RBCK1 Gene
protein-coding GIFtS : 54 GCID: GC20 P000388
RanBP-type and C3HC4-type zinc finger containing 1 chromosome 20 open reading frame 18 )C20orf18 )
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Aliasesfor RBCK1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RanBP-Type And C3HC4-Type Zinc Finger Containing 1 1 2 HOIL-12 3 C20orf181 2 3 XAP32 3 RNF541 2 3 HBV-Associated Factor 42 3 UBCE7IP31 2 3 RING Finger Protein 542 3 XAP41 2 3 Chromosome 20 Open Reading Frame 181 HOIL11 2 5 HBV Associated Factor 42 RBCK21 2 RanBP-Type And C3HC4-Type Zinc Finger-Containing Protein 12 ZRANB41 2 RBCC Protein Interacting With PKC12 Heme-Oxidized IRP2 Ubiquitin Ligase 12 3 Ubiquitin Conjugating Enzyme 7 Interacting Protein 32 Hepatitis B Virus X-Associated Protein 42 3 EC 6.3.2.-3 Ubiquitin-Conjugating Enzyme 7-Interacting Protein 32 3
Export aliases for RBCK1 gene to outside databases Previous GC identifer: GC20P000337
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Summariesfor RBCK1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RBCK1 : The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: HOIL1_HUMAN, Q9BYM8 Function : E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such asUBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types Gene Wiki entry for RBCK1
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Genomic Viewsfor RBCK1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011387.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RBCK1 gene promoter:ER-alpha Elk-1 HOXA3 Brachyury LCR-F1 NF-kappaB NF-kappaB1 Arnt Other transcription factors Search SABiosciences Chromatin IP Primers for RBCK1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13 RBCK1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20P000388: view genomic region
(about GC identifiers )
Start: 388,142 bp from pter End:
411,610 bp from pter
Size: 23,469 bases Orientation:
plus strand
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Proteinsfor RBCK1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: HOIL1_HUMAN, Q9BYM8 See
protein sequence )Recommended Name: Size : 510 amino acids; 57572 DaSubunit : Forms homodimers in vitro (By similarity). Component of the LUBAC complex (linear ubiquitin chain assemblycomplex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) and with UBE2L3. Interacts with PRKCH. Interacts with the HBV pX/HBx protein, which is required to activate transcription of the viral genome. Isoform 1 and isoform 2 interact with IREB2 only in iron-rich conditions. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner. Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1. Interacts with IRF3
Sequence caution : Sequence=AAH15219.2; Type=Erroneous initiation; Note=Translation N-terminally extended;3 PDB 3D structures from :2CRC (3D) 2LGY (3D) 4DBG (3D) Secondary accessions : O95623 Q86SL2 Q96BS3 Q9BYM9Alternative splicing : 3 isoforms : Q9BYM8-1 Q9BYM8-3 Q9BYM8-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for RBCK1: NX_Q9BYM8 Post-translational modifications:
Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome (By similarity)1 Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity (By similarity)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BYM8 RBCK1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_006453.1 NP_112506.2 ENSEMBL proteins: ENSP00000415080 ENSP00000371649 ENSP00000348632 ENSP00000405288 ENSP00000417173 ENSP00000387799 ENSP00000254960 ENSP00000371616 ENSP00000383106 ENSP00000393841 Reactome Protein details: Q9BYM8 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing RBCK1 Antibody Products: Assay Products for RBCK1:
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Protein
Domains /for RBCK1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q9BYM8 ProtoNet protein and cluster: Q9BYM8
3 Blocks protein families : IPB000626 IPB001841 IPB001876 UniProtKB/Swiss-Prot: HOIL1_HUMAN, Q9BYM8 Domain : The RanBP2-type zinc finger, also called Npl4 zinc finger (NZF), mediates binding to 'M-1'-linkedpolyubiquitins (By similarity) Domain : The UBL domain mediates association with RNF31 via interaction with its UBA domainSimilarity : Contains 1 IBR-type zinc fingerSimilarity : Contains 1 RanBP2-type zinc fingerSimilarity : Contains 2 RING-type zinc fingersSimilarity : Contains 1 ubiquitin-like domain
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Functionfor RBCK1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: HOIL1_HUMAN, Q9BYM8 Function : E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such asUBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types Induction : By viral transfectionEnzyme Number (IUBMB): EC 6.3.2.- 1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): RBCK1 (NM_031229 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBCK1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBCK1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBCK1
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8 ): About this table
About GeneDecksing Animal Models: Rbck1 tm1Kiwa for RBCK12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rbck1) :About GeneDecksing
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Pathways & Interactionsfor RBCK1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Antigen processing: Ubiquitination & Proteasome degradation 2 Immune System
Pathway sources See GeneCards unified pathways Show all pathways 5 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RBCK1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/53 Interacting proteins for RBCK1 (Q9BYM8 1 , 2 , 3 ENSP00000348632 4 via UniProtKB, MINT, STRING , and/or I2D (see all 53 )About this table Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
About GeneDecksing
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Drugs & Compoundsfor RBCK1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RBCK1 RBCK1 / HOIL1
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Transcriptsfor RBCK1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RBCK1 gene (4 alternative transcripts): NM_006462.4 NM_031229.2 NM_031227.1 NM_031228.1 Unigene Cluster for RBCK1:
RanBP-type and C3HC4-type zinc finger containing 1 Hs.247280 [show with all ESTs ] Unigene Representative Sequence: NM_031229 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000411647 ENST00000465226 ENST00000382214 (uc010fzy.3 ) ENST00000356286 (uc002wdp.4 uc002wdq.4 )ENST00000415942 (uc010zpl.1 uc010zpm.1 uc002wdr.4 ) ENST00000475269 (uc002wdo.3 )ENST00000441733 ENST00000353660 ENST00000400245 ENST00000382181 ENST00000400247 ENST00000414880 ENST00000468272 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): RBCK1 (NM_031229 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBCK1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBCK1
Additional cDNA sequence: AB107766.1 AK297524.1 AK303357.1 AK309414.1 BC014116.2 BC015219.2 BC016301.2 U67322.1
22 DOTS entries : DT.91812875 DT.413058
DT.454224 DT.97848260 DT.100798097 DT.100811424 DT.95170996 DT.95094464 DT.100798098 DT.100798102 DT.92463083 DT.120813206 DT.120813220 DT.75167355 DT.95170992 DT.97835477 DT.102832175 DT.95170993 DT.95170994 DT.95171001 DT.100798094 DT.120813189 24/407 AceView cDNA sequences (see all 407 ):
BE396413 BP431583 BI820740 NM_006462 BC016301 BQ927611 BU540444 AW151341 BM920785 NM_031229 BQ961742 BQ948128 BQ687582 BQ052558 CA447652 BE732019 BQ688614 BQ936448 BC000983 AW276485 BM784635 BQ932913 BU197040 CR625598 GeneLoc Exon Structure 5/17 Alternative Splicing Database (ASD) splice patterns (SP) for RBCK1 (see all 17 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · SP1 : - - SP2 : SP3 : - - - - - - - - - - SP4 : - - - - - - SP5 :
ExUns: 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for RBCK1
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Expression for RBCK1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RBCK1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTGCAAAATG
About this image See RBCK1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RBCK1 SOURCE GeneReport for Unigene cluster: Hs.247280 SABiosciences Expression via Pathway-Focused PCR Array including RBCK1 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBCK1
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Orthologsfor RBCK1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for RBCK1 gene from 4/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for RBCK1 (if available)TreeFam Gene Tree for RBCK1 (if available)
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Paralogsfor RBCK1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RBCK1 gene SHARPIN 2 1 SIMAP similar gene for RBCK1 using alignment to 9 protein entries: HOIL1_HUMAN (see all proteins ):SHARPIN About GeneDecksing
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Genomic Variantsfor RBCK1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 20 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for RBCK1 (388142 - 411610 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RBCK1: -- Human Gene Mutation Database (HGMD) : RBCK1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor RBCK1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 610924
OMIM disorders : --3 : About MalaCards hepatitis b hepatitis breast cancer 1 disease from the University of Copenhagen DISEASES database for RBCK1 :Glycogen storage disease IV Export disorders for RBCK1 gene to outside databases
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Publicationsfor RBCK1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RBCK1 gene, integrated from 9 sources (see all 52 ):(articles sorted by number of sources associating them with RBCK1) Utopia : connect your pdf to the dynamic
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. (PubMed id 18711448) 1 , 2 , 9(2008) Solution structure of the E3 ligase HOIL-1 Ubl domain. (PubMed id 22517668) 1 , 2 (2012) A non-canonical UBA-UBL interaction forms the linear-u biquitin-chain assembly complex. (PubMed id 22430200) 1 , 2 (2012) Involvement of linear polyubiquitylation of NEMO in N F-kappaB activation. (PubMed id 19136968) 1 , 2 (2009) Recruitment of the linear ubiquitin chain assembly co mplex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. (PubMed id 20005846) 1 , 2 (2009) RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PubMed id 17449468) 1 , 2 (2007) A ubiquitin ligase complex assembles linear polyubiquitin chains. (PubMed id 17006537) 1 , 2 (2006) Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569) 1 , 2 (2005) An unappreciated role for RNA surveillance. (PubMed id 14759258) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004)
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External Searches for RBCK1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RBCK1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing RBCK1 gene
(According to HUGE )
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Specialized Databases showing RBCK1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for RBCK1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RBCK1 gene: RBCK1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RBCK1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RBCK1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for RBCK1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RBCK1 OriGene 3'-UTR Clone for RBCK1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RBCK1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RBCK1 OriGene Custom Protein Services for RBCK1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBCK1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for RBCK1
RBCK1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBCK1
ThermoFisher Antibodies for RBCK1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RBCK1
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