RBM18 Gene
protein-coding GIFtS: 46
GCID: GC09M125001
|
|
RNA binding motif protein 18
| |
Aliases
for RBM18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| RNA Binding Motif Protein 181 2 | | RNA-Binding Motif Protein 182 3 | | MGC27341 | | Probable RNA-Binding Protein 182 |
| External Ids: | HGNC: 284131 | Entrez Gene: 924002 | Ensembl: ENSG000001194467 | UniProtKB: Q96H353 | | ORGUL members: | |
|---|
| NONCODE:n407656 | |
Export aliases for RBM18 gene to outside databasesPrevious GC identifers: GC09M120378 GC09M122081 GC09M124041 GC09M094616
|---|
Summaries
for RBM18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RBM18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM18 gene promoter:
POU3F1 GCNF Lmo2 FOXD3 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 HNF-1A GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q33.2 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q34.11RBM18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M125001: view genomic region
(about GC identifiers)
Start:
|
125,001,834 bp from pter |
End:
|
125,027,143 bp from pter |
Size:
|
25,310 bases |
Orientation:
|
minus strand |
|
Proteins
for RBM18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM18_HUMAN, Q96H35 (See
protein sequence)Recommended Name: Probable RNA-binding protein 18 Size: 190 amino acids; 21649 Da
Secondary accessions: B3KQ89Explore the universe of human proteins at neXtProt for RBM18: NX_Q96H35
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96H35
RBM18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149108.1
ENSEMBL proteins: ENSP00000409315
Human Recombinant Protein Products:
RBM18 Antibody Products:
Assay Products for RBM18: |
Protein
Domains /
Families
for RBM18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96H35ProtoNet protein and cluster: Q96H35 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: RBM18_HUMAN, Q96H35Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for RBM18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RBM18 (NM_033117) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM18 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
RBM18 for ontologies About GeneDecksing
|
Pathways & Interactions
for RBM18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM18
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for RBM18 (Q96H353 ENSP000004093154) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for RBM18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM18
Search CenterWatch for drugs/clinical trials and news about RBM18
|
Transcripts
for RBM18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM18 gene: NM_033117.3 Unigene Cluster for RBM18: RNA binding motif protein 18 Hs.415842 [show with all ESTs]Unigene Representative Sequence: NR_0271253 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417201(uc004blz.2 uc010mvy.2 uc004bma.2 uc011lyp.1)
ENST00000491850 ENST00000483428
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBM18 (NM_033117) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM18 |
Additional cDNA sequence: AK026870.1 AK057676.1 AK299625.1 AK301050.1 AK310008.1 AK310807.1 AL389986.1 BC008942.2 BC019319.1 NR_027125.1 NR_027126.1 8 DOTS entries: DT.100024381 DT.440969 DT.100865678 DT.121172621 DT.109083 DT.95169161 DT.121172575 DT.95169163 24/234 AceView cDNA sequences (see all 234): AI018555 AA761985 AA258028 CR618364 AI672945 BU783829 BQ069604 AA083879 BC019319 BX401816 AI383248 BX091428 AW237105 AW016341 CF528572 BM917536 CR607872 BX365121 AW128915 AI950292 AW340172 AI050925 BM800481 AA379323
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RBM18 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | | | | | - | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for RBM18
|
Expression
for RBM18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAGCATTTG
About this image
See RBM18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM18
SOURCE GeneReport for Unigene cluster: Hs.415842
SABiosciences Custom PCR Arrays for RBM18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBM18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM18 |
Orthologs
for RBM18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBM18 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rbm181 , 5 |
RNA binding motif protein 181, 5 |
93.86(n)1
98.95(a)1 |
|
2 (24.19 cM)5
678891 NM_026434.41 NP_080710.11
361160795 |
chicken
(Gallus gallus) |
Aves |
RBM181 |
RNA binding motif protein 18 |
82.98(n)
93.16(a) |
|
417111 XM_415396.3 XP_415396.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.44472 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.65(n) |
|
BJ060816.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc733322 |
hypothetical protein MGC73332 |
77.18(n) |
|
393766 BC059651.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG144141 |
CG14414 |
51.96(n)
41.91(a) |
|
32394 NM_167410.3 NP_727783.3 |
ENSEMBL Gene Tree for RBM18 (if available)
TreeFam Gene Tree for RBM18 (if available) |
Paralogs
for RBM18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RBM18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM18 (125001834 - 125027143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RBM18
1 CNV: 6714 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM18 |
|
Disorders
/ Diseases
for RBM18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RBM18 for disorders About MalaCards
RBM18 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RBM18 (1 document)
Export disorders for RBM18 gene to outside databases
|
Publications
for RBM18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBM18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for RBM18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBM18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM18 gene:
Search GeneIP for patents involving RBM18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RBM18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM18 | | | OriGene Protein Over-expression Lysate for RBM18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBM18 | | OriGene 3'-UTR Clone for RBM18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBM18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM18 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RBM18 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RBM18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM18 |
|  |  |  | | | | ThermoFisher Antibodies for RBM18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM18 |
|
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