RBBP4 Gene
protein-coding GIFtS: 67
GCID: GC01P033116
|
|
retinoblastoma binding protein 4(Previous name: retinoblastoma-binding protein 4 )
| |
Aliases
for RBBP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinoblastoma Binding Protein 41 2 | | RBBP-42 3 | | Retinoblastoma-Binding Protein 41 2 3 | | CAF-1 Subunit C2 3 | | NURF551 2 | | CAF-I 48 KDa Subunit2 3 | | Chromatin Assembly Factor 1 Subunit C2 3 | | CAF-I P482 3 | | Chromatin Assembly Factor I P48 Subunit2 3 | | RbAp481 | | Nucleosome-Remodeling Factor Subunit RBAP482 3 | | Chromatin Assembly Factor/CAF-1 P48 Subunit2 | | Retinoblastoma-Binding Protein P482 3 | | Histone-Binding Protein RBBP42 | | RBAP482 3 | | MSI1 Protein Homolog2 |
Export aliases for RBBP4 gene to outside databasesPrevious GC identifers: GC01P032927 GC01P032058 GC01P032543 GC01P032619 GC01P032785 GC01P032889 GC01P031231 |
Summaries
for RBBP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBBP4:
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeatproteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of theMi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histonedeacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component oftranscriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein toregulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsivegenes. Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep2008)
UniProtKB/Swiss-Prot: RBBP4_HUMAN, Q09028Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors andhistone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component ofseveral complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex,which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC)complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling andhistone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation andnucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; andthe NURF (nucleosome remodeling factor) complex
Gene Wiki entry for RBBP4
|
Genomic Views
for RBBP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBBP4 gene promoter:
COUP-TF1 COUP-TF p53 COUP FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBBP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBBP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35.1RBBP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P033116: view genomic region
(about GC identifiers)
Start:
|
33,116,743 bp from pter |
End:
|
33,151,812 bp from pter |
Size:
|
35,070 bases |
Orientation:
|
plus strand |
|
Proteins
for RBBP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBBP4_HUMAN, Q09028 (See
protein sequence)Recommended Name: Histone-binding protein RBBP4 Size: 425 amino acids; 47656 Da
Subunit: Interacts with SUV39H1 and HDAC7 (By similarity). Binds directly to helix 1 of the histone fold of histone H4,a region that is not accessible when H4 is in chromatin. Subunit of the chromatin assembly factor 1 (CAF-1) complex,which is composed of RBBP4, CHAF1B and CHAF1A. Subunit of the core histone deacetylase (HDAC) complex, which iscomposed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30,SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may alsoassociate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRDcomplex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associatewith HDAC1. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. Part of thenucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viralprotein-binding domain of the retinoblastoma protein (RB1). Interacts with SPEN/MINT. Interacts with BRCA1. Interactswith CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Component of theDREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2,RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependentgenes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for RBBP4:2XU7 (3D)
3GFC (3D)
Secondary accessions: B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9Alternative splicing: 4 isoforms: Q09028-1 Q09028-2 Q09028-3 Q09028-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RBBP4: NX_Q09028
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q09028
RBBP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001128727.1 NP_001128728.1 NP_005601.1
ENSEMBL proteins: ENSP00000398242 ENSP00000362592 ENSP00000432780 ENSP00000434925 ENSP00000436663 ENSP00000362584 ENSP00000432774 ENSP00000396057 ENSP00000437210 ENSP00000389437 ENSP00000436986 ENSP00000433805 ENSP00000432298 ENSP00000436565 ENSP00000442384 Reactome Protein details: Q09028
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
RBBP4 for ontologies About GeneDecksing
RBBP4 Antibody Products:
Assay Products for RBBP4: |
Protein
Domains /
Families
for RBBP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBBP4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q09028ProtoNet protein and cluster: Q09028 1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature
UniProtKB/Swiss-Prot: RBBP4_HUMAN, Q09028Similarity: Belongs to the WD repeat RBAP46/RBAP48/MSI1 familySimilarity: Contains 6 WD repeats |
Function
for RBBP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBBP4_HUMAN, Q09028Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors andhistone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component ofseveral complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex,which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC)complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling andhistone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation andnucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; andthe NURF (nucleosome remodeling factor) complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RBBP4 (NM_001135256) | |  | Sino Biological Human cDNA Clone for RBBP4 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBBP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBBP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBBP4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RBBP4 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for RBBP4:
|
Pathways & Interactions
for RBBP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RSF Complex Binds the Centromere. | | | 2 | Transcription_Sin3 and NuRD in transcription regulation | | | 3 | Development_Notch Signaling Pathway | | | 4 | Transcription_P53 signaling pathway | | | 5 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for RBBP4 (see all 6)
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RBBP4
1 
Cell Signaling Technology (CST) Pathway for RBBP4
5  GeneGo (Thomson Reuters) Pathways for RBBP4
5/6  BioSystems Pathways for RBBP4 (see all 6)
5/9 
Reactome Pathways for RBBP4 (see all 9)
RBBP4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBBP4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/837 Interacting proteins for RBBP4 (Q090281, 2, 3 ENSP000003625924) via UniProtKB, MINT, STRING, and/or I2D (see all 837)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
RBBP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for RBBP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBBP4
Search CenterWatch for drugs/clinical trials and news about RBBP4
|
Transcripts
for RBBP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBBP4 gene (3 alternative transcripts): NM_001135255.1 NM_001135256.1 NM_005610.2 Unigene Cluster for RBBP4: Retinoblastoma binding protein 4 Hs.16003 [show with all ESTs]Unigene Representative Sequence: NM_00561018/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000414241 ENST00000373493(uc001bvr.3 uc001bvs.3 uc010ohj.2 uc010ohk.2)
ENST00000527118 ENST00000401893 ENST00000524393 ENST00000526193 ENST00000492348
ENST00000525506 ENST00000465780 ENST00000373485 ENST00000477563 ENST00000458695
ENST00000490500 ENST00000445722 ENST00000475321 ENST00000531983 ENST00000463378
ENST00000460669
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RBBP4 (NM_001135256) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBBP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBBP4 |
Additional cDNA sequence: AF085904.1 AK054859.1 AK056356.1 AK056550.1 AK222779.1 AK299251.1 AK312571.1 BC003092.1 BC015123.1 BC053904.1 BC075836.1 BT007309.1 X71810.1 X74262.1 24/32 DOTS entries (see all 32): DT.455410 DT.100861479 DT.121463449 DT.121463615 DT.318186 DT.91970046 DT.100799516 DT.92455261 DT.100037462 DT.100770926 DT.75124591 DT.100861478 DT.100861488 DT.120815332 DT.97859978 DT.100861485 DT.102833845 DT.102938 DT.121463394 DT.40189296 DT.95169498 DT.95169504 DT.100861474 DT.100861475 24/574 AceView cDNA sequences (see all 574): BQ051433 AL119637 AU117027 AA999738 AU117757 AA703653 BE464607 T98530 AI799252 BU933985 BM469581 CR600272 BU507241 AL045286 AA292984 CR611583 BQ937712 AA354104 R74343 AA290659 BM458082 CD673211 BX953916 BM855434
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RBBP4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RBBP4
|
Expression
for RBBP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBBP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAACTGTG
About this image
See RBBP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBBP4
SOURCE GeneReport for Unigene cluster: Hs.16003
SABiosciences Expression via Pathway-Focused PCR Array including RBBP4: | Polycomb & Trithorax Complexes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBBP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBBP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBBP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBBP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBBP4 |
Orthologs
for RBBP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RBBP4 gene from 8/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RBBP41 |
retinoblastoma binding protein 4 |
86.04(n)
99.76(a) |
|
395658 NM_204852.1 NP_990183.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RBBP46 |
-- |
100(a) |
1 ↔ 1 |
GL344283.1(48387-55556) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.5372 |
Xenopus laevis retinoblastoma A associated protein more |
82.44(n) |
|
AF073787.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.27412 |
Danio rerio mRNA similar to retinoblastoma binding more |
81.28(n) |
|
BC063984.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Caf11 , 3 |
negative regulation of transcription by
homeotic more3
Chromatin assembly factor 1 subunit1 |
91(a)3
74.15(n)1
91.06(a)1 |
|
3 88E33
418361 NM_001170146.11 NP_001163617.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
rba-13
lin-531 |
retinablastoma-binding protein RBAP46 like3
Protein LIN-531 |
54(a)3
66.83(n)1
73.4(a)1 |
|
I(9624662-9626157)3
1728021 NM_060151.51 NP_492552.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MSI16NFC026(see all 3) |
histone-binding protein RBBP4(see all 3) |
66(a)54(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
5(23556012-23558245) 2(7281462-7283646) |
rice
(Oryza sativa) |
Liliopsida |
Os.373452 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
74.28(n) |
|
AK059114.1 |
ENSEMBL Gene Tree for RBBP4 (if available)
TreeFam Gene Tree for RBBP4 (if available) |
Paralogs
for RBBP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBBP4 gene
- RBBP72 RFWD22
18/28 SIMAP similar genes for RBBP4 using alignment to 11 protein entries: RBBP4_HUMAN (see all proteins)
(see all similar genes):RBBP7 AURA2 UTY TMEM14B ZNF564 APOD
LOC100506792 SPATS2L THOC3 LINC00596 NF2 TSEN2
SHANK2 FAM175A NEK4 HECW1 SEPT2 LYRM4
RBBP4 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for RBBP4 (see all 6)
PGOHUM00000248048 PGOHUM00000237685 PGOHUM00000235127 PGOHUM00000235304 PGOHUM00000243216
|
Genomic Variants
for RBBP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBBP4 (33116743 - 33151812 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RBBP4
1 CNV: 5484 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBBP4 |
|
Disorders
/ Diseases
for RBBP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBBP4 for disorders About GeneDecksing
OMIM gene information: 602923
OMIM disorders: --
16  diseases for RBBP4: About MalaCardsretinoblastoma charcot-marie-tooth neuropathy tuberous sclerosis sjogren's syndrome
dermatomyositis neuropathy hepatocellular carcinoma cervical cancer
cervicitis thyroid cancer thyroiditis lung cancer
breast cancer carcinoma malaria intermediate charcot-marie-tooth neuropathy
1 disease from the University of Copenhagen DISEASES database for RBBP4:Retinoblastoma 2 Novoseek disease relationships for RBBP4 gene About this table
Human Genome Epidemiology (HuGE) Navigator: RBBP4 (3 documents)
Export disorders for RBBP4 gene to outside databases
|
Publications
for RBBP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBBP4 gene, integrated from 9 sources (see all 158):
(articles sorted by number of sources associating them with RBBP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of human NURF: a regulator of Engrailed gene expression. (PubMed id 14609955)1, 2, 3 Barak O....Shiekhattar R. (2003)
- A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. (PubMed id 8350924)1, 2, 3 Qian Y.-W....Lee E.Y.-H.P. (1993)
- RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein. (PubMed id 10734134)1, 2, 9 Nicolas E.... Trouche D. (2000)
- SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PubMed id 9651585)1, 2, 9 Zhang Y.... Reinberg D. (1998)
- LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PubMed id 17671431)1, 2, 9 Schmit F.... Gaubatz S. (2007)
- MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. (PubMed id 15701600)1, 2, 9 Jin S.-G.... Pfeifer G.P. (2005)
- Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). (PubMed id 11784859)1, 2, 9 Kuzmichev A.... Reinberg D. (2002)
- Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. (PubMed id 11118440)1, 2, 9 Skowyra D.... Qin J. (2001)
- BRCA1 interacts with components of the histone deacetylase complex. (PubMed id 10220405)1, 2, 9 Yarden R.I. and Brody L.C. (1999)
- A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. (PubMed id 9520398)1, 2, 9 Hassig C.A.... Schreiber S.L. (1998)
|
External Searches for RBBP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBBP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBBP4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBBP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RBBP4 gene:
Search GeneIP for patents involving RBBP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBBP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RBBP4 | | OriGene shRNA RFP for RBBP4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBBP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBBP4 | | | OriGene Protein Over-expression Lysate for RBBP4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBBP4 | | OriGene 3'-UTR Clone for RBBP4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBBP4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RBBP4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RBBP4 | | OriGene Custom Protein Services for RBBP4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBBP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBBP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBBP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBBP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBBP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBBP4 |
| |
 |  |  |  | |
| | Antibodies & Assays for RBBP4 |
| | | | Search Tocris compounds for RBBP4 |
| |  |  |  |  | | | | | | Recombinant Protein for RBBP4 |
|
 |
 |
 |
 | | | RBBP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBBP4 |
|  |  |  | | | | ThermoFisher Antibody for RBBP4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBBP4 |
|
|
|
|
