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Aliases for RBM14-RBM4 Gene

Aliases for RBM14-RBM4 Gene

  • RBM14-RBM4 Readthrough 2 3 5
  • Transcriptional Coactivator CoAZ 3
  • RBM14/RBM4 Fusion 3
  • COAZ 3

External Ids for RBM14-RBM4 Gene

Previous GeneCards Identifiers for RBM14-RBM4 Gene

  • GC11U901759
  • GC11P066388

Summaries for RBM14-RBM4 Gene

Entrez Gene Summary for RBM14-RBM4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This fusion protein contains RRM and zinc finger domains, and it functions to stimulate transcription in a hormone and receptor-dependent manner. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBM14-RBM4 Gene

RBM14-RBM4 (RBM14-RBM4 Readthrough) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is RBM14.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM14-RBM4 Gene

Genomics for RBM14-RBM4 Gene

Regulatory Elements for RBM14-RBM4 Gene

Promoters for RBM14-RBM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM14-RBM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM14-RBM4 Gene

Chromosome:
11
Start:
66,616,582 bp from pter
End:
66,646,473 bp from pter
Size:
29,892 bases
Orientation:
Plus strand

Genomic View for RBM14-RBM4 Gene

Genes around RBM14-RBM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM14-RBM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM14-RBM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM14-RBM4 Gene

Proteins for RBM14-RBM4 Gene

  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A0MSL8
    Recommended name:
    Protein RBM14-RBM4
    Protein Accession:
    A0A0A0MSL8

    Protein attributes for RBM14-RBM4 Gene

    Size:
    147 amino acids
    Molecular mass:
    15972 Da
    Quaternary structure:
    No Data Available
  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYI9
    Recommended name:
    Protein RBM14-RBM4
    Protein Accession:
    A0A0A6YYI9

    Protein attributes for RBM14-RBM4 Gene

    Size:
    118 amino acids
    Molecular mass:
    12894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM14-RBM4 Gene

Proteomics data for RBM14-RBM4 Gene at MOPED

Post-translational modifications for RBM14-RBM4 Gene

No Post-translational modifications

Other Protein References for RBM14-RBM4 Gene

No data available for DME Specific Peptides for RBM14-RBM4 Gene

Domains & Families for RBM14-RBM4 Gene

Protein Domains for RBM14-RBM4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM14-RBM4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RBM14-RBM4 Gene

Function for RBM14-RBM4 Gene

Gene Ontology (GO) - Molecular Function for RBM14-RBM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RBM14-RBM4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBM14-RBM4 Gene

Localization for RBM14-RBM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM14-RBM4 Gene COMPARTMENTS Subcellular localization image for RBM14-RBM4 gene
Compartment Confidence
nucleus 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM14-RBM4 Gene

Pathways & Interactions for RBM14-RBM4 Gene

SuperPathways for RBM14-RBM4 Gene

No Data Available

Interacting Proteins for RBM14-RBM4 Gene

Gene Ontology (GO) - Biological Process for RBM14-RBM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM14-RBM4 Gene

Drugs & Compounds for RBM14-RBM4 Gene

No Compound Related Data Available

Transcripts for RBM14-RBM4 Gene

mRNA/cDNA for RBM14-RBM4 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RBM14-RBM4 Gene

No ASD Table

Relevant External Links for RBM14-RBM4 Gene

GeneLoc Exon Structure for
RBM14-RBM4
ECgene alternative splicing isoforms for
RBM14-RBM4

Expression for RBM14-RBM4 Gene

mRNA expression in normal human tissues for RBM14-RBM4 Gene

genes like me logo Genes that share expression patterns with RBM14-RBM4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RBM14-RBM4 Gene

Orthologs for RBM14-RBM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM14-RBM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM4 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm21992 36
  • 55 (a)
ManyToMany
Rbm4 36
  • 73 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RBM4 36
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rbm4.1 36
  • 34 (a)
ManyToMany
rbm4.2 36
  • 34 (a)
ManyToMany
rbm4.3 36
  • 34 (a)
ManyToMany
zgc:77262 36
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta lark 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnp-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for RBM14-RBM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBM14-RBM4 Gene

ENSEMBL:
Gene Tree for RBM14-RBM4 (if available)
TreeFam:
Gene Tree for RBM14-RBM4 (if available)

Paralogs for RBM14-RBM4 Gene

Paralogs for RBM14-RBM4 Gene

genes like me logo Genes that share paralogs with RBM14-RBM4: view

Variants for RBM14-RBM4 Gene

Sequence variations from dbSNP and Humsavar for RBM14-RBM4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs485316 -- 66,630,996(-) tccat(C/T)ttaaa intron-variant
rs510356 -- 66,631,651(-) aaaaG(A/G)ATAGT intron-variant
rs535211 -- 66,633,009(-) AATAA(A/G)AGATG intron-variant
rs484262 -- 66,632,210(+) TTCTA(A/G)TAGTG intron-variant
rs495264 -- 66,632,981(-) GGACA(A/G)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM14-RBM4 Gene

Variant ID Type Subtype PubMed ID
nsv522277 CNV Loss 19592680
nsv363 CNV Insertion 18451855
nsv897789 CNV Gain 21882294
nsv518919 CNV Loss 19592680
esv990794 OTHER Inversion 20482838

Variation tolerance for RBM14-RBM4 Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM14-RBM4 Gene

HapMap Linkage Disequilibrium report
RBM14-RBM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM14-RBM4 Gene

Disorders for RBM14-RBM4 Gene

Relevant External Links for RBM14-RBM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM14-RBM4

No disorders were found for RBM14-RBM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM14-RBM4 Gene

Publications for RBM14-RBM4 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for RBM14-RBM4 Gene

Sources for RBM14-RBM4 Gene

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