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RBM10 Gene

protein-coding   GIFtS: 60
GCID: GC0XP047004

RNA Binding Motif Protein 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Motif Protein 101 2     RNA-Binding Protein S1-12 3
DXS8237E2 3 5     TARPS2 5
G Patch Domain-Containing Protein 92 3     KIAA01223 5
GPATC92 3     ZRANB52
GPATCH92 3     RNA-Binding Protein 102
S1-12 3     RNA-Binding Motif Protein 103

External Ids:    HGNC: 98961   Entrez Gene: 82412   Ensembl: ENSG000001828727   OMIM: 3000805   UniProtKB: P981753   

Export aliases for RBM10 gene to outside databases

Previous GC identifers: GC0XP045807 GC0XP045265 GC0XP045830 GC0XP046050 GC0XP046760 GC0XP046889 GC0XP044717


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBM10 Gene:
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The
encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in
this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple
transcript variants.(provided by RefSeq, Mar 2011)

GeneCards Summary for RBM10 Gene:
RBM10 (RNA binding motif protein 10) is a protein-coding gene. Diseases associated with RBM10 include tarp syndrome, and lymphogranuloma venereum. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM6.

UniProtKB/Swiss-Prot: RBM10_HUMAN, P98175
Function: May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA
homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity)

Gene Wiki entry for RBM10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBM10 gene promoter:
         ER-alpha   C/EBPbeta   p53   MyoD   LUN-1   Nkx2-5   Arnt   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBM10 promoter sequence
   Search Chromatin IP Primers for RBM10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3

RBM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBM10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047004:  view genomic region     (about GC identifiers)

Start:
47,004,268 bp from pter      End:
47,046,214 bp from pter
Size:
41,947 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RBM10_HUMAN, P98175 (See protein sequence)
Recommended Name: RNA-binding protein 10  
Size: 930 amino acids; 103533 Da
Subunit: Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of
MYSM1, PCAF, RBM10 and KIF11/TRIP5
Sequence caution: Sequence=AAB33572.1; Type=Frameshift; Positions=696; Sequence=BAA09471.1; Type=Erroneous
initiation; Sequence=CAB70731.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAB70731.1; Type=Frameshift; Positions=Several;
2 PDB 3D structures from and Proteopedia for RBM10:
2LXI (3D)        2M2B (3D)    
Secondary accessions: C4AM81 Q14136 Q5JRR2 Q9BTE4 Q9BTX0 Q9NTB1
Alternative splicing: 4 isoforms:  P98175-1   P98175-2   P98175-3   P98175-4   

Explore the universe of human proteins at neXtProt for RBM10: NX_P98175

Explore proteomics data for RBM10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBM10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001191395.1  NP_001191396.1  NP_001191397.1  NP_005667.2  NP_690595.1  

    ENSEMBL proteins: 
     ENSP00000366829   ENSP00000329659   ENSP00000328848  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPATCH: G patch domain containing
    RBM: RNA binding motif (RRM) containing
    ZRANB: Zinc fingers, RAN-binding domain containing

    Selected InterPro protein domains (see all 6):
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015880 Znf_C2H2-like
     IPR000467 G_patch_dom
     IPR001876 Znf_RanBP2
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P98175

    ProtoNet protein and cluster: P98175

    3 Blocks protein domains:
    IPB000467 D111/G-patch domain
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: RBM10_HUMAN, P98175
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    RBM10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM10_HUMAN, P98175
    Function: May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA
    homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity)

         Genatlas biochemistry entry for RBM10:
    RNA binding motif protein 10,expressed probe DXS8237-clone1,1,3kb,homolog to RBM5 located on chromosome 3,in a
    region duplicated from Xp11.3-p11.23

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    RBM10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBM10:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rbm10):
     normal 

    RBM10 for phenotypes           About GeneDecksing

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target RBM10:
    hsa-mir-1226-3p (MIRT036471), hsa-mir-20a-5p (MIRT050535), hsa-mir-615-3p (MIRT039700), hsa-mir-222-3p (MIRT046742), hsa-mir-186-5p (MIRT045311), hsa-mir-92a-3p (MIRT049482), hsa-mir-92b-3p (MIRT040646), hsa-mir-324-3p (MIRT042904)

    Block miRNA regulation of human, mouse, rat RBM10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RBM10:
    hsa-miR-224 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidRBM10 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBM10_HUMAN, P98175: Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains,
    which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II
    transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles
    or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA
    domains)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    RBM10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBM10
    Interactions:

        Search GeneGlobe Interaction Network for RBM10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBM10 (P981751, 2, 3 ENSP000003668294) via UniProtKB, MINT, STRING, and/or I2D (see all 755)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX15O431431, 2, ENSP000003367414EBI-721525,EBI-1237044 MINT-8331756 MINT-8333999 MINT-6489355 STRING: ENSP00000336741
    IKQ131231, 2, ENSP000003963014EBI-721525,EBI-713456 MINT-7945693 MINT-8332240 MINT-8334934 STRING: ENSP00000396301
    PRPF19Q9UMS41, 2, ENSP000002275244EBI-721525,EBI-395746 MINT-7945693 MINT-8332196 MINT-8334912 STRING: ENSP00000227524
    SF3B4Q154271, 2, ENSP000002716284EBI-721525,EBI-348469 MINT-7945693 MINT-8333801 MINT-8332427 STRING: ENSP00000271628
    DHX38Q926201, 2, ENSP000002684824EBI-721525,EBI-1043041 MINT-8334945 MINT-8332207 STRING: ENSP00000268482
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006397mRNA processing IEA--
    GO:0008150biological_process ND--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0008380RNA splicing IEA--

    RBM10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBM10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RBM10 gene (5 alternative transcripts): 
    NM_001204466.1  NM_001204467.1  NM_001204468.1  NM_005676.4  NM_152856.2  

    Unigene Cluster for RBM10:

    RNA binding motif protein 10
    Hs.401509  [show with all ESTs]
    Unigene Representative Sequence: NM_001204468
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377604(uc004dhe.2 uc004dhf.3 uc004dhi.3 uc004dhh.3 uc010nhq.3 uc004dhg.3)
    ENST00000345781 ENST00000496012 ENST00000478410 ENST00000329236
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate RBM10:
    hsa-miR-224 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidRBM10 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): RBM10 (NM_005676)
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      QuantiTect SYBR Green Assays in human, mouse, rat RBM10
      QuantiFast Probe-based Assays in human, mouse, rat RBM10

    Additional mRNA sequence: 

    AK000962.1 AK024839.1 AK025854.1 AK225175.1 AK292758.1 AL137421.1 BC000681.2 BC003089.1 
    BC004181.2 BC008733.2 BC024153.2 BX537969.1 D50912.1 U35373.1 

    13 DOTS entries:

    DT.454683  DT.100889289  DT.101983909  DT.91763340  DT.100889319  DT.121643281  DT.95208020  DT.95208037 
    DT.121282101  DT.75150606  DT.91763346  DT.40116071  DT.95208046 

    Selected AceView cDNA sequences (see all 357):

    BQ064595 BU156291 BQ636501 CB045546 BU625087 BQ051523 BC000681 BC003089 
    D50912 AA908960 BX342222 BC004181 AI969679 BM564265 BG059925 NM_005676 
    AL537676 BM663829 CD514214 AK025854 NM_152856 AW249225 BU845541 CA388640 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RBM10 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:                                -     -                       -     -     -     -                                   -                                       
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                    -                                       

    ExUns: 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for RBM10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBM10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGGTGTCC
    RBM10 Expression
    About this image

    RBM10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBM10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401509
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBM10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RBM10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbm101 , 5 RNA binding motif protein 101, 5 90.2(n)1
    96.23(a)1
      X (16.11 cM)5
    2367321  NM_145627.21  NP_663602.11 
     206175035 
    lizard
    (Anolis carolinensis)
    Reptilia RBM106
    RNA binding motif protein 10
    77(a)
    1 ↔ 1
    2(68925269-68955715)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018825541 RNA-binding protein 10-like 64.17(n)
    62.77(a)
      101882554  XM_005170562.1  XP_005170619.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48961 , 3 RNA binding3
    CG48961
    29(a)3
    48.72(n)1
    39.5(a)1
      21F23
    333051  NM_134739.61  NP_608583.51 
    worm
    (Caenorhabditis elegans)
    Secernentea T08B2.56
    Protein T08B2.5, isoform d (T08B2.5) mRNA, complet...
    21(a)
    1 → many
    I(6215669-6219911) WBGene00020346


    ENSEMBL Gene Tree for RBM10 (if available)
    TreeFam Gene Tree for RBM10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBM10 gene
    RBM62  RBM52  
    2 SIMAP similar genes for RBM10 using alignment to 2 protein entries:     RBM10_HUMAN (see all proteins):
    DKFZp686E2459    RBM5

    RBM10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBM10 (see all 571)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354864
    A colorectal cancer sample4--see VAR_0354862 R H mis40--------
    rs1425556301,2
    --46921820(+) TCTATA/GTTTAC 5 -- us2k10--------
    rs44924991,2
    C,F,A,H--46922026(+) ctggcG/Atacag 5 -- us2k119Minor allele frequency- A:0.47NS EA NA WA CSA 1971
    rs128357171,2
    C--46922099(+) GAGGTT/GAGTAT 5 -- us2k12Minor allele frequency- G:0.00NA 4
    rs128357261,2
    C--46922117(+) GTACTG/TATTAT 5 -- us2k10--------
    rs1479581471,2
    C--46922146(+) AGAAAC/TACCTC 5 -- us2k10--------
    rs1874862241,2
    --46922148(+) AAACAC/TCTCAC 5 -- us2k10--------
    rs1419081531,2
    C--46922216(+) ACTTAC/TGAAGT 5 -- us2k10--------
    rs1929483611,2
    --46922426(+) ACAGCA/GGACCT 5 -- us2k10--------
    rs1436513791,2
    --46922434(+) CCTGGC/TAGCCC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for RBM10 (47004268 - 47046214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RBM10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740136CNV Deletion23290073
    esv2740135CNV Deletion23290073
    nsv6886CNV Loss18451855

    Human Gene Mutation Database (HGMD): RBM10
    Locus Specific Mutation Databases (LSDB): RBM10

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBM10
    DNA2.0 Custom Variant and Variant Library Synthesis for RBM10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300080   
    OMIM disorders: 311900  
    UniProtKB/Swiss-Prot: RBM10_HUMAN, P98175
  • TARP syndrome (TARPS) [MIM:311900]: A disorder characterized by the Robin sequence (micrognathia,
    glossoptosis and cleft palate), talipes equinovarus and cardiac defects. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 10 diseases for RBM10:    
    About MalaCards
    tarp syndrome    lymphogranuloma venereum    talipes equinovarus    cleft palate
    breast and colorectal cancer    ataxia    multiple myeloma    myeloma
    breast cancer    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for RBM10:
    Lymphogranuloma venereum

    RBM10 for disorders           About GeneDecksing


    Export disorders for RBM10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBM10 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with RBM10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. (PubMed id 8808293)1, 2, 3, 9 Coleman M.P....Davies K.E. (Genomics 1996)
    2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate. (PubMed id 20451169)1, 2 Johnston J.J.... Biesecker L.G. (Am. J. Hum. Genet. 2010)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity. (PubMed id 18315527)1, 2 Inoue A.... Tani T. (Biol. Cell 2008)
    6. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. (PubMed id 17707232)1, 2 Zhu P.... Rosenfeld M.G. (Mol. Cell 2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PubMed id 11944989)1, 9 Thiselton D.L.... Meindl A. (Genomics 2002)
    10. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8241 HGNC: 9896 AceView: RBM10 Ensembl:ENSG00000182872 euGenes: HUgn8241
    ECgene: RBM10 H-InvDB: RBM10

    (According to HUGE)
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    HUGE: KIAA0122

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBM10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBM10 gene:
    Search GeneIP for patents involving RBM10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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