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Aliases for RBKS Gene

Aliases for RBKS Gene

  • Ribokinase 2 3
  • RBSK 3 4
  • EC 4

External Ids for RBKS Gene

Previous GeneCards Identifiers for RBKS Gene

  • GC02M027978
  • GC02M027915
  • GC02M027857
  • GC02M028004

Summaries for RBKS Gene

Entrez Gene Summary for RBKS Gene

  • This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for RBKS Gene

RBKS (Ribokinase) is a Protein Coding gene. Among its related pathways are Pentose phosphate pathway (KEGG). GO annotations related to this gene include ribokinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBKS Gene

Genomics for RBKS Gene

Regulatory Elements for RBKS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBKS Gene

27,781,364 bp from pter
27,891,098 bp from pter
109,735 bases
Minus strand

Genomic View for RBKS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBKS Gene

Proteins for RBKS Gene

  • Protein details for RBKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A9UK04
    • B4DV96

    Protein attributes for RBKS Gene

    322 amino acids
    Molecular mass:
    34143 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBKS Gene

    Alternative splice isoforms for RBKS Gene


neXtProt entry for RBKS Gene

Proteomics data for RBKS Gene at MOPED

Post-translational modifications for RBKS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBKS Gene

Antibody Products

No data available for DME Specific Peptides for RBKS Gene

Domains for RBKS Gene

Suggested Antigen Peptide Sequences for RBKS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the carbohydrate kinase PfkB family.
  • Belongs to the carbohydrate kinase PfkB family.
genes like me logo Genes that share domains with RBKS: view

No data available for Gene Families for RBKS Gene

Function for RBKS Gene

Molecular function for RBKS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-ribose = ADP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid, N-(phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate.

Enzyme Numbers (IUBMB) for RBKS Gene

Gene Ontology (GO) - Molecular Function for RBKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004747 ribokinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RBKS: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBKS

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RBKS Gene

Localization for RBKS Gene

Subcellular locations from

Jensen Localization Image for RBKS Gene COMPARTMENTS Subcellular localization image for RBKS gene
Compartment Confidence
plasma membrane 3
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for RBKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RBKS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RBKS Gene

Pathways for RBKS Gene

SuperPathways for RBKS Gene

genes like me logo Genes that share pathways with RBKS: view

Pathways by source for RBKS Gene

1 KEGG pathway for RBKS Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9H477-RBSK_HUMAN

  • Pathway: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2

Interacting Proteins for RBKS Gene

Gene Ontology (GO) - Biological Process for RBKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006014 D-ribose metabolic process --
GO:0019303 D-ribose catabolic process IEA --
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with RBKS: view

Compounds for RBKS Gene

(8) HMDB Compounds for RBKS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • 2'-Deoxy-D-ribose
Deoxyribose 1-phosphate
  • 2-deoxy-D-ribose-1-phosphate
Deoxyribose 5-phosphate
  • 2-deoxy-alpha-D-ribose 5-phosphate

(4) Novoseek inferred chemical compound relationships for RBKS Gene

Compound -log(P) Hits PubMed IDs
ribose 75.3 3
pyridoxal 69.4 4
vitamin b6 50.4 1
atp 48.8 1
genes like me logo Genes that share compounds with RBKS: view

Transcripts for RBKS Gene

Unigene Clusters for RBKS Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBKS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBKS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -

Relevant External Links for RBKS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBKS Gene

mRNA expression in normal human tissues for RBKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBKS Gene

This gene is overexpressed in Liver (8.0) and Adrenal Gland (7.0).

Protein differential expression in normal tissues for RBKS Gene

This gene is overexpressed in Retina (8.9), Liver (8.6), and Liver, secretome (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBKS Gene

SOURCE GeneReport for Unigene cluster for RBKS Gene Hs.11916

genes like me logo Genes that share expressions with RBKS: view

Expression partners for RBKS Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RBKS Gene

Orthologs for RBKS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBKS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBKS 35
  • 89.54 (n)
  • 88.51 (a)
  • 88 (a)
(Canis familiaris)
Mammalia RBKS 35
  • 89.13 (n)
  • 87.89 (a)
  • 88 (a)
(Mus musculus)
Mammalia Rbks 35
  • 85.82 (n)
  • 86.34 (a)
Rbks 16
Rbks 36
  • 86 (a)
(Pan troglodytes)
Mammalia RBKS 35
  • 99.69 (n)
  • 99.38 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rbks 35
  • 85.2 (n)
  • 87.58 (a)
(Monodelphis domestica)
Mammalia RBKS 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RBKS 36
  • 82 (a)
(Gallus gallus)
Aves RBKS 35
  • 74.64 (n)
  • 73.09 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia RBKS 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbks 35
  • 68.88 (n)
  • 72.43 (a)
(Danio rerio)
Actinopterygii rbks 35
  • 65.56 (n)
  • 67.11 (a)
rbks 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002608 35
  • 48.46 (n)
  • 43.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13369 35
  • 51.4 (n)
  • 47.55 (a)
CG13369 36
  • 44 (a)
CG17010 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea F07A11.5 35
  • 51.03 (n)
  • 45.52 (a)
F07A11.5 36
  • 42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03498g 35
  • 45.49 (n)
  • 37.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBK1 35
  • 46.64 (n)
  • 35.76 (a)
RBK1 36
  • 28 (a)
RBK1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G17160 35
  • 41.15 (n)
  • 29.66 (a)
(Oryza sativa)
Liliopsida Os01g0665400 35
  • 40.72 (n)
  • 31.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04339 35
  • 46.84 (n)
  • 39.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16G5.02c 35
  • 45.92 (n)
  • 40.56 (a)
Species with no ortholog for RBKS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBKS Gene

Gene Tree for RBKS (if available)
Gene Tree for RBKS (if available)

Paralogs for RBKS Gene

(1) SIMAP similar genes for RBKS Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RBKS: view

No data available for Paralogs for RBKS Gene

Variants for RBKS Gene

Sequence variations from dbSNP and Humsavar for RBKS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs898034 -- 27,867,953(+) TAAAT(C/T)CACTG intron-variant
rs1973116 -- 27,865,051(+) cgcga(C/T)ggctc intron-variant
rs2337371 -- 27,887,717(+) TACTA(A/G)TGATT intron-variant
rs2337373 -- 27,870,055(-) ctgca(A/G)cccat utr-variant-5-prime, intron-variant
rs3935148 -- 27,798,099(-) GTGGG(A/T)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBKS Gene

Variant ID Type Subtype PubMed ID
nsv507004 CNV Insertion 20534489
nsv873758 CNV Loss 21882294
esv268461 CNV Insertion 20981092
esv274540 CNV Insertion 20981092
nsv873759 CNV Loss 21882294
esv2675195 CNV Deletion 23128226
dgv1162e1 CNV Complex 17122850
nsv873760 CNV Loss 21882294

Relevant External Links for RBKS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBKS Gene

Disorders for RBKS Gene

Relevant External Links for RBKS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RBKS Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RBKS Gene

Publications for RBKS Gene

  1. Identification and characterization of human ribokinase and comparison of its properties with E. coli ribokinase and human adenosine kinase. (PMID: 17585908) Park J. … Gupta R.S. (FEBS Lett. 2007) 3 4 23
  2. Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. (PMID: 8382990) Bork P. … Valencia A. (Protein Sci. 1993) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for RBKS Gene

  • Addgene plasmids for RBKS

Sources for RBKS Gene

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