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Aliases for RBM14 Gene

Aliases for RBM14 Gene

  • RNA Binding Motif Protein 14 2 3 5
  • RRM-Containing Coactivator Activator/Modulator 3 4
  • Synaptotagmin-Interacting Protein 3 4
  • SYT-Interacting Protein 3 4
  • Paraspeckle Protein 2 3 4
  • PSP2 3 4
  • SIP 3 4
  • RNA-Binding Motif Protein 14 4
  • Transmembrane Protein 137 3
  • SYT Interacting Protein 2
  • Coactivator Activator 2
  • TMEM137 3
  • SYTIP1 3
  • COAA 3

External Ids for RBM14 Gene

Previous GeneCards Identifiers for RBM14 Gene

  • GC11P068918
  • GC11P068065
  • GC11P066634
  • GC11P066159
  • GC11P066140
  • GC11P066384
  • GC11P062712
  • GC11P066620
  • GC11P066622

Summaries for RBM14 Gene

Entrez Gene Summary for RBM14 Gene

  • This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RBM14 Gene

RBM14 (RNA Binding Motif Protein 14) is a Protein Coding gene. Diseases associated with RBM14 include farber lipogranulomatosis. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM14-RBM4.

UniProtKB/Swiss-Prot for RBM14 Gene

  • Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.

Gene Wiki entry for RBM14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM14 Gene

Genomics for RBM14 Gene

Regulatory Elements for RBM14 Gene

Promoters for RBM14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM14 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM14 Gene

Chromosome:
11
Start:
66,616,582 bp from pter
End:
66,629,934 bp from pter
Size:
13,353 bases
Orientation:
Plus strand

Genomic View for RBM14 Gene

Genes around RBM14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM14 Gene

Proteins for RBM14 Gene

  • Protein details for RBM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PK6-RBM14_HUMAN
    Recommended name:
    RNA-binding protein 14
    Protein Accession:
    Q96PK6
    Secondary Accessions:
    • B0LM41
    • B3KMN4
    • D6RGD8
    • O75932
    • Q2PYN1
    • Q53GV1
    • Q68DQ9
    • Q96PK5

    Protein attributes for RBM14 Gene

    Size:
    669 amino acids
    Molecular mass:
    69492 Da
    Quaternary structure:
    • Isoform 1 interacts with NCOA6, CITED1 and XRCC5/KU86. Isoform 1 interacts with SS18 isoform 1. Isoform 1 interacts with SS18 isoform 2.

    Three dimensional structures from OCA and Proteopedia for RBM14 Gene

    Alternative splice isoforms for RBM14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM14 Gene

Proteomics data for RBM14 Gene at MOPED

Post-translational modifications for RBM14 Gene

  • Ubiquitination at Lys 135
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM14 Gene

Antibody Products

No data available for DME Specific Peptides for RBM14 Gene

Domains & Families for RBM14 Gene

Gene Families for RBM14 Gene

Protein Domains for RBM14 Gene

Suggested Antigen Peptide Sequences for RBM14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PK6

UniProtKB/Swiss-Prot:

RBM14_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM14: view

Function for RBM14 Gene

Molecular function for RBM14 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.

Gene Ontology (GO) - Molecular Function for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IPI 11443112
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM14: view
genes like me logo Genes that share phenotypes with RBM14: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM14 Gene

Localization for RBM14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM14 Gene

Nucleus. Nucleus, nucleolus. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM14 Gene COMPARTMENTS Subcellular localization image for RBM14 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IPI 11443112
genes like me logo Genes that share ontologies with RBM14: view

Pathways & Interactions for RBM14 Gene

SuperPathways for RBM14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair NAS 11443112
GO:0030520 intracellular estrogen receptor signaling pathway NAS 11443112
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 11443112
GO:0046600 negative regulation of centriole replication IMP 25385835
genes like me logo Genes that share ontologies with RBM14: view

No data available for Pathways by source and SIGNOR curated interactions for RBM14 Gene

Drugs & Compounds for RBM14 Gene

No Compound Related Data Available

Transcripts for RBM14 Gene

Unigene Clusters for RBM14 Gene

RNA binding motif protein 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM14 Gene

No ASD Table

Relevant External Links for RBM14 Gene

GeneLoc Exon Structure for
RBM14
ECgene alternative splicing isoforms for
RBM14

Expression for RBM14 Gene

mRNA expression in normal human tissues for RBM14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.8) and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM14 Gene



SOURCE GeneReport for Unigene cluster for RBM14 Gene Hs.533712

mRNA Expression by UniProt/SwissProt for RBM14 Gene

Q96PK6-RBM14_HUMAN
Tissue specificity: Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with RBM14: view

Protein tissue co-expression partners for RBM14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RBM14 Gene

Orthologs for RBM14 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM14 35
  • 95.17 (n)
  • 99.1 (a)
RBM14 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM14 35
  • 96.26 (n)
  • 99.7 (a)
RBM14 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm14 35
  • 93.77 (n)
  • 98.36 (a)
Rbm14 16
Rbm14 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBM14 35
  • 99.9 (n)
  • 99.85 (a)
RBM14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911677 35
  • 94.12 (n)
  • 98.65 (a)
oppossum
(Monodelphis domestica)
Mammalia RBM14 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM14 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM14 35
  • 64.54 (n)
  • 60.49 (a)
RBM14 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM14 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm14 35
  • 54.41 (n)
  • 50.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398498 35
zebrafish
(Danio rerio)
Actinopterygii rbm14a 36
  • 25 (a)
OneToMany
rbm14b 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lark 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnp-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for RBM14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM14 Gene

ENSEMBL:
Gene Tree for RBM14 (if available)
TreeFam:
Gene Tree for RBM14 (if available)

Paralogs for RBM14 Gene

Paralogs for RBM14 Gene

(4) SIMAP similar genes for RBM14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RBM14: view

Variants for RBM14 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBM14 Gene

Variant ID Type Subtype PubMed ID
nsv522277 CNV Loss 19592680
nsv363 CNV Insertion 18451855
nsv897789 CNV Gain 21882294

Variation tolerance for RBM14 Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM14 Gene

HapMap Linkage Disequilibrium report
RBM14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RBM14 Gene

Disorders for RBM14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
farber lipogranulomatosis
  • acid ceramidase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search RBM14 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBM14

Human Genome Epidemiology (HuGE) Navigator
RBM14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM14
genes like me logo Genes that share disorders with RBM14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM14 Gene

Publications for RBM14 Gene

  1. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). (PMID: 11443112) Iwasaki T. … Ko L. (J. Biol. Chem. 2001) 3 4 23 67
  2. Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers. (PMID: 16878147) Sui Y. … Ko L. (Oncogene 2007) 3 23
  3. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. (PMID: 15919756) Iwasaki T. … Chin W.W. (Endocrinology 2005) 3 23
  4. The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (PMID: 9285794) Brett D. … Goodwin G. (Hum. Mol. Genet. 1997) 2 3
  5. RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. (PMID: 25385835) Shiratsuchi G. … Kitagawa D. (EMBO J. 2015) 3

Products for RBM14 Gene

Sources for RBM14 Gene

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