RBAK Gene
protein-coding GIFtS: 47
GCID: GC07P005023
|
|
RB-associated KRAB zinc finger
| |
Aliases
for RBAK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RB-Associated KRAB Zinc Finger1 2 | | ZNF7691 2 3 | | Zinc Finger Protein 7692 3 | | RB-Associated KRAB Repressor2 3 | | RB-Associated KRAB Zinc Finger Protein2 | | HRBaK1 |
Export aliases for RBAK gene to outside databasesPrevious GC identifers: GC07P004729 GC07P004829 GC07P004858 GC07P005052 GC07P004990 GC07P004994 |
Summaries
for RBAK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RBAK:
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interactingproteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcriptionfactor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif.Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus.(provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: RBAK_HUMAN, Q9NYW8Function: May repress E2F-dependent transcription. May promote AR-dependent transcription
|
Genomic Views
for RBAK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RBAK gene promoter:
GR GR-beta SREBP-1c C/EBPalpha SREBP-1b NRF-2 SREBP-1a c-Myb GR-alpha Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RBAK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBAK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.1RBAK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P005023: view genomic region
(about GC identifiers)
Start:
|
5,023,349 bp from pter |
End:
|
5,112,854 bp from pter |
Size:
|
89,506 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 5,131,908-5,155,474 |
|
Proteins
for RBAK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBAK_HUMAN, Q9NYW8 (See
protein sequence)Recommended Name: RB-associated KRAB zinc finger protein Size: 714 amino acids; 82995 Da
Subunit: Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR
Subcellular location: Nucleus
Secondary accessions: A6NDF2 A8KAK4 B2RN44 B9EGS1 F8W6M7Alternative splicing: 2 isoforms: Q9NYW8-1 Q9NYW8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RBAK: NX_Q9NYW8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYW8
RBAK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191385.1 NP_066986.1
ENSEMBL proteins: ENSP00000385560 ENSP00000275423 ENSP00000380112 ENSP00000380120
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RBAK for ontologies About GeneDecksing
RBAK Antibody Products:
Assay Products for RBAK: |
Protein
Domains /
Families
for RBAK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RBAK for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NYW8ProtoNet protein and cluster: Q9NYW8 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: RBAK_HUMAN, Q9NYW8Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for RBAK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBAK_HUMAN, Q9NYW8Function: May repress E2F-dependent transcription. May promote AR-dependent transcription
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBAK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBAK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RBAK (NM_021163) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBAK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBAK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBAK |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RBAK for ontologies About GeneDecksing
|
Pathways & Interactions
for RBAK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RBAK
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for RBAK (Q9NYW83 ENSP000002754234) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
RBAK for ontologies About GeneDecksing
|
Drugs & Compounds
for RBAK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RBAK
Search CenterWatch for drugs/clinical trials and news about RBAK
|
Transcripts
for RBAK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RBAK gene (2 alternative transcripts): NM_001204456.1 NM_021163.3 Unigene Cluster for RBAK: RB-associated KRAB zinc finger Hs.396178 [show with all ESTs]Unigene Representative Sequence: NM_0211636 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000407184(uc003snr.3) ENST00000353796 ENST00000396904(uc021zzc.1)
ENST00000476992 ENST00000498308(uc010kst.3) ENST00000396912(uc010kss.1 uc003sns.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBAK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBAK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RBAK (NM_021163) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RBAK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBAK |
Additional cDNA sequence: AK093275.1 AK293069.1 BC136675.1 BC136676.1 8 DOTS entries: DT.413956 DT.445470 DT.95219963 DT.121112553 DT.95110506 DT.412874 DT.97862726 DT.95222906 24/329 AceView cDNA sequences (see all 329): CK429258 AA746299 CA436370 BG941068 BE303029 AA627128 AA732600 BF055141 F11246 AI024759 AI018503 AA912708 AI024605 CR619754 F08909 AI468075 BU785403 AA804908 AK093275 BE350347 NM_203393 BM817557 AI380539 BU187037
GeneLoc Exon Structure
|
Expression
for RBAK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RBAK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTTAAAC
About this image
See RBAK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RBAK
SOURCE GeneReport for Unigene cluster: Hs.396178
UniProtKB/Swiss-Prot: RBAK_HUMAN, Q9NYW8Tissue specificity: Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta
SABiosciences Custom PCR Arrays for RBAK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBAK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RBAK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBAK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBAK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBAK |
Orthologs
for RBAK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for RBAK (if available)
TreeFam Gene Tree for RBAK (if available) |
Paralogs
for RBAK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RBAK gene
- ZNF3342 ENSG000002673602 ZNF7822 ZNF122 ZNF5102 ZNF5672 ZNF33A2 ZNF7172
- ZNF487P2 ZNF37A2 ZNF2482 ZNF33B2 ZNF3822
18/407 SIMAP similar genes for RBAK using alignment to 3 protein entries: RBAK_HUMAN (see all proteins)
(see all similar genes):POM121C PMS2P3 ZNF300P1 MGC12518 ZNF12 HZF11
ZNF32 ZNF702P ZNF81 ZNF789 ZNF852 ZNF101
ZNF323 ZNF66 ZNF768 ZNF283 ZNF420 ZFS-1
RBAK for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RBAK
PGOHUM00000258252 PGOHUM00000258255
|
Genomic Variants
for RBAK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RBAK (5023349 - 5112854 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RBAK: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBAK |
|
Disorders
/ Diseases
for RBAK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RBAK for disorders About GeneDecksing
OMIM gene information: 608191
OMIM disorders: --
3  diseases for RBAK: About MalaCardsretinoblastoma hyperaldosteronism familial hyperaldosteronism
Human Genome Epidemiology (HuGE) Navigator: RBAK (1 document)
Export disorders for RBAK gene to outside databases
|
Publications
for RBAK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RBAK gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with RBAK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. (PubMed id 10702291)1, 2, 9 Skapek S.X....Lee E.Y.-H.P. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity. (PubMed id 14664718)1, 2 Hofman K.... Heyns W. (2003)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- [Review for the regulatory functions of KRAB zinc fin ger proteins in embryonic development and tumorgenesis of higher vertebrates] (PubMed id 20466629)1 Ma Z.F....Jiang Y. (2010)
- Identification of candidate genes for human pituitary development by EST analysis. (PubMed id 19284880)1 Ma Y....Hao X. (2009)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. (PubMed id 18307725)1 Jeske Y.W....Stowasser M. (2008)
- No evidence for coding region mutations in the retinoblastoma-associated Kruppel-associated box protein gene (RBaK) causing familial hyperaldosteronism type II. (PubMed id 17121540)1 So A....Stowasser M. (2006)
|
External Searches for RBAK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RBAK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RBAK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RBAK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RBAK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RBAK gene:
Search GeneIP for patents involving RBAK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RBAK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RBAK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RBAK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RBAK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RBAK | | OriGene 3'-UTR Clone for RBAK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RBAK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RBAK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RBAK | | OriGene Custom Protein Services for RBAK | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RBAK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RBAK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RBAK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RBAK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RBAK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RBAK |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RBAK |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RBAK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RBAK |
|  |  |  | | | | Search ThermoFisher Antibodies for RBAK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RBAK |
|
|
|
|
