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Aliases for RBM15 Gene

Aliases for RBM15 Gene

  • RNA Binding Motif Protein 15 2 3 5
  • One-Twenty Two Protein 1 3 4
  • One Twenty-Two 2 3
  • OTT1 3 4
  • OTT 3 4
  • Putative RNA-Binding Protein 15 3
  • RNA-Binding Motif Protein 15 4
  • One Twenty Two Protein 3
  • SPEN 3

External Ids for RBM15 Gene

Previous GeneCards Identifiers for RBM15 Gene

  • GC01P111298
  • GC01P109748
  • GC01P109983
  • GC01P110179
  • GC01P110180
  • GC01P110593
  • GC01P110682
  • GC01P110876
  • GC01P108753
  • GC01P110882

Summaries for RBM15 Gene

Entrez Gene Summary for RBM15 Gene

  • Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

GeneCards Summary for RBM15 Gene

RBM15 (RNA Binding Motif Protein 15) is a Protein Coding gene. Diseases associated with RBM15 include Megakaryoblastic Acute Myeloid Leukemia With T(1;22)(P13;Q13) and Megakaryocytic Leukemia. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM15B.

UniProtKB/Swiss-Prot for RBM15 Gene

  • May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.

Gene Wiki entry for RBM15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM15 Gene

Genomics for RBM15 Gene

Regulatory Elements for RBM15 Gene

Enhancers for RBM15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F110382 1.6 FANTOM5 Ensembl ENCODE 13.3 +46.1 46106 3.5 PKNOX1 FOS CREM SMARCA5 ZNF362 HCFC1 CBFB USF2 CEBPB ZEB2 PROK1 RBM15 SLC16A4 LAMTOR5 LOC440600 LAMTOR5-AS1 STRIP1 CD53 GC01P110380
GH01F110307 1.3 Ensembl ENCODE 12.3 -29.4 -29423 3.2 CTCF BHLHE40 CEBPB CEBPG ZFHX2 ZNF316 CEBPA SMC3 HMBOX1 FOS LOC440600 RBM15 KCNC4 KCNC4-AS1 SLC16A4 ENSG00000200536 LOC105378897 ENSG00000235526 PROK1 KCNA10
GH01F110312 1.1 Ensembl ENCODE 12.3 -25.6 -25615 0.8 WRNIP1 ZNF2 RAD21 ZNF366 ZNF143 ZNF654 REST KLF16 GLIS1 ZNF524 LOC440600 PROK1 RBM15 KCNC4 KCNC4-AS1 ENSG00000200536 ENSG00000235526 LOC105378897 ENSG00000258634 UBL4B
GH01F110380 1.1 Ensembl ENCODE 10.9 +42.5 42475 1.8 ZNF274 ZNF384 EBF1 MYC PROK1 SLC16A4 LOC440600 RBM15 LAMTOR5 GC01P110380
GH01F110412 1.2 Ensembl ENCODE 10.7 +74.6 74584 1.2 HDGF HDAC1 CBX3 ARNT TBL1XR1 RAD21 RFX5 CHAMP1 GATA2 ZNF143 PROK1 LOC440600 RBM15 GC01M110420 LAMTOR5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBM15 on UCSC Golden Path with GeneCards custom track

Promoters for RBM15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000670731 574 3601 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 PPARGC1A MEF2D

Genomic Location for RBM15 Gene

Chromosome:
1
Start:
110,338,426 bp from pter
End:
110,373,218 bp from pter
Size:
34,793 bases
Orientation:
Plus strand

Genomic View for RBM15 Gene

Genes around RBM15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM15 Gene

Proteins for RBM15 Gene

  • Protein details for RBM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T37-RBM15_HUMAN
    Recommended name:
    Putative RNA-binding protein 15
    Protein Accession:
    Q96T37
    Secondary Accessions:
    • A1A693
    • Q3ZB86
    • Q4V760
    • Q5D058
    • Q5T613
    • Q86VW9
    • Q96PE4
    • Q96SC5
    • Q96SC6
    • Q96SC9
    • Q96SD0
    • Q96T38
    • Q9BRA5
    • Q9H6R8
    • Q9H9Y0

    Protein attributes for RBM15 Gene

    Size:
    977 amino acids
    Molecular mass:
    107189 Da
    Quaternary structure:
    • Interacts with Epstein-Barr virus BSFL2/BMLF1. Interacts (via SPOC domain) with SETD1B. Interacts with NXF1, the interaction is required to promote mRNA export. Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).
    SequenceCaution:
    • Sequence=BAB14088.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15185.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM15 Gene

Post-translational modifications for RBM15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM15 Gene

No data available for DME Specific Peptides for RBM15 Gene

Domains & Families for RBM15 Gene

Gene Families for RBM15 Gene

Graphical View of Domain Structure for InterPro Entry

Q96T37

UniProtKB/Swiss-Prot:

RBM15_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
  • Belongs to the RRM Spen family.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
  • Contains 1 SPOC domain.
Family:
  • Belongs to the RRM Spen family.
genes like me logo Genes that share domains with RBM15: view

Function for RBM15 Gene

Molecular function for RBM15 Gene

UniProtKB/Swiss-Prot Function:
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.

Gene Ontology (GO) - Molecular Function for RBM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IBA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 16129689
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM15: view
genes like me logo Genes that share phenotypes with RBM15: view

Animal Models for RBM15 Gene

MGI Knock Outs for RBM15:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBM15 Gene

Localization for RBM15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM15 Gene

Nucleus. Nucleus membrane; Peripheral membrane protein. Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes at the nuclear pore with DBP5 and NXF1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM15 Gene COMPARTMENTS Subcellular localization image for RBM15 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA,IDA 24100041
GO:0016020 membrane IEA --
GO:0016607 nuclear speck IEA,IDA 24100041
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with RBM15: view

Pathways & Interactions for RBM15 Gene

SuperPathways for RBM15 Gene

No Data Available

SIGNOR curated interactions for RBM15 Gene

Activates:

Gene Ontology (GO) - Biological Process for RBM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0001569 branching involved in blood vessel morphogenesis IEA --
GO:0007221 positive regulation of transcription of Notch receptor target IEA --
GO:0016032 viral process IEA --
GO:0045638 negative regulation of myeloid cell differentiation IEA --
genes like me logo Genes that share ontologies with RBM15: view

No data available for Pathways by source for RBM15 Gene

Transcripts for RBM15 Gene

Unigene Clusters for RBM15 Gene

RNA binding motif protein 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM15 Gene

No ASD Table

Relevant External Links for RBM15 Gene

GeneLoc Exon Structure for
RBM15
ECgene alternative splicing isoforms for
RBM15

Expression for RBM15 Gene

mRNA expression in normal human tissues for RBM15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM15 Gene

This gene is overexpressed in Cerebrospinal fluid (33.9) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM15 Gene



Protein tissue co-expression partners for RBM15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM15 Gene:

RBM15

SOURCE GeneReport for Unigene cluster for RBM15 Gene:

Hs.435947
genes like me logo Genes that share expression patterns with RBM15: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM15 Gene

Orthologs for RBM15 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM15 34 35
  • 98.9 (n)
cow
(Bos Taurus)
Mammalia RBM15 34 35
  • 93.37 (n)
dog
(Canis familiaris)
Mammalia RBM15 34 35
  • 91.76 (n)
rat
(Rattus norvegicus)
Mammalia Rbm15 34
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Rbm15 34 16 35
  • 90.31 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM15 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM15 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859595 34
  • 73.04 (n)
RBM15 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm15 34
  • 63.77 (n)
Str.7059 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19505 34
zebrafish
(Danio rerio)
Actinopterygii rbm15 34 35
  • 62.45 (n)
Dr.15490 34
fruit fly
(Drosophila melanogaster)
Insecta nito 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grld-1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for RBM15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM15 Gene

ENSEMBL:
Gene Tree for RBM15 (if available)
TreeFam:
Gene Tree for RBM15 (if available)

Paralogs for RBM15 Gene

Paralogs for RBM15 Gene

(1) SIMAP similar genes for RBM15 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RBM15 Gene

genes like me logo Genes that share paralogs with RBM15: view

Variants for RBM15 Gene

Sequence variations from dbSNP and Humsavar for RBM15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1046002 -- 110,362,953(-) GTTCT(C/T)AATTA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1055013 -- 110,372,675(+) GAATC(C/T)TGTTT intron-variant, nc-transcript-variant
rs10857819 -- 110,361,776(+) TTTTT(A/G)CATGT intron-variant
rs10857820 -- 110,362,303(+) ATAAC(A/G)ATGAT intron-variant
rs11102092 -- 110,357,812(+) AATTC(C/T)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM15 Gene

Variant ID Type Subtype PubMed ID
nsv946137 CNV duplication 23825009

Variation tolerance for RBM15 Gene

Residual Variation Intolerance Score: 3.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM15 Gene

Human Gene Mutation Database (HGMD)
RBM15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM15 Gene

Disorders for RBM15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RBM15 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)
  • megakaryoblastic aml with t(1;22)(p13;q13)
megakaryocytic leukemia
  • acute megakaryoblastic leukaemia, fab m7
pancreatic cystadenoma
  • cystadenoma of pancreas
microcystic adenoma
  • adenoma microcystic
kidney angiomyolipoma
  • angiomyolipoma of kidney
- elite association - COSMIC cancer census association via MalaCards
Search RBM15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RBM15_HUMAN
  • Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. {ECO:0000269 PubMed:11344311, ECO:0000269 PubMed:11431691}.

Relevant External Links for RBM15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM15
genes like me logo Genes that share disorders with RBM15: view

No data available for Genatlas for RBM15 Gene

Publications for RBM15 Gene

  1. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. (PMID: 11431691) Ma Z. … Hitzler J.K. (Nat. Genet. 2001) 2 3 4 22 64
  2. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PMID: 16129689) Hiriart E. … Manet E. (J. Biol. Chem. 2005) 3 4 22 64
  3. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. (PMID: 11344311) Mercher T. … Bernard O.A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 64
  4. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. (PMID: 24100041) Horiuchi K. … Hamakubo T. (J. Biol. Chem. 2013) 3 4 64
  5. Rbm15-Mkl1 Interacts with the Setd1b Histone H3-Lys4 Methyltransferase via a SPOC Domain That Is Required for Cytokine- Independent Proliferation. (PMID: 22927943) Lee J.H. … Skalnik D.G. (PLoS ONE 2012) 3 4 64

Products for RBM15 Gene

Sources for RBM15 Gene

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