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Aliases for RBBP7 Gene

Aliases for RBBP7 Gene

  • Retinoblastoma Binding Protein 7 2 3
  • Retinoblastoma-Binding Protein 7 2 2 3 4
  • Histone Acetyltransferase Type B Subunit 2 2 3 4
  • Retinoblastoma-Binding Protein P46 2 3 4
  • G1/S Transition Control Protein-Binding Protein RbAp46 2 3
  • Nucleosome-Remodeling Factor Subunit RBAP46 3 4
  • Retinoblastoma-Binding Protein RbAp46 2 3
  • RbAp46 3 4
  • RBBP-7 3 4
  • Histone-Binding Protein RBBP7 3

External Ids for RBBP7 Gene

Summaries for RBBP7 Gene

Entrez Gene Summary for RBBP7 Gene

  • This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBBP7 Gene

RBBP7 (Retinoblastoma Binding Protein 7) is a Protein Coding gene. Diseases associated with RBBP7 include retinoblastoma. Among its related pathways are Cell Cycle, Mitotic and Cellular Senescence. An important paralog of this gene is RBBP4.

UniProtKB/Swiss-Prot for RBBP7 Gene

  • Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Gene Wiki entry for RBBP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBBP7 Gene

Genomics for RBBP7 Gene

Genomic Location for RBBP7 Gene

Start:
16,839,283 bp from pter
End:
16,870,414 bp from pter
Size:
31,132 bases
Orientation:
Minus strand

Genomic View for RBBP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBBP7 Gene

Regulatory Elements for RBBP7 Gene

Proteins for RBBP7 Gene

  • Protein details for RBBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16576-RBBP7_HUMAN
    Recommended name:
    Histone-binding protein RBBP7
    Protein Accession:
    Q16576
    Secondary Accessions:
    • Q5JP00

    Protein attributes for RBBP7 Gene

    Size:
    425 amino acids
    Molecular mass:
    47820 Da
    Quaternary structure:
    • Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1.

    Three dimensional structures from OCA and Proteopedia for RBBP7 Gene

    Alternative splice isoforms for RBBP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBBP7 Gene

Proteomics data for RBBP7 Gene at MOPED

Post-translational modifications for RBBP7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21, Lys101, Lys119, Lys142, Lys155, Lys159, and Lys316

Other Protein References for RBBP7 Gene

No data available for DME Specific Peptides for RBBP7 Gene

Domains for RBBP7 Gene

Gene Families for RBBP7 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

RBBP7_HUMAN
Family:
  • Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.:
    • Q16576
Similarity:
  • Contains 7 WD repeats.:
    • Q16576
genes like me logo Genes that share domains with RBBP7: view

Function for RBBP7 Gene

Molecular function for RBBP7 Gene

UniProtKB/Swiss-Prot Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Gene Ontology (GO) - Molecular Function for RBBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with RBBP7: view

Phenotypes for RBBP7 Gene

genes like me logo Genes that share phenotypes with RBBP7: view

miRNA for RBBP7 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBBP7 Gene

Localization for RBBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBBP7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBBP7 Gene COMPARTMENTS Subcellular localization image for RBBP7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16791210
GO:0005654 nucleoplasm TAS --
GO:0016581 NuRD complex IDA 19644445
GO:0035098 ESC/E(Z) complex IDA 20075857
genes like me logo Genes that share ontologies with RBBP7: view

Pathways for RBBP7 Gene

genes like me logo Genes that share pathways with RBBP7: view

Gene Ontology (GO) - Biological Process for RBBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006260 DNA replication IEA --
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly TAS --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RBBP7: view

Transcripts for RBBP7 Gene

Unigene Clusters for RBBP7 Gene

Retinoblastoma binding protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBBP7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - -
SP7: -
SP8: - -
SP9: - - -
SP10: - - -
SP11:
SP12: -

ExUns: 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RBBP7 Gene

GeneLoc Exon Structure for
RBBP7
ECgene alternative splicing isoforms for
RBBP7

Expression for RBBP7 Gene

mRNA expression in normal human tissues for RBBP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBBP7 Gene

SOURCE GeneReport for Unigene cluster for RBBP7 Gene Hs.495755

genes like me logo Genes that share expressions with RBBP7: view

Orthologs for RBBP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBBP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBBP7 36
  • 98.75 (n)
  • 98.24 (a)
RBBP7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBBP7 36
  • 94.08 (n)
  • 98.82 (a)
RBBP7 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBBP7 36
  • 92.89 (n)
  • 95.52 (a)
RBBP7 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbbp7 36
  • 93.21 (n)
  • 99.05 (a)
Rbbp7 16
Rbbp7 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBBP7 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBBP7 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbbp7 36
  • 93.68 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves RBBP7 36
  • 82.11 (n)
  • 93.59 (a)
RBBP7 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rbbp7-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76124 36
rbbp7 36
  • 82.07 (n)
  • 94.08 (a)
zebrafish
(Danio rerio)
Actinopterygii rbb4l 36
  • 77.41 (n)
  • 89.34 (a)
rbb4l 37
  • 85 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Caf1 38
  • 86 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-53 37
  • 71 (a)
ManyToMany
rba-1 37
  • 52 (a)
ManyToMany
rba-1 38
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAT2 37
  • 37 (a)
OneToMany
Species with no ortholog for RBBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBBP7 Gene

ENSEMBL:
Gene Tree for RBBP7 (if available)
TreeFam:
Gene Tree for RBBP7 (if available)

Paralogs for RBBP7 Gene

Paralogs for RBBP7 Gene

Selected SIMAP similar genes for RBBP7 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for RBBP7 Gene

genes like me logo Genes that share paralogs with RBBP7: view

Variants for RBBP7 Gene

Sequence variations from dbSNP and Humsavar for RBBP7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1802850 -- 16,853,718(-) GTCAT(C/T)GTTTG missense, reference
rs1802851 -- 16,863,057(-) TGGGG(A/C)CTCAT reference, missense
rs1871515 -- 16,867,892(-) gccca(G/T)gcaac intron-variant
rs2127514 -- 16,868,458(-) ATCTA(A/C)GTCCT intron-variant
rs2170084 -- 16,863,263(-) ATGTG(A/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBBP7 Gene

Variant ID Type Subtype PubMed ID
esv259795 OTHER Complex 20981092
nsv511654 CNV Gain 21212237
esv29438 CNV Loss 19812545

Relevant External Links for RBBP7 Gene

HapMap Linkage Disequilibrium report
RBBP7

Disorders for RBBP7 Gene

(1) MalaCards Diseases for RBBP7 Gene

Search for RBBP7 Gene in MalaCards »

(3) Novoseek inferred disease relationships for RBBP7 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 77.7 13
wilms tumor 52.5 3
tumors 0 3

Relevant External Links for RBBP7

Genetic Association Database (GAD)
RBBP7
Human Genome Epidemiology (HuGE) Navigator
RBBP7
genes like me logo Genes that share disorders with RBBP7: view

No data available for UniProtKB/Swiss-Prot for RBBP7 Gene

Publications for RBBP7 Gene

  1. BRCA1 interacts with components of the histone deacetylase complex. (PMID: 10220405) Yarden R.I. … Brody L.C. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  2. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. (PMID: 10444591) Zhang Y. … Reinberg D. (Genes Dev. 1999) 3 4 23
  3. Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. (PMID: 7503932) Qian Y.-W. … Lee E.Y.-H.P. (J. Biol. Chem. 1995) 2 3 4
  4. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. (PMID: 9150135) Zhang Y. … Reinberg D. (Cell 1997) 3 4
  5. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. (PMID: 9427644) Verreault A. … Stillman B. (Curr. Biol. 1998) 3 4

Products for RBBP7 Gene

Sources for RBBP7 Gene

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