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Aliases for RBM14 Gene

Aliases for RBM14 Gene

  • RNA Binding Motif Protein 14 2 3
  • PSP2 3 4 6
  • SIP 3 4 6
  • RRM-Containing Coactivator Activator/Modulator 3 4
  • Synaptotagmin-Interacting Protein 3 4
  • SYT-Interacting Protein 3 4
  • Paraspeckle Protein 2 3 4
  • COAA 3 6
  • RNA-Binding Motif Protein 14 4
  • Transmembrane Protein 137 3
  • SYT Interacting Protein 2
  • RNA-Binding Protein 14 3
  • Coactivator Activator 2
  • TMEM137 3
  • SYTIP1 3

External Ids for RBM14 Gene

Previous GeneCards Identifiers for RBM14 Gene

  • GC11P068918
  • GC11P068065
  • GC11P066634
  • GC11P066159
  • GC11P066140
  • GC11P066384
  • GC11P062712

Summaries for RBM14 Gene

Entrez Gene Summary for RBM14 Gene

  • This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RBM14 Gene

RBM14 (RNA Binding Motif Protein 14) is a Protein Coding gene. Diseases associated with RBM14 include farber lipogranulomatosis and lipogranulomatosis. GO annotations related to this gene include RNA binding and protein binding, bridging. An important paralog of this gene is RBM14-RBM4.

UniProtKB/Swiss-Prot for RBM14 Gene

  • Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1

Gene Wiki entry for RBM14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM14 Gene

Genomics for RBM14 Gene

Regulatory Elements for RBM14 Gene

Genomic Location for RBM14 Gene

Start:
66,616,582 bp from pter
End:
66,629,934 bp from pter
Size:
13,353 bases
Orientation:
Plus strand

Genomic View for RBM14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM14 Gene

Proteins for RBM14 Gene

  • Protein details for RBM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PK6-RBM14_HUMAN
    Recommended name:
    RNA-binding protein 14
    Protein Accession:
    Q96PK6
    Secondary Accessions:
    • B0LM41
    • B3KMN4
    • D6RGD8
    • O75932
    • Q2PYN1
    • Q53GV1
    • Q68DQ9
    • Q96PK5

    Protein attributes for RBM14 Gene

    Size:
    669 amino acids
    Molecular mass:
    69492 Da
    Quaternary structure:
    • Isoform 1 interacts with NCOA6, CITED1 and XRCC5/KU86. Isoform 1 interacts with SS18 isoform 1. Isoform 1 interacts with SS18 isoform 2.

    Three dimensional structures from OCA and Proteopedia for RBM14 Gene

    Alternative splice isoforms for RBM14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM14 Gene

Proteomics data for RBM14 Gene at MOPED

Post-translational modifications for RBM14 Gene

  • Ubiquitination at Lys135, Lys148, and Lys198
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM14 Gene

No data available for DME Specific Peptides for RBM14 Gene

Domains for RBM14 Gene

Gene Families for RBM14 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBM14 Gene

Suggested Antigen Peptide Sequences for RBM14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PK6

UniProtKB/Swiss-Prot:

RBM14_HUMAN :
  • Q96PK6
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM14: view

Function for RBM14 Gene

Molecular function for RBM14 Gene

UniProtKB/Swiss-Prot Function: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1

Gene Ontology (GO) - Molecular Function for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001104 RNA polymerase II transcription cofactor activity NAS 11443112
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 11443112
GO:0005515 protein binding IPI 15919756
genes like me logo Genes that share ontologies with RBM14: view

Phenotypes for RBM14 Gene

GenomeRNAi human phenotypes for RBM14:
genes like me logo Genes that share phenotypes with RBM14: view

miRNA for RBM14 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM14 Gene

Localization for RBM14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM14 Gene

Nucleus. Nucleus, nucleolus. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM14 Gene COMPARTMENTS Subcellular localization image for RBM14 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IPI 11443112
GO:0005730 nucleolus IEA --
GO:0016592 mediator complex NAS 11443112
genes like me logo Genes that share ontologies with RBM14: view

Pathways for RBM14 Gene

SuperPathways for RBM14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication NAS 11443112
GO:0006281 DNA repair NAS 11443112
GO:0006310 DNA recombination NAS 11443112
GO:0006366 transcription from RNA polymerase II promoter NAS 11443112
GO:0009725 response to hormone TAS 11443112
genes like me logo Genes that share ontologies with RBM14: view

No data available for Pathways by source for RBM14 Gene

Transcripts for RBM14 Gene

Unigene Clusters for RBM14 Gene

RNA binding motif protein 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM14 Gene

No ASD Table

Relevant External Links for RBM14 Gene

GeneLoc Exon Structure for
RBM14
ECgene alternative splicing isoforms for
RBM14

Expression for RBM14 Gene

mRNA expression in normal human tissues for RBM14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM14 Gene

SOURCE GeneReport for Unigene cluster for RBM14 Gene Hs.533712

mRNA Expression by UniProt/SwissProt for RBM14 Gene

Q96PK6-RBM14_HUMAN
Tissue specificity: Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes
genes like me logo Genes that share expressions with RBM14: view

No data available for mRNA differential expression in normal tissues for RBM14 Gene

Orthologs for RBM14 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM14 35
  • 99.9 (n)
  • 99.85 (a)
RBM14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM14 35
  • 95.17 (n)
  • 99.1 (a)
RBM14 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM14 35
  • 96.26 (n)
  • 99.7 (a)
RBM14 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm14 35
  • 93.77 (n)
  • 98.36 (a)
Rbm14 16
Rbm14 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM14 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM14 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911677 35
  • 94.12 (n)
  • 98.65 (a)
chicken
(Gallus gallus)
Aves RBM14 35
  • 64.54 (n)
  • 60.49 (a)
RBM14 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM14 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398498 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm14 35
  • 54.41 (n)
  • 50.32 (a)
zebrafish
(Danio rerio)
Actinopterygii rbm14a 36
  • 25 (a)
OneToMany
rbm14b 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lark 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnp-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for RBM14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM14 Gene

ENSEMBL:
Gene Tree for RBM14 (if available)
TreeFam:
Gene Tree for RBM14 (if available)

Paralogs for RBM14 Gene

Paralogs for RBM14 Gene

Selected SIMAP similar genes for RBM14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RBM14: view

Variants for RBM14 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBM14 Gene

Variant ID Type Subtype PubMed ID
nsv522277 CNV Loss 19592680
nsv363 CNV Insertion 18451855
nsv897789 CNV Gain 21882294

Relevant External Links for RBM14 Gene

HapMap Linkage Disequilibrium report
RBM14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RBM14 Gene

Disorders for RBM14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RBM14 Gene including...

Search for RBM14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RBM14 Gene

(1) Novoseek inferred disease relationships for RBM14 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for RBM14

Human Genome Epidemiology (HuGE) Navigator
RBM14
genes like me logo Genes that share disorders with RBM14: view

No data available for UniProtKB/Swiss-Prot for RBM14 Gene

Publications for RBM14 Gene

  1. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. (PMID: 15919756) Iwasaki T. … Chin W.W. (Endocrinology 2005) 3 4 23
  2. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). (PMID: 11443112) Iwasaki T. … Ko L. (J. Biol. Chem. 2001) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RBM14 Gene

Sources for RBM14 Gene

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