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Aliases for RBM14-RBM4 Gene

Aliases for RBM14-RBM4 Gene

  • RBM14-RBM4 Readthrough 2 3 5
  • Transcriptional Coactivator CoAZ 3
  • RBM14-RBM4 Protein 3
  • RBM14/RBM4 Fusion 3
  • COAZ 3

External Ids for RBM14-RBM4 Gene

Previous GeneCards Identifiers for RBM14-RBM4 Gene

  • GC11U901759
  • GC11P066388

Summaries for RBM14-RBM4 Gene

Entrez Gene Summary for RBM14-RBM4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This fusion protein contains RRM and zinc finger domains, and it functions to stimulate transcription in a hormone and receptor-dependent manner. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBM14-RBM4 Gene

RBM14-RBM4 (RBM14-RBM4 Readthrough) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is RBM4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM14-RBM4 Gene

Genomics for RBM14-RBM4 Gene

Regulatory Elements for RBM14-RBM4 Gene

Enhancers for RBM14-RBM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F066578 1.2 Ensembl ENCODE 11.2 -37.3 -37299 0.7 HDGF ATF1 ARID4B SIN3A ZNF2 RAD21 ZNF335 SLC30A9 EGR1 SCRT2 RBM14 LOC105369352 ENSG00000258297 LOC105369353 MUS81 ACTN3 ZDHHC24 RBM4B DPP3 LOC101928069
GH11F066636 1.1 ENCODE 11.4 +21.8 21754 3.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ACTN3 EIF1AD CORO1B RBM4B ENSG00000258297 RBM14 RBM14-RBM4 RNU4-39P ZDHHC24 ENSG00000255320
GH11F066676 1.1 ENCODE 10.7 +61.2 61240 2.8 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RN7SL12P SPTBN2 C11orf80 LRFN4 PC ACTN3 ZDHHC24 RBM14-RBM4 RBM14 RNU4-39P
GH11F066685 0.6 ENCODE 10.7 +69.9 69934 2.0 CTCF ZFP64 ZBTB11 ZNF623 ZNF518A ZNF781 RN7SL12P SPTBN2 C11orf80 KLC2 LRFN4 PC ACTN3 ZDHHC24 RBM14-RBM4 LOC100505504
GH11F066643 0.5 Ensembl 11.3 +27.1 27071 0.5 SCRT1 POLR2A SCRT2 MLLT1 RBM4B RBM14 RBM14-RBM4 RNU4-39P ZDHHC24 ACTN3 RBM4 GC11M066657
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM14-RBM4 on UCSC Golden Path with GeneCards custom track

Promoters for RBM14-RBM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RBM14-RBM4 Gene

66,616,582 bp from pter
66,646,473 bp from pter
29,892 bases
Plus strand

Genomic View for RBM14-RBM4 Gene

Genes around RBM14-RBM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM14-RBM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM14-RBM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM14-RBM4 Gene

Proteins for RBM14-RBM4 Gene

  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein RBM14-RBM4
    Protein Accession:

    Protein attributes for RBM14-RBM4 Gene

    147 amino acids
    Molecular mass:
    15972 Da
    Quaternary structure:
    No Data Available
  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein RBM14-RBM4
    Protein Accession:

    Protein attributes for RBM14-RBM4 Gene

    118 amino acids
    Molecular mass:
    12894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM14-RBM4 Gene

Post-translational modifications for RBM14-RBM4 Gene

No Post-translational modifications

Other Protein References for RBM14-RBM4 Gene

No data available for DME Specific Peptides for RBM14-RBM4 Gene

Domains & Families for RBM14-RBM4 Gene

Protein Domains for RBM14-RBM4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM14-RBM4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RBM14-RBM4 Gene

Function for RBM14-RBM4 Gene

Gene Ontology (GO) - Molecular Function for RBM14-RBM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RBM14-RBM4: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBM14-RBM4 Gene

Localization for RBM14-RBM4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM14-RBM4 gene
Compartment Confidence
nucleus 5
cytosol 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM14-RBM4 Gene

Pathways & Interactions for RBM14-RBM4 Gene

SuperPathways for RBM14-RBM4 Gene

No Data Available

Interacting Proteins for RBM14-RBM4 Gene

Gene Ontology (GO) - Biological Process for RBM14-RBM4 Gene


No data available for Pathways by source and SIGNOR curated interactions for RBM14-RBM4 Gene

Transcripts for RBM14-RBM4 Gene

mRNA/cDNA for RBM14-RBM4 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RBM14-RBM4 Gene

No ASD Table

Relevant External Links for RBM14-RBM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM14-RBM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM14-RBM4 Gene

genes like me logo Genes that share expression patterns with RBM14-RBM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RBM14-RBM4 Gene

Orthologs for RBM14-RBM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM14-RBM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM4 35
  • 75 (a)
(Canis familiaris)
Mammalia -- 35
  • 74 (a)
(Mus musculus)
Mammalia Rbm4 35
  • 73 (a)
Gm21992 35
  • 55 (a)
(Bos Taurus)
Mammalia RBM4 35
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
(Gallus gallus)
Aves -- 35
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
(Danio rerio)
Actinopterygii rbm4.1 35
  • 34 (a)
rbm4.2 35
  • 34 (a)
rbm4.3 35
  • 34 (a)
zgc:77262 35
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta lark 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea rnp-1 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
Species where no ortholog for RBM14-RBM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBM14-RBM4 Gene

Gene Tree for RBM14-RBM4 (if available)
Gene Tree for RBM14-RBM4 (if available)

Paralogs for RBM14-RBM4 Gene

Paralogs for RBM14-RBM4 Gene

genes like me logo Genes that share paralogs with RBM14-RBM4: view

Variants for RBM14-RBM4 Gene

Sequence variations from dbSNP and Humsavar for RBM14-RBM4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1043359 -- 66,639,937(+) GCAAA(A/G)CCTCA intron-variant, reference, missense
rs1043360 -- 66,639,939(+) AAAAC(C/T)TCAAC intron-variant, reference, synonymous-codon
rs1043362 -- 66,639,945(+) TCAAC(A/C)AAGTT intron-variant, reference, synonymous-codon
rs1043363 -- 66,639,951(+) AAGTT(A/G)CATGT intron-variant, reference, synonymous-codon
rs1043367 -- 66,639,954(+) TTGCA(C/T)GTGGG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RBM14-RBM4 Gene

Variant ID Type Subtype PubMed ID
nsv975943 CNV duplication 23825009
nsv522277 CNV loss 19592680
nsv518919 CNV loss 19592680
nsv363 CNV insertion 18451855
esv990794 OTHER inversion 20482838
esv3547919 CNV deletion 23714750

Variation tolerance for RBM14-RBM4 Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM14-RBM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM14-RBM4 Gene

Disorders for RBM14-RBM4 Gene

Relevant External Links for RBM14-RBM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RBM14-RBM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM14-RBM4 Gene

Publications for RBM14-RBM4 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3 64

Products for RBM14-RBM4 Gene

Sources for RBM14-RBM4 Gene

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