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Aliases for RBM19 Gene

Aliases for RBM19 Gene

  • RNA Binding Motif Protein 19 2 3
  • RNA-Binding Motif Protein 19 4
  • KIAA0682 4

External Ids for RBM19 Gene

Previous GeneCards Identifiers for RBM19 Gene

  • GC12M112671
  • GC12M112717
  • GC12M114259
  • GC12M111264

Summaries for RBM19 Gene

Entrez Gene Summary for RBM19 Gene

  • This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]

GeneCards Summary for RBM19 Gene

RBM19 (RNA Binding Motif Protein 19) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for RBM19 Gene

  • Plays a role in embryo pre-implantation development.

Gene Wiki entry for RBM19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM19 Gene

Genomics for RBM19 Gene

Regulatory Elements for RBM19 Gene

Genomic Location for RBM19 Gene

113,816,738 bp from pter
113,966,371 bp from pter
149,634 bases
Minus strand

Genomic View for RBM19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM19 Gene

Proteins for RBM19 Gene

  • Protein details for RBM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable RNA-binding protein 19
    Protein Accession:
    Secondary Accessions:
    • A8K5X9
    • Q9BPY6
    • Q9UFN5

    Protein attributes for RBM19 Gene

    960 amino acids
    Molecular mass:
    107332 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31657.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM19 Gene

neXtProt entry for RBM19 Gene

Proteomics data for RBM19 Gene at MOPED

Post-translational modifications for RBM19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM19 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RBM19

No data available for DME Specific Peptides for RBM19 Gene

Domains for RBM19 Gene

Gene Families for RBM19 Gene

  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBM19 Gene

Suggested Antigen Peptide Sequences for RBM19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y4C8
  • Contains 6 RRM (RNA recognition motif) domains.
  • Belongs to the RRM MRD1 family.
genes like me logo Genes that share domains with RBM19: view

Function for RBM19 Gene

Molecular function for RBM19 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in embryo pre-implantation development.

Gene Ontology (GO) - Molecular Function for RBM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM19: view

Phenotypes for RBM19 Gene

MGI mutant phenotypes for RBM19:
inferred from 1 alleles
GenomeRNAi human phenotypes for RBM19:
genes like me logo Genes that share phenotypes with RBM19: view

Animal Model Products

CRISPR Products

miRNA for RBM19 Gene

miRTarBase miRNAs that target RBM19

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM19 Gene

Localization for RBM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM19 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Chromosome. Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RBM19 Gene COMPARTMENTS Subcellular localization image for RBM19 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RBM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm ISS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with RBM19: view

Pathways for RBM19 Gene

SuperPathways for RBM19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0040019 positive regulation of embryonic development ISS --
genes like me logo Genes that share ontologies with RBM19: view

No data available for Pathways by source for RBM19 Gene

Transcripts for RBM19 Gene

Unigene Clusters for RBM19 Gene

RNA binding motif protein 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM19 Gene

No ASD Table

Relevant External Links for RBM19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM19 Gene

mRNA expression in normal human tissues for RBM19 Gene

Protein differential expression in normal tissues for RBM19 Gene

This gene is overexpressed in Lung (15.8), Pancreatic juice (9.6), Bone marrow stromal cell (7.9), and Adrenal (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM19 Gene

SOURCE GeneReport for Unigene cluster for RBM19 Gene Hs.7482

mRNA Expression by UniProt/SwissProt for RBM19 Gene

Tissue specificity: Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).
genes like me logo Genes that share expressions with RBM19: view

Expression partners for RBM19 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBM19 Gene

Orthologs for RBM19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBM19 35
  • 85.97 (n)
  • 86.04 (a)
RBM19 36
  • 80 (a)
(Canis familiaris)
Mammalia RBM19 35
  • 84.43 (n)
  • 84.54 (a)
RBM19 36
  • 84 (a)
(Mus musculus)
Mammalia Rbm19 35
  • 81.23 (n)
  • 82.65 (a)
Rbm19 16
Rbm19 36
  • 82 (a)
(Pan troglodytes)
Mammalia RBM19 35
  • 99.31 (n)
  • 99.27 (a)
RBM19 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rbm19 35
  • 81.31 (n)
  • 83.32 (a)
(Monodelphis domestica)
Mammalia RBM19 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RBM19 36
  • 52 (a)
(Gallus gallus)
Aves RBM19 35
  • 70.37 (n)
  • 70.12 (a)
RBM19 36
  • 68 (a)
(Anolis carolinensis)
Reptilia RBM19 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm19 35
  • 63.8 (n)
  • 61 (a)
(Danio rerio)
Actinopterygii npo 35
rbm19 35
  • 63.93 (n)
  • 63.27 (a)
rbm19 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4171 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005249 35
  • 53.86 (n)
  • 47.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3335 35
  • 51.63 (n)
  • 43.21 (a)
CG3335 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea rbd-1 35
  • 49.6 (n)
  • 46.25 (a)
rbd-1 36
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR035C 35
  • 51.36 (n)
  • 42.38 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14949g 35
  • 47.27 (n)
  • 39.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRD1 35
  • 46.37 (n)
  • 38.96 (a)
MRD1 36
  • 32 (a)
MRD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G19610 35
  • 48.88 (n)
  • 39.78 (a)
(Oryza sativa)
Liliopsida Os04g0611500 35
  • 49.44 (n)
  • 41.58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13198 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02611 35
  • 51.39 (n)
  • 41.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP22H7.02c 35
  • 46.43 (n)
  • 41.93 (a)
Species with no ortholog for RBM19:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM19 Gene

Gene Tree for RBM19 (if available)
Gene Tree for RBM19 (if available)

Paralogs for RBM19 Gene

Selected SIMAP similar genes for RBM19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBM19: view

No data available for Paralogs for RBM19 Gene

Variants for RBM19 Gene

Sequence variations from dbSNP and Humsavar for RBM19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs731745 -- 113,900,866(-) CCTTC(A/T)TCACT intron-variant
rs736640 -- 113,878,275(-) GACAC(C/T)GGGTG intron-variant
rs759904 -- 113,852,253(-) CCCCC(A/C)TGCTA intron-variant
rs759905 -- 113,844,472(-) GGGAG(A/G)CTGGC intron-variant
rs759906 -- 113,844,022(-) AGAGG(A/C)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM19 Gene

Variant ID Type Subtype PubMed ID
esv22413 CNV Loss 19812545
nsv899531 CNV Loss 21882294
esv2746389 CNV Deletion 23290073
esv2666992 CNV Deletion 23128226
nsv509477 CNV Insertion 20534489
esv2658799 CNV Deletion 23128226
nsv899532 CNV Loss 21882294
esv2746390 CNV Deletion 23290073
esv2746391 CNV Deletion 23290073

Relevant External Links for RBM19 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM19 Gene

Disorders for RBM19 Gene

Relevant External Links for RBM19

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RBM19 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RBM19 Gene

Publications for RBM19 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  5. Rbm19 is a nucleolar protein expressed in crypt/progenitor cells of the intestinal epithelium. (PMID: 16027046) Lorenzen J.A. … Mayer A.N. (Gene Expr. Patterns 2005) 3 4

Products for RBM19 Gene

Sources for RBM19 Gene

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