RBM15 Gene
protein-coding GIFtS: 50
GCID: GC01P110882
|
|
RNA binding motif protein 15
| |
Aliases
for RBM15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 151 2 | | SPEN2 5 | | OTT1 2 3 5 | | One Twenty Two Protein2 | | OTT11 2 3 | | One Twenty-Two2 | | One-Twenty Two Protein 12 3 | | Putative RNA-Binding Protein 152 | | RNA-Binding Motif Protein 152 3 | | |
Export aliases for RBM15 gene to outside databasesPrevious GC identifers: GC01P111298 GC01P109748 GC01P109983 GC01P110179 GC01P110180 GC01P110593 GC01P110682 GC01P110876 GC01P108753 |
Summaries
for RBM15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBM15:
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signalingpathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 (PubMed16129689)).(supplied by OMIM, Feb 2009)
UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37Function: May be implicated in HOX gene regulation
Gene Wiki entry for RBM15
|
Genomic Views
for RBM15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM15 gene promoter:
Egr-2 Egr-3 TBP SRY Ik-2 Egr-1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13RBM15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P110882: view genomic region
(about GC identifiers)
Start:
|
110,881,128 bp from pter |
End:
|
110,889,303 bp from pter |
Size:
|
8,176 bases |
Orientation:
|
plus strand |
|
Proteins
for RBM15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37 (See
protein sequence)Recommended Name: Putative RNA-binding protein 15 Size: 977 amino acids; 107189 Da
Subunit: Interacts with Epstein-Barr virus BSFL2/BMLF1
Subcellular location: Nucleus
Sequence caution: Sequence=BAB14088.1; Type=Erroneous initiation; Sequence=BAB15185.1; Type=Erroneous initiation;
Secondary accessions: Q4V760 Q5D058 Q5T613 Q96PE4 Q96SC5 Q96SC6 Q96SC9 Q96SD0 Q96T38 Q9BRA5 Q9H6R8Q9H9Y0Alternative splicing: 3 isoforms: Q96T37-1 Q96T37-2 Q96T37-3 Explore the universe of human proteins at neXtProt for RBM15: NX_Q96T37
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96T37
RBM15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001188474.1 NP_073605.4
ENSEMBL proteins: ENSP00000358799
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RBM15 for ontologies About GeneDecksing
RBM15 Antibody Products:
Assay Products for RBM15: |
Protein
Domains /
Families
for RBM15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM15 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96T37ProtoNet protein and cluster: Q96T37 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB012921 SPOC
UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37Similarity: Belongs to the RRM Spen familySimilarity: Contains 3 RRM (RNA recognition motif) domainsSimilarity: Contains 1 SPOC domain |
Function
for RBM15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37Function: May be implicated in HOX gene regulation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RBM15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM15 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RBM15 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Rbm15tm1.1Dgg for RBM15
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rbm15):
RBM15 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RBM15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBM15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/590 Interacting proteins for RBM15 (Q96T372, 3 ENSP000003587994) via UniProtKB, MINT, STRING, and/or I2D (see all 590)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0001569 | patterning of blood vessels |
IEA | -- | | GO:0007221 | positive regulation of transcription of Notch receptor target |
IEA | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- |
RBM15 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBM15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM15
Search CenterWatch for drugs/clinical trials and news about RBM15
|
Transcripts
for RBM15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM15 gene (2 alternative transcripts): NM_001201545.1 NM_022768.4 Unigene Clusters for RBM15: RNA binding motif protein 15 Hs.435947 [show with all ESTs], Hs.708172 [show with all ESTs]Unigene Representative Sequences: BC042587, AB2096802 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369784(uc001dzl.1 uc001dzm.1) ENST00000487146
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM15 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBM15 (NM_013286) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM15 |
Additional cDNA sequence: AB209680.1 BC069656.1 BC069701.1 BC069719.1 BC069739.1 BC069755.1 7 DOTS entries: DT.87016432 DT.211537 DT.75103092 DT.97768794 DT.100658991 DT.100680563 DT.95276844 24/60 AceView cDNA sequences (see all 60): AI871508 BU685828 BC042587 AI634112 AI869382 BE221286 AI093558 BE222623 CB529546 BC062316 AF086464 BF448359 BX101314 BC006397 AI478458 AI375793 BE505017 BG760350 NM_022768 BE466151 AI458718 T35210 AA235957 AI423840
GeneLoc Exon Structure
|
Expression
for RBM15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCTCTGAT
About this image
See RBM15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM15
SOURCE GeneReport for Unigene clusters: Hs.435947 Hs.708172
SABiosciences Custom PCR Arrays for RBM15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBM15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM15 |
Orthologs
for RBM15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBM15 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008595951 |
putative RNA-binding protein 15-like |
71.46(n)
79.47(a) |
|
100859595 XM_003642736.1 XP_003642784.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.195052 |
Xenopus laevis transcribed sequence with weak similarity more |
74.81(n) |
|
AW638365.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.154902 |
Transcribed sequence with moderate similarity to protein more |
75.55(n) |
|
CK238148.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nito1 |
spenito |
48.29(n)
43.31(a) |
|
35756 NM_136495.2 NP_610339.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
grld-11 |
Protein GRLD-1 |
44.49(n)
32.6(a) |
|
176827 NM_171237.4 NP_741283.1 |
ENSEMBL Gene Tree for RBM15 (if available)
TreeFam Gene Tree for RBM15 (if available) |
Paralogs
for RBM15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBM15 gene
- RBM15B2 SPEN2
1 SIMAP similar gene for RBM15 using alignment to 4 protein entries: RBM15_HUMAN (see all proteins):RBM15B
RBM15 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RBM15
PGOHUM00000251332
|
Genomic Variants
for RBM15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM15 (110881128 - 110889303 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBM15: --
Human Gene Mutation Database (HGMD): RBM15
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM15 |
|
Disorders
/ Diseases
for RBM15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBM15 for disorders About GeneDecksing
OMIM gene information: 606077
OMIM disorders: --
UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37
Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocationt(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblasticleukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each geneand is the candidate oncogene
13  diseases for RBM15: About MalaCardsmegakaryoblastic leukemia microcystic adenoma acute megakaryoblastic leukemia megakaryocytic leukemia
pancreatic cystadenoma acute myeloid leukemia myeloid leukemia kaposi's sarcoma
cystadenoma leukemia sarcoma adenoma
pancreatitis
1 disease from the University of Copenhagen DISEASES database for RBM15:Megakaryocytic leukemia Export disorders for RBM15 gene to outside databases
|
Publications
for RBM15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM15 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with RBM15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. (PubMed id 11431691)1, 2, 3, 9 Ma Z.... Hitzler J.K. (2001)
- Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. (PubMed id 11344311)1, 2, 3 Mercher T....Bernard O.A. (2001)
- Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PubMed id 16129689)1, 2, 9 Hiriart E.... Manet E. (2005)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. (PubMed id 19586903)1, 9 Uranishi H....Felber B.K. (2009)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for RBM15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBM15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RBM15 gene:
Search GeneIP for patents involving RBM15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBM15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM15 |
| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM15 |
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