RBM15B Gene
protein-coding GIFtS: 46
GCID: GC03P051428
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|
RNA binding motif protein 15B
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Aliases
for RBM15B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 15B1 2 | | Chromosome 3p21.1 Gene Sequence2 | | OTT31 2 3 5 | | HuOTT33 | | HUMAGCGB1 2 5 | | One Twenty Two Protein 32 | | One-Twenty Two Protein 32 3 | | Putative RNA-Binding Protein 15B2 | | RNA-Binding Motif Protein 15B2 3 | | HuOTT33 |
Export aliases for RBM15B gene to outside databasesPrevious GC identifer: GC03P051405 |
Summaries
for RBM15B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBM15B:
Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signalingpathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 (PubMed16129689)).(supplied by OMIM, Feb 2009)
UniProtKB/Swiss-Prot: RB15B_HUMAN, Q8NDT2Function: May function in the regulation of alternative or illicit splicing
|
Genomic Views
for RBM15B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM15B gene promoter:
ER-alpha CBF-C GATA-2 Egr-2 CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM15B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM15B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.2 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21.1RBM15B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P051428: view genomic region
(about GC identifiers)
Start:
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51,428,731 bp from pter |
End:
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51,435,339 bp from pter |
Size:
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6,609 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr3+,PATCHES 51,427,023-51,433,631 |
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Proteins
for RBM15B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RB15B_HUMAN, Q8NDT2 (See
protein sequence)Recommended Name: Putative RNA-binding protein 15B Size: 890 amino acids; 97205 Da
Subunit: Interacts (via the SPOC domain) with Epstein-Barr virus BMLF1 (via the N-terminus); the interaction is direct.May interact with NCOR2
Subcellular location: Nucleus, nucleoplasm. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasmwith a granular staining pattern and excluded from the nucleoli
Sequence caution: Sequence=AAH01367.2; Type=Erroneous initiation; Sequence=AAS50153.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part; Sequence=CAD38547.2; Type=Erroneousinitiation;
Secondary accessions: Q6QE19 Q9BV96Explore the universe of human proteins at neXtProt for RBM15B: NX_Q8NDT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NDT2
RBM15B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037418.3
ENSEMBL proteins: ENSP00000313890
Human Recombinant Protein Products for RBM15B:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RBM15B for ontologies About GeneDecksing
RBM15B Antibody Products:
Assay Products for RBM15B: |
Protein
Domains /
Families
for RBM15B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM15B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NDT2ProtoNet protein and cluster: Q8NDT2 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB012921 SPOC
UniProtKB/Swiss-Prot: RB15B_HUMAN, Q8NDT2Similarity: Belongs to the RRM Spen familySimilarity: Contains 3 RRM (RNA recognition motif) domainsSimilarity: Contains 1 SPOC domain |
Function
for RBM15B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RB15B_HUMAN, Q8NDT2Function: May function in the regulation of alternative or illicit splicing Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RBM15B for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RBM15B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM15B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM15B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM15B |
|
Pathways & Interactions
for RBM15B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM15B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/10 Interacting proteins for RBM15B (Q8NDT23 ENSP000003138904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
RBM15B for ontologies About GeneDecksing
|
Drugs & Compounds
for RBM15B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM15B
Search CenterWatch for drugs/clinical trials and news about RBM15B / RB15B
|
Transcripts
for RBM15B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM15B gene: NM_013286.4 Unigene Cluster for RBM15B: RNA binding motif protein 15B Hs.118738 [show with all ESTs]Unigene Representative Sequence: NM_0132861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000323686(uc003dbd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM15B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM15B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBM15B (NM_013286) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM15B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM15B |
Additional cDNA sequence: AL831838.1 AY545557.1 BC001367.2 BC121184.2 5 DOTS entries: DT.91768433 DT.95180335 DT.101982209 DT.100796654 DT.120920388 24/310 AceView cDNA sequences (see all 310): W68817 BU740194 BM716239 AA369886 CA425648 BQ019061 BE256129 AA489414 BG480312 BU733494 BU688198 BQ773469 AI261723 AI910922 AI784359 BM714025 CA417112 AI632540 BU625458 BU184619 BQ641242 AA939105 BE502788 AI243366
GeneLoc Exon Structure
|
Expression
for RBM15B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM15B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RBM15B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM15B
SOURCE GeneReport for Unigene cluster: Hs.118738
UniProtKB/Swiss-Prot: RB15B_HUMAN, Q8NDT2Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for RBM15B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM15B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RBM15B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM15B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM15B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM15B |
Orthologs
for RBM15B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBM15B gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for RBM15B (if available)
TreeFam Gene Tree for RBM15B (if available) |
Paralogs
for RBM15B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBM15B gene
- SPEN2 RBM152
1 SIMAP similar gene for RBM15B using alignment to 4 protein entries: RB15B_HUMAN (see all proteins):RBM15
RBM15B for paralogs About GeneDecksing
|
Genomic Variants
for RBM15B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM15B (51428731 - 51435339 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBM15B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM15B |
|
Disorders
/ Diseases
for RBM15B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBM15B for disorders About GeneDecksing
OMIM gene information: 612602
OMIM disorders: --
5  diseases for RBM15B: About MalaCardsmegakaryoblastic leukemia acute megakaryoblastic leukemia kaposi's sarcoma sarcoma
leukemia
Export disorders for RBM15B gene to outside databases
|
Publications
for RBM15B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM15B gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with RBM15B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PubMed id 16129689)1, 2, 3, 9 Hiriart E.... Manet E. (2005)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. (PubMed id 19586903)1, 9 Uranishi H....Felber B.K. (2009)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Kaposi's sarcoma-associated herpesvirus ORF57 interac ts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of v iral ORF59. (PubMed id 21106733)1 Majerciak V....Zheng Z.M. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. (PubMed id 19336002)1 Zhou W....Zhang L. (2009)
|
External Searches for RBM15B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM15B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM15B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBM15B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM15B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM15B gene:
Search GeneIP for patents involving RBM15B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM15B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | RBM15B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM15B |
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