RBM12 Gene
protein-coding GIFtS: 47
GCID: GC20M034236
|
|
RNA binding motif protein 12
| |
Aliases
for RBM12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 121 2 | | RNA-Binding Motif Protein 122 3 | | SWAN1 2 3 | | SH3/WW Domain Anchor Protein In The Nucleus2 3 | | HRIHFB20911 2 | | RNA-Binding Protein 122 | | KIAA07651 3 | | |
Export aliases for RBM12 gene to outside databasesPrevious GC identifers: GC20U990034 GC20M033933 GC20M034882 GC20M034930 GC20M034931 GC20M033678 GC20M033700 GC20M031014 |
Summaries
for RBM12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBM12:
This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-richregions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTRresults in four transcript variants. All variants encode the same protein. (provided by RefSeq, Nov 2010)
Gene Wiki entry for RBM12
|
Genomic Views
for RBM12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBM12 gene promoter:
TBP GR Sox5 AML1a Pax-5 SEF-1 (1) GR-alpha AP-2gamma
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBM12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.21RBM12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M034236: view genomic region
(about GC identifiers)
Start:
|
34,236,847 bp from pter |
End:
|
34,252,878 bp from pter |
Size:
|
16,032 bases |
Orientation:
|
minus strand |
|
Proteins
for RBM12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM12_HUMAN, Q9NTZ6 (See
protein sequence)Recommended Name: RNA-binding protein 12 Size: 932 amino acids; 97395 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAA34485.2; Type=Erroneous initiation;
5 PDB 3D structures from  and Proteopedia  for RBM12:1WEL (3D)
2CPY (3D)
2DNN (3D)
2EK1 (3D)
2EK6 (3D)
Secondary accessions: B3KRU2 E1P5R6 O94865 Q8N3B1 Q9H196Explore the universe of human proteins at neXtProt for RBM12: NX_Q9NTZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NTZ6
RBM12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001185767.1 NP_001185769.1 NP_006038.2 NP_690051.1
ENSEMBL proteins: ENSP00000363228 ENSP00000352668 ENSP00000363217 ENSP00000411036 ENSP00000392642 ENSP00000411692
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RBM12 for ontologies About GeneDecksing
RBM12 Antibody Products:
Assay Products for RBM12: |
Protein
Domains /
Families
for RBM12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NTZ6ProtoNet protein and cluster: Q9NTZ6 UniProtKB/Swiss-Prot: RBM12_HUMAN, Q9NTZ6Similarity: Contains 3 RRM (RNA recognition motif) domains |
Function
for RBM12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM12 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): RBM12 (NM_006047) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
RBM12 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RBM12:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rbm12):
RBM12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RBM12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for RBM12 (Q9NTZ62, 3 ENSP000003526684) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for RBM12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM12
Search CenterWatch for drugs/clinical trials and news about RBM12
|
Transcripts
for RBM12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM12 gene (4 alternative transcripts): NM_001198838.1 NM_001198840.1 NM_006047.5 NM_152838.3 Unigene Cluster for RBM12: RNA binding motif protein 12 Hs.700188 [show with all ESTs]Unigene Representative Sequence: NM_0060476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374114(uc002xdq.3 uc002xds.3 uc002xdr.3 uc021wcq.1)
ENST00000359646 ENST00000374104 ENST00000424458 ENST00000431148 ENST00000435161
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM12 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): RBM12 (NM_006047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM12 |
Additional cDNA sequence: AB015336.1 AB018308.2 AF345332.1 AF393214.1 AJ289772.1 AK026963.1 AK074945.1 AK092239.1 AK299371.1 AL833222.1 AL834472.1 BC012787.2 BC013981.2 22 DOTS entries: DT.443908 DT.91821024 DT.120831381 DT.120831387 DT.92034435 DT.100643510 DT.97767293 DT.95362823 DT.95173784 DT.120831340 DT.120831332 DT.120831388 DT.100782949 DT.120831255 DT.91659619 DT.91773693 DT.95222475 DT.99983905 DT.100672094 DT.100875912 DT.120831454 DT.95357282 24/865 AceView cDNA sequences (see all 865): AI494515 AA593773 BU145800 BQ059469 BE391286 BM757881 BQ227517 AI571479 BU501791 T41150 CR606579 BQ642650 BM970442 AI474397 BU146477 NM_152928 BQ064910 CR624522 CA313148 T34853 BE740556 BQ424718 BI254653 BM800770
GeneLoc Exon Structure
|
Expression
for RBM12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCCTTTG
About this image
See RBM12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM12
SOURCE GeneReport for Unigene cluster: Hs.700188
SABiosciences Custom PCR Arrays for RBM12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM12
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RBM12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM12 |
Orthologs
for RBM12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBM12 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for RBM12 (if available)
TreeFam Gene Tree for RBM12 (if available) |
Paralogs
for RBM12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBM12 gene
- HNRNPH32 RBM12B2 ESRP12 HNRNPH22 GRSF12 ESRP22 HNRNPH12 HNRNPF2
2 SIMAP similar genes for RBM12 using alignment to 4 protein entries: RBM12_HUMAN (see all proteins):DKFZp667H197 RBM12B
RBM12 for paralogs About GeneDecksing
|
Genomic Variants
for RBM12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM12 |
|
Disorders
/ Diseases
for RBM12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBM12 for disorders About GeneDecksing
OMIM gene information: 607179
OMIM disorders: --
4  diseases for RBM12: About MalaCardsgas gangrene acute monocytic leukemia monocytic leukemia leukemia
1 disease from the University of Copenhagen DISEASES database for RBM12:Gas gangrene Export disorders for RBM12 gene to outside databases
|
Publications
for RBM12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM12 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with RBM12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning, chromosomal assignment, and genomic structure of a human gene encoding a novel member of the RBM family. (PubMed id 11435693)1, 2, 3 Stover C.M....Schwaeble W.J. (2001)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (1998)
- Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example. (PubMed id 18831769)1, 9 Yang W....Lau Y.L. (2008)
|
External Searches for RBM12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM12 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RBM12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM12 gene:
Search GeneIP for patents involving RBM12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RBM12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM12 | | | OriGene Protein Over-expression Lysate for RBM12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBM12 | | OriGene 3'-UTR Clone for RBM12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RBM12 | | OriGene Custom Protein Services for RBM12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBM12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBM12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBM12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RBM12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RBM12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM12 |
|  |  |  | | | | Search ThermoFisher Antibodies for RBM12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM12 |
|
|
|
|
