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Aliases for RBFOX3 Gene

Aliases for RBFOX3 Gene

  • RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3 2 3
  • Hexaribonucleotide Binding Protein 3 2 3
  • Neuronal Nuclei 2 3
  • Fox-1 Homolog C 3 4
  • RNA Binding Protein Fox-1 Homolog 3 3
  • HRNBP3 3
  • FOX-3 3
  • FOX3 3
  • NEUN 3

External Ids for RBFOX3 Gene

Previous GeneCards Identifiers for RBFOX3 Gene

  • GC17M072508
  • GC17M077086

Summaries for RBFOX3 Gene

GeneCards Summary for RBFOX3 Gene

RBFOX3 (RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3) is a Protein Coding gene. Diseases associated with RBFOX3 include pediatric ependymoma and central neurocytoma. Among its related pathways are Neuroscience. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBFOX1.

UniProtKB/Swiss-Prot for RBFOX3 Gene

  • RNA-binding protein that regulates alternative splicing events.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBFOX3 Gene

Genomics for RBFOX3 Gene

Genomic Location for RBFOX3 Gene

79,089,345 bp from pter
79,611,101 bp from pter
521,757 bases
Minus strand

Genomic View for RBFOX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBFOX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBFOX3 Gene

No data available for Regulatory Elements for RBFOX3 Gene

Proteins for RBFOX3 Gene

  • Protein details for RBFOX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA binding protein fox-1 homolog 3
    Protein Accession:
    Secondary Accessions:
    • B4DEG6
    • B4DF29

    Protein attributes for RBFOX3 Gene

    312 amino acids
    Molecular mass:
    33873 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBFOX3 Gene


neXtProt entry for RBFOX3 Gene

Proteomics data for RBFOX3 Gene at MOPED

Post-translational modifications for RBFOX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RBFOX3 (NeuN)

No data available for DME Specific Peptides for RBFOX3 Gene

Domains for RBFOX3 Gene

Gene Families for RBFOX3 Gene

Protein Domains for RBFOX3 Gene

Suggested Antigen Peptide Sequences for RBFOX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with RBFOX3: view

Function for RBFOX3 Gene

Molecular function for RBFOX3 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that regulates alternative splicing events.

Gene Ontology (GO) - Molecular Function for RBFOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RBFOX3: view
genes like me logo Genes that share phenotypes with RBFOX3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBFOX3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBFOX3 Gene

Localization for RBFOX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBFOX3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for RBFOX3 Gene COMPARTMENTS Subcellular localization image for RBFOX3 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RBFOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0043025 neuronal cell body --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with RBFOX3: view

Pathways for RBFOX3 Gene

SuperPathways for RBFOX3 Gene

Superpath Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with RBFOX3: view

Pathways by source for RBFOX3 Gene

1 Cell Signaling Technology pathway for RBFOX3 Gene

Interacting Proteins for RBFOX3 Gene

Gene Ontology (GO) - Biological Process for RBFOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0043484 regulation of RNA splicing --
genes like me logo Genes that share ontologies with RBFOX3: view

Transcripts for RBFOX3 Gene

mRNA/cDNA for RBFOX3 Gene

(12) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBFOX3 Gene

RNA binding protein, fox-1 homolog (C. elegans) 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBFOX3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBFOX3 Gene

No ASD Table

Relevant External Links for RBFOX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBFOX3 Gene

mRNA expression in normal human tissues for RBFOX3 Gene

mRNA differential expression in normal tissues according to GTEx for RBFOX3 Gene

This gene is overexpressed in Brain - Cerebellum (9.0), Brain - Cerebellar Hemisphere (8.8), Brain - Cortex (4.4), and Colon - Sigmoid (4.2).

Protein differential expression in normal tissues for RBFOX3 Gene

This gene is overexpressed in Heart (42.3) and Frontal cortex (26.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RBFOX3 Gene

SOURCE GeneReport for Unigene cluster for RBFOX3 Gene Hs.135229

genes like me logo Genes that share expressions with RBFOX3: view

Expression partners for RBFOX3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RBFOX3 Gene

Orthologs for RBFOX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBFOX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBFOX3 35
  • 99.79 (n)
  • 100 (a)
  • 85 (a)
(Mus musculus)
Mammalia Rbfox3 16
Rbfox3 36
  • 78 (a)
(Bos Taurus)
Mammalia RBFOX3 36
  • 69 (a)
(Canis familiaris)
Mammalia RBFOX3 36
  • 82 (a)
(Monodelphis domestica)
Mammalia RBFOX3 36
  • 81 (a)
(Gallus gallus)
Aves LOC100857589 35
  • 84.57 (n)
  • 94.93 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia RBFOX3 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbfox3 35
  • 72.68 (n)
  • 83.33 (a)
(Danio rerio)
Actinopterygii LOC100330510 35
  • 77.47 (n)
  • 85.67 (a)
rbfox3 36
  • 71 (a)
RBFOX3 (3 of 3) 36
  • 74 (a)
rbfox3l 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta A2bp1 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea asd-1 36
  • 21 (a)
fox-1 36
  • 22 (a)
spn-4 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3750 36
  • 30 (a)
Species with no ortholog for RBFOX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBFOX3 Gene

Gene Tree for RBFOX3 (if available)
Gene Tree for RBFOX3 (if available)

Paralogs for RBFOX3 Gene

Paralogs for RBFOX3 Gene

(6) SIMAP similar genes for RBFOX3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RBFOX3: view

Variants for RBFOX3 Gene

Sequence variations from dbSNP and Humsavar for RBFOX3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2016339 -- 79,171,329(+) CGCTG(A/C)CATCT intron-variant
rs2016112 -- 79,171,696(+) GGCTC(A/T)AGTGA intron-variant
rs2013204 -- 79,207,949(-) CCATA(C/T)TGTTT intron-variant
rs2009214 -- 79,102,367(+) GGGGC(C/T)GCAGC intron-variant
rs2007979 -- 79,127,567(+) AAAAC(A/G)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBFOX3 Gene

Variant ID Type Subtype PubMed ID
dgv3284n71 CNV Loss 21882294
nsv523650 CNV Loss 19592680
nsv470610 CNV Loss 18288195
nsv908905 CNV Gain 21882294
dgv3285n71 CNV Loss 21882294
nsv833556 CNV Loss 17160897
dgv3286n71 CNV Loss 21882294
nsv2157 CNV Insertion 18451855
nsv908911 CNV Loss 21882294
dgv3287n71 CNV Loss 21882294
nsv524700 CNV Loss 19592680
nsv527899 CNV Loss 19592680
nsv908914 CNV Loss 21882294
nsv833557 CNV Loss 17160897
nsv908916 CNV Loss 21882294
nsv908917 CNV Loss 21882294
esv2716325 CNV Deletion 23290073
esv2664266 CNV Deletion 23128226
esv2716326 CNV Deletion 23290073
nsv112361 CNV Insertion 16902084
esv1233971 CNV Insertion 17803354
nsv817775 CNV Loss 17921354
esv2658402 CNV Deletion 23128226
nsv522632 CNV Loss 19592680
dgv3288n71 CNV Loss 21882294
nsv908922 CNV Loss 21882294
esv2716327 CNV Deletion 23290073
esv2000452 CNV Deletion 18987734
esv2716328 CNV Deletion 23290073
nsv470612 CNV Gain 18288195
nsv527021 CNV Loss 19592680
esv2716330 CNV Deletion 23290073
esv1010966 CNV Deletion 20482838
esv2668337 CNV Deletion 23128226
dgv1001e1 CNV Complex 17122850
nsv833558 CNV Loss 17160897
nsv908923 CNV Loss 21882294
essv17993 CNV CNV 17122850
esv998420 CNV Deletion 20482838
nsv528997 CNV Loss 19592680
nsv529010 CNV Gain 19592680
nsv908924 CNV Loss 21882294
nsv908925 CNV Loss 21882294
nsv470613 CNV Loss 18288195
esv2716331 CNV Deletion 23290073
esv2676824 CNV Deletion 23128226
esv2716332 CNV Deletion 23290073
esv2716333 CNV Deletion 23290073
esv2716334 CNV Deletion 23290073
esv2657181 CNV Deletion 23128226
nsv518325 CNV Loss 19592680
nsv833560 CNV Loss 17160897
dgv3289n71 CNV Loss 21882294
nsv908927 CNV Loss 21882294
nsv517744 CNV Gain+Loss 19592680
nsv908929 CNV Loss 21882294
esv23168 CNV Loss 19812545
nsv457924 CNV Gain 19166990
nsv470614 CNV Gain 18288195
nsv527752 CNV Gain 19592680
dgv3290n71 CNV Gain 21882294
nsv817776 CNV Gain 17921354
dgv3291n71 CNV Gain 21882294
dgv374n27 CNV Gain 19166990
nsv442427 CNV CNV 18776908
nsv908943 CNV Loss 21882294
nsv908944 CNV Gain 21882294
nsv908945 CNV Loss 21882294
esv2716335 CNV Deletion 23290073
nsv828115 CNV Gain 20364138
nsv908946 CNV Loss 21882294
nsv457966 CNV Loss 19166990
esv2716336 CNV Deletion 23290073
esv2661992 CNV Deletion 23128226
esv2716337 CNV Deletion 23290073
esv2716338 CNV Deletion 23290073
esv2716339 CNV Deletion 23290073
esv2716341 CNV Deletion 23290073
esv1345308 CNV Deletion 17803354
esv2666578 CNV Deletion 23128226
esv2716342 CNV Deletion 23290073

Relevant External Links for RBFOX3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBFOX3 Gene

Disorders for RBFOX3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RBFOX3 Gene in MalaCards »

(2) Diseases for RBFOX3 Gene

Relevant External Links for RBFOX3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with RBFOX3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RBFOX3 Gene

Publications for RBFOX3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. (PMID: 16260614) Underwood J.G. … Black D.L. (Mol. Cell. Biol. 2005) 2 3
  3. Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. (PMID: 19713214) Kim K.K. … Kawamoto S. (J. Biol. Chem. 2009) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression. (PMID: 23371454) Hagel C. … Kordes U. (J. Neurooncol. 2013) 3

Products for RBFOX3 Gene

Sources for RBFOX3 Gene

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