Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBM14-RBM4 Gene

Aliases for RBM14-RBM4 Gene

  • RBM14-RBM4 Readthrough 2 3 5
  • Transcriptional Coactivator CoAZ 3
  • RBM14-RBM4 Protein 3
  • RBM14/RBM4 Fusion 3
  • COAZ 3

External Ids for RBM14-RBM4 Gene

Previous GeneCards Identifiers for RBM14-RBM4 Gene

  • GC11U901759
  • GC11P066388

Summaries for RBM14-RBM4 Gene

Entrez Gene Summary for RBM14-RBM4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This fusion protein contains RRM and zinc finger domains, and it functions to stimulate transcription in a hormone and receptor-dependent manner. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBM14-RBM4 Gene

RBM14-RBM4 (RBM14-RBM4 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is RBM4.

Additional gene information for RBM14-RBM4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM14-RBM4 Gene

Genomics for RBM14-RBM4 Gene

GeneHancer (GH) Regulatory Elements for RBM14-RBM4 Gene

Promoters and enhancers for RBM14-RBM4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I066615 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.4 1352 4.8 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RBM14 PIR40941 RBM14-RBM4 PIR51437 GC11M066616 RBM4 ACTN3 EIF1AD KDM2A RAD9A
GH11I066636 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +21.8 21754 3.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 RBM4 ACTN3 EIF1AD RBM14 KDM2A SART1 ENSG00000255320 ENSG00000258297 CORO1B RELA
GH11I066676 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 +61.2 61239 2.8 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 RBM4B GC11P066677 RN7SL12P SPTBN2 C11orf80 LRFN4 PC ACTN3 ZDHHC24 RBM14-RBM4
GH11I066578 Enhancer 1 Ensembl ENCODE 11.2 -37.3 -37299 0.7 ATF1 RB1 ARID4B SIN3A ZNF2 ZBTB7B RAD21 EGR1 ZNF143 FOS ZDHHC24 ACTN3 RBM4B DPP3 LOC101928069 MRPL11 PELI3 RBM14 RBM14-RBM4 RNU4-39P
GH11I066685 Enhancer 0.2 ENCODE 10.7 +69.9 69933 2 RN7SL12P SPTBN2 C11orf80 LRFN4 PC ACTN3 ZDHHC24 RBM14-RBM4 LOC100505504 RBM14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM14-RBM4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RBM14-RBM4 Gene

Genomic Locations for RBM14-RBM4 Gene
29,892 bases
Plus strand

Genomic View for RBM14-RBM4 Gene

Genes around RBM14-RBM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM14-RBM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM14-RBM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM14-RBM4 Gene

Proteins for RBM14-RBM4 Gene

  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    RBM14-RBM4 readthrough
    Protein Accession:

    Protein attributes for RBM14-RBM4 Gene

    147 amino acids
    Molecular mass:
    15972 Da
    Quaternary structure:
    No Data Available
  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein RBM14-RBM4
    Protein Accession:

    Protein attributes for RBM14-RBM4 Gene

    118 amino acids
    Molecular mass:
    12894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM14-RBM4 Gene

Post-translational modifications for RBM14-RBM4 Gene

No Post-translational modifications

Other Protein References for RBM14-RBM4 Gene

No data available for DME Specific Peptides for RBM14-RBM4 Gene

Domains & Families for RBM14-RBM4 Gene

Gene Families for RBM14-RBM4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM14-RBM4 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM14-RBM4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RBM14-RBM4 Gene

Function for RBM14-RBM4 Gene

Gene Ontology (GO) - Molecular Function for RBM14-RBM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBM14-RBM4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM14-RBM4 Gene

Localization for RBM14-RBM4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM14-RBM4 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM14-RBM4 Gene

Pathways & Interactions for RBM14-RBM4 Gene

SuperPathways for RBM14-RBM4 Gene

No Data Available

Interacting Proteins for RBM14-RBM4 Gene

Gene Ontology (GO) - Biological Process for RBM14-RBM4 Gene


No data available for Pathways by source and SIGNOR curated interactions for RBM14-RBM4 Gene

Drugs & Compounds for RBM14-RBM4 Gene

No Compound Related Data Available

Transcripts for RBM14-RBM4 Gene

mRNA/cDNA for RBM14-RBM4 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM14-RBM4 Gene

No ASD Table

Relevant External Links for RBM14-RBM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM14-RBM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM14-RBM4 Gene

Evidence on tissue expression from TISSUES for RBM14-RBM4 Gene

  • Nervous system(4.2)
  • Skin(4.1)
  • Lung(4)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with RBM14-RBM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM14-RBM4 Gene

Orthologs for RBM14-RBM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM14-RBM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM4 34
  • 75 (a)
(Canis familiaris)
Mammalia -- 34
  • 74 (a)
(Mus musculus)
Mammalia Rbm4 34
  • 73 (a)
Gm21992 34
  • 55 (a)
(Bos Taurus)
Mammalia RBM4 34
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
(Gallus gallus)
Aves -- 34
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
(Danio rerio)
Actinopterygii rbm4.3 34
  • 34 (a)
rbm4.2 34
  • 34 (a)
rbm4.1 34
  • 34 (a)
zgc:77262 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta lark 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea rnp-1 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
Species where no ortholog for RBM14-RBM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBM14-RBM4 Gene

Gene Tree for RBM14-RBM4 (if available)
Gene Tree for RBM14-RBM4 (if available)

Paralogs for RBM14-RBM4 Gene

Paralogs for RBM14-RBM4 Gene

genes like me logo Genes that share paralogs with RBM14-RBM4: view

Variants for RBM14-RBM4 Gene

Sequence variations from dbSNP and Humsavar for RBM14-RBM4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000086987 -- 66,638,683(+) C/T intron_variant
rs1000146641 -- 66,626,189(+) A/G intron_variant
rs1000177182 -- 66,640,753(+) T/A intron_variant
rs1000181826 -- 66,628,323(+) C/T intron_variant
rs1000260185 -- 66,628,146(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM14-RBM4 Gene

Variant ID Type Subtype PubMed ID
esv3547919 CNV deletion 23714750
esv990794 OTHER inversion 20482838
nsv363 CNV insertion 18451855
nsv518919 CNV loss 19592680
nsv522277 CNV loss 19592680
nsv975943 CNV duplication 23825009

Variation tolerance for RBM14-RBM4 Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM14-RBM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM14-RBM4 Gene

Disorders for RBM14-RBM4 Gene

Additional Disease Information for RBM14-RBM4

No disorders were found for RBM14-RBM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM14-RBM4 Gene

Publications for RBM14-RBM4 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q … Chinnaiyan AM (Nature communications 2014) 3 58

Products for RBM14-RBM4 Gene

Sources for RBM14-RBM4 Gene

Loading form....