RBM19 Gene
protein-coding GIFtS: 52
GCID: GC12M114259
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RNA binding motif protein 19
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Aliases
for RBM19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 191 2 | | KIAA06821 3 | | RNA-Binding Motif Protein 192 3 | | DKFZp586F10231 | | Probable RNA-Binding Protein 192 |
Export aliases for RBM19 gene to outside databasesPrevious GC identifers: GC12M112671 GC12M112717 GC12M111264 |
Summaries
for RBM19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBM19:
This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved inregulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have beenidentified.(provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: RBM19_HUMAN, Q9Y4C8Function: Plays a role in embryo pre-implantation development (By similarity)
Gene Wiki entry for RBM19
|
Genomic Views
for RBM19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM19 gene promoter:
c-Fos STAT1 AP-1 p53 p300 STAT1beta STAT1alpha STAT3 c-Jun ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.21 Ensembl cytogenetic band: 12q24.21 HGNC cytogenetic band: 12q24.21RBM19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M114259: view genomic region
(about GC identifiers)
Start:
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114,254,543 bp from pter |
End:
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114,404,176 bp from pter |
Size:
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149,634 bases |
Orientation:
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minus strand |
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Proteins
for RBM19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM19_HUMAN, Q9Y4C8 (See
protein sequence)Recommended Name: Probable RNA-binding protein 19 Size: 960 amino acids; 107332 Da
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Chromosome(By similarity). Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cellstages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocystdevelopment, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage,localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomalsheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolusupon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase,metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB
Sequence caution: Sequence=BAA31657.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for RBM19:2DGW (3D)
Secondary accessions: Q9BPY6 Q9UFN5Explore the universe of human proteins at neXtProt for RBM19: NX_Q9Y4C8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4C8
RBM19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001140170.1 NP_001140171.1 NP_057280.2
ENSEMBL proteins: ENSP00000442053 ENSP00000376344 ENSP00000261741 ENSP00000449604
Human Recombinant Protein Products for RBM19:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RBM19 for ontologies About GeneDecksing
RBM19 Antibody Products:
Assay Products for RBM19: |
Protein
Domains /
Families
for RBM19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM19 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y4C8ProtoNet protein and cluster: Q9Y4C8 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: RBM19_HUMAN, Q9Y4C8Similarity: Belongs to the RRM MRD1 familySimilarity: Contains 6 RRM (RNA recognition motif) domains |
Function
for RBM19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RBM19_HUMAN, Q9Y4C8Function: Plays a role in embryo pre-implantation development (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RBM19 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RBM19:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rbm19):
RBM19 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM19 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM19 (see all 3)
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Synthesis Service for RBM19 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM19 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM19 |
|
Pathways & Interactions
for RBM19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM19
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/50 Interacting proteins for RBM19 (Q9Y4C82, 3 ENSP000002617414) via UniProtKB, MINT, STRING, and/or I2D (see all 50)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0040019 | positive regulation of embryonic development |
ISS | -- |
RBM19 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBM19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM19
Search CenterWatch for drugs/clinical trials and news about RBM19
|
Transcripts
for RBM19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM19 gene (3 alternative transcripts): NM_001146698.1 NM_001146699.1 NM_016196.3 Unigene Cluster for RBM19: RNA binding motif protein 19 Hs.7482 [show with all ESTs]Unigene Representative Sequence: NM_0011466997 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000553232 ENST00000545145(uc009zwi.2) ENST00000392561 ENST00000261741(uc001tvn.4 uc001tvm.3)
ENST00000552384 ENST00000552386 ENST00000546876
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM19 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM19 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RBM19 (NM_016196) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM19 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM19 |
Additional cDNA sequence: AB014582.1 AK291444.1 AK314606.1 AL117547.1 BC004289.1 BC006137.1 6 DOTS entries: DT.209686 DT.95069368 DT.100787673 DT.121183319 DT.86852597 DT.95069359 24/141 AceView cDNA sequences (see all 141): BX412391 BX283922 BM666208 AA284782 BX283743 AL117547 AI399723 BE393410 BM853086 CB240913 NM_016196 BX439491 CF125622 AI301349 AI632112 BM550832 BU680488 AI418330 CB529111 BM451361 AA812695 AW451116 AI264818 BM665021
GeneLoc Exon Structure
|
Expression
for RBM19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAAATTTA
About this image
See RBM19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM19
SOURCE GeneReport for Unigene cluster: Hs.7482
UniProtKB/Swiss-Prot: RBM19_HUMAN, Q9Y4C8Tissue specificity: Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at proteinlevel)
SABiosciences Custom PCR Arrays for RBM19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM19
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBM19 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM19 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM19 |
Orthologs
for RBM19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBM19 gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for RBM19 (if available)
TreeFam Gene Tree for RBM19 (if available) |
Paralogs
for RBM19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBM19 gene
- NCL2 SART32
3 SIMAP similar genes for RBM19 using alignment to 2 protein entries: RBM19_HUMAN (see all proteins):FUSIP1 HNRNPA1 PABPC4
RBM19 for paralogs About GeneDecksing
|
Genomic Variants
for RBM19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM19 (114254543 - 114404176 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RBM19
1 Indel: 71585 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM19 |
|
Disorders
/ Diseases
for RBM19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBM19 for disorders About GeneDecksing
1  disease for RBM19: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: RBM19 (3 documents)
Export disorders for RBM19 gene to outside databases
|
Publications
for RBM19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM19 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with RBM19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Rbm19 is a nucleolar protein expressed in crypt/progenitor cells of the intestinal epithelium. (PubMed id 16027046)1, 2 Lorenzen J.A....Mayer A.N. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for RBM19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM19 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RBM19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM19 gene:
Search GeneIP for patents involving RBM19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM19 |
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