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Aliases for RBM15B Gene

Aliases for RBM15B Gene

  • RNA Binding Motif Protein 15B 2 3 5
  • RNA-Binding Motif Protein 15B 3 4
  • One-Twenty Two Protein 3 3 4
  • HuOTT3 3 4
  • OTT3 3 4
  • Chromosome 3p21.1 Gene Sequence 3
  • One Twenty Two Protein 3 3

External Ids for RBM15B Gene

Previous GeneCards Identifiers for RBM15B Gene

  • GC03P051405
  • GC03P051428

Summaries for RBM15B Gene

Entrez Gene Summary for RBM15B Gene

  • Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

GeneCards Summary for RBM15B Gene

RBM15B (RNA Binding Motif Protein 15B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM15.

UniProtKB/Swiss-Prot for RBM15B Gene

  • May function in the regulation of alternative or illicit splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM15B Gene

Genomics for RBM15B Gene

Regulatory Elements for RBM15B Gene

Enhancers for RBM15B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RBM15B on UCSC Golden Path with GeneCards custom track

Promoters for RBM15B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM15B on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM15B Gene

51,391,268 bp from pter
51,397,908 bp from pter
6,641 bases
Plus strand

Genomic View for RBM15B Gene

Genes around RBM15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM15B Gene

Proteins for RBM15B Gene

  • Protein details for RBM15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA-binding protein 15B
    Protein Accession:
    Secondary Accessions:
    • A4QPG7
    • Q6QE19
    • Q9BV96

    Protein attributes for RBM15B Gene

    890 amino acids
    Molecular mass:
    97205 Da
    Quaternary structure:
    • Interacts (via the SPOC domain) with Epstein-Barr virus BMLF1 (via the N-terminus); the interaction is direct. May interact with NCOR2.
    • Sequence=AAH01367.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS50153.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=CAD38547.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM15B Gene


neXtProt entry for RBM15B Gene

Proteomics data for RBM15B Gene at MOPED

Post-translational modifications for RBM15B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM15B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBM15B Gene

Domains & Families for RBM15B Gene

Gene Families for RBM15B Gene

Suggested Antigen Peptide Sequences for RBM15B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM Spen family.
  • Contains 3 RRM (RNA recognition motif) domains.
  • Contains 1 SPOC domain.
  • Belongs to the RRM Spen family.
genes like me logo Genes that share domains with RBM15B: view

Function for RBM15B Gene

Molecular function for RBM15B Gene

UniProtKB/Swiss-Prot Function:
May function in the regulation of alternative or illicit splicing.

Gene Ontology (GO) - Molecular Function for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA,IBA --
GO:0003723 RNA binding NAS 16129689
genes like me logo Genes that share ontologies with RBM15B: view
genes like me logo Genes that share phenotypes with RBM15B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM15B Gene

Localization for RBM15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM15B Gene

Nucleus, nucleoplasm. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli.

Subcellular locations from

Jensen Localization Image for RBM15B Gene COMPARTMENTS Subcellular localization image for RBM15B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 16129689
genes like me logo Genes that share ontologies with RBM15B: view

Pathways & Interactions for RBM15B Gene

SuperPathways for RBM15B Gene

No Data Available

Interacting Proteins for RBM15B Gene

Gene Ontology (GO) - Biological Process for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006397 mRNA processing IEA --
GO:0006913 NOT nucleocytoplasmic transport IDA 16129689
genes like me logo Genes that share ontologies with RBM15B: view

No data available for Pathways by source and SIGNOR curated interactions for RBM15B Gene

Drugs & Compounds for RBM15B Gene

No Compound Related Data Available

Transcripts for RBM15B Gene

mRNA/cDNA for RBM15B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(310) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBM15B Gene

RNA binding motif protein 15B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM15B Gene

No ASD Table

Relevant External Links for RBM15B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM15B Gene

mRNA expression in normal human tissues for RBM15B Gene

Protein differential expression in normal tissues from HIPED for RBM15B Gene

This gene is overexpressed in Fetal Brain (15.1), Peripheral blood mononuclear cells (9.7), and Monocytes (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RBM15B Gene

SOURCE GeneReport for Unigene cluster for RBM15B Gene Hs.118738

mRNA Expression by UniProt/SwissProt for RBM15B Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RBM15B: view

Protein tissue co-expression partners for RBM15B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBM15B Gene

Orthologs for RBM15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBM15B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBM15B 35
  • 89.2 (n)
  • 95.05 (a)
(Canis familiaris)
Mammalia RBM15B 35
  • 89.64 (n)
  • 95.38 (a)
(Mus musculus)
Mammalia Rbm15b 35
  • 86.31 (n)
  • 93.23 (a)
Rbm15b 16
(Pan troglodytes)
Mammalia RBM15B 35
  • 99.63 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rbm15b 35
  • 86.23 (n)
  • 93 (a)
(Gallus gallus)
Aves MANF 35
  • 76.28 (n)
  • 85.02 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm15b 35
  • 64.53 (n)
  • 67.36 (a)
Str.11287 35
Species with no ortholog for RBM15B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RBM15B Gene

Gene Tree for RBM15B (if available)
Gene Tree for RBM15B (if available)

Paralogs for RBM15B Gene

Paralogs for RBM15B Gene

(1) SIMAP similar genes for RBM15B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RBM15B: view

Variants for RBM15B Gene

Sequence variations from dbSNP and Humsavar for RBM15B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs753452 -- 51,394,961(+) GGGCC(C/T)GGGAG utr-variant-3-prime
rs1051291 -- 51,394,216(+) TGTCC(A/C)CCACC utr-variant-3-prime
rs11540366 -- 51,394,336(-) AAAAA(A/T)AAAAA utr-variant-3-prime
rs3050035 -- 51,394,553(+) ACTTA(-/TTTA)CACTC utr-variant-3-prime
rs34018524 -- 51,390,083(+) AGTGC(-/T)TTTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RBM15B Gene

Variant ID Type Subtype PubMed ID
nsv876779 CNV Loss 21882294

Variation tolerance for RBM15B Gene

Residual Variation Intolerance Score: 1.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RBM15B Gene

Disorders for RBM15B Gene

Relevant External Links for RBM15B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBM15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM15B Gene

Publications for RBM15B Gene

  1. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PMID: 16129689) Hiriart E. … Manet E. (J. Biol. Chem. 2005) 2 3 4 23 67
  2. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. (PMID: 19586903) Uranishi H. … Felber B.K. (J. Biol. Chem. 2009) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RBM15B Gene

Sources for RBM15B Gene