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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBM14-RBM4 Gene

protein-coding   GIFtS: 21
GCID: GC11P066388

RBM14-RBM4 Readthrough

  Search for RBM14-RBM4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RBM14-RBM4 Readthrough1 2
COAZ2
RBM14-RBM4 Protein2
RBM14/RBM4 Fusion2
Transcriptional Coactivator CoAZ2

External Ids:    HGNC: 388401   Entrez Gene: 1005267372   Ensembl: ENSG000002486437   UniProtKB: F2Z2W24   

Export aliases for RBM14-RBM4 gene to outside databases

Previous GC identifer: GC11U901759


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBM14-RBM4 Gene:
This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding
motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple
transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual
gene product. This fusion protein contains RRM and zinc finger domains, and it functions to stimulate
transcription in a hormone and receptor-dependent manner. (provided by RefSeq, Nov 2010)

GeneCards Summary for RBM14-RBM4 Gene: 
RBM14-RBM4 (RBM14-RBM4 readthrough) is a protein-coding gene. An important paralog of this gene is RBM4.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RBM14-RBM4
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM14-RBM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

RBM14-RBM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM14-RBM4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066388:  view genomic region     (about GC identifiers)

Start:
66,384,053 bp from pter      End:
66,413,944 bp from pter
Size:
29,892 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/TrEMBL: F2Z2W2 (See protein sequence)
Recommended Name: Protein RBM14-RBM4  
Size: 147 amino acids; 15972 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

RBM14-RBM4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins (2 alternative transcripts): 
NP_001185774.1  NP_001185775.1  

ENSEMBL proteins: 
 ENSP00000388552   ENSP00000395880   ENSP00000421279  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RBM: RNA binding motif (RRM) containing

2 InterPro protein domains:
 IPR012677 Nucleotide-bd_a/b_plait
 IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry F2Z2W2

ProtoNet protein and cluster: F2Z2W2


RBM14-RBM4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding ----
GO:0003676nucleic acid binding ----
GO:0008270zinc ion binding ----
     
RBM14-RBM4 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM14-RBM4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Search CenterWatch for drugs/clinical trials and news about RBM14-RBM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for RBM14-RBM4 gene (2 alternative transcripts): 
NM_001198845.1  NM_001198846.1  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000412278(uc009yrk.3 uc021qmb.1) ENST00000421355 ENST00000500635

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBM14-RBM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RBM14-RBM4 Expression
About this image

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RBM14-RBM4 gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
50(a)
1 → many
JH375703.1(4929-7849)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
48(a)
1 → many
GL343961.1(42871-54220)
zebrafish
(Danio rerio)
Actinopterygii rbm4.16
rbm4.26
(see all 4)
RNA binding motif protein 4.2
(see all 4)
33(a)
31(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
7(23968556-23973894)
7(23963174-23967956)
fruit fly
(Drosophila melanogaster)
Insecta lark6
lark
28(a)
1 → many
3L(7332366-7334996)
worm
(Caenorhabditis elegans)
Secernentea rnp-16
RNA-binding protein rnp-1
18(a)
1 → many
V(12192275-12194445)
        Species with no ortholog for RBM14-RBM4

ENSEMBL Gene Tree for RBM14-RBM4 (if available)
TreeFam Gene Tree for RBM14-RBM4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RBM14-RBM4 gene
RBM42  RBM4B2  RBM142  
4 SIMAP similar genes for RBM14-RBM4 using alignment to 1 protein entry:     F2Z2W2_HUMAN:
RBM14    RBM4    RALY    RBM4B

RBM14-RBM4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/120 SNPs in RBM14-RBM4 are shown (see all 120)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1480425231,2
--66397912(+) CCAGCC/TGTGGT 2 -- int10--------
rs1848299621,2
--66397947(+) TCCAGC/GTGAGG 2 -- int10--------
rs1905334601,2
--66398043(+) ACCCCA/GTCTGA 2 -- int10--------
rs1387946121,2
C--66398061(+) ATAAA-/AACCAACA 2 -- int10--------
rs1997686281,2
--66398065(+) AAACA-/ACAACAA 2 -- int10--------
rs1818189431,2
--66398068(+) CAACAA/GCAAAA 2 -- int10--------
rs1853613031,2
--66398091(+) TTGGTA/GTAGAC 2 -- int10--------
rs1113298301,2
F--66398211(+) ACCTCA/CGGCTC 2 -- int12Minor allele frequency- C:0.05CSA WA 120
rs1453080971,2
C--66398269(+) CTCCC-/TCTTCTTG 2 -- int10--------
rs1425761811,2
C--66398297(+) ACATAC/TTAGGA 2 -- int10--------

HapMap Linkage Disequilibrium report for RBM14-RBM4 (66384053 - 66413944 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for RBM14-RBM4:    About this table     
Variant IDTypeSubtypePubMed ID
nsv363CNV Insertion18451855
nsv522277CNV Loss19592680
nsv518919CNV Loss19592680
nsv897789CNV Gain21882294
esv990794OTHER Inversion20482838

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RBM14-RBM4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBM14-RBM4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
  2. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
  4. Functional Pre- mRNA trans-Splicing of Coactivator CoAA and Corepressor RBM4 during Stem/Progenitor Cell Differentiation. (PubMed id 19416963)1 Brooks Y.S.... Ko L. (2009)
  5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100526737 HGNC: 38840 Ensembl:ENSG00000248643 euGenes: HUgn100526737 ECgene: RBM14-RBM4
H-InvDB: RBM14-RBM4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RBM14-RBM4 gene:
Search GeneIP for patents involving RBM14-RBM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

 
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 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for RBM14-RBM4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM14-RBM4
 Browse SwitchGear 3'UTR luciferase reporter plasmids for RBM14-RBM4
 Browse SwitchGear Promoter luciferase reporter plasmids for RBM14-RBM4
 Search ThermoFisher Antibodies for RBM14-RBM4
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBM14-RBM4
 inGenious Targeting Laboratory - Custom generated mouse model solutions for RBM14-RBM4
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RBM14-RBM4
Customized:
 lentivirus for stable overexpression of RBM14-RBM4
 lentivirus expression plasmids for stable overexpression of RBM14-RBM4
 adenovirus for overexpression of RBM14-RBM4
 Search LSBio for Antibodies for RBM14-RBM4
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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