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Aliases for RBM17 Gene

Aliases for RBM17 Gene

  • RNA Binding Motif Protein 17 2 3
  • SPF45 3 4 6
  • RNA-Binding Motif Protein 17 3 4
  • 45 KDa-Splicing Factor 3 4
  • Splicing Factor 45kDa 2 3
  • Splicing Factor 45 3

External Ids for RBM17 Gene

Summaries for RBM17 Gene

Entrez Gene Summary for RBM17 Gene

  • This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]

GeneCards Summary for RBM17 Gene

RBM17 (RNA Binding Motif Protein 17) is a Protein Coding gene. Among its related pathways are Spliceosome and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for RBM17 Gene

  • Splice factor that binds to the single-stranded 3AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.

Gene Wiki entry for RBM17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM17 Gene

Genomics for RBM17 Gene

Genomic Location for RBM17 Gene

Start:
6,088,986 bp from pter
End:
6,117,459 bp from pter
Size:
28,474 bases
Orientation:
Plus strand

Genomic View for RBM17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM17 Gene

Regulatory Elements for RBM17 Gene

Proteins for RBM17 Gene

  • Protein details for RBM17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I25-SPF45_HUMAN
    Recommended name:
    Splicing factor 45
    Protein Accession:
    Q96I25
    Secondary Accessions:
    • Q96GY6

    Protein attributes for RBM17 Gene

    Size:
    401 amino acids
    Molecular mass:
    44962 Da
    Quaternary structure:
    • Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2.

    Three dimensional structures from OCA and Proteopedia for RBM17 Gene

neXtProt entry for RBM17 Gene

Proteomics data for RBM17 Gene at MOPED

Post-translational modifications for RBM17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM17 Gene

No data available for DME Specific Peptides for RBM17 Gene

Domains for RBM17 Gene

Gene Families for RBM17 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • GPATCH :G patch domain containing

Suggested Antigen Peptide Sequences for RBM17 Gene

Graphical View of Domain Structure for InterPro Entry

Q96I25

UniProtKB/Swiss-Prot:

SPF45_HUMAN
Domain:
  • Contains 1 G-patch domain.:
    • Q96I25
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q96I25
genes like me logo Genes that share domains with RBM17: view

Function for RBM17 Gene

Molecular function for RBM17 Gene

UniProtKB/Swiss-Prot Function: Splice factor that binds to the single-stranded 3AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.

Gene Ontology (GO) - Molecular Function for RBM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 17577209
genes like me logo Genes that share ontologies with RBM17: view
genes like me logo Genes that share phenotypes with RBM17: view

miRNA for RBM17 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM17 Gene

Localization for RBM17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM17 Gene COMPARTMENTS Subcellular localization image for RBM17 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RBM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with RBM17: view

Pathways for RBM17 Gene

SuperPathways for RBM17 Gene

Superpath Contained pathways
1 Spliceosome
2 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RBM17: view

Pathways by source for RBM17 Gene

1 BioSystems pathway for RBM17 Gene
1 KEGG pathway for RBM17 Gene

Gene Ontology (GO) - Biological Process for RBM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IMP 17589525
genes like me logo Genes that share ontologies with RBM17: view

Transcripts for RBM17 Gene

Unigene Clusters for RBM17 Gene

RNA binding motif protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM17 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12: -
SP13:

ExUns: 13c · 13d ^ 14
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13: -

Relevant External Links for RBM17 Gene

GeneLoc Exon Structure for
RBM17
ECgene alternative splicing isoforms for
RBM17

Expression for RBM17 Gene

mRNA expression in normal human tissues for RBM17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM17 Gene

SOURCE GeneReport for Unigene cluster for RBM17 Gene Hs.498548

genes like me logo Genes that share expressions with RBM17: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM17 Gene

Orthologs for RBM17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM17 35
  • 100 (n)
  • 100 (a)
RBM17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM17 35
  • 91.77 (n)
  • 99 (a)
RBM17 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM17 35
  • 90.94 (n)
  • 99.25 (a)
RBM17 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm17 35
  • 90.36 (n)
  • 99.25 (a)
Rbm17 16
Rbm17 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM17 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM17 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm17 35
  • 90.69 (n)
  • 99.5 (a)
chicken
(Gallus gallus)
Aves RBM17 35
  • 83.29 (n)
  • 95.76 (a)
RBM17 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM17 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11721 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm17 35
  • 77.02 (n)
  • 87.12 (a)
Str.10970 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9911 35
zebrafish
(Danio rerio)
Actinopterygii rbm17 35
  • 73.18 (n)
  • 84.26 (a)
rbm17 36
  • 79 (a)
OneToOne
zgc55840 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009296 35
  • 32.99 (n)
  • 20.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spf45 35
  • 50.48 (n)
  • 47.11 (a)
Spf45 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F58B3.7 35
  • 47.65 (n)
  • 39.81 (a)
F58B3.7 36
  • 36 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.7707 35
thale cress
(Arabidopsis thaliana)
eudicotyledons DRT111 35
  • 47.81 (n)
  • 41.98 (a)
rice
(Oryza sativa)
Liliopsida Os01g0526100 35
  • 60 (n)
  • 58.75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5122 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2392 36
  • 48 (a)
OneToOne
Species with no ortholog for RBM17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM17 Gene

ENSEMBL:
Gene Tree for RBM17 (if available)
TreeFam:
Gene Tree for RBM17 (if available)

Paralogs for RBM17 Gene

Pseudogenes.org Pseudogenes for RBM17 Gene

genes like me logo Genes that share paralogs with RBM17: view

No data available for Paralogs for RBM17 Gene

Variants for RBM17 Gene

Sequence variations from dbSNP and Humsavar for RBM17 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8463 -- 6,116,449(+) TGCCA(A/G)TAGAA utr-variant-3-prime
rs1053169 -- 6,115,677(+) GACTT(C/T)TAAGA utr-variant-3-prime
rs1571025 -- 6,092,906(+) TCTGA(A/G)ACTTT intron-variant
rs1571026 -- 6,093,062(+) GCAGC(G/T)GAGAT intron-variant
rs2067567 -- 6,109,059(-) AAACT(G/T)TAACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM17 Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV Loss 18971310
nsv894815 CNV Gain 21882294
nsv5665 CNV Insertion 18451855
nsv819453 CNV Loss 19587683

Relevant External Links for RBM17 Gene

HapMap Linkage Disequilibrium report
RBM17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM17 Gene

Disorders for RBM17 Gene

Relevant External Links for RBM17

Genetic Association Database (GAD)
RBM17
Human Genome Epidemiology (HuGE) Navigator
RBM17
genes like me logo Genes that share disorders with RBM17: view

No data available for UniProtKB/Swiss-Prot for RBM17 Gene

Publications for RBM17 Gene

  1. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. (PMID: 9731529) Neubauer G. … Mann M. (Nat. Genet. 1998) 2 3 4
  2. Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. (PMID: 12015979) Lallena M.J. … Valcarcel J. (Cell 2002) 3 4 23
  3. Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. (PMID: 16061639) Perry W.L. … Dantzig A.H. (Cancer Res. 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for RBM17 Gene

Sources for RBM17 Gene

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