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Aliases for RBM12 Gene

Aliases for RBM12 Gene

  • RNA Binding Motif Protein 12 2 3
  • SH3/WW Domain Anchor Protein In The Nucleus 3 4
  • RNA-Binding Motif Protein 12 3 4
  • SWAN 3 4
  • RNA-Binding Protein 12 3
  • HRIHFB2091 3
  • KIAA0765 4

External Ids for RBM12 Gene

Summaries for RBM12 Gene

Entrez Gene Summary for RBM12 Gene

  • This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBM12 Gene

RBM12 (RNA Binding Motif Protein 12) is a Protein Coding gene. Diseases associated with RBM12 include gas gangrene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is ESRP2.

Gene Wiki entry for RBM12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM12 Gene

Genomics for RBM12 Gene

Genomic Location for RBM12 Gene

Start:
35,648,925 bp from pter
End:
35,664,956 bp from pter
Size:
16,032 bases
Orientation:
Minus strand

Genomic View for RBM12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM12 Gene

Regulatory Elements for RBM12 Gene

Proteins for RBM12 Gene

  • Protein details for RBM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTZ6-RBM12_HUMAN
    Recommended name:
    RNA-binding protein 12
    Protein Accession:
    Q9NTZ6
    Secondary Accessions:
    • B3KRU2
    • E1P5R6
    • O94865
    • Q8N3B1
    • Q9H196

    Protein attributes for RBM12 Gene

    Size:
    932 amino acids
    Molecular mass:
    97395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34485.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM12 Gene

neXtProt entry for RBM12 Gene

Proteomics data for RBM12 Gene at MOPED

Post-translational modifications for RBM12 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys349

No data available for DME Specific Peptides for RBM12 Gene

Domains for RBM12 Gene

Gene Families for RBM12 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RBM12 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RBM12_HUMAN
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.:
    • Q9NTZ6
genes like me logo Genes that share domains with RBM12: view

Function for RBM12 Gene

Gene Ontology (GO) - Molecular Function for RBM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM12: view

Phenotypes for RBM12 Gene

genes like me logo Genes that share phenotypes with RBM12: view

miRNA for RBM12 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM12 Gene

Localization for RBM12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM12 Gene COMPARTMENTS Subcellular localization image for RBM12 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RBM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RBM12: view

Pathways for RBM12 Gene

SuperPathways for RBM12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM12 Gene

None

No data available for Pathways by source for RBM12 Gene

Transcripts for RBM12 Gene

Unigene Clusters for RBM12 Gene

RNA binding motif protein 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM12 Gene

No ASD Table

Relevant External Links for RBM12 Gene

GeneLoc Exon Structure for
RBM12
ECgene alternative splicing isoforms for
RBM12

Expression for RBM12 Gene

mRNA expression in normal human tissues for RBM12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RBM12 Gene

SOURCE GeneReport for Unigene cluster for RBM12 Gene Hs.700188

genes like me logo Genes that share expressions with RBM12: view

Orthologs for RBM12 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM12 36
  • 99.86 (n)
  • 100 (a)
RBM12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM12 36
  • 93.5 (n)
  • 94.94 (a)
RBM12 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM12 36
  • 94.4 (n)
  • 95.88 (a)
RBM12 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm12 36
  • 90.97 (n)
  • 92.87 (a)
Rbm12 16
Rbm12 37
  • 87 (a)
OneToMany
RP23-220D12.12 37
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RBM12 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rbm12 36
  • 91.3 (n)
  • 92.72 (a)
chicken
(Gallus gallus)
Aves RBM12 36
  • 79.24 (n)
  • 84.31 (a)
lizard
(Anolis carolinensis)
Reptilia RBM12 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm12 36
  • 70.31 (n)
  • 69.89 (a)
zebrafish
(Danio rerio)
Actinopterygii rbm12 36
  • 71.89 (n)
  • 72.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7879 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y106G6D.7 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
OneToMany
Species with no ortholog for RBM12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM12 Gene

ENSEMBL:
Gene Tree for RBM12 (if available)
TreeFam:
Gene Tree for RBM12 (if available)

Paralogs for RBM12 Gene

Paralogs for RBM12 Gene

Selected SIMAP similar genes for RBM12 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBM12: view

Variants for RBM12 Gene

Sequence variations from dbSNP and Humsavar for RBM12 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_052217 -
VAR_052218 -

Structural Variations from Database of Genomic Variants (DGV) for RBM12 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV Gain 19592680

Relevant External Links for RBM12 Gene

HapMap Linkage Disequilibrium report
RBM12

Disorders for RBM12 Gene

(1) MalaCards Diseases for RBM12 Gene

Search for RBM12 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RBM12 Gene

genes like me logo Genes that share disorders with RBM12: view

No data available for UniProtKB/Swiss-Prot for RBM12 Gene

Publications for RBM12 Gene

  1. cDNA cloning, chromosomal assignment, and genomic structure of a human gene encoding a novel member of the RBM family. (PMID: 11435693) Stover C.M. … Schwaeble W.J. (Cytogenet. Cell Genet. 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4

Products for RBM12 Gene

Sources for RBM12 Gene

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