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RBKS Gene

protein-coding   GIFtS: 58
GCID: GC02M028004

Ribokinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ribokinase1 2
RBSK2 3
EC 2.7.1.153

External Ids:    HGNC: 303251   Entrez Gene: 640802   Ensembl: ENSG000001711747   OMIM: 6111325   UniProtKB: Q9H4773   

Export aliases for RBKS gene to outside databases

Previous GC identifers: GC02M027978 GC02M027915 GC02M027857 GC02M027745


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RBKS Gene:
This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to
form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Dec 2013)

GeneCards Summary for RBKS Gene:
RBKS (ribokinase) is a protein-coding gene. Diseases associated with RBKS include tuberculosis, and malaria. GO annotations related to this gene include ribokinase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RBKS gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RBKS promoter sequence
   Search Chromatin IP Primers for RBKS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBKS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23.3

RBKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBKS gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M028004:  view genomic region     (about GC identifiers)

Start:
28,004,231 bp from pter      End:
28,113,965 bp from pter
Size:
109,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBSK_HUMAN, Q9H477 (See protein sequence)
Recommended Name: Ribokinase  
Size: 322 amino acids; 34143 Da
1 PDB 3D structure from and Proteopedia for RBKS:
2FV7 (3D)    
Secondary accessions: A9UK04

Explore the universe of human proteins at neXtProt for RBKS: NX_Q9H477

Explore proteomics data for RBKS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBKS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001274509.1  NP_071411.1  

    ENSEMBL proteins: 
     ENSP00000306817   ENSP00000413789   ENSP00000393558   ENSP00000415975   ENSP00000413232  

    RBKS Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RBKS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011611 PfkB_dom
     IPR011877 D_ribokin_bac
     IPR002139 Ribokinase
     IPR002173 Carboh/pur_kinase_PfkB_CS

    Graphical View of Domain Structure for InterPro Entry Q9H477

    ProtoNet protein and cluster: Q9H477

    2 Blocks protein domains:
    IPB002139 Ribokinase signature
    IPB002173 Carbohydrate kinase


    UniProtKB/Swiss-Prot: RBSK_HUMAN, Q9H477
    Similarity: Belongs to the carbohydrate kinase PfkB family


    RBKS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBSK_HUMAN, Q9H477
    Catalytic activity: ATP + D-ribose = ADP + D-ribose 5-phosphate
    Enzyme regulation: Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid,
    N-(phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate

         Enzyme Number (IUBMB): EC 2.7.1.151

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004747ribokinase activity IEA--
    GO:0005524ATP binding IEA--
         
    RBKS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBKS
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBKS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBKS

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RBKS using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RBKS:
    hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRBKS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RBKS
    Predesigned siRNA for gene silencing in human, mouse, rat RBKS

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RBKS (NM_022128)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBKS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    chloroplast1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RBKS About    
    See pathways by source

    SuperPathContained pathways About
    1Pentose phosphate pathway (KEGG)
    Pentose phosphate pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RBKS):
        Pentose phosphate pathway

    UniProtKB/Swiss-Prot: RBSK_HUMAN, Q9H477
    Pathway: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2


    RBKS for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RBKS: 

              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RBKS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RBKS (Q9H4773 ENSP000003068174) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSO753903, ENSP000003420564I2D: score=1 STRING: ENSP00000342056
    ABATP804043I2D: score=1 
    ACO2Q997983I2D: score=1 
    ADI1Q9BV573I2D: score=1 
    AK2P548193I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006014D-ribose metabolic process ----
    GO:0019303D-ribose catabolic process IEA--

    RBKS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBKS (RBSK)

    8 HMDB Compounds for RBKS    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    D-Ribosed-Ribose (see all 11)50-69-1--
    D-Ribose 5-phosphateD-Ribose 5-phosphate (see all 11)3615-55-2--
    D-Ribulose 5-phosphateD-Ribulose 5-phosphate (see all 5)4151-19-3--
    Deoxyribose2'-Deoxy-D-ribose 533-67-5--
    Deoxyribose 1-phosphate2-deoxy-D-ribose-1-phosphate (see all 14)17210-42-3--
    Deoxyribose 5-phosphate2-deoxy-alpha-D-ribose 5-phosphate (see all 12)102916-66-5--

    4 Novoseek inferred chemical compound relationships for RBKS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribose 75.3 3 9843365 (1), 11563694 (1), 18560757 (1)
    pyridoxal 69.4 4 12235162 (3), 16600635 (1)
    vitamin b6 50.4 1 16600635 (1)
    atp 48.8 1 9843365 (1)



    RBKS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RBKS gene (2 alternative transcripts): 
    NM_001287580.1  NM_022128.2  

    Unigene Cluster for RBKS:

    Ribokinase
    Hs.11916  [show with all ESTs]
    Unigene Representative Sequence: BX648909
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302188(uc002rlo.1) ENST00000449378(uc010ezi.1) ENST00000458185
    ENST00000453412 ENST00000444339(uc010ymg.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RBKS using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RBKS:
    hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRBKS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RBKS
    Predesigned siRNA for gene silencing in human, mouse, rat RBKS
    Clone
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    OriGene clones in human, mouse for RBKS (see all 6)
    OriGene ORF clones in mouse, rat for RBKS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RBKS (NM_022128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBKS
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RBKS
    OriGene qSTAR qPCR primer pairs in human, mouse for RBKS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBKS
      QuantiTect SYBR Green Assays in human, mouse, rat RBKS
      QuantiFast Probe-based Assays in human, mouse, rat RBKS

    Additional mRNA sequence: 

    AJ404857.1 AK300989.1 AY643715.1 BC017425.1 BX648909.1 

    7 DOTS entries:

    DT.86841549  DT.99952795  DT.100772021  DT.101956972  DT.65287474  DT.100772013  DT.121024220 

    Selected AceView cDNA sequences (see all 90):

    AJ404857 BE221723 AI912209 CD671167 BE501861 BE218181 BM717190 CA434266 
    BQ016020 AI452781 BC014088 CR609030 AA860865 H82519 NM_022128 AI343945 
    AA348964 CD671166 CD515982 BM833322 AI203169 BU621759 BX648909 AI266440 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RBKS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:              -                                             
    SP2:                                                            


    ECgene alternative splicing isoforms for RBKS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBKS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAACAGAT
    RBKS Expression
    About this image


    RBKS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    RBKS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBKS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11916
        Pathway & Disease-focused RT2 Profiler PCR Array including RBKS: 
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBKS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBKS gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbks1 , 5 ribokinase1, 5 85.82(n)1
    86.34(a)1
      5 (17.27 cM)5
    713361  NM_153196.11  NP_694876.11 
     316244395 
    chicken
    (Gallus gallus)
    Aves RBKS1 ribokinase 74.64(n)
    73.09(a)
      421418  XM_419471.4  XP_419471.4 
    lizard
    (Anolis carolinensis)
    Reptilia RBKS6
    ribokinase
    75(a)
    1 ↔ 1
    2(125468000-125541963)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rbks1 ribokinase 68.88(n)
    72.43(a)
      496800  NM_001011336.1  NP_001011336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rbks1 ribokinase 65.56(n)
    67.11(a)
      415207  NM_001002117.1  NP_001002117.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133691 CG13369 51.4(n)
    47.55(a)
      31007  NM_130494.4  NP_569850.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F07A11.51 F07A11.5 51.03(n)
    45.52(a)
      174781  NM_064082.4  NP_496483.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RBK1(YCR036W)4
    RBK11
    Putative ribokinase4
    RBK11
    46.64(n)1
    35.76(a)1
      3(193297-194298)4
    8504021, 4  NP_009965.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G171601 AT1G17160 41.15(n)
    29.66(a)
      838287  NM_101577.4  NP_173159.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g06654001 Os01g0665400 40.72(n)
    31.49(a)
      4326855  NM_001050331.1  NP_001043796.1 


    ENSEMBL Gene Tree for RBKS (if available)
    TreeFam Gene Tree for RBKS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBKS gene
    1 SIMAP similar gene for RBKS using alignment to 5 protein entries:     RBSK_HUMAN (see all proteins):
    RBSK

    RBKS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBKS (see all 1739)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75666791,2
    C--28003811(+) gttatC/Gctccc 1 -- ds50010--------
    rs1170801401,2
    C,F--28004114(+) CAGCTG/CCCCCT 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1142127071,2
    C,F--28004197(+) CCATAT/GGGTGC 1 -- ds50011Minor allele frequency- G:0.08WA 118
    rs1407365141,2
    C--28004286(+) AATTCC/TGGTTG 1 -- ut310--------
    rs1150201911,2
    C,F--28004329(+) ATCGTT/CATAAA 1 -- ut311Minor allele frequency- C:0.01WA 118
    rs1875240871,2
    --28004364(+) CGTAAA/CAGAAC 1 -- ut310--------
    rs1901282591,2
    --28004424(+) CAGGAA/GCAGCC 1 -- ut310--------
    rs1827271001,2
    C--28004465(+) TTTATA/TTTGGG 1 -- ut310--------
    rs2003108411,2
    C--28004570(+) AATTGA/C/GATCTG 3 S C F mis10--------
    rs1504259901,2
    C,F--28004583(+) GAGCAT/CGTCTT 2 /M /V mis11Minor allele frequency- C:0.00NA 4550

    HapMap Linkage Disequilibrium report for RBKS (28004231 - 28113965 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RBKS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675195CNV Deletion23128226
    nsv507004CNV Insertion20534489
    esv274540CNV Insertion20981092
    esv268461CNV Insertion20981092
    nsv873758CNV Loss21882294
    nsv873759CNV Loss21882294
    nsv873760CNV Loss21882294
    dgv1162e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBKS
    DNA2.0 Custom Variant and Variant Library Synthesis for RBKS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611132    OMIM disorders: --

    2 diseases for RBKS:    
    About MalaCards
    tuberculosis    malaria


    RBKS for disorders           About GeneDecksing

    Genetic Association Database (GAD): RBKS
    Human Genome Epidemiology (HuGE) Navigator: RBKS (1 document)

    Export disorders for RBKS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBKS gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RBKS)
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    1. Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase. (PubMed id 17585908)1, 2, 9 Park J.... Gupta R.S. (FEBS Lett. 2007)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. (PubMed id 8382990)1, 3 Bork P....Valencia A. (Protein Sci. 1993)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. (PubMed id )2 
    9. Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily. (PubMed id 15458630)9 Zhang Y....Ealick S.E. (Structure 2004)
    10. The effect of inorganic phosphate on the activity of bacterial ribokinase. (PubMed id 11563694)9 Maj M.C. and Gupta R.S. (J. Protein Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64080 HGNC: 30325 AceView: RBKS Ensembl:ENSG00000171174 euGenes: HUgn64080
    ECgene: RBKS Kegg: 64080 H-InvDB: RBKS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBKS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBKS gene:
    Search GeneIP for patents involving RBKS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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