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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBM18 Gene

protein-coding   GIFtS: 47
GCID: GC09M125001

RNA Binding Motif Protein 18

  Search for RBM18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RNA Binding Motif Protein 181 2
RNA-Binding Motif Protein 182 3
Probable RNA-Binding Protein 182

External Ids:    HGNC: 284131   Entrez Gene: 924002   Ensembl: ENSG000001194467   UniProtKB: Q96H353   
ORGUL members:         
NONCODE14:n407656      

Export aliases for RBM18 gene to outside databases

Previous GC identifers: GC09M120378 GC09M122081 GC09M124041 GC09M094616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RBM18 Gene: 
RBM18 (RNA binding motif protein 18) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include RNA binding and nucleotide binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBM18 gene promoter:
         POU3F1   GCNF   Lmo2   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-1A   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM18 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBM18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34.11

RBM18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM18 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M125001:  view genomic region     (about GC identifiers)

Start:
124,999,903 bp from pter      End:
125,027,143 bp from pter
Size:
27,241 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBM18_HUMAN, Q96H35 (See protein sequence)
Recommended Name: Probable RNA-binding protein 18  
Size: 190 amino acids; 21649 Da
Secondary accessions: B3KQ89

Explore the universe of human proteins at neXtProt for RBM18: NX_Q96H35

Explore proteomics data for RBM18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96H35

  • RBM18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RBM18 Protein Expression
    REFSEQ proteins: NP_149108.1  
    ENSEMBL proteins: 
     ENSP00000409315  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q96H35

    ProtoNet protein and cluster: Q96H35

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM18_HUMAN, Q96H35
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    RBM18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    RBM18 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RBM18 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBM18 
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    SwitchGear 3'UTR luciferase reporter plasmidRBM18 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM18

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for RBM18 (Q96H353 ENSP000004093154) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD23BP547273I2D: score=2 
    EPHA3ENSP000003374514STRING: ENSP00000337451
    NDUFAB1ENSP000000075164STRING: ENSP00000007516
    TMEM27ENSP000003696994STRING: ENSP00000369699
    --ENSP000004101224STRING: ENSP00000410122
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBM18

    Search CenterWatch for drugs/clinical trials and news about RBM18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RBM18 gene: 
    NM_033117.3  

    Unigene Cluster for RBM18:

    RNA binding motif protein 18
    Hs.415842  [show with all ESTs]
    Unigene Representative Sequence: NR_027125
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417201(uc004blz.2 uc010mvy.2 uc004bma.2 uc011lyp.1)
    ENST00000491850 ENST00000483428
    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate RBM18 (see all 30):
    hsa-miR-3685 hsa-miR-607 hsa-miR-520d-5p hsa-miR-522 hsa-miR-548k hsa-miR-4263 hsa-miR-624* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidRBM18 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RBM18
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    GenScript: all cDNA clones in your preferred vector: RBM18 (NM_033117)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBM18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM18
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                         Customized lentivirus expression plasmids for stable overexpression of RBM18 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RBM18
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM18

    Additional mRNA sequence: 

    AK026870.1 AK057676.1 AK299625.1 AK301050.1 AK310008.1 AK310807.1 AL389986.1 BC008942.2 
    BC019319.1 NR_027125.1 NR_027126.1 

    8 DOTS entries:

    DT.100024381  DT.440969  DT.100865678  DT.121172621  DT.109083  DT.95169161  DT.121172575  DT.95169163 

    24/234 AceView cDNA sequences (see all 234):

    BU783829 BC008942 AA316864 BX091428 AI338718 CR618364 AI250652 AI018555 
    AI915955 CK826132 AI224495 AA761985 AA379323 CA422403 AW016341 AI023872 
    CF528572 AL389986 CR607872 BM271980 NM_033117 AW340172 BX394527 BQ069604 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RBM18    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                    -                 -                       -               
    SP2:                    -                 -                                       
    SP3:                    -     -           -                       -               
    SP4:                    -                                                         
    SP5:                                      -                       -               


    ECgene alternative splicing isoforms for RBM18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBM18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGCATTTG
    RBM18 Expression
    About this image


    See RBM18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBM18

    SOURCE GeneReport for Unigene cluster: Hs.415842
        SABiosciences Custom PCR Arrays for RBM18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RBM18 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm181 , 5 RNA binding motif protein 181, 5 93.86(n)1
    98.95(a)1
      2 (24.19 cM)5
    678891  NM_026434.41  NP_080710.11 
     361160795 
    chicken
    (Gallus gallus)
    Aves RBM181 RNA binding motif protein 18 82.98(n)
    93.16(a)
      417111  XM_415396.3  XP_415396.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.44472 Xenopus laevis transcribed sequence with moderate similarity more 77.65(n)    BJ060816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733322 hypothetical protein MGC73332 77.18(n)   393766  BC059651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG144141 CG14414 51.96(n)
    41.91(a)
      32394  NM_167410.3  NP_727783.3 


    ENSEMBL Gene Tree for RBM18 (if available)
    TreeFam Gene Tree for RBM18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/466 SNPs in RBM18 are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70335381,2
    C,F,H--125001437(+) CAAGAG/CACAGA 3 -- ds500119Minor allele frequency- C:0.06NS EA NA WA 1778
    rs725373581,2
    C--125001510(+) TTTTT-/T/    
       TG
    /TT
    TKAGA
    3 -- ds50010--------
    rs802208931,2
    C--125001512(+) TTTTTG/TAGACG 3 -- ds50010--------
    rs1181917561,2
    C,F--125001516(+) TGAGAC/TGGTGT 3 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1807578611,2
    --125001562(+) AATCTC/TGGCTC 3 -- ds50010--------
    rs1458673861,2
    --125001701(+) ATTACA/GTTTTG 3 -- ds50010--------
    rs349941331,2
    C,F--125001749(+) TCATAC/TGTCTC 3 -- ds50015Minor allele frequency- T:0.03NA WA 244
    rs1176322271,2
    C,F--125001750(+) CATACG/ATCTCT 3 -- ds50011Minor allele frequency- A:0.01NA 120
    rs736630561,2
    C,F--125001762(+) CTCAGT/CATTTC 3 -- ds50013Minor allele frequency- C:0.19WA CSA 122
    rs1857152951,2
    --125001940(+) CTTTCA/CGCATA 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for RBM18 (124999903 - 125027143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RBM18:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv416680CNV Loss16902084
    nsv523017CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RBM18 for disorders           About MalaCards

    RBM18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RBM18
    Human Genome Epidemiology (HuGE) Navigator: RBM18 (1 document)

    Export disorders for RBM18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBM18 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RBM18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92400 HGNC: 28413 AceView: RBM18 Ensembl:ENSG00000119446 euGenes: HUgn92400
    ECgene: RBM18 H-InvDB: RBM18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBM18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RBM18 gene:
    Search GeneIP for patents involving RBM18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Proteins for RBM18
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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