Aliases for RBBP6 Gene
External Ids for RBBP6 Gene
Previous GeneCards Identifiers for RBBP6 Gene
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RBBP6 Gene
RBBP6 (RB Binding Protein 6, Ubiquitin Ligase) is a Protein Coding gene. Diseases associated with RBBP6 include Retinoblastoma and Esophageal Cancer. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include nucleic acid binding and ligase activity.
UniProtKB/Swiss-Prot for RBBP6 Gene
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).