Aliases for RBM15 Gene
External Ids for RBM15 Gene
Previous GeneCards Identifiers for RBM15 Gene
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
GeneCards Summary for RBM15 Gene
RBM15 (RNA Binding Motif Protein 15) is a Protein Coding gene. Diseases associated with RBM15 include 'megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)' and megakaryocytic leukemia. Among its related pathways are Notch-mediated HES/HEY network and Notch signaling pathway (Pathway Interaction Database). GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SPEN.
UniProtKB/Swiss-Prot for RBM15 Gene
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.