Aliases for RBM14 Gene
External Ids for RBM14 Gene
Previous GeneCards Identifiers for RBM14 Gene
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for RBM14 Gene
RBM14 (RNA Binding Motif Protein 14) is a Protein Coding gene. Diseases associated with RBM14 include Farber Lipogranulomatosis. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM14-RBM4.
UniProtKB/Swiss-Prot for RBM14 Gene
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.