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Aliases for RBBP7 Gene

Aliases for RBBP7 Gene

  • RB Binding Protein 7, Chromatin Remodeling Factor 2 3 5
  • Retinoblastoma-Binding Protein 7 2 2 3 4
  • Histone Acetyltransferase Type B Subunit 2 2 3 4
  • Retinoblastoma-Binding Protein P46 2 3 4
  • G1/S Transition Control Protein-Binding Protein RbAp46 2 3
  • Nucleosome-Remodeling Factor Subunit RBAP46 3 4
  • Retinoblastoma-Binding Protein RbAp46 2 3
  • RbAp46 3 4
  • RBBP-7 3 4
  • Retinoblastoma Binding Protein 7 2
  • Histone-Binding Protein RBBP7 3
  • RB Binding Protein 7 2

External Ids for RBBP7 Gene

Previous GeneCards Identifiers for RBBP7 Gene

  • GC0XM016594
  • GC0XM015730
  • GC0XM016063
  • GC0XM016225
  • GC0XM016226
  • GC0XM016622
  • GC0XM014625

Summaries for RBBP7 Gene

Entrez Gene Summary for RBBP7 Gene

  • This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBBP7 Gene

RBBP7 (RB Binding Protein 7, Chromatin Remodeling Factor) is a Protein Coding gene. Diseases associated with RBBP7 include Retinoblastoma and Wilms Tumor Susceptibility-5. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include RNA binding. An important paralog of this gene is RBBP4.

UniProtKB/Swiss-Prot for RBBP7 Gene

  • Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Gene Wiki entry for RBBP7 Gene

Additional gene information for RBBP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBBP7 Gene

Genomics for RBBP7 Gene

Regulatory Elements for RBBP7 Gene

Enhancers for RBBP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH016770 1.3 Ensembl ENCODE 24 +98.6 98555 2 HNRNPUL1 ARNT ARID4B FEZF1 ZNF2 YY1 ZNF302 ZNF143 FOS NFYC RBBP7 NHS GC0XP016767 TXLNG
GH0XH016824 1.2 Ensembl ENCODE 25.8 +43.5 43454 4 TBP FOXA2 ZNF133 INSM2 ARID4B BATF BRCA1 ZBTB40 RAD21 RFX5 RBBP7 TXLNG ENSG00000201467 CTPS2 GC0XP016842 RPL12P49
GH0XH016837 1.1 Ensembl ENCODE 27.3 +31.1 31128 3 FOXA2 BRCA1 ZNF2 RFX5 EGR1 ZNF366 RCOR1 CEBPB NR2F2 MAFF RBBP7 ENSG00000201467 GC0XP016842 RPL12P49
GH0XH016785 1.4 FANTOM5 ENCODE 16.7 +83.7 83684 2 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 FOS SP3 RBBP7 TXLNG RPL12P49
GH0XH016822 0.6 ENCODE 34 +47.1 47102 2 JUND JUN SCRT2 ZNF629 FOS ZBTB33 PRDM1 RBBP7 TXLNG ENSG00000201467 GC0XP016842 RPL12P49
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBBP7 on UCSC Golden Path with GeneCards custom track

Promoters for RBBP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244874 442 2801 HDGF PKNOX1 ATF1 ARNT SIN3A FEZF1 BRCA1 GLIS2 ZNF143 ZNF207

Genomic Location for RBBP7 Gene

Chromosome:
X
Start:
16,839,283 bp from pter
End:
16,870,442 bp from pter
Size:
31,160 bases
Orientation:
Minus strand

Genomic View for RBBP7 Gene

Genes around RBBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBBP7 Gene

Proteins for RBBP7 Gene

  • Protein details for RBBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16576-RBBP7_HUMAN
    Recommended name:
    Histone-binding protein RBBP7
    Protein Accession:
    Q16576
    Secondary Accessions:
    • Q5JP00

    Protein attributes for RBBP7 Gene

    Size:
    425 amino acids
    Molecular mass:
    47820 Da
    Quaternary structure:
    • Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12 (PubMed:12435631). The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (PubMed:7503932, PubMed:10220405). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1. Interacts with CENPA (PubMed:25556658).

    Three dimensional structures from OCA and Proteopedia for RBBP7 Gene

    Alternative splice isoforms for RBBP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBBP7 Gene

Post-translational modifications for RBBP7 Gene

  • Ubiquitination at Lys101, isoforms=2142, Lys155, Lys159, and isoforms=2316
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RBBP7 Gene

Domains & Families for RBBP7 Gene

Graphical View of Domain Structure for InterPro Entry

Q16576

UniProtKB/Swiss-Prot:

RBBP7_HUMAN :
  • Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
Family:
  • Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
genes like me logo Genes that share domains with RBBP7: view

Function for RBBP7 Gene

Molecular function for RBBP7 Gene

UniProtKB/Swiss-Prot Function:
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Gene Ontology (GO) - Molecular Function for RBBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 7503932
genes like me logo Genes that share ontologies with RBBP7: view
genes like me logo Genes that share phenotypes with RBBP7: view

Animal Models for RBBP7 Gene

MGI Knock Outs for RBBP7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBBP7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBBP7 Gene

Localization for RBBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBBP7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBBP7 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RBBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16791210
GO:0005654 nucleoplasm TAS,IDA --
GO:0005829 cytosol IDA --
GO:0016581 NuRD complex IDA,IEA 19644445
GO:0035098 ESC/E(Z) complex IDA 20075857
genes like me logo Genes that share ontologies with RBBP7: view

Pathways & Interactions for RBBP7 Gene

genes like me logo Genes that share pathways with RBBP7: view

Gene Ontology (GO) - Biological Process for RBBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 7503932
genes like me logo Genes that share ontologies with RBBP7: view

No data available for SIGNOR curated interactions for RBBP7 Gene

Drugs & Compounds for RBBP7 Gene

No Compound Related Data Available

Transcripts for RBBP7 Gene

Unigene Clusters for RBBP7 Gene

Retinoblastoma binding protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBBP7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBBP7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - -
SP7: -
SP8: - -
SP9: - - -
SP10: - - -
SP11:
SP12: -

ExUns: 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RBBP7 Gene

GeneLoc Exon Structure for
RBBP7
ECgene alternative splicing isoforms for
RBBP7

Expression for RBBP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBBP7 Gene

Protein differential expression in normal tissues from HIPED for RBBP7 Gene

This gene is overexpressed in Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBBP7 Gene



Protein tissue co-expression partners for RBBP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBBP7 Gene:

RBBP7

SOURCE GeneReport for Unigene cluster for RBBP7 Gene:

Hs.495755

Evidence on tissue expression from TISSUES for RBBP7 Gene

  • Kidney(4.6)
  • Liver(4.4)
  • Nervous system(4.4)
  • Lung(3.4)
  • Intestine(3.1)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Gall bladder(2.8)
  • Heart(2.8)
  • Lymph node(2.8)
  • Muscle(2.8)
  • Pancreas(2.8)
  • Skin(2.8)
  • Spleen(2.8)
  • Stomach(2.8)
  • Thyroid gland(2.8)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with RBBP7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBBP7 Gene

Orthologs for RBBP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBBP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBBP7 33 34
  • 98.75 (n)
oppossum
(Monodelphis domestica)
Mammalia RBBP7 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBBP7 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBBP7 33 34
  • 94.08 (n)
rat
(Rattus norvegicus)
Mammalia Rbbp7 33
  • 93.68 (n)
mouse
(Mus musculus)
Mammalia Rbbp7 33 16 34
  • 93.21 (n)
dog
(Canis familiaris)
Mammalia RBBP7 33 34
  • 92.89 (n)
chicken
(Gallus gallus)
Aves RBBP7 33 34
  • 82.11 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbbp7 33
  • 82.07 (n)
MGC76124 33
African clawed frog
(Xenopus laevis)
Amphibia rbbp7-prov 33
zebrafish
(Danio rerio)
Actinopterygii rbb4l 33 34
  • 77.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Caf1 35
  • 86 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-53 34
  • 71 (a)
ManyToMany
rba-1 35 34
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAT2 34
  • 37 (a)
OneToMany
Species where no ortholog for RBBP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBBP7 Gene

ENSEMBL:
Gene Tree for RBBP7 (if available)
TreeFam:
Gene Tree for RBBP7 (if available)

Paralogs for RBBP7 Gene

Paralogs for RBBP7 Gene

(4) SIMAP similar genes for RBBP7 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for RBBP7 Gene

genes like me logo Genes that share paralogs with RBBP7: view

Variants for RBBP7 Gene

Sequence variations from dbSNP and Humsavar for RBBP7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000078108 -- 16,846,144(+) ACAAT(A/G)GATAC intron-variant
rs1000084735 -- 16,862,459(+) GAATA(C/T)TGTAA intron-variant
rs1000248276 -- 16,858,367(+) CAAAA(C/T)ATGTC intron-variant
rs1000306588 -- 16,866,163(+) GTCTC(A/G)ATATA intron-variant
rs1000359868 -- 16,866,332(+) ACCAG(C/T)CTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBBP7 Gene

Variant ID Type Subtype PubMed ID
esv29438 CNV loss 19812545
esv3302821 CNV tandem duplication 20981092
nsv1141051 CNV deletion 24896259
nsv511654 CNV gain 21212237

Variation tolerance for RBBP7 Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBBP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBBP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBBP7 Gene

Disorders for RBBP7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBBP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
wilms tumor susceptibility-5
  • wilms tumor
- elite association - COSMIC cancer census association via MalaCards
Search RBBP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RBBP7

Genetic Association Database (GAD)
RBBP7
Human Genome Epidemiology (HuGE) Navigator
RBBP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBBP7
genes like me logo Genes that share disorders with RBBP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBBP7 Gene

Publications for RBBP7 Gene

  1. BRCA1 interacts with components of the histone deacetylase complex. (PMID: 10220405) Yarden RI … Brody LC (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 22 60
  2. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. (PMID: 10444591) Zhang Y … Reinberg D (Genes & development 1999) 3 4 22 60
  3. Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. (PMID: 7503932) Qian YW … Lee EY (The Journal of biological chemistry 1995) 2 3 4 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Analysis of interaction partners of H4 histone by a new proteomics approach. (PMID: 19862764) Saade E … Ogryzko V (Proteomics 2009) 3 22 60

Products for RBBP7 Gene

Sources for RBBP7 Gene

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