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Aliases for RBM12 Gene

Aliases for RBM12 Gene

  • RNA Binding Motif Protein 12 2 3
  • SH3/WW Domain Anchor Protein In The Nucleus 3 4
  • RNA-Binding Motif Protein 12 3 4
  • SWAN 3 4
  • RNA-Binding Protein 12 3
  • HRIHFB2091 3
  • KIAA0765 4

External Ids for RBM12 Gene

Previous GeneCards Identifiers for RBM12 Gene

  • GC20U990034
  • GC20M033933
  • GC20M034882
  • GC20M034930
  • GC20M034931
  • GC20M033678
  • GC20M033700
  • GC20M034236
  • GC20M031014

Summaries for RBM12 Gene

Entrez Gene Summary for RBM12 Gene

  • This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBM12 Gene

RBM12 (RNA Binding Motif Protein 12) is a Protein Coding gene. Diseases associated with RBM12 include gas gangrene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is ESRP2.

Gene Wiki entry for RBM12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM12 Gene

Genomics for RBM12 Gene

Regulatory Elements for RBM12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM12 Gene

35,648,925 bp from pter
35,664,956 bp from pter
16,032 bases
Minus strand

Genomic View for RBM12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM12 Gene

Proteins for RBM12 Gene

  • Protein details for RBM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 12
    Protein Accession:
    Secondary Accessions:
    • B3KRU2
    • E1P5R6
    • O94865
    • Q8N3B1
    • Q9H196

    Protein attributes for RBM12 Gene

    932 amino acids
    Molecular mass:
    97395 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34485.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM12 Gene

neXtProt entry for RBM12 Gene

Proteomics data for RBM12 Gene at MOPED

Post-translational modifications for RBM12 Gene

  • Ubiquitination at Lys349
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RBM12 Gene

Domains for RBM12 Gene

Gene Families for RBM12 Gene

Protein Domains for RBM12 Gene


Suggested Antigen Peptide Sequences for RBM12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 RRM (RNA recognition motif) domains.
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM12: view

Function for RBM12 Gene

Gene Ontology (GO) - Molecular Function for RBM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM12: view

Phenotypes for RBM12 Gene

genes like me logo Genes that share phenotypes with RBM12: view

Animal Model Products

miRNA for RBM12 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM12 Gene

Localization for RBM12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM12 Gene

Subcellular locations from

Jensen Localization Image for RBM12 Gene COMPARTMENTS Subcellular localization image for RBM12 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RBM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RBM12: view

Pathways for RBM12 Gene

SuperPathways for RBM12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM12 Gene


No data available for Pathways by source for RBM12 Gene

Transcripts for RBM12 Gene

Unigene Clusters for RBM12 Gene

RNA binding motif protein 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM12 Gene

No ASD Table

Relevant External Links for RBM12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM12 Gene

mRNA expression in normal human tissues for RBM12 Gene

Protein differential expression in normal tissues for RBM12 Gene

This gene is overexpressed in Lymph node (14.2) and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RBM12 Gene

SOURCE GeneReport for Unigene cluster for RBM12 Gene Hs.700188

genes like me logo Genes that share expressions with RBM12: view

Expression partners for RBM12 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM12 Gene

Orthologs for RBM12 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBM12 35
  • 93.5 (n)
  • 94.94 (a)
RBM12 36
  • 93 (a)
(Canis familiaris)
Mammalia RBM12 35
  • 94.4 (n)
  • 95.88 (a)
RBM12 36
  • 97 (a)
(Mus musculus)
Mammalia Rbm12 35
  • 90.97 (n)
  • 92.87 (a)
Rbm12 16
Rbm12 36
  • 87 (a)
RP23-220D12.12 36
  • 85 (a)
(Pan troglodytes)
Mammalia RBM12 35
  • 99.86 (n)
  • 100 (a)
RBM12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rbm12 35
  • 91.3 (n)
  • 92.72 (a)
(Monodelphis domestica)
Mammalia RBM12 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
(Gallus gallus)
Aves RBM12 35
  • 79.24 (n)
  • 84.31 (a)
(Anolis carolinensis)
Reptilia RBM12 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm12 35
  • 70.31 (n)
  • 69.89 (a)
(Danio rerio)
Actinopterygii rbm12 35
  • 71.89 (n)
  • 72.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7879 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea Y106G6D.7 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
Species with no ortholog for RBM12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM12 Gene

Gene Tree for RBM12 (if available)
Gene Tree for RBM12 (if available)

Paralogs for RBM12 Gene

Paralogs for RBM12 Gene

(2) SIMAP similar genes for RBM12 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBM12: view

Variants for RBM12 Gene

Sequence variations from dbSNP and Humsavar for RBM12 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_052218 -
VAR_052217 -

Structural Variations from Database of Genomic Variants (DGV) for RBM12 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV Gain 19592680

Relevant External Links for RBM12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM12 Gene

Disorders for RBM12 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RBM12 Gene in MalaCards »

(1) Disease for RBM12 Gene

(1) University of Copenhagen DISEASES for RBM12 Gene

genes like me logo Genes that share disorders with RBM12: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for RBM12 Gene

Publications for RBM12 Gene

  1. cDNA cloning, chromosomal assignment, and genomic structure of a human gene encoding a novel member of the RBM family. (PMID: 11435693) Stover C.M. … Schwaeble W.J. (Cytogenet. Cell Genet. 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4

Products for RBM12 Gene

Sources for RBM12 Gene

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