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Aliases for RBL2 Gene

Aliases for RBL2 Gene

  • Retinoblastoma-Like 2 2 3
  • 130 KDa Retinoblastoma-Associated Protein 3 4
  • Retinoblastoma-Related Protein 2 3 4
  • RBR-2 3 4
  • P130 3 4
  • PRB2 3 4
  • Rb2 3 4
  • Retinoblastoma-Like Protein 2 3

External Ids for RBL2 Gene

Previous GeneCards Identifiers for RBL2 Gene

  • GC16P043882
  • GC16P053523
  • GC16P053206
  • GC16P053246
  • GC16P053247
  • GC16P052025
  • GC16P039355

Summaries for RBL2 Gene

GeneCards Summary for RBL2 Gene

RBL2 (Retinoblastoma-Like 2) is a Protein Coding gene. Diseases associated with RBL2 include unilateral retinoblastoma and bilateral retinoblastoma. Among its related pathways are PI3K-Akt signaling pathway and Cell Cycle, Mitotic. An important paralog of this gene is RB1.

UniProtKB/Swiss-Prot for RBL2 Gene

  • Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor

Gene Wiki entry for RBL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBL2 Gene

Genomics for RBL2 Gene

Regulatory Elements for RBL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBL2 Gene

Start:
53,433,977 bp from pter
End:
53,491,649 bp from pter
Size:
57,673 bases
Orientation:
Plus strand

Genomic View for RBL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBL2 Gene

Proteins for RBL2 Gene

  • Protein details for RBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08999-RBL2_HUMAN
    Recommended name:
    Retinoblastoma-like protein 2
    Protein Accession:
    Q08999
    Secondary Accessions:
    • B7Z913
    • Q15073
    • Q16084
    • Q8NE70
    • Q92812

    Protein attributes for RBL2 Gene

    Size:
    1139 amino acids
    Molecular mass:
    128367 Da
    Quaternary structure:
    • Interacts with AATF. Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).

    Alternative splice isoforms for RBL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBL2 Gene

Proteomics data for RBL2 Gene at MOPED

Post-translational modifications for RBL2 Gene

  • During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.
  • Ubiquitination at Lys384
  • Modification sites at PhosphoSitePlus

Other Protein References for RBL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RBL2 (Rb-like 2)

No data available for DME Specific Peptides for RBL2 Gene

Domains for RBL2 Gene

Protein Domains for RBL2 Gene

Suggested Antigen Peptide Sequences for RBL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q08999

UniProtKB/Swiss-Prot:

RBL2_HUMAN :
  • Q08999
Family:
  • Belongs to the retinoblastoma protein (RB) family.
genes like me logo Genes that share domains with RBL2: view

No data available for Gene Families for RBL2 Gene

Function for RBL2 Gene

Molecular function for RBL2 Gene

GENATLAS Biochemistry: retinoblastoma related protein RB2/p130,involved in cell cycle regulation interacting with E2F-like transcription factor and with cyclin (A/E) CDK2 complexes
UniProtKB/Swiss-Prot Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor

Gene Ontology (GO) - Molecular Function for RBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 1331501
genes like me logo Genes that share ontologies with RBL2: view
genes like me logo Genes that share phenotypes with RBL2: view

Animal Models for RBL2 Gene

MGI Knock Outs for RBL2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RBL2 Gene

Localization for RBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBL2 Gene COMPARTMENTS Subcellular localization image for RBL2 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RBL2: view

Pathways for RBL2 Gene

genes like me logo Genes that share pathways with RBL2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for RBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007049 cell cycle --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with RBL2: view

Compounds for RBL2 Gene

(9) Novoseek inferred chemical compound relationships for RBL2 Gene

Compound -log(P) Hits PubMed IDs
hpvs 49 3
polypropylene glycol 41.8 1
lactacystin 28.2 2
threonine 22.4 1
tgf beta1 20.8 4
genes like me logo Genes that share compounds with RBL2: view

Transcripts for RBL2 Gene

Unigene Clusters for RBL2 Gene

Retinoblastoma-like 2 (p130):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - -
SP3:
SP4:
SP5:

ExUns: 22a · 22b ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for RBL2 Gene

GeneLoc Exon Structure for
RBL2
ECgene alternative splicing isoforms for
RBL2

Expression for RBL2 Gene

mRNA expression in normal human tissues for RBL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBL2 Gene

SOURCE GeneReport for Unigene cluster for RBL2 Gene Hs.513609

genes like me logo Genes that share expressions with RBL2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBL2 Gene

Orthologs for RBL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBL2 35
  • 99.77 (n)
  • 99.91 (a)
RBL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBL2 35
  • 92.68 (n)
  • 96.14 (a)
RBL2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBL2 35
  • 93.97 (n)
  • 97.28 (a)
RBL2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbl2 35
  • 87.7 (n)
  • 91.82 (a)
Rbl2 16
Rbl2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBL2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBL2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbl2 35
  • 87.27 (n)
  • 91.18 (a)
chicken
(Gallus gallus)
Aves RBL2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBL2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30216 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbl2 35
  • 68.6 (n)
  • 68.88 (a)
zebrafish
(Danio rerio)
Actinopterygii rbl2 35
  • 63.39 (n)
  • 64.97 (a)
rbl2 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006477 35
  • 40.41 (n)
  • 28.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rbf 35
  • 45.83 (n)
  • 34.95 (a)
Rbf 36
  • 30 (a)
ManyToMany
Rbf2 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-35 36
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4197 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4619 36
  • 36 (a)
OneToMany
Species with no ortholog for RBL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBL2 Gene

ENSEMBL:
Gene Tree for RBL2 (if available)
TreeFam:
Gene Tree for RBL2 (if available)

Paralogs for RBL2 Gene

Paralogs for RBL2 Gene

Selected SIMAP similar genes for RBL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RBL2: view

Variants for RBL2 Gene

Sequence variations from dbSNP and Humsavar for RBL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3929 -- 53,490,396(+) CTGAT(C/G)AGTTA utr-variant-3-prime
rs10748 -- 53,470,809(+) ATGAA(C/T)TGAGG synonymous-codon, reference
rs14725 -- 53,470,814(+) NTGAG(A/G)AAAAA synonymous-codon, reference
rs1072910 -- 53,465,687(+) TGGCA(A/G)TTAGG intron-variant
rs1072911 -- 53,465,813(+) cttgg(C/T)aagta intron-variant

Relevant External Links for RBL2 Gene

HapMap Linkage Disequilibrium report
RBL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RBL2 Gene

Disorders for RBL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for RBL2 Gene including...

Search for RBL2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RBL2 Gene

(17) Novoseek inferred disease relationships for RBL2 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 92.1 90
tumors 49 38
myeloid leukemia 30.9 1
cancer 28.8 6
osteosarcoma 25.8 2

Relevant External Links for RBL2

Genetic Association Database (GAD)
RBL2
Human Genome Epidemiology (HuGE) Navigator
RBL2
genes like me logo Genes that share disorders with RBL2: view

No data available for UniProtKB/Swiss-Prot for RBL2 Gene

Publications for RBL2 Gene

  1. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. (PMID: 8253383) Li Y. … Whyte P. (Genes Dev. 1993) 3 4 23
  2. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. (PMID: 8253384) Hannon G.J. … Beach D. (Genes Dev. 1993) 3 4 23
  3. The pRb-related protein p130 is regulated by phosphorylation- dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). (PMID: 12435635) Tedesco D. … Reed S.I. (Genes Dev. 2002) 3 4 23
  4. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. (PMID: 8361765) Mayol X. … Giordano A. (Oncogene 1993) 2 3 4
  5. Genomic structure of the human retinoblastoma-related Rb2/p130 gene. (PMID: 8643454) Baldi A. … Giordano A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4

Products for RBL2 Gene

Sources for RBL2 Gene

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