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Aliases for RBM15B Gene

Aliases for RBM15B Gene

  • RNA Binding Motif Protein 15B 2 3 5
  • HuOTT3 3 4
  • OTT3 3 4
  • Putative RNA-Binding Protein 15B 3
  • Chromosome 3p21.1 Gene Sequence 3
  • RNA-Binding Motif Protein 15B 4
  • One Twenty Two Protein 3 3
  • One-Twenty Two Protein 3 4

External Ids for RBM15B Gene

Previous GeneCards Identifiers for RBM15B Gene

  • GC03P051405
  • GC03P051428

Summaries for RBM15B Gene

Entrez Gene Summary for RBM15B Gene

  • Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

GeneCards Summary for RBM15B Gene

RBM15B (RNA Binding Motif Protein 15B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM15.

UniProtKB/Swiss-Prot for RBM15B Gene

  • May function in the regulation of alternative or illicit splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM15B Gene

Genomics for RBM15B Gene

Regulatory Elements for RBM15B Gene

Enhancers for RBM15B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F051668 0.4 ENCODE 10.1 +279.6 279593 4.1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 KLF13 SP3 SP5 TEX264 DCAF1 RNU6ATAC29P RBM15B RAD54L2 DOCK3 GRM2 PIR41340 RNA5SP132
GH03F051024 1.4 FANTOM5 Ensembl ENCODE 1.2 -366.1 -366125 2.1 KLF1 ZNF146 USF1 MAX FEZF1 ZBTB48 PATZ1 SCRT2 ZNF416 PRDM10 RAD54L2 DOCK3 TEX264 DCAF1 RBM15B ST13P14 GC03M051294
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBM15B on UCSC Golden Path with GeneCards custom track

Promoters for RBM15B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000459239 332 1601 ATF1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ETS1 YY1 ZNF143 SP3

Genomic Location for RBM15B Gene

51,391,268 bp from pter
51,397,908 bp from pter
6,641 bases
Plus strand

Genomic View for RBM15B Gene

Genes around RBM15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM15B Gene

Proteins for RBM15B Gene

  • Protein details for RBM15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA-binding protein 15B
    Protein Accession:
    Secondary Accessions:
    • A4QPG7
    • Q6QE19
    • Q9BV96

    Protein attributes for RBM15B Gene

    890 amino acids
    Molecular mass:
    97205 Da
    Quaternary structure:
    • Interacts (via the SPOC domain) with Epstein-Barr virus BMLF1 (via the N-terminus); the interaction is direct. May interact with NCOR2.
    • Sequence=AAH01367.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS50153.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=CAD38547.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM15B Gene


neXtProt entry for RBM15B Gene

Post-translational modifications for RBM15B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM15B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBM15B Gene

Domains & Families for RBM15B Gene

Gene Families for RBM15B Gene

Suggested Antigen Peptide Sequences for RBM15B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM Spen family.
  • Contains 3 RRM (RNA recognition motif) domains.
  • Contains 1 SPOC domain.
  • Belongs to the RRM Spen family.
genes like me logo Genes that share domains with RBM15B: view

Function for RBM15B Gene

Molecular function for RBM15B Gene

UniProtKB/Swiss-Prot Function:
May function in the regulation of alternative or illicit splicing.

Gene Ontology (GO) - Molecular Function for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IBA --
GO:0003723 RNA binding NAS 16129689
GO:0005515 protein binding IPI 16129689
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM15B: view
genes like me logo Genes that share phenotypes with RBM15B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM15B Gene

Localization for RBM15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM15B Gene

Nucleus, nucleoplasm. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli.

Subcellular locations from

Jensen Localization Image for RBM15B Gene COMPARTMENTS Subcellular localization image for RBM15B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA,IDA 16129689
GO:0005730 NOT nucleolus IDA 16129689
genes like me logo Genes that share ontologies with RBM15B: view

Pathways & Interactions for RBM15B Gene

SuperPathways for RBM15B Gene

No Data Available

Interacting Proteins for RBM15B Gene

Gene Ontology (GO) - Biological Process for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 16129689
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0006913 NOT nucleocytoplasmic transport IDA 16129689
genes like me logo Genes that share ontologies with RBM15B: view

No data available for Pathways by source and SIGNOR curated interactions for RBM15B Gene

Transcripts for RBM15B Gene

mRNA/cDNA for RBM15B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(310) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBM15B Gene

RNA binding motif protein 15B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM15B Gene

No ASD Table

Relevant External Links for RBM15B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM15B Gene

Protein differential expression in normal tissues from HIPED for RBM15B Gene

This gene is overexpressed in Fetal Brain (15.1), Peripheral blood mononuclear cells (9.7), and Monocytes (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM15B Gene

Protein tissue co-expression partners for RBM15B Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM15B Gene:


SOURCE GeneReport for Unigene cluster for RBM15B Gene:


mRNA Expression by UniProt/SwissProt for RBM15B Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RBM15B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBM15B Gene

Orthologs for RBM15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBM15B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM15B 34
  • 99.63 (n)
(Canis familiaris)
Mammalia RBM15B 34
  • 89.64 (n)
(Bos Taurus)
Mammalia RBM15B 34
  • 89.2 (n)
(Mus musculus)
Mammalia Rbm15b 34 16
  • 86.31 (n)
(Rattus norvegicus)
Mammalia Rbm15b 34
  • 86.23 (n)
(Gallus gallus)
Aves MANF 34
  • 76.28 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm15b 34
  • 64.53 (n)
Str.11287 34
Species where no ortholog for RBM15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RBM15B Gene

Gene Tree for RBM15B (if available)
Gene Tree for RBM15B (if available)

Paralogs for RBM15B Gene

Paralogs for RBM15B Gene

(1) SIMAP similar genes for RBM15B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RBM15B: view

Variants for RBM15B Gene

Sequence variations from dbSNP and Humsavar for RBM15B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1051291 -- 51,394,216(+) TGTCC(A/C)CCACC utr-variant-3-prime
rs111598583 -- 51,391,315(+) GCGGC(C/G)CCGGG utr-variant-5-prime
rs112066805 -- 51,395,903(+) TTTTG(-/T)TTTTT nc-transcript-variant, utr-variant-3-prime
rs112178539 -- 51,390,892(+) CAATG(C/T)CCCAG upstream-variant-2KB
rs112281347 -- 51,391,098(+) CAGAG(C/G)GCGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RBM15B Gene

Variant ID Type Subtype PubMed ID
dgv8321n54 CNV loss 21841781
nsv475628 CNV novel sequence insertion 20440878
nsv479147 CNV novel sequence insertion 20440878
nsv480643 CNV novel sequence insertion 20440878
nsv590276 CNV loss 21841781
nsv590277 CNV loss 21841781

Variation tolerance for RBM15B Gene

Residual Variation Intolerance Score: 1.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM15B Gene

Disorders for RBM15B Gene

Relevant External Links for RBM15B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBM15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM15B Gene

Publications for RBM15B Gene

  1. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PMID: 16129689) Hiriart E. … Manet E. (J. Biol. Chem. 2005) 2 3 4 22 64
  2. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. (PMID: 19586903) Uranishi H. … Felber B.K. (J. Biol. Chem. 2009) 3 22 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for RBM15B Gene

Sources for RBM15B Gene

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