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Aliases for RBFA Gene

Aliases for RBFA Gene

  • Ribosome Binding Factor A (Putative) 2 3 5
  • C18orf22 3 4
  • Chromosome 18 Open Reading Frame 22 2
  • HsT169 3

External Ids for RBFA Gene

Previous HGNC Symbols for RBFA Gene

  • C18orf22

Previous GeneCards Identifiers for RBFA Gene

  • GC18P077795

Summaries for RBFA Gene

GeneCards Summary for RBFA Gene

RBFA (Ribosome Binding Factor A (Putative)) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBFA Gene

Genomics for RBFA Gene

Regulatory Elements for RBFA Gene

Promoters for RBFA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBFA on UCSC Golden Path with GeneCards custom track

Genomic Location for RBFA Gene

Chromosome:
18
Start:
80,034,346 bp from pter
End:
80,050,652 bp from pter
Size:
16,307 bases
Orientation:
Plus strand

Genomic View for RBFA Gene

Genes around RBFA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBFA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBFA Gene

Proteins for RBFA Gene

  • Protein details for RBFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0V3-RBFA_HUMAN
    Recommended name:
    Putative ribosome-binding factor A, mitochondrial
    Protein Accession:
    Q8N0V3
    Secondary Accessions:
    • Q6PF07
    • Q8WZ65
    • Q9H776

    Protein attributes for RBFA Gene

    Size:
    343 amino acids
    Molecular mass:
    38359 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBFA Gene

    Alternative splice isoforms for RBFA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBFA Gene

Proteomics data for RBFA Gene at MOPED

Post-translational modifications for RBFA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBFA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBFA Gene

Domains & Families for RBFA Gene

Suggested Antigen Peptide Sequences for RBFA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0V3

UniProtKB/Swiss-Prot:

RBFA_HUMAN :
  • Belongs to the RbfA family.
Family:
  • Belongs to the RbfA family.
genes like me logo Genes that share domains with RBFA: view

No data available for Gene Families for RBFA Gene

Function for RBFA Gene

genes like me logo Genes that share phenotypes with RBFA: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBFA Gene

Localization for RBFA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBFA Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBFA Gene COMPARTMENTS Subcellular localization image for RBFA gene
Compartment Confidence
mitochondrion 4
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for RBFA Gene

Pathways & Interactions for RBFA Gene

SuperPathways for RBFA Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with RBFA: view

No data available for Pathways by source and SIGNOR curated interactions for RBFA Gene

Drugs & Compounds for RBFA Gene

No Compound Related Data Available

Transcripts for RBFA Gene

Unigene Clusters for RBFA Gene

Ribosome binding factor A (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBFA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for RBFA Gene

GeneLoc Exon Structure for
RBFA
ECgene alternative splicing isoforms for
RBFA

Expression for RBFA Gene

mRNA expression in normal human tissues for RBFA Gene

Protein differential expression in normal tissues from HIPED for RBFA Gene

This gene is overexpressed in Pancreas (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBFA Gene



SOURCE GeneReport for Unigene cluster for RBFA Gene Hs.728931

genes like me logo Genes that share expression patterns with RBFA: view

Protein tissue co-expression partners for RBFA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBFA Gene

Orthologs for RBFA Gene

This gene was present in the common ancestor of animals.

Orthologs for RBFA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBFA 35
  • 75.87 (n)
  • 70.28 (a)
RBFA 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBFA 35
  • 70.63 (n)
  • 62.83 (a)
RBFA 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbfa 35
  • 72.1 (n)
  • 63.08 (a)
Rbfa 16
Rbfa 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBFA 35
  • 99.55 (n)
  • 99.33 (a)
RBFA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbfa 35
  • 72.35 (n)
  • 63.23 (a)
oppossum
(Monodelphis domestica)
Mammalia RBFA 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBFA 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBFA 35
  • 55.95 (n)
  • 42.53 (a)
RBFA 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBFA 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rbfa 35
  • 56.5 (n)
  • 44.49 (a)
rbfa 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15916 36
  • 24 (a)
OneToOne
Species with no ortholog for RBFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBFA Gene

ENSEMBL:
Gene Tree for RBFA (if available)
TreeFam:
Gene Tree for RBFA (if available)

Paralogs for RBFA Gene

Pseudogenes.org Pseudogenes for RBFA Gene

genes like me logo Genes that share paralogs with RBFA: view

No data available for Paralogs for RBFA Gene

Variants for RBFA Gene

Sequence variations from dbSNP and Humsavar for RBFA Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs748338 - 80,037,492(+) TTAAC(A/G)TGGAG reference, missense
rs3744872 - 80,045,856(+) CGCTC(A/C)ACAAG reference, synonymous-codon, missense
rs3744873 - 80,045,949(+) AGATG(A/C)AAAAG reference, missense, utr-variant-3-prime
rs748337 -- 80,037,321(+) TCTTC(C/T)TGATG intron-variant
rs1320693 -- 80,046,509(+) GGGGT(A/G)AGAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RBFA Gene

Variant ID Type Subtype PubMed ID
nsv428359 CNV Gain 18775914
nsv910009 CNV Loss 21882294
nsv470437 CNV Loss 18288195
nsv910065 CNV Gain 21882294
esv28269 CNV Gain 19812545

Variation tolerance for RBFA Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.66; 89.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBFA Gene

HapMap Linkage Disequilibrium report
RBFA
Human Gene Mutation Database (HGMD)
RBFA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBFA Gene

Disorders for RBFA Gene

Relevant External Links for RBFA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBFA

No disorders were found for RBFA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBFA Gene

Publications for RBFA Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3

Products for RBFA Gene

Sources for RBFA Gene

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