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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBBP7 Gene

protein-coding   GIFtS: 63
GCID: GC0XM016772

Retinoblastoma Binding Protein 7

(Previous name: retinoblastoma-binding protein 7)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Retinoblastoma Binding Protein 71 2     Nucleosome-Remodeling Factor Subunit RBAP462 3
Retinoblastoma-Binding Protein 71 2 3     RBBP-72 3
Histone Acetyltransferase Type B Subunit 21 2 3     RbAp462
Retinoblastoma-Binding Protein P461 2 3     Histone-Binding Protein RBBP72
G1/S Transition Control Protein-Binding Protein RbAp461 2     RBAP463
Retinoblastoma-Binding Protein RbAp461 2     

External Ids:    HGNC: 98901   Entrez Gene: 59312   Ensembl: ENSG000001020547   OMIM: 3008255   UniProtKB: Q165763   

Export aliases for RBBP7 gene to outside databases

Previous GC identifers: GC0XM016594 GC0XM015730 GC0XM016063 GC0XM016225 GC0XM016226 GC0XM016622 GC0XM014625


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBBP7 Gene:
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat
proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell
proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor
complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with
BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for RBBP7 Gene: 
RBBP7 (retinoblastoma binding protein 7) is a protein-coding gene. Diseases associated with RBBP7 include retinoblastoma, and non-hodgkin lymphoma, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Packaging Of Telomere Ends. GO annotations related to this gene include protein binding. An important paralog of this gene is RFWD2.

UniProtKB/Swiss-Prot: RBBP7_HUMAN, Q16576
Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases
and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component
of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase
(HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase
(HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome
remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by
histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of
homeotic genes during development; and the NURF (nucleosome remodeling factor) complex

Gene Wiki entry for RBBP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBBP7 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-1   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBBP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBBP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBBP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.22

RBBP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBBP7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM016772:  view genomic region     (about GC identifiers)

Start:
16,857,406 bp from pter      End:
16,888,537 bp from pter
Size:
31,132 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBBP7_HUMAN, Q16576 (See protein sequence)
Recommended Name: Histone-binding protein RBBP7  
Size: 425 amino acids; 47820 Da
Subunit: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is
in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit
of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC
complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1
to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form
the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact
with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least
EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the
nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the
viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may
be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for RBBP7:
3CFS (3D)        3CFV (3D)    
Secondary accessions: Q5JP00
Alternative splicing: 2 isoforms:  Q16576-1   Q16576-2   (No experimental confirmation available. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 13)

Explore the universe of human proteins at neXtProt for RBBP7: NX_Q16576

Explore proteomics data for RBBP7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16576

  • RBBP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RBBP7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001185648.1  NP_002884.1  

    ENSEMBL proteins: 
     ENSP00000415747   ENSP00000369427   ENSP00000369424   ENSP00000386068   ENSP00000402796  
     ENSP00000392714   ENSP00000417791   ENSP00000417507  
    Reactome Protein details: Q16576
    Human Recombinant Protein Products for RBBP7: 
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    Cloud-Clone Corp. Proteins for RBBP7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016581NuRD complex IDA19644445
    GO:0035098ESC/E(Z) complex IDA--

    RBBP7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR022052 Histone-bd_RBBP4
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q16576

    ProtoNet protein and cluster: Q16576

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: RBBP7_HUMAN, Q16576
    Similarity: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family
    Similarity: Contains 7 WD repeats


    RBBP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBBP7_HUMAN, Q16576
    Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases
    and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component
    of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase
    (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase
    (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome
    remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by
    histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of
    homeotic genes during development; and the NURF (nucleosome remodeling factor) complex

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17255935
         
    RBBP7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RBBP7:
     Increased cell number in G1, a 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rbbp7):
     embryogenesis  hematopoietic system  immune system 

    RBBP7 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RBBP7 
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    SwitchGear 3'UTR luciferase reporter plasmidRBBP7 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RBBP7 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    2Packaging Of Telomere Ends
    Nucleosome assembly0.46
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    3Transcription P53 signaling pathway
    Transcription P53 signaling pathway0.98
    4Cell Cycle
    Cell Cycle0.84
    5Meiotic Synapsis
    Chromosome Maintenance0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for RBBP7 (see all 6)
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RBBP7
        DNA Methylation and Transcriptional Repression

    1 Cell Signaling Technology (CST) Pathway for RBBP7
        Chromatin Regulation / Acetylation

    5 GeneGo (Thomson Reuters) Pathways for RBBP7
        Transcription P53 signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Development Notch Signaling Pathway

    5 BioSystems Pathways for RBBP7
        EGFR1 Signaling Pathway
    Signaling events mediated by HDAC Class I
    Hedgehog signaling events mediated by Gli proteins
    Regulation of nuclear SMAD2/3 signaling
    Regulation of Telomerase

    4        Reactome Pathways for RBBP7
        Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Chromosome Maintenance



    RBBP7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBBP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/968 Interacting proteins for RBBP7 (Q165761, 2, 3 ENSP000003694274) via UniProtKB, MINT, STRING, and/or I2D (see all 968)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628051, 3, ENSP000003529804EBI-352227,EBI-302023 I2D: score=3 STRING: ENSP00000352980
    HIST1H4LP628051, 3, ENSP000003482584EBI-352227,EBI-302023 I2D: score=3 STRING: ENSP00000348258
    HIST4H4P628051, 3, ENSP000003507674EBI-352227,EBI-302023 I2D: score=3 STRING: ENSP00000350767
    HIST1H4BP628051, 3EBI-352227,EBI-302023 I2D: score=3 
    HIST1H4CP628051, 3EBI-352227,EBI-302023 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006260DNA replication IEA--
    GO:0006334nucleosome assembly TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development TAS7503932

    RBBP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBBP7

    Search CenterWatch for drugs/clinical trials and news about RBBP7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RBBP7 gene (2 alternative transcripts): 
    NM_001198719.1  NM_002893.3  

    Unigene Cluster for RBBP7:

    Retinoblastoma binding protein 7
    Hs.495755  [show with all ESTs]
    Unigene Representative Sequence: AK127332
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425696 ENST00000380087(uc004cxt.3) ENST00000330735 ENST00000465244
    ENST00000380084(uc004cxs.2) ENST00000404022 ENST00000481586 ENST00000444437
    ENST00000416035 ENST00000486166(uc010nez.3) ENST00000468092 ENST00000493145

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK091911.1 AK127332.1 AK291567.1 AK310309.1 BC114500.1 BC114501.1 CR541701.1 U35143.1 
    X72841.1 

    24/36 DOTS entries (see all 36):

    DT.95376562  DT.100880564  DT.100880557  DT.95376690  DT.100031134  DT.40258382  DT.100880552  DT.91772245 
    DT.100031137  DT.121292438  DT.97860397  DT.95377288  DT.121292473  DT.91772229  DT.100880553  DT.101980328 
    DT.121292394  DT.91772241  DT.100842911  DT.100880555  DT.121292355  DT.121292451  DT.121292478  DT.95376547 

    24/745 AceView cDNA sequences (see all 745):

    AA411907 BP871690 D57699 BM670268 AA040345 AI359571 R97008 CR624515 
    BE044365 BE900909 CA441528 CB306482 AA813156 BM451108 AA846636 AU279753 
    BI492367 BM823424 BU631818 BQ926393 CR611848 BQ000609 BQ220335 CB997945 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RBBP7 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a ·
    SP1:              -     -                                                                 -                 -     -     -                 -                     
    SP2:                    -                                                                 -                 -     -     -                 -                     
    SP3:                                                                                      -           -                                                         
    SP4:                                                                                      -                 -     -     -                 -     -     -         
    SP5:              -     -                                   -                                                                                                   

    ExUns: 13b · 13c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RBBP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBBP7 expression in normal human tissues (normalized intensities)      RBBP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCTTGAT
    RBBP7 Expression
    About this image


    RBBP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See RBBP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBBP7

    SOURCE GeneReport for Unigene cluster: Hs.495755
        SABiosciences Expression via Pathway-Focused PCR Arrays including RBBP7: 
              Polycomb & Trithorax Complexes in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RBBP7 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbbp71 , 5 retinoblastoma binding protein 71, 5 93.21(n)1
    99.05(a)1
      X (74.97 cM)5
    2456881  NM_009031.31  NP_033057.31 
     1627604025 
    chicken
    (Gallus gallus)
    Aves RBBP71 retinoblastoma binding protein 7 82.11(n)
    93.59(a)
      395390  NM_204670.1  NP_990001.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia rbbp7-prov2 retinoblastoma binding protein 7 81.87(n)    BC042283.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rbb4l6
    retinoblastoma binding protein 4, like
    89(a)
    1 ↔ 1
    11(12802549-12826559)
    fruit fly
    (Drosophila melanogaster)
    Insecta Caf13 negative regulation of transcription by
    homeotic more
    86(a)   3 88E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea rba-13 retinablastoma-binding protein RBAP46
    like
    51(a)   I(9624662-9626157)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAT26
    Subunit of the Hat1p-Hat2p histone acetyltransfera...
    36(a)
    1 → many
    V(47168-48373)


    ENSEMBL Gene Tree for RBBP7 (if available)
    TreeFam Gene Tree for RBBP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBBP7 gene
    RFWD22  RBBP42  
    4 SIMAP similar genes for RBBP7 using alignment to 8 protein entries:     RBBP7_HUMAN (see all proteins):
    RBBP4    WSB1    POC1B    DAW1

    RBBP7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RBBP7
    PGOHUM00000238099


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/413 SNPs in RBBP7 are shown (see all 413)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387782281,2
    F--16863170(+) CCTTGT/ACCCTC 4 /G syn11Minor allele frequency- A:0.00NA 4544
    rs2007560391,2
    --16863189(+) ATGTCA/GTGACA 4 T M mis10--------
    rs1404230151,2
    --16863409(+) AATTCA/CGTATG 2 -- int10--------
    rs1504127871,2
    --16863495(+) GCATCA/GTTTAG 2 -- int10--------
    rs48285351,2
    C,F,A,H--16863589(+) ACTTGG/CTGTCA 2 -- int111Minor allele frequency- C:0.29NS EA WA NA CSA 430
    rs1428807741,2
    --16863684(+) CTCCAC/GTGTAT 2 -- int10--------
    rs1855487001,2
    --16863775(+) GGACGA/GAGCAC 2 -- int10--------
    rs1895234071,2
    --16863783(+) CACCAC/TATGGG 2 -- int10--------
    rs1808671061,2
    --16863887(+) TATTAC/TATTAT 2 -- int10--------
    rs59697281,2
    C,F,H--16864303(+) CAAGTA/GATACT 2 -- int119Minor allele frequency- G:0.37NS EA WA NA CSA 1988

    HapMap Linkage Disequilibrium report for RBBP7 (16857406 - 16888537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RBBP7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29438CNV Loss19812545
    nsv511654CNV Gain21212237
    esv259795OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300825    OMIM disorders: --

    10 diseases for RBBP7:    About MalaCards
    retinoblastoma    non-hodgkin lymphoma    hodgkin's lymphoma    wilms tumor
    eosinophilia    dermatomyositis    mental retardation    thyroiditis
    lung cancer    breast cancer


    RBBP7 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RBBP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 77.7 15 15682465 (2), 17201172 (2), 17927911 (1), 12767060 (1) (see all 11)
    wilms tumor 52.5 3 12767060 (1), 9765217 (1), 11433396 (1)
    tumors 0 3 11433396 (2), 12767060 (1)

    Genetic Association Database (GAD): RBBP7
    Human Genome Epidemiology (HuGE) Navigator: RBBP7 (3 documents)

    Export disorders for RBBP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBBP7 gene, integrated from 9 sources (see all 137):
    (articles sorted by number of sources associating them with RBBP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. (PubMed id 7503932)1, 2, 3 Qian Y.-W. and Lee E.Y.-H.P. (1995)
    2. BRCA1 interacts with components of the histone deacetylase complex. (PubMed id 10220405)1, 2, 9 Yarden R.I. and Brody L.C. (1999)
    3. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. (PubMed id 10444591)1, 2, 9 Zhang Y....Reinberg D. (1999)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. (PubMed id 18571423)1, 2 Murzina N.V....Laue E.D. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. MBD3L1 is a transcriptional repressor that interacts with methyl-CpG- binding protein 2 (MBD2) and components of the NuRD complex. (PubMed id 15456747)1, 2 Jiang C.-L.... Pfeifer G.P. (2004)
    8. Isolation of human NURF: a regulator of Engrailed gene expression. (PubMed id 14609955)1, 2 Barak O....Shiekhattar R. (2003)
    9. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. (PubMed id 12920132)1, 2 Yao Y.-L. and Yang W.-M. (2003)
    10. Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). (PubMed id 11784859)1, 2 Kuzmichev A.... Reinberg D. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5931 HGNC: 9890 AceView: RBBP7 Ensembl:ENSG00000102054 euGenes: HUgn5931
    ECgene: RBBP7 H-InvDB: RBBP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBBP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RBBP7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RBBP7 gene:
    Search GeneIP for patents involving RBBP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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