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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RBBP7 Gene

protein-coding GIFtS: 63
GCID: GC0XM016772

retinoblastoma binding protein 7

(Previous name: retinoblastoma-binding protein 7 )

Explore 12 diseases affiliated with
RBBP7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Retinoblastoma Binding Protein 7¹ ²		RBBP-7² ³
Retinoblastoma-Binding Protein 7¹ ² ³		G1/S Transition Control Protein-Binding Protein RbAp46²
RbAp46¹ ²		Histone-Binding Protein RBBP7²
Histone Acetyltransferase Type B Subunit 2² ³		Retinoblastoma-Binding Protein RbAp46²
Nucleosome-Remodeling Factor Subunit RBAP46² ³		RBAP46³
Retinoblastoma-Binding Protein P46² ³

External Ids:	HGNC: 9890¹	Entrez Gene: 5931²	Ensembl: ENSG00000102054⁷	OMIM: 300825⁵	UniProtKB: Q16576³

Export aliases for RBBP7 gene to outside databases

Previous GC identifers: GC0XM016594 GC0XM015730 GC0XM016063 GC0XM016225 GC0XM016226 GC0XM016622 GC0XM014625

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBBP7:

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat

proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell

proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor

complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1

tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: RBBP7_HUMAN, Q16576

Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and

histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of

several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT)

complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC)

complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and

histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and

nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development;

and the NURF (nucleosome remodeling factor) complex

Gene Wiki entry for RBBP7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RBBP7 gene promoter:
E2F-3a E2F-4 E2F-5 AP-1 ATF-2 E2F-2 E2F E2F-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RBBP7 promoter sequence

Search SABiosciences Chromatin IP Primers for RBBP7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBBP7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.22

RBBP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBBP7 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM016772: view genomic region (about GC identifiers)

Start:	16,857,406 bp from pter	End:	16,888,537 bp from pter
Size:	31,132 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBBP7_HUMAN, Q16576 (See protein sequence)

Recommended Name: Histone-binding protein RBBP7

Size: 425 amino acids; 47820 Da

Subunit: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in

chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the

core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex

associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the

SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome

remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and

MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4,

RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor

(NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of

the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of

phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1

Subcellular location: Nucleus

2 PDB 3D structures from and Proteopedia for RBBP7:

3CFS (3D)

3CFV (3D)

Secondary accessions: Q5JP00

Alternative splicing: 2 isoforms: Q16576-1 Q16576-2 (No experimental confirmation available. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 13)

Explore the universe of human proteins at neXtProt for RBBP7: NX_Q16576

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16576

RBBP7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001185648.1 NP_002884.1

ENSEMBL proteins:

ENSP00000415747 ENSP00000369427 ENSP00000369424 ENSP00000386068 ENSP00000402796

ENSP00000392714 ENSP00000418139 ENSP00000417791 ENSP00000417507

Reactome Protein details: Q16576
Human Recombinant Protein Products:

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	Novus Biologicals RBBP7 Protein Novus Biologicals RBBP7 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RBBP7

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0016581	NuRD complex	IDA	19644445
GO:0035098	ESC/E(Z) complex	IDA	--

RBBP7 for ontologies About GeneDecksing

RBBP7 Antibody Products:

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	ThermoFisher Antibody for RBBP7

Assay Products for RBBP7:

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	Uscn ELISAs and CLIAs for RBBP7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RBBP7 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR019775 WD40_repeat_CS

IPR022052 Histone-bd_RBBP4

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR017986 WD40_repeat_dom

Graphical View of Domain Structure for InterPro Entry Q16576

ProtoNet protein and cluster: Q16576

1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: RBBP7_HUMAN, Q16576

Similarity: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RBBP7_HUMAN, Q16576

Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and

histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of

several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT)

complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC)

complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and

histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and

nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development;

and the NURF (nucleosome remodeling factor) complex

miRNA Products:		OriGene 3'-UTR Clone: RBBP7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RBBP7
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate RBBP7:
		hsa-miR-181c hsa-miR-518a-5p hsa-miR-101 hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
		SwitchGear 3'UTR luciferase reporter plasmid: RBBP7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBBP7

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19497860

RBBP7 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RBBP7:

Increased cell number in G1, a

Animal Models:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rbbp7):

embryogenesis

hematopoietic system

immune system

RBBP7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

RSF Complex Binds the Centromere.

	RSF Complex Binds the Centromere.	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere	1.00
	Nucleosome assembly	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere.	0.96

Transcription_Sin3 and NuRD in transcription regulation

Transcription_Sin3 and NuRD in transcription regulation

1.00

Transcription Sin3 and NuRD in transcription regulation

0.96

Development_Notch Signaling Pathway

Development_Notch Signaling Pathway

1.00

Development Notch Signaling Pathway

0.97

Transcription_P53 signaling pathway

Transcription_P53 signaling pathway

1.00

Transcription P53 signaling pathway

0.98

Development NOTCH1-mediated pathway for NF-KB activity modulation

Development NOTCH1-mediated pathway for NF-KB activity modulation

1.00

Development_NOTCH1-mediated pathway for NF-KB activity modulation

0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for RBBP7 (see all 6)

	Development Notch Signaling Pathway
	Transcription Sin3 and NuRD in transcription regulation
	Histone modification
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RBBP7

DNA Methylation and Transcriptional Repression

1 Cell Signaling Technology (CST) Pathway for RBBP7

Chromatin Regulation / Acetylation

5 GeneGo (Thomson Reuters) Pathways for RBBP7

	Transcription P53 signaling pathway
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription Sin3 and NuRD in transcription regulation
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Development Notch Signaling Pathway

5 BioSystems Pathways for RBBP7

	EGFR1 Signaling Pathway
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by HDAC Class I
	Regulation of Telomerase
	Regulation of nuclear SMAD2/3 signaling

5/6 Reactome Pathways for RBBP7 (see all 6)

	Deposition of New CENPA-containing Nucleosomes at the Centromere.
	Nucleosome assembly
	Cell Cycle
	RSF Complex Binds the Centromere.
	Deposition of New CENPA-containing Nucleosomes at the Centromere

RBBP7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RBBP7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/927 Interacting proteins for RBBP7 (Q16576^{1, 2, 3} ENSP00000369427⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 927)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805¹^,³, ENSP00000352980⁴	EBI-3505029,EBI-302023 I2D: score=3 STRING: ENSP00000352980
HIST1H4L	P62805¹^,³, ENSP00000348258⁴	EBI-3505029,EBI-302023 I2D: score=3 STRING: ENSP00000348258
HIST4H4	P62805¹^,³, ENSP00000350767⁴	EBI-3505029,EBI-302023 I2D: score=3 STRING: ENSP00000350767
HIST1H4B	P62805¹^,³	EBI-3505029,EBI-302023 I2D: score=3
HIST1H4C	P62805¹^,³	EBI-3505029,EBI-302023 I2D: score=3

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006260	DNA replication	IEA	--
GO:0006334	nucleosome assembly	TAS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--

RBBP7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RBBP7
Search CenterWatch for drugs/clinical trials and news about RBBP7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RBBP7 gene (2 alternative transcripts):

NM_001198719.1 NM_002893.3

Unigene Cluster for RBBP7:

Retinoblastoma binding protein 7

Hs.495755 [show with all ESTs]

Unigene Representative Sequence: AK127332

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000425696 ENST00000380087(uc004cxt.3) ENST00000330735 ENST00000380084(uc004cxs.2)

ENST00000465244 ENST00000404022 ENST00000481586 ENST00000444437 ENST00000416035

ENST00000486166(uc010nez.3) ENST00000465042 ENST00000468092 ENST00000493145

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate RBBP7:
		hsa-miR-181c hsa-miR-518a-5p hsa-miR-101 hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
		SwitchGear 3'UTR luciferase reporter plasmid: RBBP7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP7 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AK091911.1 AK127332.1 AK291567.1 AK310309.1 BC114500.1 BC114501.1 CR541701.1 U35143.1

X72841.1

24/36 DOTS entries (see all 36):

DT.95376562 DT.100880564 DT.100880557 DT.95376690 DT.100031134 DT.40258382 DT.100880552 DT.91772245

DT.100031137 DT.121292438 DT.97860397 DT.95377288 DT.121292473 DT.91772229 DT.100880553 DT.101980328

DT.121292394 DT.91772241 DT.100842911 DT.100880555 DT.121292355 DT.121292451 DT.121292478 DT.95376547

24/745 AceView cDNA sequences (see all 745):

BM699147 BQ000890 AI188952 F01457 AI433489 AU130143 AU116966 BI091969

BQ220335 AI619805 AV708644 CB215549 BG035964 CD513497 AI571050 AA411907

AA771883 BE883366 AA424052 BE044365 BU629635 BQ432370 CA423866 BM670268

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RBBP7 (see all 12) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	^	13a	·
SP1:					-		-																						-						-		-		-						-
SP2:							-																						-						-		-		-						-
SP3:																													-				-
SP4:																													-						-		-		-						-		-		-
SP5:					-		-												-

ExUns:	13b	·	13c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RBBP7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RBBP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGCTTGAT

About this image

RBBP7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RBBP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBBP7

SOURCE GeneReport for Unigene cluster: Hs.495755

SABiosciences Expression via Pathway-Focused PCR Arrays including RBBP7:

Polycomb & Trithorax Complexes in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBBP7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBBP7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBBP7 gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RBBP7¹	retinoblastoma binding protein 7	82.11(n) 93.59(a)		395390 NM_204670.1 NP_990001.1
African clawed frog (Xenopus laevis)	Amphibia	rbbp7-prov²	retinoblastoma binding protein 7	81.87(n)		BC042283.1
zebrafish (Danio rerio)	Actinopterygii	rbb4l⁶	retinoblastoma binding protein 4, like	89(a)	1 ↔ 1	11(12802549-12826559)
fruit fly (Drosophila melanogaster)	Insecta	Caf1³	negative regulation of transcription by homeotic more	86(a)		3 88E3 --
worm (Caenorhabditis elegans)	Secernentea	rba-1³	retinablastoma-binding protein RBAP46 like	51(a)		I(9624662-9626157) --
thale cress (Arabidopsis thaliana)	eudicotyledons	MSI1⁶ NFC02⁶ (see all 3)	histone-binding protein RBBP4 (see all 3)	65(a) 53(a) (see all 3)	many ↔ many many ↔ many (see all 3)	5(23556012-23558245) 2(7281462-7283646)
rice (Oryza sativa)	Liliopsida	-- --	WD domain, G-beta repeat domain containing protein... WD domain, G-beta repeat domain containing protein...	64(a) 49(a)	many ↔ many many ↔ many	3(24619371-24627583) 9(21275966-21280139)

ENSEMBL Gene Tree for RBBP7 (if available)
TreeFam Gene Tree for RBBP7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RBBP7 gene

RBBP4² RFWD2²

4 SIMAP similar genes for RBBP7 using alignment to 9 protein entries: RBBP7_HUMAN (see all proteins):

RBBP4 WSB1 POC1B WDR69

RBBP7 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RBBP7
PGOHUM00000238099

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57547802^1,2	C,	--	16862515(+)	`GAGGAC/TACGAA`	4	--	ut3¹ ds500¹		2		WA CSA	3
rs181875876^1,2		--	16862521(+)	`ACGAAC/TTGTTA`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs185289966^1,2		--	16862719(+)	`TTCTAC/TTCAAA`	4	--	ds500¹		0	--	--	--	--
rs3214937^1,2	C	--	16862740(+)	`CCCCG-/CCCCCC`	4	--	ds500¹		0	--	--	--	--
rs199744009^1,2	C	--	16862875(-)	`TTCTCA/CAACTA`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs189795519^1,2		--	16863010(+)	`CAACAA/GCTCAC`	4	--	ds500¹ ut3¹		0	--	--	--	--
rs181164513^1,2		--	16863046(+)	`AAGAAA/GCCATA`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs199796174^1,2		--	16863116(+)	`ATTCAC/TGTAGC`	4	--	ds500¹ ut3¹		0	--	--	--	--
rs201656534^1,2		--	16863122(+)	`GTAGCA/GTTACA`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs138778228^1,2	F	--	16863170(+)	`CCTTGT/ACCCTC`	4	/G	syn¹		1		NA	4544

HapMap Linkage Disequilibrium report for RBBP7 (16857406 - 16888537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RBBP7
1 CNV: 73938

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RBBP7 for disorders           About GeneDecksing

OMIM gene information: 300825    OMIM disorders: --

12 diseases for RBBP7:    About MalaCards

retinoblastoma b-cell non-hodgkin lymphoma non-hodgkin lymphoma hodgkin's lymphoma

wilms tumor dermatomyositis eosinophilia hematopoiesis

lung cancer breast cancer thyroiditis malaria

3 Novoseek disease relationships for RBBP7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	77.7	15	15682465 (2), 17201172 (2), 17927911 (1), 12767060 (1) (see all 11)
wilms tumor	52.5	3	12767060 (1), 9765217 (1), 11433396 (1)
tumors	0	3	11433396 (2), 12767060 (1)

Human Genome Epidemiology (HuGE) Navigator: RBBP7 (3 documents)

Export disorders for RBBP7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RBBP7 gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with RBBP7)

Utopia: connect your pdf to the dynamic
world of online information

Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. (PubMed id 7503932)^{1, 2, 3} Qian Y.-W. and Lee E.Y.-H.P. (1995)
BRCA1 interacts with components of the histone deacetylase complex. (PubMed id 10220405)^{1, 2, 9} Yarden R.I. and Brody L.C. (1999)
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. (PubMed id 10444591)^{1, 2, 9} Zhang Y....Reinberg D. (1999)
Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. (PubMed id 18571423)^{1, 2} Murzina N.V....Laue E.D. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
MBD3L1 is a transcriptional repressor that interacts with methyl-CpG- binding protein 2 (MBD2) and components of the NuRD complex. (PubMed id 15456747)^{1, 2} Jiang C.-L.... Pfeifer G.P. (2004)
Isolation of human NURF: a regulator of Engrailed gene expression. (PubMed id 14609955)^{1, 2} Barak O....Shiekhattar R. (2003)
The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. (PubMed id 12920132)^{1, 2} Yao Y.-L. and Yang W.-M. (2003)
Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). (PubMed id 11784859)^{1, 2} Kuzmichev A.... Reinberg D. (2002)
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. (PubMed id 12435631)^{1, 2} Kuzmichev A....Reinberg D. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5931	HGNC: 9890	AceView: RBBP7	Ensembl:ENSG00000102054	euGenes: HUgn5931
ECgene: RBBP7	H-InvDB: RBBP7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RBBP7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RBBP7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RBBP7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RBBP7 gene:
Search GeneIP for patents involving RBBP7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RBBP7 Gene

retinoblastoma binding protein 7

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RBBP7 Gene

retinoblastoma binding protein 7

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