Aliases for RBL1 Gene
Aliases for RBL1 Gene
External Ids for RBL1 Gene
- HGNC: 9893
- Entrez Gene: 5933
- Ensembl: ENSG00000080839
- OMIM: 116957
- UniProtKB: P28749
Previous GeneCards Identifiers for RBL1 Gene
- GC20M035354
- GC20M036264
- GC20M036311
- GC20M035059
- GC20M035624
- GC20M032361
Summaries for RBL1 Gene
-
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RBL1 Gene
RBL1 (RB Transcriptional Corepressor Like 1) is a Protein Coding gene. Diseases associated with RBL1 include Retinoblastoma and Bilateral Retinoblastoma. Among its related pathways are Validated targets of C-MYC transcriptional repression and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is RBL2.
UniProtKB/Swiss-Prot for RBL1 Gene
-
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBL1 Gene
Genomics for RBL1 Gene
Regulatory Elements for RBL1 Gene
Enhancers for RBL1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RBL1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RBL1 gene promoter:
Regulatory Element Products
Genomic Location for RBL1 Gene
- Chromosome:
- 20
- Start:
- 36,996,349 bp from pter
- End:
- 37,096,000 bp from pter
- Size:
- 99,652 bases
- Orientation:
- Minus strand
Genomic View for RBL1 Gene
Genes around RBL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by Ensembl
- 20q11.23 by Entrez Gene
- 20q11.23 by HGNC
RBL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBL1 Gene
Proteins for RBL1 Gene
-
Protein details for RBL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28749-RBL1_HUMAN
- Recommended name:
- Retinoblastoma-like protein 1
- Protein Accession:
- P28749
- A8K2W5
- Q4VXA0
- Q8N5K6
- Q9H1L5
- Q9H1M1
Protein attributes for RBL1 Gene
- Size:
- 1068 amino acids
- Molecular mass:
- 120847 Da
- Quaternary structure:
-
- Interacts with KMT5B, KMT5C and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with KDM5A. Interacts with SV40 and JC virus large T antigens.
Three dimensional structures from OCA and Proteopedia for RBL1 Gene
Protein Expression for RBL1 Gene
Post-translational modifications for RBL1 Gene
- Exists in both phosphorylated and unphosphorylated forms, and T, but not E1A, binds only to the unphosphorylated form. Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RBL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RBL1
-
Abcam antibodies for RBL1
- Invitrogen Antibodies for RBL1
- antibodies-online Antibodies for RBL1: See all 108
- GeneTex RBL1 antibody for RBL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RBL1
Protein Products
-
OriGene Purified Proteins for RBL1
- Search Origene for MassSpec and Protein Over-expression Lysates for RBL1
- Origene Custom Protein Services for RBL1
- antibodies-online Proteins for RBL1: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RBL1
-
Abcam proteins for RBL1
Assay Products
- antibodies-online Kits for RBL1: See all 25
No data available for DME Specific Peptides for RBL1 Gene
Domains & Families for RBL1 Gene
Protein Domains for RBL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RBL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P28749- Family:
-
- Belongs to the retinoblastoma protein (RB) family.
No data available for Gene Families for RBL1 Gene
Function for RBL1 Gene
Molecular function for RBL1 Gene
- GENATLAS Biochemistry:
- retinoblastoma product related protein,p107,involved in cell cycle regulation,interacting with transcription factor E2F-4 and with cyclin E/A-CDK2 complexes,may be altered in a limited subset of hematologic malignancies
- UniProtKB/Swiss-Prot Function:
- Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 1331501 |
| GO:0008134 | transcription factor binding | IPI | 16360038 |
| GO:1990841 | promoter-specific chromatin binding | IDA | 25100735 |
Phenotypes for RBL1 Gene
- MGI mutant phenotypes for RBL1:
-
inferred from 8 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for RBL1:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability
- Decreased Aire reporter expression
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased circadian period length
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
Animal Models for RBL1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RBL1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RBL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RBL1 gene
- Search ViGene Biosciences for RBL1
CRISPR Products
-
OriGene CRISPR knockouts for RBL1
-
Applied Biological Materials CRISPR for RBL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBL1
- GenScript: Design CRISPR guide RNA sequences for RBL1
miRNA for RBL1 Gene
- miRTarBase miRNAs that target RBL1
-
- hsa-mir-17-5p (MIRT005851)
- hsa-mir-20a-5p (MIRT005858)
- hsa-mir-106b-5p (MIRT005866)
- hsa-mir-580-3p (MIRT445708)
- hsa-mir-526b-5p (MIRT445709)
- hsa-mir-3646 (MIRT445710)
- hsa-mir-3662 (MIRT445711)
- hsa-mir-6806-5p (MIRT496131)
- hsa-mir-5685 (MIRT496132)
- hsa-mir-4690-3p (MIRT496133)
- hsa-mir-4717-5p (MIRT496134)
- hsa-mir-449c-5p (MIRT496135)
- hsa-mir-34b-5p (MIRT496136)
- hsa-mir-2682-5p (MIRT496137)
- hsa-mir-940 (MIRT496138)
- hsa-mir-6893-5p (MIRT496139)
- hsa-mir-6808-5p (MIRT496140)
- hsa-mir-6511a-5p (MIRT496141)
- hsa-mir-1910-3p (MIRT496142)
- hsa-mir-6815-3p (MIRT572717)
- hsa-mir-6882-3p (MIRT572718)
- hsa-mir-22-3p (MIRT572719)
- hsa-mir-646 (MIRT572720)
- hsa-mir-892b (MIRT572721)
- hsa-mir-193b-3p (MIRT572722)
- hsa-mir-193a-3p (MIRT572723)
- hsa-mir-5089-5p (MIRT635334)
- hsa-mir-6878-3p (MIRT635335)
- hsa-mir-6783-3p (MIRT635336)
- hsa-mir-1343-3p (MIRT635337)
- hsa-mir-6744-3p (MIRT635338)
- hsa-mir-4757-5p (MIRT635339)
- hsa-mir-6778-3p (MIRT635340)
- hsa-mir-4707-3p (MIRT635341)
- hsa-mir-6506-5p (MIRT635342)
- hsa-mir-619-5p (MIRT635343)
- hsa-mir-212-5p (MIRT635344)
- hsa-mir-6742-3p (MIRT635345)
- hsa-mir-6852-5p (MIRT635346)
- hsa-mir-939-3p (MIRT635347)
- hsa-mir-186-3p (MIRT635348)
- hsa-mir-6838-3p (MIRT635349)
- hsa-mir-6507-3p (MIRT635350)
- hsa-mir-150-5p (MIRT645545)
- hsa-mir-5698 (MIRT666706)
- hsa-mir-8057 (MIRT666707)
- hsa-mir-143-5p (MIRT666708)
- hsa-mir-24-3p (MIRT666709)
- hsa-mir-4284 (MIRT666710)
- hsa-mir-6722-5p (MIRT666711)
- hsa-mir-122-5p (MIRT666712)
- hsa-mir-504-3p (MIRT666713)
- hsa-mir-6499-3p (MIRT666714)
- hsa-mir-5693 (MIRT666715)
- hsa-mir-6813-3p (MIRT666716)
miRNA Products
- Search ViGene Biosciences for RBL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for RBL1
- Browse OriGene Inhibitory RNA Products For RBL1
-
ViGene Biosciences ready-to-package AAV shRNAs for RBL1 gene
Clone Products
- Sino Biological Human cDNA Clone for RBL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RBL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RBL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RBL1
-
ViGene Biosciences adenoviral particle packaged cDNA for RBL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RBL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RBL1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBL1 Gene
Localization for RBL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBL1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
Pathways & Interactions for RBL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell cycle Cell cycle (generic schema) |
.31
|
|
| 2 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 3 | Cell cycle |
.58
|
.58
|
| 4 | Cell Cycle, Mitotic |
.83
|
|
| 5 | Cyclins and Cell Cycle Regulation |
.31
|
|
Pathways by source for RBL1 Gene
8 BioSystems pathways for RBL1 Gene
15 Reactome pathways for RBL1 Gene
3 KEGG pathways for RBL1 Gene
2 GeneGo (Thomson Reuters) pathways for RBL1 Gene
3 Qiagen pathways for RBL1 Gene
Interacting Proteins for RBL1 Gene
Selected Interacting proteins:
ENSP00000362768
P28749-RBL1_HUMAN
for RBL1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
Transcripts for RBL1 Gene
mRNA/cDNA for RBL1 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (61) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RBL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RBL1
-
Applied Biological Materials CRISPR for RBL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBL1
- GenScript: Design CRISPR guide RNA sequences for RBL1
miRNA Products
- Search ViGene Biosciences for RBL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for RBL1
- Browse OriGene Inhibitory RNA Products For RBL1
-
ViGene Biosciences ready-to-package AAV shRNAs for RBL1 gene
Clone Products
- Sino Biological Human cDNA Clone for RBL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RBL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RBL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for RBL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Cerebellum
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
This gene is overexpressed in Serum (39.5) and Monocytes (21.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of RBL1 Gene:
RBL1SOURCE GeneReport for Unigene cluster for RBL1 Gene:
Hs.207745Evidence on tissue expression from TISSUES for RBL1 Gene
- Nervous system(2.4)
- Adrenal gland(2.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for RBL1
-
OriGene qPCR primer pairs and template standards for RBL1
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBL1 Gene
Orthologs for RBL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RBL1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RBL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | RBL1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Rbl1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rbl1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RBL1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | RBL1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RBL1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rbl1 34 |
|
||
| Str.7030 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | rbl1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rbf 36 35 |
|
||
| Rbf2 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | lin-35 34 35 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RBR1 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0533500 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4619 35 |
|
OneToMany |
- Species where no ortholog for RBL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RBL1 Gene
(2) SIMAP similar genes for RBL1 Gene using alignment to 4 proteins:
Variants for RBL1 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011456 | -- | 37,044,097(+) | ACAGG(C/T)AGGAA | reference, missense | |
| rs1000031273 | -- | 37,096,837(+) | CTGAG(A/C/T)GCCTT | upstream-variant-2KB | |
| rs1000044352 | -- | 37,003,481(+) | GCTGG(A/C)CTTTC | intron-variant | |
| rs1000153257 | -- | 37,096,330(+) | TTTGG(G/T)GCAGG | upstream-variant-2KB | |
| rs1000154159 | -- | 37,051,354(+) | TTGGT(A/G)TTTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4304n100 | CNV | gain | 25217958 |
| esv3645750 | CNV | gain | 21293372 |
| esv3645751 | CNV | gain | 21293372 |
| nsv1058953 | CNV | gain | 25217958 |
| nsv585951 | CNV | loss | 21841781 |
| nsv585952 | CNV | loss | 21841781 |
| nsv962578 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
8.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.87;
48.34% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RBL1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBL1 Gene
Disorders for RBL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
|
| bilateral retinoblastoma |
|
|
| sensory system cancer |
|
|
| unilateral retinoblastoma |
|
|
| retinal cancer |
|
|
Search RBL1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for RBL1
No data available for UniProtKB/Swiss-Prot and Genatlas for RBL1 Gene
Publications for RBL1 Gene
- Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. (PMID: 1833063) Ewen M.E. … Livingston D.M. (Cell 1991) 2 3 4 22 64
- Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. (PMID: 11884610) Leng X. … Harper J.W. (Mol. Cell. Biol. 2002) 3 4 22 64
- Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. (PMID: 7791762) Zhu L. … Chang L.S. (Mol. Cell. Biol. 1995) 3 4 22 64
- Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. (PMID: 7935440) Kim Y.W. … Kaye F.J. (Mol. Cell. Biol. 1994) 3 4 22 64
- Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. (PMID: 8319904) Zhu L. … Harlow E. (Genes Dev. 1993) 3 4 22 64
Products for RBL1 Gene
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- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for RBL1
- Novus Biologicals proteins and lysates for RBL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for RBL1
- Abcam proteins for RBL1
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for RBL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for RBL1: See all 108
- antibodies-online Kits for RBL1: See all 25
- antibodies-online Proteins for RBL1: See all 8
- Search antibodies-online for peptides
- GeneTex RBL1 antibody for RBL1
- Search GeneTex for Proteins for RBL1
- ViGene Biosciences adenoviral particle packaged cDNA for RBL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RBL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RBL1 gene
- Search ViGene Biosciences for RBL1
- Santa Cruz Biotechnology (SCBT) Antibodies for RBL1
- Search Santa Cruz Biotechnology (SCBT) for RBL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RBL1
- Horizon Cell Lines for RBL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for RBL1
- VectorBuilder custom plasmid, inducible vectors for RBL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RBL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RBL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio