RBL2 Gene
protein-coding GIFtS: 64
GCID: GC16P053467
|
|
retinoblastoma-like 2 (p130)
| |
Aliases
for RBL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinoblastoma-Like 2 (P130)1 2 | | P1302 | | Rb21 2 | | PRB22 | | P1302 | | Retinoblastoma-Like Protein 22 | | Retinoblastoma-Related Protein 22 3 | | RB23 | | 130 KDa Retinoblastoma-Associated Protein2 3 | | PRb21 | | RBR-22 3 | | |
Export aliases for RBL2 gene to outside databasesPrevious GC identifers: GC16P043882 GC16P053523 GC16P053206 GC16P053246 GC16P053247 GC16P052025 GC16P039355 |
Summaries
for RBL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RBL2_HUMAN, Q08999Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintainingoverall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetictranscriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor byrecruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associatespreferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of theadenovirus E1A protein. May act as a tumor suppressor
Gene Wiki entry for RBL2 (Retinoblastoma-like protein 2)
|
Genomic Views
for RBL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBL2 gene promoter:
TBP ISGF-3 HTF Nkx2-5 Tal-1beta Evi-1 SRY CBF-B CBF-A ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q12.2 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q12.2RBL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P053467: view genomic region
(about GC identifiers)
Start:
|
53,467,889 bp from pter |
End:
|
53,525,561 bp from pter |
Size:
|
57,673 bases |
Orientation:
|
plus strand |
|
Proteins
for RBL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBL2_HUMAN, Q08999 (See
protein sequence)Recommended Name: Retinoblastoma-like protein 2 Size: 1139 amino acids; 128367 Da
Subunit: Interacts with AATF. Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAMcomplex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1,RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. Itdissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1
Subcellular location: Nucleus
Developmental stage: G0-restricted expression
Secondary accessions: Q15073 Q16084 Q92812Explore the universe of human proteins at neXtProt for RBL2: NX_Q08999
Post-translational modifications:
During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B.Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08999
RBL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005602.3
ENSEMBL proteins: ENSP00000462464 ENSP00000262133 ENSP00000443744 ENSP00000444685 Reactome Protein details: Q08999
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
RBL2 for ontologies About GeneDecksing
RBL2 Antibody Products:
Assay Products for RBL2: |
Protein
Domains /
Families
for RBL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBL2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08999ProtoNet protein and cluster: Q08999 2 Blocks protein families: IPB002720 Retinoblastoma-associated protein IPB006670 Cyclin
UniProtKB/Swiss-Prot: RBL2_HUMAN, Q08999Similarity: Belongs to the retinoblastoma protein (RB) family |
Function
for RBL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBL2_HUMAN, Q08999Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintainingoverall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetictranscriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor byrecruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associatespreferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of theadenovirus E1A protein. May act as a tumor suppressor Genatlas biochemistry entry for RBL2:retinoblastoma related protein RB2/p130,involved in cell cycle regulation interacting with E2F-like transcriptionfactor and with cyclin (A/E) CDK2 complexes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RBL2 (NM_005611) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBL2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RBL2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RBL2:
Animal Models:
Mouse knock-outs for RBL2: Rbl2tm1Mru Rbl2tm1Tyj Rbl2tm1Htr Rbl2tm2.1Tyj
15/19 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Rbl2) (see all 19):
RBL2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RBL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Cell cycle (generic schema) | | | 2 | Cell cycle_Role of SCF complex in cell cycle regulation | | | 3 | Cell Cycle | | | 4 | Cell cycle ESR1 regulation of G1/S transition | | | 5 | Cyclins and Cell Cycle Regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for RBL2
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RBL2
4  GeneGo (Thomson Reuters) Pathways for RBL2
5/8  BioSystems Pathways for RBL2 (see all 8)
5/6 
Reactome Pathways for RBL2 (see all 6)
2 
Kegg Pathways (Kegg details for RBL2):
RBL2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/94 Interacting proteins for RBL2 (Q089991, 2, 3 ENSP000002621334) via UniProtKB, MINT, STRING, and/or I2D (see all 94)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| E2F4 | Q162542, 3, ENSP000003686864 | MINT-8309355 MINT-8309367 MINT-8309378 I2D:
score=5 STRING: ENSP00000368686 | | PPP2CA | P677752, 3, ENSP000004184474 | MINT-8204421 MINT-8204406 I2D:
score=2 STRING: ENSP00000418447 | | RBBP8 | Q997082, 3, ENSP000003230504 | MINT-16160 MINT-16159 I2D:
score=3 STRING: ENSP00000323050 | | LIN54 | Q6MZP72, 3, ENSP000003419474 | MINT-7239362 I2D:
score=3 STRING: ENSP00000341947 | | RBL1 | P287492, 3, ENSP000003627684 | MINT-8204414 I2D:
score=2 STRING: ENSP00000362768 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000080 | G1 phase of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0016568 | chromatin modification |
IEA | -- |
RBL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RBL2 for compounds About GeneDecksing
 Browse Tocris compounds for RBL2
9 Novoseek chemical compound relationships for RBL2 gene About this table
Search CenterWatch for drugs/clinical trials and news about RBL2
|
Transcripts
for RBL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBL2 gene: NM_005611.3 Unigene Cluster for RBL2: Retinoblastoma-like 2 (p130) Hs.513609 [show with all ESTs]Unigene Representative Sequence: BC0344909 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000567964 ENST00000262133(uc010vgv.1 uc002ehi.4) ENST00000544405
ENST00000379935(uc002ehj.3 uc010vgw.2) ENST00000561512 ENST00000562850
ENST00000562837 ENST00000564605 ENST00000544545
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RBL2 (NM_005611) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBL2 |
Additional cDNA sequence: AK123139.1 AK129969.1 AK300047.1 AK304283.1 AK307881.1 BC034490.1 BX537767.1 S67171.1 X74594.1 X76061.1 14 DOTS entries: DT.448175 DT.91760647 DT.101982580 DT.102842873 DT.75187900 DT.91760638 DT.101972380 DT.100726254 DT.437607 DT.120659947 DT.40265189 DT.95360299 DT.91681351 DT.100653052 24/298 AceView cDNA sequences (see all 298): BM976473 AI459215 AA883913 AV716056 AL702815 AI784550 BQ771822 AW118278 AI248936 AW505566 AW512616 AI201018 AA829754 R39808 AI754024 BQ182434 AI651085 BG181097 AA169617 BM853433 BE221314 BP382980 AL602812 AI418390
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RBL2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for RBL2
|
Expression
for RBL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTGTAAC
About this image
See RBL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBL2
SOURCE GeneReport for Unigene cluster: Hs.513609
SABiosciences Expression via Pathway-Focused PCR Arrays including RBL2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBL2 |
Orthologs
for RBL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBL2 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4251116-- |
Uncharacterized protein |
79(a)67(a) |
1 ↔ many1 ↔ many |
Un(51969014-51984765) 11(5083336-5103410) |
lizard
(Anolis carolinensis) |
Reptilia |
RBL26 |
-- |
74(a) |
1 ↔ 1 |
LGc(430460-453890) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.302162 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.98(n) |
|
48025346 |
zebrafish
(Danio rerio) |
Actinopterygii |
rbl21 |
retinoblastoma-like 2 (p130) |
63.01(n)
64.29(a) |
|
100331892 XM_002666954.2 XP_002667000.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rbf1 |
Retinoblastoma-family protein |
45.97(n)
35.08(a) |
|
31027 NM_080297.2 NP_525036.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
lin-356 |
abnormal cell LINeage family member (lin-35) |
20(a) |
1 → many |
I(5807712-5815640) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATRBR16 |
Retinoblastoma-related protein 1 |
20(a) |
1 → many |
3(3913412-3919170) |
rice
(Oryza sativa) |
Liliopsida |
---- |
retinoblastoma-related protein-like, putative, exp...retinoblastoma-related protein-like, putative, exp... |
21(a)20(a) |
many ↔ manymany ↔ many |
8(26919480-26925624) 11(18967142-18973591) |
ENSEMBL Gene Tree for RBL2 (if available)
TreeFam Gene Tree for RBL2 (if available) |
Paralogs
for RBL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBL2 gene
- RB12 RBL12
3 SIMAP similar genes for RBL2 using alignment to 5 protein entries: RBL2_HUMAN (see all proteins):DKFZp781K2028 RB1 RBL1
RBL2 for paralogs About GeneDecksing
|
Genomic Variants
for RBL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBL2 (53467889 - 53525561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBL2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBL2 |
|
Disorders
/ Diseases
for RBL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBL2 for disorders About GeneDecksing
OMIM gene information: 180203
OMIM disorders: --
20/46  diseases for RBL2 (see all 46): About MalaCardsretinoblastoma unilateral retinoblastoma non-hodgkin lymphoma soft tissue sarcoma
bilateral retinoblastoma oral squamous cell carcinoma squamous cell carcinoma hodgkin's lymphoma
cytomegalovirus infection chronic lymphocytic leukemia burkitt's lymphoma lymphocytic leukemia
myeloid leukemia kaposi's sarcoma malignant glioma carcinoma
ovarian cancer bladder carcinoma sarcoma osteosarcoma
1 disease from the University of Copenhagen DISEASES database for RBL2:Retinoblastoma 10/17 Novoseek disease relationships for RBL2 gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoblastoma |
92.1 |
101 |
12454024 (3), 9092557 (2), 9916999 (2), 9192669 (2) (see all 84) |
| tumors |
49 |
46 |
9192669 (3), 10621854 (2), 19151761 (2), 8084002 (1) (see all 34) |
| myeloid leukemia |
30.9 |
1 |
18294958 (1) |
| cancer |
28.8 |
6 |
19887614 (2), 9271426 (1), 8622649 (1), 19014670 (1) (see all 5) |
| osteosarcoma |
25.8 |
2 |
11152455 (1), 11521191 (1) |
| papilloma |
22.3 |
1 |
9192669 (1) |
| allelic loss |
13.3 |
2 |
10621854 (1), 8253383 (1) |
| breast carcinoma |
4.67 |
3 |
11506494 (1), 10621854 (1), 8253383 (1) |
| prostate cancer |
2.33 |
1 |
18418057 (1) |
| carcinoma squamous cell |
0 |
5 |
10621854 (2), 11710944 (1) |
Human Genome Epidemiology (HuGE) Navigator: RBL2 (6 documents)
Export disorders for RBL2 gene to outside databases
|
Publications
for RBL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBL2 gene, integrated from 9 sources (see all 328):
(articles sorted by number of sources associating them with RBL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic structure of the human retinoblastoma-related Rb2/p130 gene. (PubMed id 8643454)1, 2, 3 Baldi A....Giordano A. (1996)
- Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. (PubMed id 8361765)1, 2, 3 Mayol X.... Giordano A. (1993)
- The pRb-related protein p130 is regulated by phosphorylation- dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). (PubMed id 12435635)1, 2, 9 Tedesco D.... Reed S.I. (2002)
- The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. (PubMed id 8253383)1, 2, 9 Li Y.... Whyte P. (1993)
- Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. (PubMed id 8253384)1, 2, 9 Hannon G.J.... Beach D. (1993)
- LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PubMed id 17671431)1, 2 Schmit F.... Gaubatz S. (2007)
- The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. (PubMed id 16600870)1, 2 Kong L.-J.... Nevins J.R. (2006)
- Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb. (PubMed id 12450794)1, 2 Bruno T.... Fanciulli M. (2002)
- Phosphorylation of the retinoblastoma-related protein p130 in growth- arrested cells. (PubMed id 11042701)1, 2 Canhoto A.J.... DeCaprio J.A. (2000)
- SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells. (PubMed id 12717421)1, 9 Bhattacharya S....Grana X. (2003)
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External Searches for RBL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RBL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RBL2 gene
(According to HUGE)
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Specialized Databases showing RBL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RBL2 gene:
Search GeneIP for patents involving RBL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RBL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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