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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBBP6 Gene

protein-coding   GIFtS: 53
GCID: GC16P024458

retinoblastoma binding protein 6

(Previous name: retinoblastoma-binding protein 6 )
 Explore 6 diseases affiliated with
RBBP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RBBP6    

Aliases
for RBBP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Retinoblastoma Binding Protein 61 2     RBQ-12 3
Retinoblastoma-Binding Protein 61 2 3     P53-Associated Cellular Protein Of Testis2 3
PACT1 2 3     MY0382
P2P-R1 2     E3 Ubiquitin-Protein Ligase RBBP62
SNAMA1 2     RB-Binding Q-Protein 12
Proliferation Potential-Related Protein2 3     EC 6.3.2.-3
Protein P2P-R2 3     P2PR3
Retinoblastoma-Binding Q Protein 12 3     RBQ13

External Ids:    HGNC: 98891   Entrez Gene: 59302   Ensembl: ENSG000001222577   OMIM: 6009385   UniProtKB: Q7Z6E93   

Export aliases for RBBP6 gene to outside databases

Previous GC identifers: GC16P023966 GC16P024666 GC16P024494 GC16P024518 GC16P024517 GC16P022641


Summaries
for RBBP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RBBP6:
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB
suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of
pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively
spliced transcript variants that encode different isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: RBBP6_HUMAN, Q7Z6E9
Function: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the
proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in
increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53,
leading to both apoptosis and cell growth

Gene Wiki entry for RBBP6


Genomic Views
for RBBP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBBP6 gene promoter:
         AP-1   ATF-2   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RBBP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBBP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBBP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p12.2

RBBP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBBP6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P024458:  view genomic region     (about GC identifiers)

Start:
 24,549,014 bp from pter      End:
 24,584,184 bp from pter
Size:
 35,171 bases      Orientation:
 plus strand

Proteins
for RBBP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RBBP6_HUMAN, Q7Z6E9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RBBP6  
Size: 1792 amino acids; 201564 Da
Subunit: Interacts with p53/TP53 and RB1 (By similarity). Interacts also with MDM2 and YBX1. Interacts with NEK6
Subcellular location: Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with
mitotic chromosomes. Co-localizes with NEK6 in the centrosome
Sequence caution: Sequence=AAG43155.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH63524.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAL05625.1;
Type=Frameshift; Positions=198; Sequence=AAL68925.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Sequence=BAB15600.1; Type=Erroneous initiation; Sequence=CAA59445.1; Type=Frameshift; Positions=198, 1048, 1098;
4 PDB 3D structures from and Proteopedia for RBBP6:
2C7H (3D)        2YSA (3D)        2YUR (3D)        3ZTG (3D)    
Secondary accessions: Q147T5 Q15290 Q6DKH4 Q6P4C2 Q6YNC9 Q7Z6E8 Q8N0V2 Q96PH3 Q9H3I8 Q9H5M5 Q9NPX4
Alternative splicing: 4 isoforms:  Q7Z6E9-1   Q7Z6E9-2   Q7Z6E9-3   Q7Z6E9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RBBP6: NX_Q7Z6E9

Post-translational modifications:

  • Phosphorylated by NEK61
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z6E9

    • RBBP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_008841.2  NP_061173.1  NP_116015.2  

    ENSEMBL proteins: 
     ENSP00000456750   ENSP00000457716   ENSP00000460821   ENSP00000317872   ENSP00000390537  
     ENSP00000370427   ENSP00000316291  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RBBP6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005694chromosome IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--


    RBBP6 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RBBP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RBBP6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR014891 DWNN_domain
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q7Z6E9

    ProtoNet protein and cluster: Q7Z6E9

    3 Blocks protein families:
    IPB001841 Zn-finger
    IPB001878 C2HC-type zinc-finger signature
    IPB003613 Zn-finger


    UniProtKB/Swiss-Prot: RBBP6_HUMAN, Q7Z6E9
    Similarity: Contains 1 CCHC-type zinc finger
    Similarity: Contains 1 DWNN domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RBBP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RBBP6_HUMAN, Q7Z6E9
    Function: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the
    proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in
    increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53,
    leading to both apoptosis and cell growth

         Genatlas biochemistry entry for RBBP6:
    RB1 binding nuclear protein (140kDa)

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    hsa-miR-142-5p hsa-miR-15a hsa-miR-4272 hsa-miR-25 hsa-miR-485-3p hsa-miR-519a hsa-miR-3171 hsa-miR-374c
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA18851979
    GO:0005515protein binding IPI18624398
    GO:0008270zinc ion binding IEA--


    RBBP6 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for RBBP6:
     Decreased POU5F1-GFP protein e  G0/1 arrest  Increased G1 DNA content  Increased cell death in DLD-1  
     Increased cell size  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Rbbp6tm1Xya for RBBP6
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rbbp6):
     cellular  embryogenesis  growth/size  mortality/aging 

    RBBP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RBBP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RBBP6_HUMAN, Q7Z6E9
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBBP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for RBBP6 (Q7Z6E91, 2, 3 ENSP000003178724) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF7Q166291, 3, ENSP000003259054EBI-2117026,EBI-398885 I2D: score=2 STRING: ENSP00000325905
    ZFYVE9O954052, 3MINT-62051 I2D: score=3 
    SMN1Q166373, ENSP000003700834I2D: score=2 STRING: ENSP00000370083
    SMN2Q166373, ENSP000003701194I2D: score=2 STRING: ENSP00000370119
    ANAPC16Q96DE53, ENSP000002993814I2D: score=2 STRING: ENSP00000299381
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA18851979


    RBBP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RBBP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RBBP6
    Search CenterWatch for drugs/clinical trials and news about RBBP6 

    Transcripts
    for RBBP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RBBP6 gene (3 alternative transcripts): 
    NM_006910.4  NM_018703.3  NM_032626.5  

    Unigene Cluster for RBBP6:

    Retinoblastoma binding protein 6
    Hs.188553  [show with all ESTs]
    Unigene Representative Sequence: NM_006910
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564314 ENST00000567686 ENST00000568015 ENST00000568316 ENST00000319715(uc010vcb.1 uc002dmh.3 uc002dmi.3 uc010bxr.3)
    ENST00000452655(uc002dmg.3) ENST00000381039 ENST00000348022 ENST00000564726
    ENST00000562430(uc002dmk.3) ENST00000562683 ENST00000570185

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate RBBP6 (see all 45):
    hsa-miR-142-5p hsa-miR-15a hsa-miR-4272 hsa-miR-25 hsa-miR-485-3p hsa-miR-519a hsa-miR-3171 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: RBBP6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBBP6 (see all 3)
    OriGene siRNA: RBBP6
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    Clone
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    Additional cDNA sequence: 

    AB112074.1 AB112075.1 AF116625.1 AF352051.1 AK026954.1 AK303040.1 AL359564.1 AY072922.1 
    BC015318.1 BC029352.1 BC029649.2 BC030964.1 BC063524.1 BC073938.1 BC101139.2 BC101140.2 
    BC101141.2 BC101142.1 BC114353.1 BC114354.1 BC118667.1 BC139830.1 BX648661.1 X85133.1 

    24/28 DOTS entries (see all 28):

    DT.100821932  DT.95233345  DT.113675  DT.92446588  DT.97829576  DT.97845275  DT.91711090  DT.92446571 
    DT.75119167  DT.100821929  DT.414004  DT.120723069  DT.114782  DT.405577  DT.120723063  DT.100821931 
    DT.100821930  DT.410884  DT.92046161  DT.120723052  DT.120723017  DT.410885  DT.91692527  DT.91692528 

    24/413 AceView cDNA sequences (see all 413):

    AI825622 CA848998 CA393015 AU148320 BM848239 BX648661 AW206193 CD364898 
    AA149597 BM849187 AA806475 AI493321 AA991554 CB529253 BQ024596 CD722970 
    AA807682 AV661215 BU628501 AW166501 BM973234 BM786373 AA279311 CD245357 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RBBP6 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a ·
    SP1:                                                  -                 -     -     -           -                                               -               
    SP2:                                                  -                 -     -     -           -                                               -               
    SP3:                                                                                                                                            -               
    SP4:                                                  -                 -     -     -           -                                               -               
    SP5:              -     -     -     -     -           -                 -     -     -           -                                                               

    ExUns: 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b
    SP1:  -           -                                                               
    SP2:  -           -                                   -                           
    SP3:  -           -                                   -                           
    SP4:  -     -     -     -     -     -     -     -     -     -     -               
    SP5:                                                                              


    ECgene alternative splicing isoforms for RBBP6

    Expression
    for RBBP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBBP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RBBP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBBP6

    SOURCE GeneReport for Unigene cluster: Hs.188553

    UniProtKB/Swiss-Prot: RBBP6_HUMAN, Q7Z6E9
    Tissue specificity: Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney,
    liver and lung. Overexpressed in esophageal cancer

        SABiosciences Expression via Pathway-Focused PCR Array including RBBP6: 
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    In Situ
    Assay Products:     
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    Orthologs
    for RBBP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBBP6 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rbbp61 , 5 retinoblastoma binding protein 61, 5 85.79(n)1
    88.81(a)1    		   7 (67.42 cM)5
    196471  NM_011247.21  NP_035377.21 
     1229656865 
    chicken
    (Gallus gallus)    		 Aves RBBP61 retinoblastoma binding protein 6 76.4(n)
    77.53(a)    		   416569  XM_414870.2  XP_414870.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RBBP66
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343883.1(31595-44692)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.341172 Xenopus laevis transcribed sequence with strong similarity more 82.14(n)    BJ614254.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.180392 Transcribed sequence with weak similarity to protein more 77.14(n)    BG737479.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta snama1 something that sticks like glue 41.64(n)
    31.12(a)    		   37857  NM_138040.3  NP_611884.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-2141 Protein TAG-214 46.32(n)
    34.42(a)    		   172720  NM_001037886.1  NP_001032975.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G474301 DWNN domain, a CCHC-type zinc finger 46.78(n)
    36.13(a)    		   834790  NM_124114.3  NP_199554.2 
    rice
    (Oryza sativa)    		 Liliopsida Os10g04310001 hypothetical protein 49.53(n)
    35.55(a)    		   4348695  NM_001071200.1  NP_001064665.2 


    ENSEMBL Gene Tree for RBBP6 (if available)
    TreeFam Gene Tree for RBBP6 (if available) 

    Paralogs
    for RBBP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RBBP6 gene
    2 SIMAP similar genes for RBBP6 using alignment to 5 protein entries:     RBBP6_HUMAN (see all proteins):
    TRIM5    RAD18

    RBBP6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RBBP6
    PGOHUM00000238849


    Genomic Variants
    for RBBP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/604 NCBI SNPs in RBBP6 are shown (see all 604)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs778739131,2
    		F,--24548924(+) AATAGA/TCAACA 3 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1115646781,2
    		C,--24548946(+) GACATC/-CCCCC 3 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1840485831,2
    		--24549101(+) TTCGGA/TGTGAA 3 -- us2k10--------
    rs668281281,2
    		C,--24549554(+) CTATCT/CGCAAG 3 -- us2k15Minor allele frequency- C:0.23WA CSA NA EA 361
    rs802482081,2
    		C,F,--24549571(+) GAAGAA/GAAGAC 3 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1887295141,2
    		--24549775(+) CCTGTA/GAAATT 3 -- us2k10--------
    rs113118591,2
    		C,--24549795(+) GAGGA-/ACATGG 3 -- us2k10--------
    rs283619501,2
    		C,F,H,--24549817(+) ATAATA/GACTAT 3 -- us2k119Minor allele frequency- G:0.23NS EA NA WA CSA 2341
    rs1509041181,2
    		--24549915(+) ACTGAA/GGGGGT 3 -- us2k10--------
    rs1386910271,2
    		--24549988(+) CATCCC/TCTTCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RBBP6 (24549014 - 24584184 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RBBP6: --

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    Disorders / Diseases
    for RBBP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RBBP6 for disorders           About GeneDecksing

    OMIM gene information: 600938    OMIM disorders: --

    6 diseases for RBBP6:    About MalaCards
    retinoblastoma    esophageal cancer    esophagitis    lung cancer
    pancreatic cancer    pancreatitis


    Export disorders for RBBP6 gene to outside databases

    Publications
    for RBBP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBBP6 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with RBBP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product. (PubMed id 8595913)1, 2, 3, 9 Sakai Y.... Taya Y. (1995)
    2. DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways. (PubMed id 16396680)1, 2, 3 Pugh D.J....Rees D.J. (2006)
    3. Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis. (PubMed id 15475430)1, 2, 9 Yoshitake Y.... Nishimura Y. (2004)
    4. RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. (PubMed id 18851979)1, 2 Chibi M....Pugh D.J. (2008)
    5. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. (PubMed id 17470788)1, 2 Li L....He F. (2007)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity. (PubMed id 12064457)1, 2 Gao S.... Scott R.E. (2002)

    External Searches for RBBP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing RBBP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5930 HGNC: 9889 AceView: RBBP6 Ensembl:ENSG00000122257 euGenes: HUgn5930
    ECgene: RBBP6 H-InvDB: RBBP6

    Other Databases showing RBBP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RBBP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBBP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RBBP6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RBBP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RBBP6 gene:
    Search GeneIP for patents involving RBBP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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