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Aliases for RBBP9 Gene

Aliases for RBBP9 Gene

  • Retinoblastoma Binding Protein 9 2 3 5
  • Retinoblastoma-Binding Protein 9 2 3 4
  • Retinoblastoma-Binding Protein 10 3 4
  • B5T-Overexpressed Gene Protein 3 4
  • RBBP-10 3 4
  • RBBP-9 3 4
  • RBBP10 3 4
  • BOG 3 4
  • B5T Overexpressed Gene Protein 3
  • Retinoma-Binding Protein 9 3
  • Protein BOG 4
  • EC 3.-.-.- 4

External Ids for RBBP9 Gene

Previous GeneCards Identifiers for RBBP9 Gene

  • GC20M018455
  • GC20M018462

Summaries for RBBP9 Gene

Entrez Gene Summary for RBBP9 Gene

  • The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBBP9 Gene

RBBP9 (Retinoblastoma Binding Protein 9) is a Protein Coding gene. Diseases associated with RBBP9 include retinoblastoma and corneal dystrophy, posterior polymorphous, 1. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for RBBP9 Gene

  • May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.

Gene Wiki entry for RBBP9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBBP9 Gene

Genomics for RBBP9 Gene

Regulatory Elements for RBBP9 Gene

Promoters for RBBP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBBP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBBP9 Gene

18,486,540 bp from pter
18,497,255 bp from pter
10,716 bases
Minus strand

Genomic View for RBBP9 Gene

Genes around RBBP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBBP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBBP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBBP9 Gene

Proteins for RBBP9 Gene

  • Protein details for RBBP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative hydrolase RBBP9
    Protein Accession:
    Secondary Accessions:
    • D3DW31
    • Q5JPH9
    • Q9H1D8

    Protein attributes for RBBP9 Gene

    186 amino acids
    Molecular mass:
    21000 Da
    Quaternary structure:
    No Data Available
    • Interacts with the serine hydrolase-directed activity-based probe fluorophosphonate-rhodamine (FP-rhodamine). This interaction is inhibited selectively and reversibly by emetine, a compound with cytotoxic activity.

    Three dimensional structures from OCA and Proteopedia for RBBP9 Gene

    Alternative splice isoforms for RBBP9 Gene


neXtProt entry for RBBP9 Gene

Proteomics data for RBBP9 Gene at MOPED

Post-translational modifications for RBBP9 Gene

  • Ubiquitination at Lys 156
  • Modification sites at PhosphoSitePlus

Other Protein References for RBBP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBBP9 Gene

Domains & Families for RBBP9 Gene

Protein Domains for RBBP9 Gene

Suggested Antigen Peptide Sequences for RBBP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RBBP9 family.
  • Belongs to the RBBP9 family.
genes like me logo Genes that share domains with RBBP9: view

No data available for Gene Families for RBBP9 Gene

Function for RBBP9 Gene

Molecular function for RBBP9 Gene

GENATLAS Biochemistry:
Bog,retinoblastoma binding protein,murine Bog homolog,inhibiting TGFB1 activity by displacing E2F1 when overexpressed
UniProtKB/Swiss-Prot Function:
May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.

Enzyme Numbers (IUBMB) for RBBP9 Gene

Gene Ontology (GO) - Molecular Function for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with RBBP9: view
genes like me logo Genes that share phenotypes with RBBP9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RBBP9

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBBP9 Gene

Localization for RBBP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBBP9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for RBBP9 Gene COMPARTMENTS Subcellular localization image for RBBP9 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RBBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RBBP9: view

Pathways & Interactions for RBBP9 Gene

SuperPathways for RBBP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBBP9 Gene


No data available for Pathways by source and SIGNOR curated interactions for RBBP9 Gene

Drugs & Compounds for RBBP9 Gene

No Compound Related Data Available

Transcripts for RBBP9 Gene

Unigene Clusters for RBBP9 Gene

Retinoblastoma binding protein 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBBP9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP2: -
SP3: - -
SP4: - -

Relevant External Links for RBBP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBBP9 Gene

mRNA expression in normal human tissues for RBBP9 Gene

Protein differential expression in normal tissues from HIPED for RBBP9 Gene

This gene is overexpressed in Oral epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBBP9 Gene

SOURCE GeneReport for Unigene cluster for RBBP9 Gene Hs.69330

mRNA Expression by UniProt/SwissProt for RBBP9 Gene

Tissue specificity: Widely expressed. Expressed at higher levels in tumor tissues than in normal tissues.
genes like me logo Genes that share expression patterns with RBBP9: view

Protein tissue co-expression partners for RBBP9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RBBP9 Gene

Orthologs for RBBP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBBP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBBP9 35
  • 87.16 (n)
  • 89.08 (a)
RBBP9 36
  • 90 (a)
(Canis familiaris)
Mammalia RBBP9 35
  • 90.86 (n)
  • 90.32 (a)
RBBP9 36
  • 87 (a)
(Mus musculus)
Mammalia Rbbp9 35
  • 92.07 (n)
  • 91.89 (a)
Rbbp9 16
Rbbp9 36
  • 91 (a)
(Pan troglodytes)
Mammalia RBBP9 35
  • 99.64 (n)
  • 100 (a)
RBBP9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rbbp9 35
  • 90.84 (n)
  • 90.66 (a)
(Monodelphis domestica)
Mammalia RBBP9 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491567 35
  • 69.83 (n)
  • 75.42 (a)
(Danio rerio)
Actinopterygii rbbp9 35
  • 67.8 (n)
  • 71.02 (a)
wufd05g11 35
rbbp9 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.792 35
Species with no ortholog for RBBP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBBP9 Gene

Gene Tree for RBBP9 (if available)
Gene Tree for RBBP9 (if available)

Paralogs for RBBP9 Gene

No data available for Paralogs for RBBP9 Gene

Variants for RBBP9 Gene

Sequence variations from dbSNP and Humsavar for RBBP9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1065444 -- 18,497,123(-) GGAGG(A/C/T)GGGGA reference, synonymous-codon, utr-variant-5-prime
rs1130201 -- 18,487,182(-) TAGCC(A/T)TATTT utr-variant-3-prime
rs2247746 -- 18,496,970(+) TTGCT(A/G)GAGGG intron-variant
rs2247757 -- 18,497,226(+) CCTGC(A/T)CCCGC utr-variant-5-prime
rs1143100 -- 18,497,115(-) GGATG(A/G/T)GACCA reference, missense, utr-variant-5-prime

Variation tolerance for RBBP9 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBBP9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RBBP9 Gene

Disorders for RBBP9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBBP9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • retinoblastoma, trilateral
corneal dystrophy, posterior polymorphous, 1
  • posterior polymorphous corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search RBBP9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBBP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RBBP9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBBP9 Gene

Publications for RBBP9 Gene

  1. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. (PMID: 9697699) Woitach J.T. … Thorgeirsson S.S. (Nat. Genet. 1998) 2 3 4 23 67
  2. Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization. (PMID: 10449909) Woitach J.T. … Thorgeirsson S.S. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. (PMID: 20080647) Shields D.J. … Cheresh D.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  4. Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10. (PMID: 12296629) Chen J.-Z. … Mao Y.-M. (Biochem. Genet. 2002) 3 23
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for RBBP9 Gene

Sources for RBBP9 Gene

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