Aliases for RBBP5 Gene
External Ids for RBBP5 Gene
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for RBBP5 Gene
RBBP5 (Retinoblastoma Binding Protein 5) is a Protein Coding gene. Diseases associated with RBBP5 include retinoblastoma. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include transcription regulatory region DNA binding and histone methyltransferase activity (H3-K4 specific).
UniProtKB/Swiss-Prot for RBBP5 Gene
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 Lys-4 methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys-4 of histone H3. Histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.