RBFA Gene
protein-coding GIFtS: 44
GCID: GC18P077795
|
|
ribosome binding factor A (putative)(Previous name: chromosome 18 open reading frame 22 )
(Previous symbol: C18orf22)
| |
Aliases
for RBFA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosome Binding Factor A (Putative)1 2 | | C18orf221 2 3 | | HsT1691 2 | | FLJ211721 | | Chromosome 18 Open Reading Frame 221 | | Putative Ribosome-Binding Factor A, Mitochondrial2 |
Export aliases for RBFA gene to outside databases |
Summaries
for RBFA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RBFA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RBFA
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBFA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBFA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23RBFA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P077795: view genomic region
(about GC identifiers)
Start:
|
77,794,346 bp from pter |
End:
|
77,810,652 bp from pter |
Size:
|
16,307 bases |
Orientation:
|
plus strand |
|
Proteins
for RBFA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBFA_HUMAN, Q8N0V3 (See
protein sequence)Recommended Name: Putative ribosome-binding factor A, mitochondrial precursor Size: 343 amino acids; 38359 Da
Subcellular location: Mitochondrion (Potential)
1 PDB 3D structure from  and Proteopedia  for RBFA:2E7G (3D)
Secondary accessions: Q6PF07 Q8WZ65 Q9H776Alternative splicing: 2 isoforms: Q8N0V3-1 Q8N0V3-2 Explore the universe of human proteins at neXtProt for RBFA: NX_Q8N0V3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N0V3
RBFA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001165438.1 NP_079081.2
ENSEMBL proteins: ENSP00000305696 ENSP00000262197
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005739 | mitochondrion |
IEA | -- |
RBFA for ontologies About GeneDecksing
RBFA Antibody Products:
Assay Products for RBFA: |
Protein
Domains /
Families
for RBFA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBFA for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N0V3ProtoNet protein and cluster: Q8N0V3 1 Blocks protein family: IPB000238 Ribosome-binding factor A
UniProtKB/Swiss-Prot: RBFA_HUMAN, Q8N0V3Similarity: Belongs to the RbfA family |
Function
for RBFA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBFA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBFA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RBFA (NM_024805) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBFA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBFA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBFA |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
RBFA for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RBFA:
|
Pathways & Interactions
for RBFA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBFA
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/232 Interacting proteins for RBFA (Q8N0V32, 3 ENSP000003056964) via UniProtKB, MINT, STRING, and/or I2D (see all 232)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
RBFA for ontologies About GeneDecksing
|
Drugs & Compounds
for RBFA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBFA
Search CenterWatch for drugs/clinical trials and news about RBFA
|
Transcripts
for RBFA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBFA gene (2 alternative transcripts): NM_001171967.1 NM_024805.2 Unigene Cluster for RBFA: Ribosome binding factor A (putative) Hs.728931 [show with all ESTs]Unigene Representative Sequence: NM_0248055 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306735(uc002lns.3) ENST00000586847 ENST00000591612 ENST00000262197(uc010drh.3)
ENST00000593019
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBFA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBFA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RBFA (NM_024805) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBFA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBFA |
Additional cDNA sequence: AF261073.2 AF439745.2 AK024825.1 BC014195.2 BC057772.1 12 DOTS entries: DT.40225429 DT.40195066 DT.95166607 DT.75184908 DT.92003359 DT.95166609 DT.40291382 DT.425370 DT.102828039 DT.97770703 DT.100754066 DT.421262 24/128 AceView cDNA sequences (see all 128): BM764475 AI679820 AW167521 BU147336 BM564799 BQ943575 AI679244 CD106379 AI500135 BM932115 AF070628 BE907584 CR593794 BM561259 CR602922 BI160545 BM547281 BC014195 CB127331 AI433441 BQ681885 AI367681 AF261073 BU729529
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RBFA About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RBFA
|
Expression
for RBFA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBFA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTGTGTGT
About this image
See RBFA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBFA
SOURCE GeneReport for Unigene cluster: Hs.728931
SABiosciences Custom PCR Arrays for RBFA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBFA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBFA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBFA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBFA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBFA |
Orthologs
for RBFA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RBFA gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for RBFA (if available)
TreeFam Gene Tree for RBFA (if available) |
Paralogs
for RBFA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBFA gene
RBFA for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RBFA
PGOHUM00000246802 PGOHUM00000241898
|
Genomic Variants
for RBFA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBFA (77794346 - 77810652 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBFA: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBFA |
|
Disorders
/ Diseases
for RBFA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RBFA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBFA gene integrated from 9 sources:
(articles sorted by number of sources associating them with RBFA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for RBFA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBFA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBFA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBFA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBFA | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBFA gene:
Search GeneIP for patents involving RBFA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBFA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RBFA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBFA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBFA | | | OriGene Protein Over-expression Lysate for RBFA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBFA | | OriGene 3'-UTR Clone for RBFA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBFA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBFA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RBFA | | OriGene Custom Protein Services for RBFA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBFA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBFA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBFA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBFA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBFA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBFA |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RBFA |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RBFA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBFA |
|  |  |  | | | | Search ThermoFisher Antibodies for RBFA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBFA |
|
|
|
|
