RBM11 Gene
protein-coding GIFtS: 48
GCID: GC21P015588
|
|
RNA binding motif protein 11
| |
Aliases
for RBM11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
|
| Aliases |
|---|
| RNA Binding Motif Protein 111 2 | | RNA-Binding Motif Protein 112 3 | | Putative Gene, RNA Binding Motif Protein 11 Like11 | | Putative RNA-Binding Protein 112 | | Splicing Regulator RBM112 |
Export aliases for RBM11 gene to outside databasesPrevious GC identifers: GC21P012252 GC21P014510 GC21P000958 |
Summaries
for RBM11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052Function: Tissue-specific splicing factor with potential implication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1
Gene Wiki entry for RBM11
|
Genomic Views
for RBM11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
|
| GC21P015588: |
GeneLoc |
Nature:405,311-319 |
Start:
|
15,588,451 bp from pter |
1,252,617 bp from centromere |
End:
|
15,600,693 bp from pter |
1,263,937 bp from centromere |
Size:
|
12,243 bases |
11,321 bases |
Orientation:
|
plus strand |
plus strand |
Proteins
for RBM11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052 (See
protein sequence)Recommended Name: Splicing regulator RBM11 Size: 281 amino acids; 32179 Da
Subunit: Homodimer
Subcellular location: Nucleus, nucleoplasm. Nucleus speckle. Note=Enriched in SRSF2-containing splicing speckles;shuttles between nucleoplasm and speckles
Sequence caution: Sequence=AAH30196.2; Type=Erroneous initiation; Sequence=AAL82535.1; Type=Frameshift; Positions=33;Sequence=BAC03638.1; Type=Frameshift; Positions=33;
1 PDB 3D structure from  and Proteopedia  for RBM11:2YWK (3D)
Secondary accessions: Q6YNC2 Q8NBA1 Q8NFF6Alternative splicing: 2 isoforms: P57052-1 P57052-2 (Incomplete sequence)Explore the universe of human proteins at neXtProt for RBM11: NX_P57052
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57052
RBM11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_658983.3
ENSEMBL proteins: ENSP00000383421
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016607 | nuclear speck |
IEA | -- |
RBM11 for ontologies About GeneDecksing
RBM11 Antibody Products:
Assay Products for RBM11: |
Protein
Domains /
Families
for RBM11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBM11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P57052ProtoNet protein and cluster: P57052 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052Similarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for RBM11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052Function: Tissue-specific splicing factor with potential implication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM11 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
RBM11 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RBM11:
|
Pathways & Interactions
for RBM11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBM11
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for RBM11 (P570522, 3 ENSP000003834214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
RBM11 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBM11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBM11
Search CenterWatch for drugs/clinical trials and news about RBM11
|
Transcripts
for RBM11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBM11 gene: NM_144770.3 Unigene Cluster for RBM11: RNA binding motif protein 11 Hs.283828 [show with all ESTs]Unigene Representative Sequence: BC0301966 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468643(uc002yjo.4 uc002yjn.4 uc002yjp.4) ENST00000468788
ENST00000495055 ENST00000461088 ENST00000400577 ENST00000475864
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBM11 (NM_144770) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBM11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM11 |
Additional cDNA sequence: AF519623.1 AK091331.1 AY077695.1 BC030196.1 5 DOTS entries: DT.95262633 DT.100745049 DT.436113 DT.91704104 DT.95237154 24 AceView cDNA sequences: BX281687 BC030196 NM_144770 AL596989 BI753557 BI603848 AY077695 AK091331 BQ186146 BX950892 BI913079 CB153254 AF519623 BX950891 BG706195 AL041993 BX104385 AX746917 D61628 AA639269 BG541166 N63517 N94835 AA737090
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RBM11 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | - | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | - | | | | - | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RBM11
|
Expression
for RBM11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBM11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCCTAGCA
About this image
See RBM11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBM11
SOURCE GeneReport for Unigene cluster: Hs.283828
UniProtKB/Swiss-Prot: RBM11_HUMAN, P57052Tissue specificity: Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary gland,spleen and kidney. Also expressed in fetal brain
SABiosciences Custom PCR Arrays for RBM11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBM11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBM11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBM11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM11 |
Orthologs
for RBM11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBM11 gene from 9/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rbm111 , 5 |
RNA binding motif protein 111, 5 |
83.19(n)1
80.67(a)1 |
|
16 (43.22 cM)5
2243441 NM_198302.21 NP_938044.11
755928445 |
chicken
(Gallus gallus) |
Aves |
RBM111 |
RNA binding motif protein 11 |
68.95(n)
61.11(a) |
|
418467 XM_416676.3 XP_416676.3 |
lizard
(Anolis carolinensis) |
Reptilia |
RBM116 |
-- |
45(a) |
1 ↔ 1 |
GL343230.1(1606855-1615586) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.260412 |
Xenopus laevis transcribed sequence with weak similarity more |
76.84(n) |
|
CD252709.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-71d15.36 |
si:dkey-71d15.3 |
25(a) |
1 ↔ 1 |
21(33942525-33953553) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG114546 |
-- |
19(a) |
1 → many |
2L(143309-144227) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y37D8A.216 |
Protein Y37D8A.21 |
20(a) |
1 → many |
III(12928269-12931766) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G101106 |
RNA recognition motif-containing protein |
23(a) |
1 → many |
4(6309393-6310869) |
rice
(Oryza sativa) |
Liliopsida |
---- |
RNA recognition motif containing protein, putative...RNA recognition motif containing protein, putative... |
18(a)10(a) |
many ↔ manymany ↔ many |
5(20885609-20888818) 1(38030455-38034513) |
ENSEMBL Gene Tree for RBM11 (if available)
TreeFam Gene Tree for RBM11 (if available) |
Paralogs
for RBM11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBM11 gene
- RBM72 ENSG000002556632
1 SIMAP similar gene for RBM11 using alignment to 2 protein entries: RBM11_HUMAN (see all proteins):RBM7
RBM11 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RBM11
PGOHUM00000243780
|
Genomic Variants
for RBM11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBM11 (15588451 - 15600693 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBM11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBM11 |
|
Disorders
/ Diseases
for RBM11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBM11 for disorders About GeneDecksing
5  diseases for RBM11: About MalaCardsintrahepatic cholangiocarcinoma down syndrome cholangiocarcinoma ataxia
neuronitis
Export disorders for RBM11 gene to outside databases
|
Publications
for RBM11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBM11 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RBM11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2, 3 Gardiner K....Davisson M. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PubMed id 12909339)1, 2 Brun M.-E.... De Sario A. (2003)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. (PubMed id 21984414)2 Pedrotti S.... Sette C. (2012)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RBM11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBM11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBM11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBM11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBM11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBM11 gene:
Search GeneIP for patents involving RBM11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBM11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RBM11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBM11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBM11 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBM11 | | OriGene 3'-UTR Clone for RBM11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBM11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBM11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for RBM11 |
| |  |  |  |  | | | | |
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 | | | RBM11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM11 |
|  |  |  | | | | Search ThermoFisher Antibodies for RBM11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBM11 |
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