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Aliases for RBM11 Gene

Aliases for RBM11 Gene

  • RNA Binding Motif Protein 11 2 3 5
  • RNA-Binding Motif Protein 11 4

External Ids for RBM11 Gene

Previous GeneCards Identifiers for RBM11 Gene

  • GC21P012252
  • GC21P014510
  • GC21P015588
  • GC21P000958

Summaries for RBM11 Gene

GeneCards Summary for RBM11 Gene

RBM11 (RNA Binding Motif Protein 11) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM7.

UniProtKB/Swiss-Prot for RBM11 Gene

  • Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5 splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.

Gene Wiki entry for RBM11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM11 Gene

Genomics for RBM11 Gene

Regulatory Elements for RBM11 Gene

Enhancers for RBM11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G014541 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +329.3 329255 8.1 PKNOX1 ATF1 SIN3A ZNF766 GATA2 CBX5 JUNB TBX21 ZNF592 MBD2 SAMSN1 SAMSN1-AS1 RBM11 HSPA13
GH21G014273 0.9 Ensembl ENCODE 9.4 +57.8 57802 1.0 NRF1 MAX UBTF RELA E2F1 ZNF579 SCRT2 HNF4A FOXP2 ZBTB33 ABCC13 RBM11 GC21P014363
GH21G014259 0.7 ENCODE 11.5 +44.3 44292 2.5 CTCF ZNF654 RFX1 ZNF175 REST RAD21 JUND ATF3 IKZF1 SMC3 RBM11 ABCC13 GC21P014363
GH21G014280 0.6 Ensembl ENCODE 11.6 +65.2 65186 0.7 ZNF592 ABCC13 RBM11 ANKRD20A11P GC21P014363
GH21G014266 0.7 ENCODE 9.9 +51.0 50995 1.2 TFAP4 HLF CEBPB CEBPG RAD21 FOXA1 YY1 CEBPA SCRT2 BCL6 ABCC13 RBM11 GC21P014363
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM11 on UCSC Golden Path with GeneCards custom track

Promoters for RBM11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000140299 295 1199 MXI1 RB1 RBBP5 CCNT2 E2F1 EGR1 NFE2 PHF8 SP3 RNF2

Genomic Location for RBM11 Gene

Chromosome:
21
Start:
14,216,106 bp from pter
End:
14,228,372 bp from pter
Size:
12,267 bases
Orientation:
Plus strand

Genomic View for RBM11 Gene

Genes around RBM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM11 Gene

Proteins for RBM11 Gene

  • Protein details for RBM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57052-RBM11_HUMAN
    Recommended name:
    Splicing regulator RBM11
    Protein Accession:
    P57052
    Secondary Accessions:
    • Q6YNC2
    • Q8NBA1
    • Q8NFF6

    Protein attributes for RBM11 Gene

    Size:
    281 amino acids
    Molecular mass:
    32179 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH30196.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL82535.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305}; Sequence=BAC03638.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM11 Gene

    Alternative splice isoforms for RBM11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM11 Gene

Post-translational modifications for RBM11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM11 Gene

No data available for DME Specific Peptides for RBM11 Gene

Domains & Families for RBM11 Gene

Gene Families for RBM11 Gene

Suggested Antigen Peptide Sequences for RBM11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM11: view

No data available for UniProtKB/Swiss-Prot for RBM11 Gene

Function for RBM11 Gene

Molecular function for RBM11 Gene

UniProtKB/Swiss-Prot Function:
Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5 splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.

Gene Ontology (GO) - Molecular Function for RBM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008266 poly(U) RNA binding IDA 21984414
GO:0042803 protein homodimerization activity IDA 21984414
genes like me logo Genes that share ontologies with RBM11: view
genes like me logo Genes that share phenotypes with RBM11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM11 Gene

Localization for RBM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM11 Gene

Nucleus, nucleoplasm. Nucleus speckle. Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM11 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RBM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21984414
GO:0005654 nucleoplasm IDA 21984414
GO:0016607 nuclear speck IDA 21984414
genes like me logo Genes that share ontologies with RBM11: view

Pathways & Interactions for RBM11 Gene

SuperPathways for RBM11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 21984414
GO:0006397 mRNA processing IEA --
GO:0007275 multicellular organism development IEA --
GO:0008380 RNA splicing IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RBM11: view

No data available for Pathways by source and SIGNOR curated interactions for RBM11 Gene

Drugs & Compounds for RBM11 Gene

No Compound Related Data Available

Transcripts for RBM11 Gene

Unigene Clusters for RBM11 Gene

RNA binding motif protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RBM11

Alternative Splicing Database (ASD) splice patterns (SP) for RBM11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: -

Relevant External Links for RBM11 Gene

GeneLoc Exon Structure for
RBM11
ECgene alternative splicing isoforms for
RBM11

Expression for RBM11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBM11 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.9).

NURSA nuclear receptor signaling pathways regulating expression of RBM11 Gene:

RBM11

SOURCE GeneReport for Unigene cluster for RBM11 Gene:

Hs.283828

mRNA Expression by UniProt/SwissProt for RBM11 Gene:

P57052-RBM11_HUMAN
Tissue specificity: Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary gland, spleen and kidney. Also expressed in fetal brain.

Evidence on tissue expression from TISSUES for RBM11 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RBM11: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM11 Gene

Orthologs for RBM11 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM11 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia RBM11 34 35
  • 89.68 (n)
cow
(Bos Taurus)
Mammalia RBM11 34 35
  • 89.27 (n)
rat
(Rattus norvegicus)
Mammalia Rbm11 34
  • 88.11 (n)
mouse
(Mus musculus)
Mammalia Rbm11 34 16 35
  • 82.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RBM11 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM11 34
  • 69.88 (n)
lizard
(Anolis carolinensis)
Reptilia RBM11 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm11 34
  • 59.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26041 34
zebrafish
(Danio rerio)
Actinopterygii RBM11 35
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11454 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.21 35
  • 22 (a)
OneToMany
Species where no ortholog for RBM11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM11 Gene

ENSEMBL:
Gene Tree for RBM11 (if available)
TreeFam:
Gene Tree for RBM11 (if available)

Paralogs for RBM11 Gene

Paralogs for RBM11 Gene

(1) SIMAP similar genes for RBM11 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RBM11 Gene

genes like me logo Genes that share paralogs with RBM11: view

Variants for RBM11 Gene

Sequence variations from dbSNP and Humsavar for RBM11 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000085994 -- 14,223,859(+) TTGGC(A/C)ATCTC intron-variant, utr-variant-5-prime
rs1000444485 -- 14,228,005(+) TTCAC(C/G)TCTTT nc-transcript-variant, utr-variant-3-prime
rs1000531068 -- 14,222,234(+) TATAT(C/T)TATAT intron-variant, utr-variant-5-prime
rs1000583269 -- 14,221,954(+) TCTGC(A/G)GCCTC intron-variant, utr-variant-5-prime
rs1001160195 -- 14,216,209(+) GGAGG(C/G)CGACA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RBM11 Gene

Variant ID Type Subtype PubMed ID
esv3646422 CNV gain 21293372
esv3893371 CNV gain 25118596
nsv1056588 CNV loss 25217958
nsv1058202 CNV loss 25217958

Variation tolerance for RBM11 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM11 Gene

Disorders for RBM11 Gene

Relevant External Links for RBM11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM11

No disorders were found for RBM11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM11 Gene

Publications for RBM11 Gene

  1. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 2 3 4 64
  2. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. (PMID: 21984414) Pedrotti S. … Sette C. (Nucleic Acids Res. 2012) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PMID: 12909339) Brun M.-E. … De Sario A. (Gene 2003) 3 4 64

Products for RBM11 Gene

  • Addgene plasmids for RBM11

Sources for RBM11 Gene

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