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Aliases for RBFOX2 Gene

Aliases for RBFOX2 Gene

  • RNA Binding Protein, Fox-1 Homolog (C. Elegans) 2 2 3
  • RBM9 3 4 6
  • FOX2 3 4 6
  • RTA 3 4 6
  • Repressor Of Tamoxifen Transcriptional Activity 3 4
  • Hexaribonucleotide-Binding Protein 2 3 4
  • RNA-Binding Motif Protein 9 3 4
  • Fox-1 Homolog B 3 4
  • HRNBP2 3 4
  • Hexaribonucleotide Binding Protein 2 2
  • RNA Binding Protein Fox-1 Homolog 2 3
  • RNA Binding Motif Protein 9 2
  • RNA-Binding Protein 9 4
  • Fox-1 Homologue 3
  • DJ106I20.3 3
  • HNRBP2 3
  • Fox-2 3
  • Fxh 3

External Ids for RBFOX2 Gene

Previous Symbols for RBFOX2 Gene

  • RBM9

Summaries for RBFOX2 Gene

Entrez Gene Summary for RBFOX2 Gene

  • This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBFOX2 Gene

RBFOX2 (RNA Binding Protein, Fox-1 Homolog (C. Elegans) 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and transcription factor binding. An important paralog of this gene is RBFOX1.

UniProtKB/Swiss-Prot for RBFOX2 Gene

  • RNA-binding protein that regulates alternative splicing events by binding to 5-UGCAUGU-3 elements. Prevents binding of U2AF2 to the 3-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.

Gene Wiki entry for RBFOX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBFOX2 Gene

Genomics for RBFOX2 Gene

Genomic Location for RBFOX2 Gene

Start:
35,738,736 bp from pter
End:
36,028,631 bp from pter
Size:
289,896 bases
Orientation:
Minus strand

Genomic View for RBFOX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBFOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBFOX2 Gene

No data available for Regulatory Elements for RBFOX2 Gene

Proteins for RBFOX2 Gene

  • Protein details for RBFOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43251-RFOX2_HUMAN
    Recommended name:
    RNA binding protein fox-1 homolog 2
    Protein Accession:
    O43251
    Secondary Accessions:
    • A4F5G8
    • A8K5Z5
    • B0QYY8
    • B0QYY9
    • Q0PRL5
    • Q0VH35
    • Q5TF71
    • Q6IC09
    • Q8TD00
    • Q8WYB1
    • Q96DZ6
    • Q96NL7
    • Q9UGW4
    • Q9UH33

    Protein attributes for RBFOX2 Gene

    Size:
    390 amino acids
    Molecular mass:
    41374 Da
    Quaternary structure:
    • Interacts with ER-alpha N-terminal activation domain

    Three dimensional structures from OCA and Proteopedia for RBFOX2 Gene

    Alternative splice isoforms for RBFOX2 Gene

neXtProt entry for RBFOX2 Gene

Proteomics data for RBFOX2 Gene at MOPED

Post-translational modifications for RBFOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys160

No data available for DME Specific Peptides for RBFOX2 Gene

Domains for RBFOX2 Gene

Gene Families for RBFOX2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

RFOX2_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • O43251
genes like me logo Genes that share domains with RBFOX2: view

Function for RBFOX2 Gene

Molecular function for RBFOX2 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that regulates alternative splicing events by binding to 5-UGCAUGU-3 elements. Prevents binding of U2AF2 to the 3-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.

Gene Ontology (GO) - Molecular Function for RBFOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003714 transcription corepressor activity IDA 11875103
GO:0003723 RNA binding IDA 11875103
GO:0003729 mRNA binding IEA --
genes like me logo Genes that share ontologies with RBFOX2: view
genes like me logo Genes that share phenotypes with RBFOX2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBFOX2 Gene

Localization for RBFOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBFOX2 Gene

Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for RBFOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11875103
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RBFOX2: view

Pathways for RBFOX2 Gene

SuperPathways for RBFOX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBFOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome ISS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0010724 regulation of definitive erythrocyte differentiation IEA --
GO:0016070 RNA metabolic process TAS 11875103
genes like me logo Genes that share ontologies with RBFOX2: view

No data available for Pathways by source for RBFOX2 Gene

Compounds for RBFOX2 Gene

(1) Novoseek inferred chemical compound relationships for RBFOX2 Gene

Compound -log(P) Hits PubMed IDs
leucine 41.3 2
genes like me logo Genes that share compounds with RBFOX2: view

Transcripts for RBFOX2 Gene

Unigene Clusters for RBFOX2 Gene

RNA binding protein, fox-1 homolog (C. elegans) 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBFOX2 Gene

No ASD Table

Relevant External Links for RBFOX2 Gene

GeneLoc Exon Structure for
RBFOX2
ECgene alternative splicing isoforms for
RBFOX2

Expression for RBFOX2 Gene

mRNA expression in normal human tissues for RBFOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBFOX2 Gene

SOURCE GeneReport for Unigene cluster for RBFOX2 Gene Hs.282998

genes like me logo Genes that share expressions with RBFOX2: view

Orthologs for RBFOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBFOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBFOX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBFOX2 36
  • 95.69 (n)
  • 98.89 (a)
RBFOX2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBFOX2 36
  • 95.6 (n)
  • 98.96 (a)
RBFOX2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbfox2 36
  • 93.29 (n)
  • 97.69 (a)
Rbfox2 16
Rbfox2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBFOX2 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBFOX2 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbfox2 36
  • 93.41 (n)
  • 97.11 (a)
chicken
(Gallus gallus)
Aves RBFOX2 36
  • 85.39 (n)
  • 93.28 (a)
RBFOX2 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBFOX2 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14636 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10051 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3239 36
zebrafish
(Danio rerio)
Actinopterygii rbfox2 37
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta A2bp1 37
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea asd-1 37
  • 24 (a)
ManyToMany
fox-1 37
  • 27 (a)
ManyToMany
spn-4 37
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3750 37
  • 34 (a)
OneToMany
Species with no ortholog for RBFOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBFOX2 Gene

ENSEMBL:
Gene Tree for RBFOX2 (if available)
TreeFam:
Gene Tree for RBFOX2 (if available)

Paralogs for RBFOX2 Gene

Paralogs for RBFOX2 Gene

Selected SIMAP similar genes for RBFOX2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RBFOX2: view

Variants for RBFOX2 Gene

Sequence variations from dbSNP and Humsavar for RBFOX2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14870 -- 35,738,780(+) CCATG(C/T)GCAAA utr-variant-3-prime
rs132596 -- 36,017,243(+) ACATG(C/T)TACAG intron-variant
rs132597 -- 36,022,232(+) ACATT(C/T)TTGTT intron-variant
rs136055 -- 35,775,286(+) GCTTC(A/G)AAGGA intron-variant
rs136613 -- 35,920,614(-) GTACT(A/G)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBFOX2 Gene

Variant ID Type Subtype PubMed ID
nsv511076 CNV Complex 20534489
nsv3612 CNV Insertion 18451855
nsv527454 CNV Gain 19592680
esv2423870 CNV Deletion 19546169
esv2724188 CNV Deletion 23290073
nsv915002 CNV Loss 21882294
nsv915003 CNV Loss 21882294
nsv483105 CNV Loss 15286789
esv2663753 CNV Deletion 23128226
nsv3613 CNV Insertion 18451855
nsv519467 CNV Gain 19592680
esv2654054 CNV Deletion 19546169
nsv3614 CNV Insertion 18451855

Relevant External Links for RBFOX2 Gene

HapMap Linkage Disequilibrium report
RBFOX2

Disorders for RBFOX2 Gene

(1) Novoseek inferred disease relationships for RBFOX2 Gene

Disease -log(P) Hits PubMed IDs
kaposi sarcoma 53 1

Relevant External Links for RBFOX2

Genetic Association Database (GAD)
RBFOX2
genes like me logo Genes that share disorders with RBFOX2: view

No data available for UniProtKB/Swiss-Prot for RBFOX2 Gene

Publications for RBFOX2 Gene

  1. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. (PMID: 18794351) Zhang C. … Zhang M.Q. (Genes Dev. 2008) 3 23

Products for RBFOX2 Gene

Sources for RBFOX2 Gene

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