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RBM11 Gene

protein-coding   GIFtS: 50
GCID: GC21P015588

RNA Binding Motif Protein 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RNA Binding Motif Protein 111 2
RNA-Binding Motif Protein 112 3
Putative Gene, RNA Binding Motif Protein 11 Like11
Putative RNA-Binding Protein 112
Splicing Regulator RBM112

External Ids:    HGNC: 98971   Entrez Gene: 540332   Ensembl: ENSG000001852727   UniProtKB: P570523   
ORGUL members:         

Export aliases for RBM11 gene to outside databases

Previous GC identifers: GC21P012252 GC21P014510 GC21P000958


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RBM11 Gene:
RBM11 (RNA binding motif protein 11) is a protein-coding gene. Diseases associated with RBM11 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM7.

UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052
Function: Tissue-specific splicing factor with potential implication in the regulation of alternative splicing
during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of
alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1

Gene Wiki entry for RBM11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM11 gene promoter:
         oct-B3   Lmo2   HSF1 (long)   C/EBPalpha   POU2F1   FOXJ2 (long isoform)   STAT3   HSF1short   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM11 promoter sequence

   Search Chromatin IP Primers for RBM11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11   Ensembl cytogenetic band:  21q11.2   HGNC cytogenetic band: 21q11
Nature(405: 311-319) cytogenetic band:   21q11
RBM11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM11 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P015588:   GeneLoc Nature:405,311-319
Start:
15,588,451 bp from pter       1,252,617 bp from centromere
End:
15,600,693 bp from pter 1,263,937 bp from centromere
Size:
12,243 bases 11,321 bases
Orientation:
plus strand plus strand

genomic clones: P98L15 P90B5


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052 (See protein sequence)
Recommended Name: Splicing regulator RBM11  
Size: 281 amino acids; 32179 Da
Subunit: Homodimer
Sequence caution: Sequence=AAH30196.2; Type=Erroneous initiation; Sequence=AAL82535.1; Type=Frameshift;
Positions=33; Sequence=BAC03638.1; Type=Frameshift; Positions=33;
1 PDB 3D structure from and Proteopedia for RBM11:
2YWK (3D)    
Secondary accessions: Q6YNC2 Q8NBA1 Q8NFF6
Alternative splicing: 2 isoforms:  P57052-1   P57052-2   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for RBM11: NX_P57052

Explore proteomics data for RBM11 at MOPED


See RBM11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_658983.3  
ENSEMBL proteins: 
 ENSP00000383421  

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Cloud-Clone Corp. CLIAs for RBM11


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RBM: RNA binding motif (RRM) containing

2 InterPro protein domains:
 IPR012677 Nucleotide-bd_a/b_plait
 IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry P57052

ProtoNet protein and cluster: P57052

1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052
Similarity: Contains 1 RRM (RNA recognition motif) domain


RBM11 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RBM11_HUMAN, P57052
Function: Tissue-specific splicing factor with potential implication in the regulation of alternative splicing
during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of
alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding IEA--
GO:0003676nucleic acid binding ----
GO:0003723RNA binding ----
GO:0008266poly(U) RNA binding IDA--
GO:0042803protein homodimerization activity IDA--
     
RBM11 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for RBM11:
 Increased cell number in G1, s 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBM11
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miRNA
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4 qRT-PCR Assays for microRNAs that regulate RBM11:
hsa-miR-9 hsa-miR-607 hsa-miR-371-5p hsa-miR-583
SwitchGear 3'UTR luciferase reporter plasmidRBM11 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat RBM11

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RBM11_HUMAN, P57052: Nucleus, nucleoplasm. Nucleus speckle. Note=Enriched in SRSF2-containing splicing speckles;
shuttles between nucleoplasm and speckles
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
extracellular1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005654nucleoplasm IDA--
GO:0005730NOT nucleolus IDA--
GO:0016607nuclear speck IDA--

RBM11 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM11
Interactions:

    Search GeneGlobe Interaction Network for RBM11

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for RBM11 (P570522, 3 ENSP000003834214) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66154 I2D: score=5 STRING: ENSP00000360441
PCBP1Q153652, 3, ENSP000003055564MINT-2873675 I2D: score=3 STRING: ENSP00000305556
DAZAP2Q150383I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA--
GO:0006397mRNA processing IEA--
GO:0007275multicellular organismal development IEA--
GO:0008380RNA splicing IEA--
GO:0030154cell differentiation IEA--

RBM11 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RBM11



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RBM11 gene: 
NM_144770.3  

Unigene Cluster for RBM11:

RNA binding motif protein 11
Hs.283828  [show with all ESTs]
Unigene Representative Sequence: BC030196
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000468643(uc002yjo.4 uc002yjn.4 uc002yjp.4) ENST00000468788
ENST00000495055 ENST00000461088 ENST00000400577 ENST00000475864
miRNA
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4 qRT-PCR Assays for microRNAs that regulate RBM11:
hsa-miR-9 hsa-miR-607 hsa-miR-371-5p hsa-miR-583
SwitchGear 3'UTR luciferase reporter plasmidRBM11 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat RBM11
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GenScript: all cDNA clones in your preferred vector: RBM11 (NM_144770)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM11
Primer
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OriGene qPCR primer pairs and template standards for RBM11
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  QuantiTect SYBR Green Assays in human, mouse, rat RBM11
  QuantiFast Probe-based Assays in human, mouse, rat RBM11

Additional mRNA sequence: 

AF519623.1 AK091331.1 AY077695.1 BC030196.1 

5 DOTS entries:

DT.95262633  DT.100745049  DT.436113  DT.91704104  DT.95237154 

24 AceView cDNA sequences:

BX281687 AL596989 NM_144770 BC030196 BI603848 BI913079 AX746917 BX104385 
BQ186146 AY077695 AF519623 BI753557 BX950891 BX950892 BG706195 AL041993 
CB153254 AK091331 AA639269 D61628 BG541166 N94835 N63517 AA737090 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RBM11    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1:                                -                                       
SP2:                                -           -                           
SP3:              -                 -           -                           
SP4:              -     -           -           -                           
SP5:              -                                                         


ECgene alternative splicing isoforms for RBM11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RBM11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGCCTAGCA
RBM11 Expression
About this image


RBM11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Neural Tube (Nervous System)
         Diencephalon
RBM11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RBM11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.283828

UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052
Tissue specificity: Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary
gland, spleen and kidney. Also expressed in fetal brain

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RBM11 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rbm111 , 5 RNA binding motif protein 111, 5 82.97(n)1
80.62(a)1
  16 (43.22 cM)5
2243441  NM_198302.21  NP_938044.11 
 755928445 
chicken
(Gallus gallus)
Aves RBM111 RNA binding motif protein 11 69.88(n)
62.39(a)
  418467  XM_416676.4  XP_416676.3 
lizard
(Anolis carolinensis)
Reptilia RBM116
RNA binding motif protein 11
48(a)
1 ↔ 1
GL343230.1(1606846-1616812)
African clawed frog
(Xenopus laevis)
Amphibia Xl.260412 Xenopus laevis transcribed sequence with weak similarity more 76.84(n)    CD252709.1 
zebrafish
(Danio rerio)
Actinopterygii RBM116
RNA binding motif protein 11
27(a)
1 ↔ 1
21(33942525-33953553) ENSDARG00000090202
fruit fly
(Drosophila melanogaster)
Insecta CG114546
--
22(a)
1 → many
2L(143309-144227)
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.216
Protein Y37D8A.21 (Y37D8A.21) mRNA, complete cds
22(a)
1 → many
III(12928379-12931867) WBGene00012558


ENSEMBL Gene Tree for RBM11 (if available)
TreeFam Gene Tree for RBM11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RBM11 gene
RBM72  ENSG000002556632  
1 SIMAP similar gene for RBM11 using alignment to 2 protein entries:     RBM11_HUMAN (see all proteins):
RBM7

RBM11 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for RBM11
PGOHUM00000243780


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RBM11 (see all 401)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs4481731,2
C,F--15586672(-) GAAAGT/ACAGCT 1 -- us2k13Minor allele frequency- A:0.17NA WA 240
rs4481721,2
C,F--15586680(-) TAAACT/ACTGAA 1 -- us2k1 tfbs32Minor allele frequency- A:0.17WA NA 238
rs1886507241,2
--15586809(+) AGAACA/GATATA 1 -- us2k10--------
rs1920768221,2
--15586858(+) GCATAC/TGCACT 1 -- us2k10--------
rs81292121,2
C,H--15586875(+) CATGCA/GATGGT 1 -- us2k15Minor allele frequency- G:0.01NS EA WA 476
rs1854407461,2
--15586960(+) TTGATG/TAGATT 1 -- us2k10--------
rs1900135821,2
--15587010(+) CATAAA/CAGAGA 1 -- us2k10--------
rs1821957971,2
--15587027(+) AGTATC/GCATTC 1 -- us2k10--------
rs1172744871,2
F--15587062(+) CCTACA/TATATG 1 -- us2k11Minor allele frequency- T:0.02EA 120
rs723389141,2
C--15587115(+) ATGAT-/AGAGG 
        
AAAGA
1 -- us2k10--------

HapMap Linkage Disequilibrium report for RBM11 (15588451 - 15600693 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RBM11:    About this table    
Variant IDTypeSubtypePubMed ID
nsv913402CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RBM11
DNA2.0 Custom Variant and Variant Library Synthesis for RBM11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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5 diseases for RBM11:    
About MalaCards
intrahepatic cholangiocarcinoma    cholangiocarcinoma    down syndrome    ataxia
neuronitis


RBM11 for disorders           About GeneDecksing


Export disorders for RBM11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RBM11 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with RBM11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2, 3 Gardiner K.... Davisson M. (Genomics 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PubMed id 12909339)1, 2 Brun M.-E.... De Sario A. (Gene 2003)
  5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
  6. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
  7. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. (PubMed id 21984414)2 Pedrotti S.... Sette C. (Nucleic Acids Res. 2012)
  8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
  9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
  10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54033 HGNC: 9897 AceView: RBM11 Ensembl:ENSG00000185272 euGenes: HUgn54033
ECgene: RBM11 H-InvDB: RBM11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RBM11 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RBM11 gene:
Search GeneIP for patents involving RBM11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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