Aliases for RBFOX2 Gene
External Ids for RBFOX2 Gene
Previous Symbols for RBFOX2 Gene
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RBFOX2 Gene
RBFOX2 (RNA Binding Protein, Fox-1 Homolog (C. Elegans) 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and transcription factor binding. An important paralog of this gene is RBFOX1.
UniProtKB/Swiss-Prot for RBFOX2 Gene
RNA-binding protein that regulates alternative splicing events by binding to 5-UGCAUGU-3 elements. Prevents binding of U2AF2 to the 3-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.