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Aliases for RBM12B Gene

Aliases for RBM12B Gene

  • RNA Binding Motif Protein 12B 2 3 5
  • RNA-Binding Motif Protein 12B 4
  • RNA-Binding Protein 12B 3
  • MGC:33837 3

External Ids for RBM12B Gene

Previous GeneCards Identifiers for RBM12B Gene

  • GC08M094813
  • GC08M089951
  • GC08M094743

Summaries for RBM12B Gene

GeneCards Summary for RBM12B Gene

RBM12B (RNA Binding Motif Protein 12B) is a Protein Coding gene. Diseases associated with RBM12B include Interleukin-7 Receptor Alpha Deficiency. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM12.

Additional gene information for RBM12B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM12B Gene

Genomics for RBM12B Gene

Regulatory Elements for RBM12B Gene

Enhancers for RBM12B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H094718 1.2 ENCODE 72.5 -979.1 -979065 2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A VIRMA RBM12B INTS8 C8orf37 ENSG00000254283 LINC01298 PSMA2P2 NDUFAF6 RPL34P18 TMEM67
GH08H093871 1.5 Ensembl ENCODE dbSUPER 36.2 -133.2 -133196 4 ATF1 ZNF133 FEZF1 ZNF766 ELK1 FOS ATF7 SP3 CAVIN1 TSHZ1 VIRMA RBM12B INTS8 GC08M093861 LOC105375646
GH08H094638 1.5 Ensembl ENCODE dbSUPER 28.8 -899.8 -899848 5 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B ETS1 GLIS2 ELK1 ZNF207 FOS INTS8 VIRMA RBM12B LOC100288748 ENSG00000253878 ESRP1
GH08H092963 1.1 ENCODE 20.1 +775.7 775681 2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 RBM12B TRIQK IRF5P1 ENSG00000253197
GH08H093955 1 ENCODE dbSUPER 21.3 -214.9 -214898 0 HDAC1 NFIB SUZ12 BMI1 ZKSCAN1 CTBP1 GATA3 ZNF548 RCOR1 HES1 RBM12B VIRMA INTS8 FAM92A LINC00535 LOC105375645 PDP1 ENSG00000253722 PIR51498 PSMA2P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM12B on UCSC Golden Path with GeneCards custom track

Promoters for RBM12B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227082 617 2801 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 MXD4

Genomic Location for RBM12B Gene

Chromosome:
8
Start:
93,729,356 bp from pter
End:
93,741,017 bp from pter
Size:
11,662 bases
Orientation:
Minus strand

Genomic View for RBM12B Gene

Genes around RBM12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM12B Gene

Proteins for RBM12B Gene

  • Protein details for RBM12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXT5-RB12B_HUMAN
    Recommended name:
    RNA-binding protein 12B
    Protein Accession:
    Q8IXT5
    Secondary Accessions:
    • A8MYB5

    Protein attributes for RBM12B Gene

    Size:
    1001 amino acids
    Molecular mass:
    118103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM12B Gene

Post-translational modifications for RBM12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM12B Gene

Domains & Families for RBM12B Gene

Gene Families for RBM12B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM12B Gene

Suggested Antigen Peptide Sequences for RBM12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM12B: view

No data available for UniProtKB/Swiss-Prot for RBM12B Gene

Function for RBM12B Gene

Gene Ontology (GO) - Molecular Function for RBM12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with RBM12B: view

Phenotypes for RBM12B Gene

GenomeRNAi human phenotypes for RBM12B:
genes like me logo Genes that share phenotypes with RBM12B: view

Animal Model Products

CRISPR Products

miRNA for RBM12B Gene

miRTarBase miRNAs that target RBM12B

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBM12B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM12B Gene

Localization for RBM12B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM12B gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM12B Gene

Pathways & Interactions for RBM12B Gene

SuperPathways for RBM12B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM12B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM12B Gene

Drugs & Compounds for RBM12B Gene

No Compound Related Data Available

Transcripts for RBM12B Gene

Unigene Clusters for RBM12B Gene

RNA binding motif protein 12B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBM12B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBM12B Gene

No ASD Table

Relevant External Links for RBM12B Gene

GeneLoc Exon Structure for
RBM12B
ECgene alternative splicing isoforms for
RBM12B

Expression for RBM12B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM12B Gene

This gene is overexpressed in Plasma (19.1), Fetal Brain (7.8), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM12B Gene



Protein tissue co-expression partners for RBM12B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM12B Gene:

RBM12B

SOURCE GeneReport for Unigene cluster for RBM12B Gene:

Hs.606916

Evidence on tissue expression from TISSUES for RBM12B Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with RBM12B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM12B Gene

Orthologs for RBM12B Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM12B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM12B 33 34
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia RBM12B 33 34
  • 87.43 (n)
dog
(Canis familiaris)
Mammalia RBM12B 33 34
  • 86.08 (n)
mouse
(Mus musculus)
Mammalia Rbm12b2 33 16 34
  • 82.59 (n)
Rbm12b1 34
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC679087 33
  • 79.51 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM12B 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM12B 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM12B 33 34
  • 69.11 (n)
lizard
(Anolis carolinensis)
Reptilia RBM12B 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491658 33
  • 59.42 (n)
Str.11100 33
zebrafish
(Danio rerio)
Actinopterygii zgc:56148 33
  • 53.99 (n)
RBM12B (2 of 2) 34
  • 35 (a)
OneToMany
RBM12B (1 of 2) 34
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7879 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y106G6D.7 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
OneToMany
Species where no ortholog for RBM12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM12B Gene

ENSEMBL:
Gene Tree for RBM12B (if available)
TreeFam:
Gene Tree for RBM12B (if available)

Paralogs for RBM12B Gene

Paralogs for RBM12B Gene

(2) SIMAP similar genes for RBM12B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RBM12B: view

Variants for RBM12B Gene

Sequence variations from dbSNP and Humsavar for RBM12B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000012792 -- 93,731,513(+) ATCAA(A/C)TTTAC utr-variant-3-prime
rs1000019856 -- 93,739,968(+) TCATC(A/G)GATCC intron-variant, upstream-variant-2KB
rs1000154700 -- 93,733,052(+) GAAAG(-/A)AAAAA utr-variant-3-prime
rs1000218085 -- 93,734,570(+) CCCTA(C/G)GGTGC reference, missense
rs1000400155 -- 93,727,126(+) ACAAA(A/G)GCAGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RBM12B Gene

Variant ID Type Subtype PubMed ID
nsv1022473 CNV loss 25217958
nsv528872 CNV loss 19592680
nsv6309 CNV insertion 18451855
nsv831399 CNV loss 17160897

Variation tolerance for RBM12B Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM12B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM12B Gene

Disorders for RBM12B Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM12B Gene - From: DISEASES

Disorder Aliases PubMed IDs
interleukin-7 receptor alpha deficiency
  • il-7r
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RBM12B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM12B
genes like me logo Genes that share disorders with RBM12B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM12B Gene

Publications for RBM12B Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for RBM12B Gene

Sources for RBM12B Gene

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