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RBFOX3 Gene

protein-coding   GIFtS: 47
GCID: GC17M077086

RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RNA Binding Protein, Fox-1 Homolog (C. Elegans) 31 2     FOX32
Hexaribonucleotide Binding Protein 31 2     HRNBP32
Neuronal Nuclei1 2     NEUN2
Fox-1 Homolog C2 3     RNA Binding Protein Fox-1 Homolog 32
FOX-32     

External Ids:    HGNC: 270971   Entrez Gene: 1467132   Ensembl: ENSG000001672817   UniProtKB: A6NFN33   
ORGUL members:         

Export aliases for RBFOX3 gene to outside databases

Previous GC identifer: GC17M072508


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RBFOX3 Gene:
RBFOX3 (RNA binding protein, fox-1 homolog (C. elegans) 3) is a protein-coding gene. Diseases associated with RBFOX3 include pediatric ependymoma, and central neurocytoma. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBFOX1.

UniProtKB/Swiss-Prot: RFOX3_HUMAN, A6NFN3
Function: RNA-binding protein that regulates alternative splicing events (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RBFOX3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RBFOX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RBFOX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

RBFOX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBFOX3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M077086:  view genomic region     (about GC identifiers)

Start:
77,085,427 bp from pter      End:
77,613,550 bp from pter
Size:
528,124 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RFOX3_HUMAN, A6NFN3 (See protein sequence)
Recommended Name: RNA binding protein fox-1 homolog 3  
Size: 312 amino acids; 33873 Da
Secondary accessions: B4DEG6

Explore the universe of human proteins at neXtProt for RBFOX3: NX_A6NFN3

Explore proteomics data for RBFOX3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RBFOX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001076044.1  
    ENSEMBL proteins: 
     ENSP00000464186   ENSP00000463964   ENSP00000463653   ENSP00000465367   ENSP00000468693  
     ENSP00000462007   ENSP00000467872   ENSP00000464946   ENSP00000408395   ENSP00000393262  

    RBFOX3 Human Recombinant Protein Products:

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    RBFOX3 Assay Products:

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    Cloud-Clone Corp. ELISAs for RBFOX3
    Cloud-Clone Corp. CLIAs for RBFOX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR025670 Fox-1_C_dom
     IPR017325 RNA-bd_Fox-1
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry A6NFN3

    ProtoNet protein and cluster: A6NFN3

    UniProtKB/Swiss-Prot: RFOX3_HUMAN, A6NFN3
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    RBFOX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFOX3_HUMAN, A6NFN3
    Function: RNA-binding protein that regulates alternative splicing events (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding ----
         
    RBFOX3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rbfox3):
     behavior/neurological  homeostasis/metabolism  integument 

    RBFOX3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RBFOX3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RBFOX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBFOX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RBFOX3

    miRNA
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    Block miRNA regulation of human, mouse, rat RBFOX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RBFOX3 (see all 34):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-429 hsa-miR-938 hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-200b hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat RBFOX3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RBFOX3 (NM_001082575)
    Sino Biological Human cDNA Clone for RBFOX3
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBFOX3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBFOX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFOX3_HUMAN, A6NFN3: Nucleus (By similarity). Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    nucleus3
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043025neuronal cell body ----
    GO:0043204perikaryon IEA--

    RBFOX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RBFOX3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RBFOX3
        Neuroscience




    RBFOX3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RBFOX3
    Interactions:

        Search GeneGlobe Interaction Network for RBFOX3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RBFOX3 (ENSP000004083954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRCENSP000003509414STRING: ENSP00000350941
    HIF1AENSP000003380184STRING: ENSP00000338018
    FYNENSP000003576564STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IEA--
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0043484regulation of RNA splicing ----

    RBFOX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RBFOX3 (RFOX3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RBFOX3 gene (2 alternative transcripts): 
    NM_001025448.1  NM_001082575.2  

    Unigene Cluster for RBFOX3:

    RNA binding protein, fox-1 homolog (C. elegans) 3
    Hs.135229  [show with all ESTs]
    Unigene Representative Sequence: AK128131
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583458(uc010dhs.3) ENST00000582043 ENST00000581393 ENST00000580155
    ENST00000578998 ENST00000582880 ENST00000582894 ENST00000584778(uc010wua.2)
    ENST00000580508 ENST00000582139 ENST00000578887 ENST00000582344 ENST00000415831
    ENST00000453134

    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate RBFOX3 (see all 34):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-429 hsa-miR-938 hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-200b hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RBFOX3
    Predesigned siRNA for gene silencing in human, mouse, rat RBFOX3
    Clone
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    OriGene clones in human, mouse for RBFOX3 (see all 8)
    OriGene ORF clones in mouse, rat for RBFOX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RBFOX3 (NM_001082575)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RBFOX3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RBFOX3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RBFOX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RBFOX3
      QuantiTect SYBR Green Assays in human, mouse, rat RBFOX3
      QuantiFast Probe-based Assays in human, mouse, rat RBFOX3

    Additional mRNA sequence: 

    AK054893.1 AK124644.1 AK128131.1 AK293617.1 AK293905.1 BC093713.1 

    10 DOTS entries:

    DT.101978972  DT.431447  DT.442970  DT.100751980  DT.87001191  DT.95343338  DT.75125698  DT.40130133 
    DT.100751979  DT.120898866 

    2 AceView cDNA sequences:

    AK054893 AI382882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RBFOX3 expression in normal human tissues (normalized intensities)      RBFOX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGTCAAA
    RBFOX3 Expression
    About this image


    RBFOX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Spinal Cord (Nervous System)
             Neural stem cells
     
     Prostate (Endocrine System)
    RBFOX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RBFOX3 Protein Expression

    Genevestigator expression for RBFOX3

    SOURCE GeneReport for Unigene cluster: Hs.135229
        Custom PCR Arrays for RBFOX3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBFOX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RBFOX3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbfox35 RNA binding protein, fox-1 homolog (C. elegans) 3   --   11 (83.22 cM) 118489762 
    chicken
    (Gallus gallus)
    Aves LOC1008575891 RNA binding protein fox-1 homolog 3-like 84.57(n)
    94.93(a)
      100857589  XM_004946288.1  XP_004946345.1 
    lizard
    (Anolis carolinensis)
    Reptilia RBFOX36
    RNA binding protein, fox-1 homolog (C. elegans) 3
    80(a)
    1 ↔ 1
    2(101543775-101619953)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rbfox31 RNA binding protein, fox-1 homolog (C. elegans) 3 72.68(n)
    83.33(a)
      100496414  XM_002932517.2  XP_002932563.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003305101 RNA binding protein fox-1 homolog 3-like 77.47(n)
    85.67(a)
      100330510  XM_002663992.3  XP_002664038.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta A2bp16
    Ataxin-2 binding protein 1
    14(a)
    1 → many
    3L(10474512-10587112)
    worm
    (Caenorhabditis elegans)
    Secernentea fox-16
    asd-16
    (see all 3)
    Protein FOX-1 (fox-1) mRNA, complete cds
    Protein ASD-1, isoform a (asd-1) mRNA, complete cd...
    (see all 3)
    22(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(2445500-2450504) WBGene00001484
    III(4197285-4202289) WBGene00011279


    ENSEMBL Gene Tree for RBFOX3 (if available)
    TreeFam Gene Tree for RBFOX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RBFOX3 gene
    RBFOX12  RBFOX22  
    6 SIMAP similar genes for RBFOX3 using alignment to 7 protein entries:     RFOX3_HUMAN (see all proteins):
    DKFZp547L059    A2BP1    RBFOX1    RBFOX2    RBM9    SRSF5

    RBFOX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RBFOX3 (see all 10612)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs722473651,2
    C--72699475(+) ACCAC-/TCAC  
            
    ACACA
    1 -- int10--------
    rs351337621,2
    C--72789723(+) ACATA-/CATA  
     
    /TTTATA
    TGTGT
    2 -- int1 cds11NA 2
    rs770801691,2
    C--72917880(+) TCCAT-/CCAT  
            
    AAGCC
    1 -- int10--------
    rs3771546891,2
    C--72919213(+) TTATCC/TGCATC 1 -- int10--------
    rs1435723041,2
    C--72920559(+) ATTGGA/GTCAAA 1 -- int10--------
    rs1407530901,2
    C--72924900(+) TCTTCC/TGTCTC 1 -- int10--------
    rs1386136501,2
    C--72924901(+) CTTCTA/GTCTCC 1 -- int10--------
    rs1178194681,2
    C,F--72928660(+) TGGGTG/AGCTGT 1 -- int11Minor allele frequency- A:0.47NA 120
    rs1473314961,2
    C--72928705(+) CAAACA/GGACAA 1 -- int10--------
    rs1402765641,2
    --72929436(+) TACCTC/GTGGTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for RBFOX3 (77085427 - 77335427 bp, first 250kb of RBFOX3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RBFOX3 (see all 81):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716341CNV Deletion23290073
    esv2657181CNV Deletion23128226
    esv2716331CNV Deletion23290073
    esv1345308CNV Deletion17803354
    esv2716335CNV Deletion23290073
    esv2668337CNV Deletion23128226
    esv2716333CNV Deletion23290073
    esv2716328CNV Deletion23290073
    esv998420CNV Deletion20482838
    esv2716342CNV Deletion23290073

    Human Gene Mutation Database (HGMD): RBFOX3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RBFOX3
    DNA2.0 Custom Variant and Variant Library Synthesis for RBFOX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    13 diseases for RBFOX3:    About MalaCards
    pediatric ependymoma    central neurocytoma    cerebral artery occlusion    brain ischemia
    neuronitis    ependymoma    cleft palate    brain disease
    cleft lip    malignant glioma    ischemia    cerebritis
    prostatitis

    4 diseases from the University of Copenhagen DISEASES database for RBFOX3:
    Cerebrovascular accident     Brain ischemia     Neurodegenerative disease     Central neurocytoma

    RBFOX3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): RBFOX3

    Export disorders for RBFOX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RBFOX3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with RBFOX3)
        Utopia: connect your pdf to the dynamic
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    1. Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. (PubMed id 16260614)1, 3 Underwood J.G....Black D.L. (Mol. Cell. Biol. 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression. (PubMed id 23371454)1 Hagel C....Kordes U. (J. Neurooncol. 2013)
    4. [NeuN nuclear protein in neurons of human brain substantia nigra]. (PubMed id 23898728)1 Sukhorukova E.G. (Morfologiia 2013)
    5. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (PubMed id 23512105)1 Beaty T.H....Ruczinski I. (Hum. Genet. 2013)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. (PubMed id 19713214)1 Kim K.K....Kawamoto S. (J. Biol. Chem. 2009)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    9. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    10. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146713 HGNC: 27097 AceView: LOC146713 Ensembl:ENSG00000167281 euGenes: HUgn146713
    ECgene: RBFOX3 H-InvDB: RBFOX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RBFOX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RBFOX3 gene:
    Search GeneIP for patents involving RBFOX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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