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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RBBP5 Gene

protein-coding   GIFtS: 54
GCID: GC01M205055

Retinoblastoma Binding Protein 5

(Previous name: retinoblastoma-binding protein 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Retinoblastoma Binding Protein 51 2     RBBP-52 3
RBQ32 3 5     Homolog (S. Cerevisiae)1
Retinoblastoma-Binding Protein 51 2     Set1c WD40 Repeat Protein1
SWD11 2     SWD1, Set1c WD40 Repeat Protein, Homolog2
Retinoblastoma-Binding Protein RBQ-32 3     

External Ids:    HGNC: 98881   Entrez Gene: 59292   Ensembl: ENSG000001172227   OMIM: 6006975   UniProtKB: Q152913   

Export aliases for RBBP5 gene to outside databases

Previous GC identifers: GC01M202782 GC01M200517 GC01M201415 GC01M202233 GC01M201787 GC01M203321 GC01M176220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RBBP5 Gene:
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of
WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell
proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the
E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have
been described for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for RBBP5 Gene: 
RBBP5 (retinoblastoma binding protein 5) is a protein-coding gene. Diseases associated with RBBP5 include retinoblastoma, and wiskott-aldrich syndrome. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot: RBBP5_HUMAN, Q15291
Function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along
the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including
that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and
trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic
transcriptional activation

Gene Wiki entry for RBBP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RBBP5 gene promoter:
         GR   RFX1   GR-beta   Lmo2   CUTL1   XBP-1   POU6F1 (c2)   Evi-1   NRF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRBBP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for RBBP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBBP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

RBBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RBBP5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205055:  view genomic region     (about GC identifiers)

Start:
205,055,270 bp from pter      End:
205,091,150 bp from pter
Size:
35,881 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBBP5_HUMAN, Q15291 (See protein sequence)
Recommended Name: Retinoblastoma-binding protein 5  
Size: 538 amino acids; 59153 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5,
WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing
complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed
of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3
and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A,
KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A,
RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Interacts with WDR5 and
ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A. Part of a complex composed at least of ASCL2,
C11orf30/EMSY, HCFC1, HSPA8, KIAA1967, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a
histone H3-specific methyltransferase activity (By similarity)
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for RBBP5:
3P4F (3D)    
Secondary accessions: A8K272 Q7Z6D8 Q8NDZ7
Alternative splicing: 2 isoforms:  Q15291-1   Q15291-2   (Contains a phosphoserine at position 490)

Explore the universe of human proteins at neXtProt for RBBP5: NX_Q15291

Explore proteomics data for RBBP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15291

  • RBBP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RBBP5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180201.1  NP_001180202.1  NP_005048.2  

    ENSEMBL proteins: 
     ENSP00000264515   ENSP00000356132  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15199122
    GO:0035097histone methyltransferase complex IPI14992727
    GO:0048188Set1C/COMPASS complex IDA17998332
    GO:0071339MLL1 complex IDA15960975

    RBBP5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q15291

    ProtoNet protein and cluster: Q15291

    UniProtKB/Swiss-Prot: RBBP5_HUMAN, Q15291
    Similarity: Contains 6 WD repeats


    RBBP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBBP5_HUMAN, Q15291
    Function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along
    the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including
    that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and
    trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic
    transcriptional activation

         Genatlas biochemistry entry for RBBP5:
    RB1 binding nuclear protein 5,with homology to TF2B

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12482968
    GO:0035064methylated histone residue binding IDA15960975
    GO:0042800contributes to histone methyltransferase activity (H3-K4 specific) IDA17355966
    GO:0044212transcription regulatory region DNA binding IDA16603732
         
    RBBP5 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RBBP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RBBP5
        Chromatin Regulation / Acetylation



    RBBP5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBBP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/922 Interacting proteins for RBBP5 (Q152911, 2, 3 ENSP000002645154) via UniProtKB, MINT, STRING, and/or I2D (see all 922)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074372, 3, ENSP000004100714MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000410071
    ENSG00000183311P074372, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000224156P074372, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000227739P074372, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000229684P074372, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006974response to DNA damage stimulus IDA17500065
    GO:0043627response to estrogen stimulus IDA16603732
    GO:0051568histone H3-K4 methylation IDA17355966

    RBBP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for RBBP5 gene (3 alternative transcripts): 
    NM_001193272.1  NM_001193273.1  NM_005057.3  

    Unigene Cluster for RBBP5:

    Retinoblastoma binding protein 5
    Hs.519230  [show with all ESTs]
    Unigene Representative Sequence: NM_005057
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264515(uc010prd.2 uc010pre.2 uc001hbu.2) ENST00000367164(uc001hbv.2)
    ENST00000484379
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    Additional mRNA sequence: 

    AK290137.1 AK296978.1 AK297540.1 BC037284.2 BC053856.1 BC075059.2 BC075060.2 X85134.1 

    6 DOTS entries:

    DT.100814660  DT.91793814  DT.101972968  DT.121330413  DT.99993441  DT.121330352 

    24/100 AceView cDNA sequences (see all 100):

    BP357482 BX475888 BM841893 BC075059 BE378702 AL119169 AA488959 CD559083 
    AW505316 AA489300 BP871752 BM452621 BX096879 BC053856 BG177847 BU430770 
    BC075060 CD518019 CF138358 BM457775 CA771071 AA339203 AA488880 AW949884 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RBBP5 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                                                                                                                                      
    SP2:                                                                                                                                -                     
    SP3:                                                        -                                                                                             
    SP4:              -     -     -                                                                                                                           
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for RBBP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RBBP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RBBP5 Expression
    About this image


    See RBBP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RBBP5

    SOURCE GeneReport for Unigene cluster: Hs.519230

    UniProtKB/Swiss-Prot: RBBP5_HUMAN, Q15291
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including RBBP5: 
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              Polycomb & Trithorax Complexes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RBBP5 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rbbp51 , 5 retinoblastoma binding protein 51, 5 92.63(n)1
    99.07(a)1
      1 (57.24 cM)5
    2134641  NM_172517.21  NP_766105.21 
     1324773675 
    chicken
    (Gallus gallus)
    Aves RBBP51 retinoblastoma binding protein 5 83.52(n)
    97.58(a)
      419826  NM_001030914.1  NP_001026085.1 
    lizard
    (Anolis carolinensis)
    Reptilia RBBP56
    Uncharacterized protein
    90(a)
    1 ↔ 1
    4(116301007-116333210)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.71002 Xenopus laevis transcribed sequence with strong similarity more 78.36(n)    BX847136.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560782 similar to retinoblastoma binding protein 5 74.28(n)   393215  BC047822.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64343
    CG55851
    CG55851 71(a)
    (best of 2)3
    60.52(n)1
    68.53(a)1
      77B43
    402391  NM_140952.21  NP_649209.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F21H12.11 , 3 Protein F21H12.11 41(a)3
    53.78(n)1
    43.84(a)1
      II(6097788-6101835)3
    1740191  NM_062821.71  NP_495222.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWD1(YAR003W)4
    SWD11
    Subunit of the COMPASS (Set1C) complex, which methylates more4
    Swd1p1
    46.13(n)1
    33.98(a)1
      1(155005-156285)4
    8512651, 4  NP_009403.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G210601 transducin/WD40 domain-containing protein 51.45(n)
    42.09(a)
      821658  NM_113000.5  NP_188743.3 
    rice
    (Oryza sativa)
    Liliopsida Os03g02079001 hypothetical protein 48.73(n)
    41.77(a)
      4332006  NM_001055863.1  NP_001049328.1 


    ENSEMBL Gene Tree for RBBP5 (if available)
    TreeFam Gene Tree for RBBP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/806 SNPs in RBBP5 are shown (see all 806)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473272441,2
    C--205055629(+) CCAAGC/TGCTGG 3 -- ut310--------
    rs1129078341,2
    C,F--205055656(+) CACCAC/TGCCCA 3 -- ut311Minor allele frequency- T:0.50WA 2
    rs1915883851,2
    --205055872(+) ATTTTA/CTCAGT 3 -- ut310--------
    rs75373221,2
    C,F,A,H--205055949(+) CACACA/GTGGAA 3 -- ut31 ese333Minor allele frequency- G:0.24NA NS EA WA CSA 2924
    rs66601501,2
    H--205056087(+) CTGGTC/TTAACT 3 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs1824145471,2
    --205056096(+) CTCATA/GACAGT 3 -- ut310--------
    rs1871482341,2
    --205056122(+) TAAGAA/GAAAAG 3 -- ut310--------
    rs1911993451,2
    --205056205(+) TGGTTC/TTAAAT 3 -- ut310--------
    rs66603421,2
    H--205056247(+) GTGCTC/TTACTT 3 -- ut314Minor allele frequency- T:0.00NS EA 420
    rs112403531,2
    C,F,A,H--205056301(+) TACCTA/GTAGGA 3 -- ut31 ese321Minor allele frequency- G:0.23NA NS EA 2366

    HapMap Linkage Disequilibrium report for RBBP5 (205055270 - 205091150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RBBP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819953CNV Loss19587683
    nsv468016CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600697    OMIM disorders: --

    6 diseases for RBBP5:    About MalaCards
    retinoblastoma    wiskott-aldrich syndrome    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    leukemia    breast cancer


    RBBP5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RBBP5

    Export disorders for RBBP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RBBP5 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with RBBP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping. (PubMed id 7558034)1, 2, 3 Saijo M.... Taya Y. (1995)
    2. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PubMed id 19131338)1, 2 Garapaty S....Samuels H.H. (2009)
    3. On the mechanism of multiple lysine methylation by th e human mixed lineage leukemia protein-1 (MLL1) core complex. (PubMed id 19556245)1, 2 Patel A....Cosgrove M.S. (2009)
    4. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (2008)
    5. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (2008)
    6. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2 Lee J.-H.... Skalnik D.G. (2007)
    7. PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex. (PubMed id 17500065)1, 2 Cho Y.W.... Ge K. (2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PubMed id 16253997)1, 2 Lee J.-H. and Skalnik D.G. (2005)
    10. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5929 HGNC: 9888 AceView: RBBP5 Ensembl:ENSG00000117222 euGenes: HUgn5929
    ECgene: RBBP5 H-InvDB: RBBP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RBBP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RBBP5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RBBP5 gene:
    Search GeneIP for patents involving RBBP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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