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Aliases for RBM12 Gene

Aliases for RBM12 Gene

  • RNA Binding Motif Protein 12 2 3 5
  • SH3/WW Domain Anchor Protein In The Nucleus 3 4
  • SWAN 3 4
  • RNA-Binding Motif Protein 12 4
  • RNA-Binding Protein 12 3
  • HRIHFB2091 3
  • KIAA0765 4

External Ids for RBM12 Gene

Previous GeneCards Identifiers for RBM12 Gene

  • GC20U990034
  • GC20M033933
  • GC20M034882
  • GC20M034930
  • GC20M034931
  • GC20M033678
  • GC20M033700
  • GC20M034236
  • GC20M031014

Summaries for RBM12 Gene

Entrez Gene Summary for RBM12 Gene

  • This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBM12 Gene

RBM12 (RNA Binding Motif Protein 12) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM12B.

Gene Wiki entry for RBM12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM12 Gene

Genomics for RBM12 Gene

Regulatory Elements for RBM12 Gene

Enhancers for RBM12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F035765 1 FANTOM5 ENCODE 62.3 -104.6 -104590 9.2 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CPNE1 RBM12 NCOA6 PHF20 AAR2 TRPC4AP PROCR RPF2P1 C20orf173 HMGB3P2
GH20F035615 0.2 ENCODE 61.9 +47.1 47129 5.0 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 CPNE1 RBM12 NCOA6 RPL36P4 AAR2 C20orf173 RPF2P1 HMGB3P2 ENSG00000242507 PROCR
GH20F036459 0.6 ENCODE 54.4 -801.8 -801808 13.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RBM12 AAR2 CPNE1 TGIF2 RBL1 RPL36P4 MYL9 TLDC2 DLGAP4-AS1 MANBAL
GH20F035436 0.8 Ensembl ENCODE 51.6 +226.9 226860 3.4 ZFP64 ZNF493 ARID4B ZNF48 GLIS2 ZNF302 ZNF143 ZNF416 KLF7 MCM3 RBM12 NCOA6 UQCC1 RPL36P4 CPNE1 AAR2 TRPC4AP MMP24-AS1 EDEM2 PROCR
GH20F035874 1.1 FANTOM5 Ensembl ENCODE 36.9 -210.6 -210562 2.6 PKNOX1 ATF1 SIN3A FEZF1 BRCA1 ZNF2 GTF3C2 KLF7 FOS SP3 CPNE1 RBM12 AAR2 RPL36P4 TRPC4AP NFS1 EIF6 RBM39 TGIF2 PHF20
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RBM12 on UCSC Golden Path with GeneCards custom track

Promoters for RBM12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000400325 1156 3201 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for RBM12 Gene

Chromosome:
20
Start:
35,648,925 bp from pter
End:
35,664,956 bp from pter
Size:
16,032 bases
Orientation:
Minus strand

Genomic View for RBM12 Gene

Genes around RBM12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM12 Gene

Proteins for RBM12 Gene

  • Protein details for RBM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTZ6-RBM12_HUMAN
    Recommended name:
    RNA-binding protein 12
    Protein Accession:
    Q9NTZ6
    Secondary Accessions:
    • B3KRU2
    • E1P5R6
    • O94865
    • Q8N3B1
    • Q9H196

    Protein attributes for RBM12 Gene

    Size:
    932 amino acids
    Molecular mass:
    97395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34485.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM12 Gene

neXtProt entry for RBM12 Gene

Post-translational modifications for RBM12 Gene

  • Ubiquitination at Lys 349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RBM12 Gene

Domains & Families for RBM12 Gene

Gene Families for RBM12 Gene

Protein Domains for RBM12 Gene

Suggested Antigen Peptide Sequences for RBM12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTZ6

UniProtKB/Swiss-Prot:

RBM12_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RBM12: view

Function for RBM12 Gene

Gene Ontology (GO) - Molecular Function for RBM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM12: view
genes like me logo Genes that share phenotypes with RBM12: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM12 Gene

Localization for RBM12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM12 Gene COMPARTMENTS Subcellular localization image for RBM12 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RBM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RBM12: view

Pathways & Interactions for RBM12 Gene

SuperPathways for RBM12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM12 Gene

Transcripts for RBM12 Gene

Unigene Clusters for RBM12 Gene

RNA binding motif protein 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM12 Gene

No ASD Table

Relevant External Links for RBM12 Gene

GeneLoc Exon Structure for
RBM12
ECgene alternative splicing isoforms for
RBM12

Expression for RBM12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM12 Gene

Protein differential expression in normal tissues from HIPED for RBM12 Gene

This gene is overexpressed in Lymph node (14.2) and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBM12 Gene



Protein tissue co-expression partners for RBM12 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM12 Gene:

RBM12

SOURCE GeneReport for Unigene cluster for RBM12 Gene:

Hs.700188
genes like me logo Genes that share expression patterns with RBM12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM12 Gene

Orthologs for RBM12 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM12 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia RBM12 34 35
  • 94.4 (n)
cow
(Bos Taurus)
Mammalia RBM12 34 35
  • 93.5 (n)
rat
(Rattus norvegicus)
Mammalia Rbm12 34
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Rbm12 34 16 35
  • 90.97 (n)
RP23-220D12.12 35
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RBM12 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RBM12 34
  • 79.24 (n)
lizard
(Anolis carolinensis)
Reptilia RBM12 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm12 34
  • 70.31 (n)
zebrafish
(Danio rerio)
Actinopterygii rbm12 34
  • 71.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7879 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y106G6D.7 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for RBM12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM12 Gene

ENSEMBL:
Gene Tree for RBM12 (if available)
TreeFam:
Gene Tree for RBM12 (if available)

Paralogs for RBM12 Gene

Paralogs for RBM12 Gene

(2) SIMAP similar genes for RBM12 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RBM12: view

Variants for RBM12 Gene

Sequence variations from dbSNP and Humsavar for RBM12 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1040694 -- 35,651,741(+) TAAAT(C/T)GTGGC intron-variant, utr-variant-3-prime
rs1040695 -- 35,656,907(+) AAGAA(C/T)ATTAG intron-variant
rs10542710 -- 35,658,803(+) CAAAA(-/AC)ACACA intron-variant
rs10635666 -- 35,658,803(+) caaaa(A/T)cacac intron-variant
rs111306810 -- 35,658,002(+) GATCA(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM12 Gene

Variant ID Type Subtype PubMed ID
esv3645717 CNV gain 21293372
nsv526188 CNV gain 19592680

Variation tolerance for RBM12 Gene

Residual Variation Intolerance Score: 3.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM12 Gene

Disorders for RBM12 Gene

Relevant External Links for RBM12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM12

No disorders were found for RBM12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM12 Gene

Publications for RBM12 Gene

  1. cDNA cloning, chromosomal assignment, and genomic structure of a human gene encoding a novel member of the RBM family. (PMID: 11435693) Stover C.M. … Schwaeble W.J. (Cytogenet. Cell Genet. 2001) 2 3 4 64
  2. Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example. (PMID: 18831769) Yang W. … Lau Y.L. (BMC Genomics 2008) 3 22 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4 64

Products for RBM12 Gene

Sources for RBM12 Gene

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