Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBBP8NL Gene

Aliases for RBBP8NL Gene

  • RBBP8 N-Terminal Like 2 3 5
  • C20orf151 3 4
  • Chromosome 20 Open Reading Frame 151 2
  • Hypothetical Protein LOC140893 2
  • RBBP8 N-Terminal-Like Protein 3

External Ids for RBBP8NL Gene

Previous HGNC Symbols for RBBP8NL Gene

  • C20orf151

Previous GeneCards Identifiers for RBBP8NL Gene

  • GC20M060986

Summaries for RBBP8NL Gene

GeneCards Summary for RBBP8NL Gene

RBBP8NL (RBBP8 N-Terminal Like) is a Protein Coding gene. An important paralog of this gene is RBBP8.

Additional gene information for RBBP8NL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBBP8NL Gene

Genomics for RBBP8NL Gene

GeneHancer (GH) Regulatory Elements for RBBP8NL Gene

Promoters and enhancers for RBBP8NL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I062425 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 555.9 -1.3 -1331 6.4 HDGF CLOCK FOXA2 NEUROD1 SIN3A ZBTB7B ZNF207 SP5 REST ZNF592 LOC105372710 RBBP8NL CABLES2 DIDO1 ARFGAP1 RPS21 YTHDF1 TAF4 LAMA5 MIR1-1
GH20I062423 Promoter 0.7 EPDnew 550.8 +3.9 3901 0.1 ZFHX2 REST EGR2 RBBP8NL CABLES2
GH20I061433 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +991.4 991399 5.2 PKNOX1 SIN3A FEZF1 ZNF2 ZBTB7B ETS1 GLIS2 FOS KLF13 REST LOC105372703 RBBP8NL CDH4 ENSG00000276786
GH20I062352 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 +65.6 65565 19.1 HDGF CLOCK SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LAMA5 LAMA5-AS1 ARFGAP1 YTHDF1 MTG2 CABLES2 OSBPL2 BHLHE23 MRGBP ADRM1
GH20I062349 Enhancer 0.5 FANTOM5 dbSUPER 1.5 +78.0 78048 0.3 CDC5L LAMA5-AS1 CABLES2 BHLHE23 LAMA5 RBBP8NL SLCO4A1 SS18L1 TAF4 MIR4758
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBBP8NL on UCSC Golden Path with GeneCards custom track

Genomic Locations for RBBP8NL Gene

Genomic Locations for RBBP8NL Gene
chr20:62,410,237-62,427,680
(GRCh38/hg38)
Size:
17,444 bases
Orientation:
Minus strand
chr20:60,985,293-61,002,629
(GRCh37/hg19)

Genomic View for RBBP8NL Gene

Genes around RBBP8NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBBP8NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBBP8NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBBP8NL Gene

Proteins for RBBP8NL Gene

  • Protein details for RBBP8NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC74-RB8NL_HUMAN
    Recommended name:
    RBBP8 N-terminal-like protein
    Protein Accession:
    Q8NC74
    Secondary Accessions:
    • B2RP98
    • Q8N4Z9
    • Q9BR75
    • Q9H0Y9

    Protein attributes for RBBP8NL Gene

    Size:
    664 amino acids
    Molecular mass:
    71432 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBBP8NL Gene

Post-translational modifications for RBBP8NL Gene

No Post-translational modifications

Other Protein References for RBBP8NL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBBP8NL Gene

Domains & Families for RBBP8NL Gene

Gene Families for RBBP8NL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBBP8NL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBBP8NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBBP8NL: view

No data available for UniProtKB/Swiss-Prot for RBBP8NL Gene

Function for RBBP8NL Gene

Phenotypes From GWAS Catalog for RBBP8NL Gene

genes like me logo Genes that share phenotypes with RBBP8NL: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBBP8NL Gene

Localization for RBBP8NL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBBP8NL gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RBBP8NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
genes like me logo Genes that share ontologies with RBBP8NL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RBBP8NL Gene

Pathways & Interactions for RBBP8NL Gene

SuperPathways for RBBP8NL Gene

No Data Available

Interacting Proteins for RBBP8NL Gene

Selected Interacting proteins: Q8NC74-RB8NL_HUMAN for RBBP8NL Gene via IID

Symbol External ID(s) Details
NFKB1

Gene Ontology (GO) - Biological Process for RBBP8NL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBBP8NL Gene

Drugs & Compounds for RBBP8NL Gene

No Compound Related Data Available

Transcripts for RBBP8NL Gene

mRNA/cDNA for RBBP8NL Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBBP8NL Gene

RBBP8 N-terminal like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBBP8NL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for RBBP8NL Gene

GeneLoc Exon Structure for
RBBP8NL
ECgene alternative splicing isoforms for
RBBP8NL

Expression for RBBP8NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBBP8NL Gene

mRNA differential expression in normal tissues according to GTEx for RBBP8NL Gene

This gene is overexpressed in Esophagus - Mucosa (x9.1).

Protein differential expression in normal tissues from HIPED for RBBP8NL Gene

This gene is overexpressed in Plasma (41.7), Platelet (12.7), and Heart (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBBP8NL Gene



Protein tissue co-expression partners for RBBP8NL Gene

NURSA nuclear receptor signaling pathways regulating expression of RBBP8NL Gene:

RBBP8NL

SOURCE GeneReport for Unigene cluster for RBBP8NL Gene:

Hs.180374
genes like me logo Genes that share expression patterns with RBBP8NL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBBP8NL Gene

Orthologs for RBBP8NL Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBBP8NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBBP8NL 33 34
  • 98.49 (n)
cow
(Bos Taurus)
Mammalia RBBP8NL 33 34
  • 78.09 (n)
dog
(Canis familiaris)
Mammalia RBBP8NL 33 34
  • 76.91 (n)
mouse
(Mus musculus)
Mammalia Rbbp8nl 33 16 34
  • 74.64 (n)
rat
(Rattus norvegicus)
Mammalia Rbbp8nl 33
  • 74.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RBBP8NL 34
  • 46 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBBP8NL 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBBP8NL 34
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBBP8NL 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75903 33
zebrafish
(Danio rerio)
Actinopterygii RBBP8NL 34
  • 24 (a)
OneToOne
Species where no ortholog for RBBP8NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBBP8NL Gene

ENSEMBL:
Gene Tree for RBBP8NL (if available)
TreeFam:
Gene Tree for RBBP8NL (if available)

Paralogs for RBBP8NL Gene

Paralogs for RBBP8NL Gene

(1) SIMAP similar genes for RBBP8NL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RBBP8NL: view

Variants for RBBP8NL Gene

Sequence variations from dbSNP and Humsavar for RBBP8NL Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000399386 -- 62,424,974(-) G/A intron_variant
rs1000543361 -- 62,425,773(-) G/A intron_variant
rs1000734976 -- 62,426,016(-) G/T intron_variant
rs1000745131 -- 62,415,349(-) C/T intron_variant
rs1001172203 -- 62,412,317(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBBP8NL Gene

Variant ID Type Subtype PubMed ID
dgv4343n100 CNV gain 25217958
dgv518n27 CNV loss 19166990
dgv7651n54 CNV loss 21841781
esv1285282 CNV insertion 17803354
esv1744911 CNV insertion 17803354
esv2422398 CNV duplication 17116639
esv2722812 CNV deletion 23290073
esv2722813 CNV deletion 23290073
esv2722814 CNV deletion 23290073
esv3324139 CNV duplication 20981092
nsv1136561 CNV deletion 24896259
nsv459065 CNV gain 19166990
nsv459067 CNV loss 19166990
nsv470556 CNV loss 18288195
nsv470557 CNV gain 18288195
nsv518296 CNV loss 19592680
nsv520024 CNV loss 19592680
nsv586496 CNV gain 21841781
nsv586497 CNV loss 21841781
nsv586498 CNV loss 21841781
nsv586499 CNV loss 21841781
nsv586500 CNV gain 21841781
nsv834024 CNV gain 17160897
nsv953302 CNV deletion 24416366

Variation tolerance for RBBP8NL Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.57; 88.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBBP8NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBBP8NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBBP8NL Gene

Disorders for RBBP8NL Gene

Additional Disease Information for RBBP8NL

No disorders were found for RBBP8NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBBP8NL Gene

Publications for RBBP8NL Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) Böhm D … Grus FH (Oncology reports 2012) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for RBBP8NL Gene

Sources for RBBP8NL Gene

Content
Loading form....