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RBM15 Gene

protein-coding   GIFtS: 51
GCID: GC01P110882

RNA Binding Motif Protein 15

  See RBM15-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif Protein 151 2     RNA-Binding Motif Protein 152 3
OTT2 3 5     SPEN2 5
One Twenty-Two1 2     One Twenty Two Protein2
One-Twenty Two Protein 12 3     Putative RNA-Binding Protein 152
OTT12 3     

External Ids:    HGNC: 149591   Entrez Gene: 647832   Ensembl: ENSG000001627757   OMIM: 6060775   UniProtKB: Q96T373   

Export aliases for RBM15 gene to outside databases

Previous GC identifers: GC01P111298 GC01P109748 GC01P109983 GC01P110179 GC01P110180 GC01P110593 GC01P110682 GC01P110876 GC01P108753


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBM15 Gene:
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling
pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 (PubMed
16129689)).(supplied by OMIM, Feb 2009)

GeneCards Summary for RBM15 Gene:
RBM15 (RNA binding motif protein 15) is a protein-coding gene. Diseases associated with RBM15 include megakaryocytic leukemia. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM15B.

UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37
Function: May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which
are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of
pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of
splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene
regulation

Gene Wiki entry for RBM15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM15 gene promoter:
         Egr-2   Egr-3   TBP   SRY   Ik-2   Egr-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM15 promoter sequence
   Search Chromatin IP Primers for RBM15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13

RBM15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM15 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110882:  view genomic region     (about GC identifiers)

Start:
110,881,128 bp from pter      End:
110,889,303 bp from pter
Size:
8,176 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37 (See protein sequence)
Recommended Name: Putative RNA-binding protein 15  
Size: 977 amino acids; 107189 Da
Subunit: Interacts with Epstein-Barr virus BSFL2/BMLF1. Interacts (via SPOC domain) with SETD1B. Interacts with
NXF1, the interaction is required to promote mRNA export
Sequence caution: Sequence=BAB14088.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15185.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1A693 Q3ZB86 Q4V760 Q5D058 Q5T613 Q86VW9 Q96PE4 Q96SC5 Q96SC6 Q96SC9
Q96SD0 Q96T38 Q9BRA5 Q9H6R8 Q9H9Y0
Alternative splicing, Alternative initiation: 4 isoforms:  Q96T37-1   Q96T37-2   Q96T37-3   Q96T37-4   (Produced by alternative initiation of isoform 2)

Explore the universe of human proteins at neXtProt for RBM15: NX_Q96T37

Explore proteomics data for RBM15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBM15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188474.1  NP_073605.4  

    ENSEMBL proteins: 
     ENSP00000358799   ENSP00000473638   ENSP00000473552  

    RBM15 Human Recombinant Protein Products:

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    antibodies-online proteins for RBM15 (2 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR012921 SPOC_C
     IPR012677 Nucleotide-bd_a/b_plait
     IPR010912 SPOC_met
     IPR016194 SPOC_like_C_dom
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q96T37

    ProtoNet protein and cluster: Q96T37

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB012921 SPOC


    UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37
    Similarity: Belongs to the RRM Spen family
    Similarity: Contains 3 RRM (RNA recognition motif) domains
    Similarity: Contains 1 SPOC domain


    Find genes that share domains with RBM15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM15_HUMAN, Q96T37
    Function: May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which
    are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of
    pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of
    splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene
    regulation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI16129689
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RBM15           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rbm15):
     cellular  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with RBM15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rbm15tm1.1Dgg for RBM15

       genOway: Develop your customized and physiologically relevant rodent model for RBM15

    miRNA
    Products:
        
    miRTarBase miRNAs that target RBM15:
    hsa-mir-196a-5p (MIRT048159), hsa-mir-320a (MIRT044789), hsa-mir-186-5p (MIRT045089), hsa-mir-769-5p (MIRT039166), hsa-mir-106b-5p (MIRT044364), hsa-mir-151a-5p (MIRT019521), hsa-mir-328-3p (MIRT043756), hsa-mir-125b-5p (MIRT046031), hsa-mir-615-3p (MIRT039949), hsa-mir-193b-3p (MIRT041415), hsa-mir-324-5p (MIRT043099), hsa-mir-423-3p (MIRT042502), hsa-mir-16-5p (MIRT051293), hsa-mir-23b-5p (MIRT038656), hsa-mir-877-3p (MIRT037187), hsa-mir-331-3p (MIRT043465), hsa-mir-92a-3p (MIRT049048)

    Block miRNA regulation of human, mouse, rat RBM15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM15 (see all 13):
    hsa-miR-22 hsa-miR-520a-5p hsa-miR-373* hsa-miR-583 hsa-miR-3692 hsa-miR-942 hsa-miR-320e hsa-miR-581
    SwitchGear 3'UTR luciferase reporter plasmidRBM15 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM15

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBM15_HUMAN, Q96T37: Nucleus. Nucleus membrane; Peripheral membrane protein. Note=Colocalizes at the nuclear pore
    with DBP5 and NXF1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with RBM15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM15
    Interactions:

        GeneGlobe Interaction Network for RBM15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBM15 (Q96T372, 3 ENSP000003587994) via UniProtKB, MINT, STRING, and/or I2D (see all 633)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8P459832, 3, ENSP000003534834MINT-8262341 I2D: score=2 STRING: ENSP00000353483
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=2 STRING: ENSP00000363970
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    UPF1Q929002, ENSP000002628034MINT-7945693 STRING: ENSP00000262803
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0001569patterning of blood vessels IEA--
    GO:0007221positive regulation of transcription of Notch receptor target IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with RBM15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM15



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RBM15 gene (2 alternative transcripts): 
    NM_001201545.1  NM_022768.4  

    Unigene Cluster for RBM15:

    RNA binding motif protein 15
    Hs.435947  [show with all ESTs]
    Unigene Representative Sequence: BC042587
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369784(uc001dzl.1 uc001dzm.1) ENST00000602849 ENST00000487146

    miRNA
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    Block miRNA regulation of human, mouse, rat RBM15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBM15 (see all 13):
    hsa-miR-22 hsa-miR-520a-5p hsa-miR-373* hsa-miR-583 hsa-miR-3692 hsa-miR-942 hsa-miR-320e hsa-miR-581
    SwitchGear 3'UTR luciferase reporter plasmidRBM15 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat RBM15

    Additional mRNA sequence: 

    AF364037.1 AF368062.1 AF368063.1 AF368064.1 AK022541.1 AK025596.1 BC000841.1 BC006397.2 
    BC010891.1 BC042587.1 BC047479.1 BC062316.1 BC098140.1 BC103493.1 BC103507.1 BC103660.1 

    4 DOTS entries:

    DT.211537  DT.87016432  DT.75103092  DT.100680563 

    Selected AceView cDNA sequences (see all 60):

    CB529546 BU685828 AF086464 AI869382 BF448359 BE505017 AI634112 BG760350 
    BX101314 AI478458 AI871508 BE221286 BE222623 BC006397 BC062316 BC042587 
    NM_022768 AI375793 AI093558 BF057134 AK022541 AW027802 AI803242 AI697986 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBM15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTCTGAT
    RBM15 Expression
    About this image


    RBM15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RBM15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435947
        Custom PCR Arrays for RBM15
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RBM15 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm151 , 5 RNA binding motif protein 151, 5 90.31(n)1
    95.07(a)1
      3 (46.83 cM)5
    2297001  NM_001045807.11  NP_001039272.11 
     1073261105 
    chicken
    (Gallus gallus)
    Aves LOC1008595951 putative RNA-binding protein 15-like 73.04(n)
    81.65(a)
      100859595  XM_003642736.2  XP_003642784.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195052 Xenopus laevis transcribed sequence with weak similarity more 74.81(n)    AW638365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.154902 Transcribed sequence with moderate similarity to protein more 75.55(n)    CK238148.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nito6
    spenito
    36(a)
    1 → many
    2R(3849991-3857320)
    worm
    (Caenorhabditis elegans)
    Secernentea grld-16
    Protein GRLD-1, isoform c
    27(a)
    1 → many
    IV(121791-126225) WBGene00017929


    ENSEMBL Gene Tree for RBM15 (if available)
    TreeFam Gene Tree for RBM15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBM15 gene
    RBM15B2  SPEN2  
    1 SIMAP similar gene for RBM15 using alignment to 1 protein entry:     RBM15_HUMAN:
    RBM15B

    Find genes that share paralogs with RBM15           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RBM15
    PGOHUM00000251332


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBM15 (see all 121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2014337181,2
    C--110883852(+) CTTACA/GAGCCA 4 K E mis10--------
    rs37387511,2
    C,F,H--110883917(-) AGATCT/CCGATC 4 /R syn121Minor allele frequency- C:0.07EA NA NS EU 9451
    rs1509003311,2
    C,F--110884030(+) CTGCGC/TTCCTT 4 A V mis12Minor allele frequency- T:0.00NA EU 5875
    rs1379443961,2
    C,F--110884068(+) GTAGCC/AGGGAT 4 /R syn11Minor allele frequency- A:0.00NA 4550
    rs1827192651,2
    --110884168(+) CCAGGG/TTGACA 4 G V mis10--------
    rs1873676671,2
    C--110884346(+) GGGGGA/GACAGC 4 G syn10--------
    rs1922485791,2
    C--110884348(+) GGGGAC/TAGCCC 4 T I mis10--------
    rs617452921,2
    C,F--110884493(+) TCAACT/CGGAGG 4 /T syn14Minor allele frequency- C:0.03NS CSA WA NA 4742
    rs2013426571,2
    --110884626(+) GAAGTC/TCTGAC 4 P S mis10--------
    rs759615951,2
    C--110884630(+) TTCTGA/CCAGCC 4 D A mis10--------

    HapMap Linkage Disequilibrium report for RBM15 (110881128 - 110889303 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RBM15: --
    Human Gene Mutation Database (HGMD): RBM15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM15
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606077    OMIM disorders: --

    UniProtKB/Swiss-Prot: RBM15_HUMAN, Q96T37
  • Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia.
    Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute
    megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains
    encoded by each gene and is the candidate oncogene

  • 1 disease for RBM15:    
    About MalaCards
    megakaryocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for RBM15:
    Megakaryocytic leukemia

    Find genes that share disorders with RBM15           About GenesLikeMe


    Export disorders for RBM15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBM15 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with RBM15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. (PubMed id 11431691)1, 2, 3, 9 Ma Z.... Hitzler J.K. (Nat. Genet. 2001)
    2. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. (PubMed id 11344311)1, 2, 3 Mercher T....Bernard O.A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    3. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PubMed id 16129689)1, 2, 9 Hiriart E.... Manet E. (J. Biol. Chem. 2005)
    4. Rbm15-Mkl1 Interacts with the Setd1b Histone H3-Lys4 Methyltransferase via a SPOC Domain That Is Required for Cytokine- Independent Proliferation. (PubMed id 22927943)1, 2 Lee J.H. and Skalnik D.G. (PLoS ONE 2012)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway. (PubMed id 17001072)1, 2 Lindtner S.... Pavlakis G.N. (J. Biol. Chem. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64783 HGNC: 14959 AceView: RBM15 Ensembl:ENSG00000162775 euGenes: HUgn64783
    ECgene: RBM15 H-InvDB: RBM15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBM15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RBM15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBM15 gene:
    Search GeneIP for patents involving RBM15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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