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RBM17 Gene

protein-coding   GIFtS: 55
GCID: GC10P006130

RNA Binding Motif Protein 17

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif Protein 171 2
SPF452 3 5
Splicing Factor 45kDa1 2
45 KDa-Splicing Factor2 3
RNA-Binding Motif Protein 172 3
Splicing Factor 452

External Ids:    HGNC: 169441   Entrez Gene: 849912   Ensembl: ENSG000001344537   OMIM: 6069355   UniProtKB: Q96I253   

Export aliases for RBM17 gene to outside databases

Previous GC identifers: GC10P006135 GC10P006171 GC10P006057


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBM17 Gene:
This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in
the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described.
Related pseudogenes exist on chromosomes 9 and 15. (provided by RefSeq, Mar 2009)

GeneCards Summary for RBM17 Gene:
RBM17 (RNA binding motif protein 17) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: SPF45_HUMAN, Q96I25
Function: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its
utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization
of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in
the HBB gene. The resulting frameshift leads to sickle cell anemia

Gene Wiki entry for RBM17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM17 gene promoter:
         AML1a   p53   ITF-2   Tal-1beta   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM17 promoter sequence
   Search Chromatin IP Primers for RBM17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

RBM17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM17 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P006130:  view genomic region     (about GC identifiers)

Start:
6,130,949 bp from pter      End:
6,159,422 bp from pter
Size:
28,474 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPF45_HUMAN, Q96I25 (See protein sequence)
Recommended Name: Splicing factor 45  
Size: 401 amino acids; 44962 Da
Subunit: Binds SXL. Associates with the spliceosome
2 PDB 3D structures from and Proteopedia for RBM17:
2PE8 (3D)        2PEH (3D)    
Secondary accessions: Q96GY6

Explore the universe of human proteins at neXtProt for RBM17: NX_Q96I25

Explore proteomics data for RBM17 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBM17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139019.1  NP_116294.1  

    ENSEMBL proteins: 
     ENSP00000369218   ENSP00000395448   ENSP00000408214   ENSP00000402303   ENSP00000406024  
     ENSP00000388638  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPATCH: G patch domain containing
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR016967 Splicing_factor_SPF45
     IPR000467 G_patch_dom
     IPR003954 RRM_dom_euk

    Graphical View of Domain Structure for InterPro Entry Q96I25

    ProtoNet protein and cluster: Q96I25

    2 Blocks protein domains:
    IPB000467 D111/G-patch domain
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)


    UniProtKB/Swiss-Prot: SPF45_HUMAN, Q96I25
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with RBM17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPF45_HUMAN, Q96I25
    Function: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its
    utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization
    of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in
    the HBB gene. The resulting frameshift leads to sickle cell anemia

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI17577209
         
    Find genes that share ontologies with RBM17           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for RBM17:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 
     Increased homologous recombina  Low eccentricity cells 

    Animal Models:
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    hsa-mir-10b-5p (MIRT047489), hsa-mir-10a-5p (MIRT025594), hsa-mir-125a-5p (MIRT021290), hsa-mir-7-5p (MIRT047772)

    Block miRNA regulation of human, mouse, rat RBM17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM17 (see all 32):
    hsa-miR-301a hsa-miR-500a hsa-miR-570 hsa-miR-3613-3p hsa-miR-2116 hsa-miR-497* hsa-miR-130b hsa-miR-433
    SwitchGear 3'UTR luciferase reporter plasmidRBM17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RBM17

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPF45_HUMAN, Q96I25: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with RBM17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RBM17 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Spliceosome
    Spliceosome


    Find genes that share SuperPaths with RBM17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RBM17
        mRNA processing



    1 Kegg Pathway  (Kegg details for RBM17):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM17
    Interactions:

        Search GeneGlobe Interaction Network for RBM17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for RBM17 (Q96I251, 2, 3 ENSP000003692184) via UniProtKB, MINT, STRING, and/or I2D (see all 794)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3B1O755331, 2, ENSP000003353214EBI-740272,EBI-876542 MINT-8332416 MINT-7945693 MINT-7947479 MINT-8333482 STRING: ENSP00000335321
    SF3A2Q154282, 3, ENSP000002214944MINT-5205539 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    DHX15O431431, 2, ENSP000003367414EBI-740272,EBI-1237044 MINT-8333988 MINT-8332493 STRING: ENSP00000336741
    SUGP1Q8IWZ81, 2, ENSP000002470014EBI-740272,EBI-2691671 MINT-8334087 MINT-8332504 STRING: ENSP00000247001
    MAP2K4P459852, 3MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with RBM17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for RBM17 (SPF45)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RBM17 gene (2 alternative transcripts): 
    NM_001145547.1  NM_032905.4  

    Unigene Cluster for RBM17:

    RNA binding motif protein 17
    Hs.498548  [show with all ESTs]
    Unigene Representative Sequence: BX648288
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379888 ENST00000437845 ENST00000432931 ENST00000418631 ENST00000467214
    ENST00000447032 ENST00000481147 ENST00000476706 ENST00000465906 ENST00000467080
    ENST00000496762 ENST00000446108(uc001ijb.3 uc010qav.2 uc001ijc.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat RBM17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM17 (see all 32):
    hsa-miR-301a hsa-miR-500a hsa-miR-570 hsa-miR-3613-3p hsa-miR-2116 hsa-miR-497* hsa-miR-130b hsa-miR-433
    SwitchGear 3'UTR luciferase reporter plasmidRBM17 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBM17
      QuantiTect SYBR Green Assays in human, mouse, rat RBM17
      QuantiFast Probe-based Assays in human, mouse, rat RBM17

    Additional mRNA sequence: 

    AF542550.1 AK021863.1 AK314952.1 BC007871.2 BC009064.1 BC039322.1 BX648288.1 

    20 DOTS entries:

    DT.100030031  DT.101982022  DT.100824415  DT.91738481  DT.121254683  DT.100824416  DT.100824421  DT.100030029 
    DT.97765011  DT.99975865  DT.100824418  DT.100824419  DT.75133917  DT.95204042  DT.100030034  DT.100726833 
    DT.100824408  DT.121254668  DT.95321889  DT.121020160 

    Selected AceView cDNA sequences (see all 389):

    AI911897 AA481965 CN480845 AI796207 AI310084 AI138610 AA194495 BE251996 
    BX494951 BQ651335 BG054545 BM672880 AI471620 CR612416 CR600086 BQ879597 
    CB108727 BQ182020 BE219957 AA159444 BU599614 AI422677 BQ649846 CA440937 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBM17 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ·
    SP1:        -     -                                         -     -           -     -                 -     -     -     -           -     -           -         
    SP2:              -                                         -     -           -     -                 -     -     -     -           -     -           -         
    SP3:                                                        -     -                                                                                             
    SP4:                                                        -     -           -     -                                                                           
    SP5:                                                                                                  -     -     -     -           -     -           -         

    ExUns: 13c · 13d ^ 14
    SP1:        -         
    SP2:        -         
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RBM17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBM17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RBM17 Expression
    About this image


    RBM17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
     
     Ovary (Reproductive System)
    RBM17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498548
        Custom PCR Arrays for RBM17
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBM17 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm171 , 5 RNA binding motif protein 171, 5 90.36(n)1
    99.25(a)1
      2 (8.85 cM)5
    769381  NM_152824.11  NP_690037.11 
     115854395 
    chicken
    (Gallus gallus)
    Aves RBM171 RNA binding motif protein 17 83.29(n)
    95.76(a)
      418248  XM_416473.4  XP_416473.1 
    lizard
    (Anolis carolinensis)
    Reptilia RBM176
    RNA binding motif protein 17
    90(a)
    1 ↔ 1
    5(653121-665838)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.117212 Xenopus laevis transcribed sequence with moderate similarity more 78.59(n)    CA973660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558402 similar to RNA binding motif protein 17 75.76(n)   393889  BC045473.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spf451 Spf45 50.48(n)
    47.11(a)
      3355114  NM_001042961.3  NP_001036426.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F58B3.71 F58B3.7 47.65(n)
    39.81(a)
      178091  NM_069797.4  NP_502198.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DRT1111 DRT111 47.81(n)
    41.98(a)
      839927  NM_102784.2  NP_174336.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g05261001 Os01g0526100 60(n)
    58.75(a)
      4323935  NM_001049761.2  NP_001043226.2 


    ENSEMBL Gene Tree for RBM17 (if available)
    TreeFam Gene Tree for RBM17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBM17 gene

    Find genes that share paralogs with RBM17           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for RBM17
    PGOHUM00000246747 PGOHUM00000236092 PGOHUM00000236464 PGOHUM00000236474


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBM17 (see all 777)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006002921,2
    --6129053(+) AGAGA-/CCCAGT 1 -- us2k10--------
    rs1865611901,2
    --6129277(+) TAAATC/TCCATG 1 -- us2k10--------
    rs756412191,2
    --6129310(+) CTAGAA/TATTAT 2 -- us2k10--------
    rs79072411,2
    C--6129451(+) TTACCC/GATATG 2 -- us2k111Minor allele frequency- G:0.09NA WA CSA 136
    rs626263441,2
    C,F--6129532(+) CTTAGA/GCACTG 2 -- us2k11Minor allele frequency- G:0.04NA 120
    rs412951191,2
    C,F--6129623(+) ATCCCC/TATTTA 2 -- us2k11Minor allele frequency- T:0.06NA 120
    rs412951211,2
    C,F--6129643(+) CTCTTC/TGTCTG 2 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1501740501,2
    --6129838(+) AATCAA/GCTTTG 2 -- us2k10--------
    rs78988901,2
    C,F,A,H--6129874(+) TTTTTT/AAATTT 2 -- us2k1 tfbs38Minor allele frequency- A:0.38NS NA WA CSA EA 486
    rs1162957711,2
    F--6129913(+) AATCTT/CGTATT 2 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for RBM17 (6130949 - 6159422 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RBM17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5665CNV Insertion18451855
    dgv1e49CNV Loss18971310
    nsv819453CNV Loss19587683
    nsv894815CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM17
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606935    OMIM disorders: --


    Find genes that share disorders with RBM17           About GenesLikeMe

    Genetic Association Database (GAD): RBM17
    Human Genome Epidemiology (HuGE) Navigator: RBM17 (2 documents)

    Export disorders for RBM17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBM17 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with RBM17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. (PubMed id 9731529)1, 2, 3 Neubauer G.... Mann M. (Nat. Genet. 1998)
    2. Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. (PubMed id 12015979)1, 2, 9 Lallena M.J.... Valcarcel J. (Cell 2002)
    3. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. (PubMed id 17676041)1, 4 Lowe C.E.... Todd J.A. (Nat. Genet. 2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. (PubMed id 16061639)1, 9 Perry W.L....Dantzig A.H. (Cancer Res. 2005)
    8. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84991 HGNC: 16944 AceView: RBM17 Ensembl:ENSG00000134453 euGenes: HUgn84991
    ECgene: RBM17 Kegg: 84991 H-InvDB: RBM17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBM17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBM17 gene:
    Search GeneIP for patents involving RBM17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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