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Aliases for RBKS Gene

Aliases for RBKS Gene

  • Ribokinase 2 3 5
  • RBSK 3 4
  • RK 3 4
  • EC 2.7.1.15 4

External Ids for RBKS Gene

Previous GeneCards Identifiers for RBKS Gene

  • GC02M027978
  • GC02M027915
  • GC02M027857
  • GC02M028004

Summaries for RBKS Gene

Entrez Gene Summary for RBKS Gene

  • This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for RBKS Gene

RBKS (Ribokinase) is a Protein Coding gene. Among its related pathways are Metabolism and Pentose phosphate pathway. GO annotations related to this gene include ribokinase activity.

UniProtKB/Swiss-Prot for RBKS Gene

  • Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBKS Gene

Genomics for RBKS Gene

Regulatory Elements for RBKS Gene

Promoters for RBKS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBKS on UCSC Golden Path with GeneCards custom track

Genomic Location for RBKS Gene

Chromosome:
2
Start:
27,781,364 bp from pter
End:
27,891,098 bp from pter
Size:
109,735 bases
Orientation:
Minus strand

Genomic View for RBKS Gene

Genes around RBKS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBKS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBKS Gene

Proteins for RBKS Gene

  • Protein details for RBKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H477-RBSK_HUMAN
    Recommended name:
    Ribokinase
    Protein Accession:
    Q9H477
    Secondary Accessions:
    • A9UK04
    • B4DV96

    Protein attributes for RBKS Gene

    Size:
    322 amino acids
    Molecular mass:
    34143 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for RBKS Gene

    Alternative splice isoforms for RBKS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBKS Gene

Proteomics data for RBKS Gene at MOPED

Post-translational modifications for RBKS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBKS Gene

Antibody Products

No data available for DME Specific Peptides for RBKS Gene

Domains & Families for RBKS Gene

Suggested Antigen Peptide Sequences for RBKS Gene

Graphical View of Domain Structure for InterPro Entry

Q9H477

UniProtKB/Swiss-Prot:

RBSK_HUMAN :
  • Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
Family:
  • Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
genes like me logo Genes that share domains with RBKS: view

No data available for Gene Families for RBKS Gene

Function for RBKS Gene

Molecular function for RBKS Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.17 mM for ribose (in the presence of 10 mM inorganic phosphate) {ECO:0000269 PubMed:17585908}; KM=3.39 mM for ribose (in the presence of 5 mM inorganic phosphate) {ECO:0000269 PubMed:17585908}; KM=6.62 mM for ribose (in the presence of 2 mM inorganic phosphate) {ECO:0000269 PubMed:17585908}; KM=30.43 mM for ribose (in the presence of 1 mM inorganic phosphate) {ECO:0000269 PubMed:17585908}; KM=0.07 mM for ATP (in the presence of 5 mM inorganic phosphate) {ECO:0000269 PubMed:17585908}; KM=0.08 mM for ATP (in the presence of 2 mM inorganic phosphate) {ECO:0000269 PubMed:17585908}; KM=0.10 mM for ATP (in the presence of 1 mM inorganic phosphate) {ECO:0000269 PubMed:17585908};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-ribose = ADP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity (By similarity). Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid, N-(phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate (PubMed:17585908).
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Enzyme Numbers (IUBMB) for RBKS Gene

genes like me logo Genes that share phenotypes with RBKS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RBKS

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBKS Gene

Localization for RBKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBKS Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBKS Gene COMPARTMENTS Subcellular localization image for RBKS gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RBKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RBKS: view

Pathways & Interactions for RBKS Gene

genes like me logo Genes that share pathways with RBKS: view

Pathways by source for RBKS Gene

2 KEGG pathways for RBKS Gene

UniProtKB/Swiss-Prot Q9H477-RBSK_HUMAN

  • Pathway: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Interacting Proteins for RBKS Gene

Gene Ontology (GO) - Biological Process for RBKS Gene

None

No data available for SIGNOR curated interactions for RBKS Gene

Drugs & Compounds for RBKS Gene

(5) Drugs for RBKS Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(8) Additional Compounds for RBKS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
deoxyribose
  • 2'-Deoxy-D-ribose
533-67-5
Deoxyribose 1-phosphate
  • 2-Deoxy-alpha-D-ribose 1-phosphate
  • 2-Deoxy-alpha-delta-ribose 1-phosphate
  • 2-Deoxy-D-erythro-pentofuranose 1-phosphate
  • 2-Deoxy-D-ribose 1-phosphate
  • 2-Deoxy-D-ribose-1-phosphate
17210-42-3
Deoxyribose 5-monophosphate
Deoxyribose 5-phosphate
  • 2-Deoxy-alpha-D-ribose 5-phosphate
  • 2-Deoxy-alpha-delta-ribose 5-phosphate
  • 2-Deoxy-D-ribose 5-phosphate
  • 2-Deoxy-D-ribose-5-phosphate
  • 2-Deoxyribose 5-phosphate
102916-66-5
genes like me logo Genes that share compounds with RBKS: view

Transcripts for RBKS Gene

Unigene Clusters for RBKS Gene

Ribokinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBKS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:

Relevant External Links for RBKS Gene

GeneLoc Exon Structure for
RBKS
ECgene alternative splicing isoforms for
RBKS

Expression for RBKS Gene

mRNA expression in normal human tissues for RBKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBKS Gene

This gene is overexpressed in Liver (x8.0) and Adrenal Gland (x7.0).

Protein differential expression in normal tissues from HIPED for RBKS Gene

This gene is overexpressed in Retina (8.9), Liver (8.6), and Liver, secretome (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBKS Gene



SOURCE GeneReport for Unigene cluster for RBKS Gene Hs.11916

genes like me logo Genes that share expression patterns with RBKS: view

Protein tissue co-expression partners for RBKS Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RBKS Gene

Orthologs for RBKS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBKS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBKS 36
  • 99 (a)
OneToOne
RBKS 35
  • 99.69 (n)
  • 99.38 (a)
cow
(Bos Taurus)
Mammalia RBKS 36
  • 88 (a)
OneToOne
RBKS 35
  • 89.54 (n)
  • 88.51 (a)
dog
(Canis familiaris)
Mammalia RBKS 35
  • 89.13 (n)
  • 87.89 (a)
RBKS 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbks 16
Rbks 35
  • 85.82 (n)
  • 86.34 (a)
Rbks 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBKS 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBKS 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbks 35
  • 85.2 (n)
  • 87.58 (a)
chicken
(Gallus gallus)
Aves RBKS 35
  • 74.64 (n)
  • 73.09 (a)
RBKS 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBKS 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbks 35
  • 68.88 (n)
  • 72.43 (a)
zebrafish
(Danio rerio)
Actinopterygii rbks 35
  • 65.56 (n)
  • 67.11 (a)
rbks 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002608 35
  • 48.46 (n)
  • 43.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13369 35
  • 51.4 (n)
  • 47.55 (a)
CG13369 36
  • 44 (a)
OneToMany
CG17010 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F07A11.5 36
  • 42 (a)
OneToOne
F07A11.5 35
  • 51.03 (n)
  • 45.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBK1 35
  • 46.64 (n)
  • 35.76 (a)
RBK1 36
  • 28 (a)
OneToOne
RBK1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03498g 35
  • 45.49 (n)
  • 37.5 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17160 35
  • 41.15 (n)
  • 29.66 (a)
rice
(Oryza sativa)
Liliopsida Os01g0665400 35
  • 40.72 (n)
  • 31.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04339 35
  • 46.84 (n)
  • 39.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16G5.02c 35
  • 45.92 (n)
  • 40.56 (a)
Species with no ortholog for RBKS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBKS Gene

ENSEMBL:
Gene Tree for RBKS (if available)
TreeFam:
Gene Tree for RBKS (if available)

Paralogs for RBKS Gene

(1) SIMAP similar genes for RBKS Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RBKS: view

No data available for Paralogs for RBKS Gene

Variants for RBKS Gene

Sequence variations from dbSNP and Humsavar for RBKS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs898034 -- 27,867,953(+) TAAAT(C/T)CACTG intron-variant
rs2337371 -- 27,887,717(+) TACTA(A/G)TGATT intron-variant
rs2337373 -- 27,870,055(-) ctgca(A/G)cccat intron-variant, utr-variant-5-prime
rs4493211 -- 27,816,605(+) TATGT(G/T)TTTTT intron-variant
rs4411654 -- 27,801,992(+) tatat(A/T)tTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBKS Gene

Variant ID Type Subtype PubMed ID
nsv507004 CNV Insertion 20534489
nsv873758 CNV Loss 21882294
esv268461 CNV Insertion 20981092
esv274540 CNV Insertion 20981092
nsv873759 CNV Loss 21882294
esv2675195 CNV Deletion 23128226
dgv1162e1 CNV Complex 17122850
nsv873760 CNV Loss 21882294

Variation tolerance for RBKS Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBKS Gene

HapMap Linkage Disequilibrium report
RBKS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBKS Gene

Disorders for RBKS Gene

Relevant External Links for RBKS

Genetic Association Database (GAD)
RBKS
Human Genome Epidemiology (HuGE) Navigator
RBKS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBKS

No disorders were found for RBKS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBKS Gene

Publications for RBKS Gene

  1. Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase. (PMID: 17585908) Park J. … Gupta R.S. (FEBS Lett. 2007) 3 4 23 67
  2. Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. (PMID: 8382990) Bork P. … Valencia A. (Protein Sci. 1993) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for RBKS Gene

Sources for RBKS Gene

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