Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RBM20 Gene

protein-coding GIFtS: 45
GCID: GC10P112395

RNA binding motif protein 20

Explore 3 diseases affiliated with
RBM20 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RNA Binding Motif Protein 20¹ ²
RNA-Binding Motif Protein 20² ³
Probable RNA-Binding Protein 20²
RNA-Binding Protein 20²

External Ids:	HGNC: 27424¹	Entrez Gene: 282996²	Ensembl: ENSG00000203867⁷	OMIM: 613171⁵	UniProtKB: Q5T481³

Export aliases for RBM20 gene to outside databases

Previous GC identifers: GC10P112199 GC10P112530 GC10P106033

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBM20:

This gene encodes a protein that likely binds RNA. Mutations in this gene have been associated with familial dilated

cardiomyopathy. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: RBM20_HUMAN, Q5T481

Function: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac

development. Regulates splicing of TTN (Titin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RBM20 gene promoter:
Tal-1 E4BP4 HNF-1A E47 C/EBPalpha S8 HNF-1 FOXJ2 TGIF RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for RBM20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q25.3

RBM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM20 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P112395: view genomic region (about GC identifiers)

Start:	112,404,155 bp from pter	End:	112,599,227 bp from pter
Size:	195,073 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBM20_HUMAN, Q5T481 (See protein sequence)

Recommended Name: RNA-binding protein 20

Size: 1227 amino acids; 134357 Da

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=CAI16577.1; Type=Erroneous gene model prediction; Sequence=CAI40091.1; Type=Erroneous gene

model prediction; Sequence=CAI40093.1; Type=Erroneous gene model prediction;

Secondary accessions: A6NIP5 B5A868 Q5JVI1

Explore the universe of human proteins at neXtProt for RBM20: NX_Q5T481

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5T481

RBM20 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001127835.1

ENSEMBL proteins:

ENSP00000358532

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: RBM20 OriGene Custom Protein Services for RBM20
	GenScript Custom Purified and Recombinant Proteins Services for RBM20
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RBM20

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--

RBM20 for ontologies About GeneDecksing

RBM20 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RBM20
	GenScript Custom Superior Antibodies Services for RBM20
	Novus Biologicals RBM20 Antibody
	Search for Antibodies for RBM20 at Abcam
	Uscn Antibodies for RBM20
	ThermoFisher Antibodies for RBM20

Assay Products for RBM20:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RBM20
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RBM20

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RBM20 for domains About GeneDecksing

5 InterPro domains/families:

IPR003604 Znf_U1

IPR012677 Nucleotide-bd_a/b_plait

IPR015880 Znf_C2H2-like

IPR000690 Znf_C2H2_matrin

IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry Q5T481

ProtoNet protein and cluster: Q5T481

UniProtKB/Swiss-Prot: RBM20_HUMAN, Q5T481

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RBM20_HUMAN, Q5T481

Function: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac

development. Regulates splicing of TTN (Titin)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBM20
		8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate RBM20 (see all 87):
		hsa-miR-607 hsa-miR-4254 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-605 hsa-miR-519a hsa-miR-3142

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM20 (see all 4) OriGene shRNA RFP: RBM20 OriGene siRNA: RBM20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM20

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RBM20

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM20 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM20 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RBM20 (NM_001134363)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM20
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBM20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RBM20
		Search LifeMap BioReagents cell lines for RBM20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM20

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	ISS	--
GO:0008270	zinc ion binding	IEA	--

RBM20 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RBM20

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006397	mRNA processing	IEA	--
GO:0007507	heart development	IMP	--
GO:0008380	RNA splicing	IEA	--
GO:0033120	positive regulation of RNA splicing	IMP	--

RBM20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBM20
Search CenterWatch for drugs/clinical trials and news about RBM20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RBM20 gene:

NM_001134363.1

Unigene Cluster for RBM20:

RNA binding motif protein 20

Hs.116630 [show with all ESTs]

Unigene Representative Sequence: EU822950

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369519(uc001kzf.2) ENST00000471172 ENST00000480343 ENST00000465774

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBM20
		8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate RBM20 (see all 87):
		hsa-miR-607 hsa-miR-4254 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-605 hsa-miR-519a hsa-miR-3142

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM20 (see all 4) OriGene shRNA RFP: RBM20 OriGene siRNA: RBM20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM20

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM20 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM20 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RBM20 (NM_001134363)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM20
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBM20

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM20 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RBM20
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM20
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM20

Additional cDNA sequence:

AK302802.1 AL832084.1 BX648563.1 EU822950.1

4 DOTS entries:

DT.101960682 DT.121303391 DT.121303394 DT.65287565

16 AceView cDNA sequences:

BX648563 BU607932 CK429431 AA195793 AL832084 AI866754 AI539118 BU622156

AL121071 BM562762 AI143495 AL121072 CB044335 AA668300 CB044334 AI378995

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBM20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCTTCACC

About this image

RBM20 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Bone

Limb

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See RBM20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM20

SOURCE GeneReport for Unigene cluster: Hs.116630

UniProtKB/Swiss-Prot: RBM20_HUMAN, Q5T481

Tissue specificity: Expressed in the heart

SABiosciences Custom PCR Arrays for RBM20

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM20 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RBM20
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM20
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM20

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RBM20 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RBM20¹	RNA binding motif protein 20	65.11(n) 60.43(a)		423892 XM_421755.3 XP_421755.3
lizard (Anolis carolinensis)	Reptilia	RBM20⁶	--	53(a)	1 ↔ 1	3(45632422-45672171)
zebrafish (Danio rerio)	Actinopterygii	LOC555579¹	probable RNA-binding protein 20-like	55.15(n) 50.96(a)		555579 XM_678130.5 XP_683222.4

ENSEMBL Gene Tree for RBM20 (if available)
TreeFam Gene Tree for RBM20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RBM20 gene

MATR3² ZNF638²

RBM20 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3814680^1,2	C,F,	--	106032803(-)	`CCGAGC/AGCGCC`	1	--	us2k¹		3	WA NA EA	358
rs72641325^1,2	C,	--	106032938(+)	`CCTCAC/AGCGGT`	1	--	us2k¹		3	NA EA	242
rs12415647^1,2	C,F,H,	--	106033632(+)	`CGCTCG/TCCCCC`	1	--	int¹		1	NA	4
rs79061914^1,2	C,F,	--	106033954(+)	`TGGTGC/ACCCTG`	1	--	int¹		1	WA	118
rs17827738^1,2	C,F,H,	--	106035152(+)	`AGGGCG/ATCTGA`	1	--	int¹		10	NA NS EA	652
rs116989862^1,2	C,F,	--	106035359(+)	`AGGATG/AGAGAC`	1	--	int¹		1	NA	120
rs77160868^1,2	F,	--	106035392(+)	`TGCTTG/ACTTTA`	1	--	int¹		1	WA	118
rs7101002^1,2	C,F,	--	106036413(+)	`ATTGTA/GTATAA`	1	--	int¹		3	WA	122
rs12240757^1,2	F,H,	--	106037186(+)	`TCACTC/TGGAAT`	1	--	int¹		6	NS EA CSA WA	506
rs12240962^1,2	C,F,H,	--	106037350(+)	`AGTCAG/AAGAGA`	1	--	int¹		12	NS EA NA CSA WA	1416

HapMap Linkage Disequilibrium report for RBM20 (112404155 - 112599227 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RBM20
1 CNV: 5612
Human Gene Mutation Database (HGMD): RBM20

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM20

DNA2.0 Custom Variant and Variant Library Synthesis for RBM20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RBM20 for disorders           About GeneDecksing

OMIM gene information: 613171
OMIM disorders: 613172
UniProtKB/Swiss-Prot: RBM20_HUMAN, Q5T481

Defects in RBM20 are the cause of cardiomyopathy dilated type 1DD (CMD1DD) [MIM:613172]. A disorder

characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and

arrhythmia. Patients are at risk of premature death

3 diseases for RBM20: About MalaCards

familial dilated cardiomyopathy dilated cardiomyopathy cardiomyopathy

1 disease from the University of Copenhagen DISEASES database for RBM20:

Dilated cardiomyopathy

Human Genome Epidemiology (HuGE) Navigator: RBM20 (1 document)

Export disorders for RBM20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RBM20 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBM20)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in ribonucleic acid binding protein gene ca use familial dilated cardiomyopathy. (PubMed id 19712804)^{1, 2, 9} Brauch K.M....Olson T.M. (2009)
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. (PubMed id 22466703)^{1, 2} Guo W....Gotthardt M. (2012)
Identification of novel mutations in RBM20 in patient s with dilated cardiomyopathy. (PubMed id 20590677)^{1, 2} Li D....Hershberger R.E. (2010)
Genetic variation in the alternative splicing regulato r RBM20 is associated with dilated cardiomyopathy. (PubMed id 22004663)¹ Refaat M.M....Ellinor P.T. (2012)
Clinical and mutational spectrum in a cohort of 105 u nrelated patients with dilated cardiomyopathy. (PubMed id 21846512)² Millat G....Rousson R. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Splicing and dilated cardiomyopathy one gene to rule them all? (PubMed id 19712805)¹ Macrae C.A. and McKenna W.J. (2009)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)² Deloukas P.... Rogers J. (2004)
Dilated Cardiomyopathy Overview (PubMed id 20301486)¹ Hershberger R.E....Parks S.B. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 282996	HGNC: 27424	AceView: RBM20	Ensembl:ENSG00000203867	euGenes: HUgn282996
ECgene: RBM20	H-InvDB: RBM20

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RBM20	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RBM20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RBM20 gene:
Search GeneIP for patents involving RBM20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for RBM20
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM20		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM20
	OriGene Protein Over-expression Lysate for RBM20		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RBM20		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM20		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM20
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RBM20		OriGene Custom Protein Services for RBM20
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBM20
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM20
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM20
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM20
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM20
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM20

	GenScript Custom Purified and Recombinant Proteins Services for RBM20		GenScript cDNA clones with any tag delivered in your preferred vector for RBM20
	GenScript Custom Assay Services for RBM20		GenScript Custom Superior Antibodies Services for RBM20
	GenScript Custom overexpressing Cell Line Services for RBM20		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RBM20 promoter
	Search Chromatin IP Primers for RBM20
	RT² qPCR Primer Assay in human, mouse, rat RBM20
	Search GNC Networks for RBM20
	SABiosciences Custom PCR Arrays for RBM20

Search Tocris compounds for RBM20

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RBM20 antibodies

	Search for Antibodies for RBM20 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for RBM20
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RBM20 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RBM20

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM20

	Browse SwitchGear 3'UTR luciferase reporter plasmids for RBM20
	Browse SwitchGear Promoter luciferase reporter plasmids for RBM20

ThermoFisher Antibodies for RBM20

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBM20

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RBM20 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RBM20 Gene

RNA binding motif protein 20

Aliases
for RBM20 gene

Summaries
for RBM20 gene

Genomic Views
for RBM20 gene

Proteins
for RBM20 gene

Protein Domains /
Families
for RBM20 gene

Function
for RBM20 gene

Pathways & Interactions
for RBM20 gene

Drugs & Compounds
for RBM20 gene

Transcripts
for RBM20 gene

Expression
for RBM20 gene

Orthologs
for RBM20 gene

Paralogs
for RBM20 gene

Genomic Variants
for RBM20 gene

Disorders / Diseases
for RBM20 gene

Publications
for RBM20 gene

External Searches for RBM20 gene

Genome Databases showing RBM20 gene

Other Databases showing RBM20 gene

Specialized Databases showing RBM20 gene

Intellectual Property
for RBM20 gene

Products
for RBM20 gene

View Random Gene

Advanced Search

Export list of displayed genes

RBM20 Gene

RNA binding motif protein 20

Aliasesfor RBM20 gene

Summariesfor RBM20 gene

Genomic Viewsfor RBM20 gene

Proteinsfor RBM20 gene

Protein Domains /Familiesfor RBM20 gene

Functionfor RBM20 gene

Pathways & Interactionsfor RBM20 gene

Drugs & Compoundsfor RBM20 gene

Transcriptsfor RBM20 gene

Expression for RBM20 gene

Orthologsfor RBM20 gene

Paralogsfor RBM20 gene

Genomic Variantsfor RBM20 gene

Disorders / Diseasesfor RBM20 gene

Publicationsfor RBM20 gene

External Searches for RBM20 gene

Genome Databases showing RBM20 gene

Other Databases showing RBM20 gene

Specialized Databases showing RBM20 gene

Intellectual Propertyfor RBM20 gene

Productsfor RBM20 gene

View Random Gene

Aliases
for RBM20 gene

Summaries
for RBM20 gene

Genomic Views
for RBM20 gene

Proteins
for RBM20 gene

Protein Domains /
Families
for RBM20 gene

Function
for RBM20 gene

Pathways & Interactions
for RBM20 gene

Drugs & Compounds
for RBM20 gene

Transcripts
for RBM20 gene

Expression
for RBM20 gene

Orthologs
for RBM20 gene

Paralogs
for RBM20 gene

Genomic Variants
for RBM20 gene

Disorders / Diseases
for RBM20 gene

Publications
for RBM20 gene

Intellectual Property
for RBM20 gene

Products
for RBM20 gene