IDA 21122810
genes like me logo Genes that share ontologies with RBM22: view

Pathways & Interactions for RBM22 Gene

genes like me logo Genes that share pathways with RBM22: view

Pathways by source for RBM22 Gene

Gene Ontology (GO) - Biological Process for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 17045351
GO:0000387 spliceosomal snRNP assembly IBA --
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006397 mRNA processing IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with RBM22: view

No data available for SIGNOR curated interactions for RBM22 Gene

Transcripts for RBM22 Gene

Unigene Clusters for RBM22 Gene

RNA binding motif protein 22:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM22 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for RBM22 Gene

GeneLoc Exon Structure for
RBM22
ECgene alternative splicing isoforms for
RBM22

Expression for RBM22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM22 Gene



Protein tissue co-expression partners for RBM22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM22 Gene:

RBM22

SOURCE GeneReport for Unigene cluster for RBM22 Gene:

Hs.713564
genes like me logo Genes that share expression patterns with RBM22: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM22 Gene

Orthologs for RBM22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM22 34 35
  • 99.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RBM22 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM22 34 35
  • 93.73 (n)
cow
(Bos Taurus)
Mammalia RBM22 34 35
  • 92.7 (n)
mouse
(Mus musculus)
Mammalia Rbm22 34 16 35
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Rbm22 34
  • 89.52 (n)
chicken
(Gallus gallus)
Aves RBM22 34 35
  • 82.94 (n)
lizard
(Anolis carolinensis)
Reptilia RBM22 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm22 34
  • 76.68 (n)
MGC76229 34
African clawed frog
(Xenopus laevis)
Amphibia cg14641-prov 34
zebrafish
(Danio rerio)
Actinopterygii RBM22 (3 of 3) 35
  • 84 (a)
OneToMany
rbm22 34 35 35
  • 75.18 (n)
wufc62e03 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004509 34
  • 60.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14641 34 35
  • 60.29 (n)
worm
(Caenorhabditis elegans)
Secernentea T11G6.8 34 35
  • 62.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM2 35 37
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07360 34
  • 57.79 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1512 34
rice
(Oryza sativa)
Liliopsida Os07g0281000 34
  • 59.57 (n)
Os.14314 34
barley
(Hordeum vulgare)
Liliopsida Hv.2670 34
wheat
(Triticum aestivum)
Liliopsida Ta.14515 34
corn
(Zea mays)
Liliopsida Zm.4129 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8471 35
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2969 34
Species where no ortholog for RBM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RBM22 Gene

ENSEMBL:
Gene Tree for RBM22 (if available)
TreeFam:
Gene Tree for RBM22 (if available)

Paralogs for RBM22 Gene

No data available for Paralogs for RBM22 Gene

Variants for RBM22 Gene

Sequence variations from dbSNP and Humsavar for RBM22 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10052610 -- 150,695,894(+) ATCAC(A/G)GAAGG intron-variant
rs10067102 -- 150,701,165(+) TTAAC(A/T)ATTGG upstream-variant-2KB
rs10067647 -- 150,696,087(+) CTATG(A/G)ACCTC intron-variant
rs10077739 -- 150,699,003(+) CACCT(A/G)GTGTA intron-variant
rs10581710 -- 150,701,438(+) TTCTG(-/TCTC)TCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RBM22 Gene

Variant ID Type Subtype PubMed ID
nsv428129 CNV loss 18775914
esv33898 CNV loss 17666407
esv29484 CNV loss 19812545
esv2759386 CNV loss 17122850

Variation tolerance for RBM22 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM22 Gene

Disorders for RBM22 Gene

Relevant External Links for RBM22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM22

No disorders were found for RBM22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM22 Gene

Publications for RBM22 Gene

  1. The influence of calcium signaling on the regulation of alternative splicing. (PMID: 19133299) Krebs J. (Biochim. Biophys. Acta 2009) 2 3 4 64
  2. Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. (PMID: 22246180) Rasche N. … Luhrmann R. (EMBO J. 2012) 3 4 64
  3. Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7. (PMID: 21122810) Janowicz A. … Krebs J. (Biochim. Biophys. Acta 2011) 3 4 64
  4. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. (PMID: 20013661) He F. … Gou L.T. (Genet. Mol. Res. 2009) 2 3 64
  5. Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. (PMID: 17045351) Montaville P. … Krebs J. (Biochim. Biophys. Acta 2006) 3 4 64

Products for RBM22 Gene

Sources for RBM22 Gene

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