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RBBP8 Gene

protein-coding GIFtS: 60

GC18P018767

retinoblastoma binding protein 8
(Previous name: retinoblastoma-binding protein 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CTIP ^², ³
CtIP ^¹, ³
RBBP-8 ^³
RIM ^¹, ², ³, ⁵

Descriptions
CtBP-interacting protein ^², ³
Retinoblastoma-interacting protein and myosin-like ^³
retinoblastoma binding protein 8 ^²
retinoblastoma-binding protein 8 ^¹
retinoblastoma-interacting myosin-like ^²

External Ids
HGNC: 9891¹
Entrez Gene: 5932²
UniProtKB: Q99708³
Ensembl: ENSG00000101773⁷

Search outside databases for aliases for RBBP8 gene

Previous GC identifers: GC18P020402 GC18P020243 GC18P018765

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RBBP8:

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among

several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation.

This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1

and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair,

and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor

suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different

isoforms have been found for this gene. More transcript variants exist, but their full-length

natures have not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: RBBP8_HUMAN, Q99708

Function: May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair,

and/or cell cycle checkpoint control

Gene Wiki entry for RBBP8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RBBP8 gene

Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2

RBBP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P018767: (about GC identifiers)

Start:	18,767,293 bp from pter
End:	18,860,447 bp from pter
Size:	93,155 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_010966.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RBBP8_HUMAN, Q99708 (See protein sequence)

Recommended Name: Retinoblastoma-binding protein 8

Size: 897 amino acids; 101942 Da

Subunit: Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the

retinoblastoma protein

Subcellular location: Nucleus. Note=Predominantly nuclear

Secondary accessions: O75371

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylation upon ionizing

radiation results in dissociation from BRCA1¹

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_002885.1 NP_976036.1 NP_976037.1

ENSEMBL proteins:

ENSP00000382627 ENSP00000354024 ENSP00000323050 ENSP00000382628 ENSP00000324019 ENSP00000382630

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CtIP)
	Human Recombinant Proteins from Abnova (RBBP8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	10764811

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Antibodies for RBBP8:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse R&D Systems for Antibodies
	Antibodies from Abcam (CtIP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for RBBP8

Assays for RBBP8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q99708

ProtoNet protein and cluster: Q99708

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RBBP8)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_203291

Applied Biosystems Silencer® siRNAs for RBBP8

Sigma-Aldrich siRNA for RBBP8

Sigma-Aldrich shRNA for RBBP8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RBBP8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002894
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002894
untagged cDNA clones in CMV expression vector (see all 3): NM_002894

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_203291

UniProtKB/Swiss-Prot: RBBP8_HUMAN, Q99708

Function: May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair,

and/or cell cycle checkpoint control

Genatlas biochemistry entry for RBBP8:

retinoblastoma binding protein,ubiquitously expressed

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rbbp8):

cellular

embryogenesis

lethality-prenatal/perinatal

life span-post-weaning/aging

tumorigenesis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11739404 17525340

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for RBBP8 (Your Favorite Gene powered by Ingenuity)

Role of BRCA1 in DNA Damage Response

GeneDecks RBBP8 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for RBBP8

5/29 Interacting proteins for RBBP8 (Q99708^{1, 2} ENSP00000354024³) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTBP1	Q13363², ENSP00000372411³	MINT-14617 MINT-14619 MINT-14618 STRING (score=.998)
RBL2	Q08999², ENSP00000262133³	MINT-16160 MINT-16159 STRING (score=.867)
BRCA1	P38398¹, ENSP00000350283³	EBI-1263531, EBI-349905 STRING (score=.999)
RB1	P06400², ENSP00000267163³	MINT-6628409 STRING (score=.98)
FAM175A	Q6UWZ7¹, ENSP00000369857³	EBI-1263531, EBI-1263451 STRING (score=.951)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	10764811
GO:0006281	DNA repair	TAS	10764811
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	10764811

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RBBP8
1 Novoseek chemical compound relationship for RBBP8 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mononucleotide	63.09	1	11429044 (1)

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2 PharmGKB drug compound relationships for RBBP8 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RBBP8)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_203291

Sigma-Aldrich siRNA for RBBP8

Sigma-Aldrich shRNA for RBBP8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002894 NM_203291 NM_203292

REFSEQ mRNAs for RBBP8 gene (3 alternative transcripts):

NM_002894.2 NM_203291.1 NM_203292.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002894 NM_203291 NM_203292

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002894
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002894
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002894

Additional cDNA sequence:

AF043431.1 AK292481.1 BC001170.1 BC030590.1 BX648221.1 U72066.1

14 DOTS entries:

DT.40110885 DT.97801054 DT.95070973 DT.100786190 DT.91747826 DT.100786187 DT.99975159 DT.100786189

DT.121102569 DT.95070978 DT.95070970 DT.121102587 DT.121102589 DT.91748341

24/144 AceView cDNA sequences (see all 144 ):

CA397322 AA588525 BU153752 NM_002894 BU165419 BU688695 AI815630 BQ008527

AA872648 AI143190 AL121284 CB134403 AA669460 AU134404 NM_203292 NM_203291

AL710887 R72771 AA172171 CB217112 BQ949160 CB134400 AA639365 BC001170

highest scoring ESTs for RBBP8:

U72066 AI554877 AI699234 AI767193 AI868589 AI873632 AW151433 AW384064 AW392426 BG182747

Unigene Cluster for RBBP8:

Retinoblastoma binding protein 8

Hs.546282 [show with all ESTs]

Unigene Representative Sequence: NM_002894

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RBBP8 (see all 7 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^
SP1:			-		-		-		-				-		-						-																								-
SP2:							-		-				-		-						-																								-
SP3:									-				-		-						-																								-						-
SP4:													-		-						-
SP5:													-		-						-

ExUns:	20	^	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for RBBP8

6 Ensembl transcripts including schematic representations:

ENST00000399721 ENST00000360790 ENST00000327155 ENST00000399722 ENST00000327174 ENST00000399725

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RBBP8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RBBP8

¹ / ² / ³

3 probe-sets matching RBBP8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35227_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U72066	1.00	0.87	0.94	1
203344_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002894	0.60	1.00	0.82	1
203344_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RBBP8 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.546282
Expression variation in blood from EXPOLDB for RBBP8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RBBP8 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RBBP8¹	--	retinoblastoma binding protein 8	88.33(n) 83(a)	480175 XM_537299.2 XP_537299.1
chimpanzee (Pan troglodytes)	RBBP8¹	--	retinoblastoma binding protein 8	99.18(n) 98.88(a)	455333 XM_001153277.1 XP_001153277.1
cow (Bos taurus)	RBBP8¹	--	retinoblastoma binding protein 8	87.76(n) 83(a)	512977 XM_590590.3 XP_590590.3
rat (Rattus norvegicus)	Rbbp8¹	--	retinoblastoma binding protein 8	82.05(n) 75.36(a)	291787 XM_214620.4 XP_214620.4
mouse (Mus musculus)	Rbbp8^{1, 5}	18⁵	retinoblastoma binding protein 8^{1, 5}	83.61(n)¹ 76.37(a)¹	225182¹ NM_001081223.1¹ NP_001074692.1¹ AA116624⁵ AI465376⁵ (see all 17)

About this table Species with no ortholog for RBBP8

ENSEMBL Gene Tree for RBBP8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RBBP8 gene

C20orf151²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/430 NCBI SNPs in RBBP8 are shown (see all 430 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 108)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9304261^1,2	A,C,F,H	18860594(+)	`TCTAGC/TATTTA`	3	--	ng3¹		4		EU EA WA	420
	rs7239066^1,2	A,C,F,H	18766021(+)	`actgcG/Atgatg`	3	--	ng5¹		4		EU EA WA	420
	rs2305885^1,2	C,F,H	18766358(+)	`ATGGGG/TAAGTG`	3	--	ng5¹		8		EU EA WA	836
	rs34678569^1,2	C,F	18826859(+)	`AAAAAA/CCATCT`	3	K/N	mis¹		5		NA EU EA WA	494
--	rs7227956^1,2	A,C	18767816(+)	`CGCTTC/GGGAGG`	3	--	ng5¹ int¹		0	--	--	--	--
--	rs7226951^1,2	A	18767203(+)	`CGCACC/TGAAGA`	3	--	ng5¹		0	--	--	--	--
--	rs7240646^1,2	A	18765941(+)	`aagaaA/Gtaaca`	3	--	ng5¹ tfbs³		0	--	--	--	--
--	rs7227168^1,2	A	18767372(+)	`GCGGGC/TTGTCC`	3	--	ng5¹ ut5¹		0	--	--	--	--
	rs971543^1,2	A,C,F,H,O	18784560(+)	`CCCACA/GATATC`	3	--	int¹		7		EU EA WA NA	560
	rs4335860^1,2	A,C,F,H	18810625(+)	`ATCCCG/ATCTGG`	3	--	int¹		7		EU EA WA NA	556

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HapMap Linkage Disequilibrium images for RBBP8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 604124

5 Novoseek disease relationships for RBBP8 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	47.28	1	14562366 (1)
microsatellite instability	39.17	1	11429044 (1)
breast cancer	28.19	21	18171986 (8), 15473135 (1)
tumors	21.19	5	9811458 (2), 10764811 (1), 12957814 (1), 16101277 (1)
cancer	12.12	2	12414815 (1), 12957814 (1)

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1 PharmGKB disease relationship for RBBP8 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12086872 12704389

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Human Genome Epidemiology Navigator: RBBP8 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/60 PubMed articles for RBBP8 gene (see all 60 ):

Molecular cloning and characterization of a novel retinoblastoma- binding protein. (PubMed id 9721205)^{1, 2, 3, 4} Fusco C.... Zervos A.S. (1998)
Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. (PubMed id 10764811)^{1, 3, 4} Yu X. and Baer R. (2000)
SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. (PubMed id 14654780)^{1, 3, 4} Germani A....Bruzzoni-Giovanelli H. (2003)
Human CtIP promotes DNA end resection. (PubMed id 17965729)^{1, 2, 3} Sartori A.A....Jackson S.P. (2007)
Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. (PubMed id 9535825)^{1, 3, 4} Schaeper U.... Chinnadurai G. (1998)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. (PubMed id 10910365)^{3, 4} Li S.... Lee W.-H. (2000)
CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. (PubMed id 18171986)^{1, 3} Wu M....Aldaz C.M. (2007)
C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3. (PubMed id 17546052)^{1, 3} Bruton R.K....Grand R.J. (2007)
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. (PubMed id 18171670)^{1, 3} Chen L....Wu X. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5932	HGNC: 9891	AceView: RBBP8	Ensembl:ENSG00000101773	euGenes: HUgn5932
ECgene: RBBP8	H-InvDB: RBBP8

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RBBP8	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RBBP8
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RBBP8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RBBP8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RBBP8		Browse antibodies at Sigma-Aldrich
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RBBP8 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for RBBP8

Summaries
for RBBP8

Genomic Location
for RBBP8

Proteins
for RBBP8

Protein Domains/
Families
for RBBP8

Gene Function
for RBBP8

Pathways & Interactions
for RBBP8

Drugs & Compounds
for RBBP8

Transcripts
for RBBP8

Expression
for RBBP8

Orthologs
for RBBP8

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SNPs/Variants
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Disorders & Mutations
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Medical News
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Services
for RBBP8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RBBP8 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor RBBP8

Summariesfor RBBP8

Genomic Locationfor RBBP8

Proteinsfor RBBP8

Protein Domains/Familiesfor RBBP8

Gene Functionfor RBBP8

Pathways & Interactionsfor RBBP8

Drugs & Compoundsfor RBBP8

Transcriptsfor RBBP8

Expression for RBBP8

Orthologsfor RBBP8

Paralogsfor RBBP8

SNPs/Variantsfor RBBP8

Disorders & Mutationsfor RBBP8

Medical Newsfor RBBP8

Publicationsfor RBBP8

Search for RBBP8

Genome Databases showing RBBP8

Other Databases showing RBBP8

Specialized Databases showing RBBP8

Licensable Technologiesfor RBBP8

Servicesfor RBBP8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RBBP8

Summaries
for RBBP8

Genomic Location
for RBBP8

Proteins
for RBBP8

Protein Domains/
Families
for RBBP8

Gene Function
for RBBP8

Pathways & Interactions
for RBBP8

Drugs & Compounds
for RBBP8

Transcripts
for RBBP8

Expression
for RBBP8

Orthologs
for RBBP8

Paralogs
for RBBP8

SNPs/Variants
for RBBP8

Disorders & Mutations
for RBBP8

Medical News
for RBBP8

Publications
for RBBP8

Licensable Technologies
for RBBP8

Services
for RBBP8