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Aliases for RBM12B Gene

Aliases for RBM12B Gene

  • RNA Binding Motif Protein 12B 2 3
  • RNA-Binding Motif Protein 12B 3 4
  • RNA-Binding Protein 12B 3
  • MGC:33837 3

External Ids for RBM12B Gene

Previous GeneCards Identifiers for RBM12B Gene

  • GC08M094813
  • GC08M089951
  • GC08M094743

Summaries for RBM12B Gene

GeneCards Summary for RBM12B Gene

RBM12B (RNA Binding Motif Protein 12B) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is ESRP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM12B Gene

Genomics for RBM12B Gene

Regulatory Elements for RBM12B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM12B Gene

93,729,356 bp from pter
93,741,040 bp from pter
11,685 bases
Minus strand

Genomic View for RBM12B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM12B Gene

Proteins for RBM12B Gene

  • Protein details for RBM12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 12B
    Protein Accession:
    Secondary Accessions:
    • A8MYB5

    Protein attributes for RBM12B Gene

    1001 amino acids
    Molecular mass:
    118103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM12B Gene

Proteomics data for RBM12B Gene at MOPED

Post-translational modifications for RBM12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM12B Gene

No data available for DME Specific Peptides for RBM12B Gene

Domains for RBM12B Gene

Gene Families for RBM12B Gene

Protein Domains for RBM12B Gene


Suggested Antigen Peptide Sequences for RBM12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 RRM (RNA recognition motif) domains.
  • Contains 4 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM12B: view

Function for RBM12B Gene

Gene Ontology (GO) - Molecular Function for RBM12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 21078624
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM12B: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM12B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM12B Gene

Localization for RBM12B Gene

Subcellular locations from

Jensen Localization Image for RBM12B Gene COMPARTMENTS Subcellular localization image for RBM12B gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM12B Gene

Pathways for RBM12B Gene

SuperPathways for RBM12B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM12B Gene


No data available for Pathways by source for RBM12B Gene

Transcripts for RBM12B Gene

Unigene Clusters for RBM12B Gene

RNA binding motif protein 12B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM12B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM12B Gene

No ASD Table

Relevant External Links for RBM12B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM12B Gene

mRNA expression in normal human tissues for RBM12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RBM12B Gene

This gene is overexpressed in Plasma (19.1), Fetal Brain (7.8), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RBM12B Gene

SOURCE GeneReport for Unigene cluster for RBM12B Gene Hs.606916

genes like me logo Genes that share expressions with RBM12B: view

Expression partners for RBM12B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM12B Gene

Orthologs for RBM12B Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM12B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBM12B 35
  • 87.43 (n)
  • 86.38 (a)
RBM12B 36
  • 86 (a)
(Canis familiaris)
Mammalia RBM12B 35
  • 86.08 (n)
  • 87.22 (a)
RBM12B 36
  • 87 (a)
(Mus musculus)
Mammalia Rbm12b2 35
  • 82.59 (n)
  • 75.93 (a)
Rbm12b2 16
Rbm12b1 36
  • 75 (a)
Rbm12b2 36
  • 75 (a)
(Pan troglodytes)
Mammalia RBM12B 35
  • 99.57 (n)
  • 99.5 (a)
RBM12B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC679087 35
  • 79.51 (n)
  • 73.28 (a)
(Monodelphis domestica)
Mammalia RBM12B 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia RBM12B 36
  • 62 (a)
(Gallus gallus)
Aves RBM12B 35
  • 69.11 (n)
  • 60.2 (a)
RBM12B 36
  • 57 (a)
(Anolis carolinensis)
Reptilia RBM12B 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491658 35
  • 59.42 (n)
  • 49.65 (a)
Str.11100 35
(Danio rerio)
Actinopterygii zgc:56148 35
  • 53.99 (n)
  • 43.23 (a)
RBM12B (1 of 2) 36
  • 27 (a)
RBM12B (2 of 2) 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7879 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea Y106G6D.7 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for RBM12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM12B Gene

Gene Tree for RBM12B (if available)
Gene Tree for RBM12B (if available)

Paralogs for RBM12B Gene

Paralogs for RBM12B Gene

(2) SIMAP similar genes for RBM12B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RBM12B: view

Variants for RBM12B Gene

Sequence variations from dbSNP and Humsavar for RBM12B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs569066714 -- 93,733,261(+) ACATT(-/CTA)CTATT cds-indel
rs568301845 -- 93,734,137(+) GGGGG(A/T)GGCCG reference, synonymous-codon
rs567991051 -- 93,737,027(+) AGAGC(A/G)AGAGC intron-variant
rs567317895 -- 93,742,822(+) GTCTC(-/A)AAAAA upstream-variant-2KB
rs566862215 -- 93,735,305(+) CATAA(C/T)GTGCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for RBM12B Gene

Variant ID Type Subtype PubMed ID
nsv528872 CNV Loss 19592680
dgv7834n71 CNV Loss 21882294
nsv831399 CNV Loss 17160897
nsv6309 CNV Insertion 18451855

Relevant External Links for RBM12B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM12B Gene

Disorders for RBM12B Gene

No disorders were found for RBM12B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RBM12B Gene

Publications for RBM12B Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3
  3. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle J.J. … Zoghbi H.Y. (Hum. Mol. Genet. 2011) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Purification and identification of endogenous polySUMO conjugates. (PMID: 21252943) Bruderer R. … Hay R.T. (EMBO Rep. 2011) 3

Products for RBM12B Gene

Sources for RBM12B Gene

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