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Aliases for RBAK Gene

Aliases for RBAK Gene

  • RB-Associated KRAB Zinc Finger 2 3
  • RB-Associated KRAB Repressor 3 4
  • Zinc Finger Protein 769 3 4
  • ZNF769 3 4
  • RB-Associated KRAB Zinc Finger Protein 3
  • HRBaK 4

External Ids for RBAK Gene

Previous GeneCards Identifiers for RBAK Gene

  • GC07P004729
  • GC07P004829
  • GC07P004858
  • GC07P005052
  • GC07P004990
  • GC07P004994
  • GC07P005023

Summaries for RBAK Gene

Entrez Gene Summary for RBAK Gene

  • This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]

GeneCards Summary for RBAK Gene

RBAK (RB-Associated KRAB Zinc Finger) is a Protein Coding gene. Diseases associated with RBAK include familial hyperaldosteronism. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for RBAK Gene

  • May repress E2F-dependent transcription. May promote AR-dependent transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBAK Gene

Genomics for RBAK Gene

Regulatory Elements for RBAK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBAK Gene

Start:
5,045,821 bp from pter
End:
5,069,488 bp from pter
Size:
23,668 bases
Orientation:
Plus strand

Genomic View for RBAK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBAK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBAK Gene

Proteins for RBAK Gene

  • Protein details for RBAK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW8-RBAK_HUMAN
    Recommended name:
    RB-associated KRAB zinc finger protein
    Protein Accession:
    Q9NYW8
    Secondary Accessions:
    • A6NDF2
    • A8KAK4
    • B2RN44
    • B9EGS1
    • F8W6M7

    Protein attributes for RBAK Gene

    Size:
    714 amino acids
    Molecular mass:
    82995 Da
    Quaternary structure:
    • Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR.

    Alternative splice isoforms for RBAK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBAK Gene

Proteomics data for RBAK Gene at MOPED

Post-translational modifications for RBAK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBAK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBAK Gene

Domains for RBAK Gene

Gene Families for RBAK Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for RBAK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYW8

UniProtKB/Swiss-Prot:

RBAK_HUMAN :
  • Q9NYW8
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with RBAK: view

Function for RBAK Gene

Molecular function for RBAK Gene

UniProtKB/Swiss-Prot Function: May repress E2F-dependent transcription. May promote AR-dependent transcription.

Gene Ontology (GO) - Molecular Function for RBAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding NAS 10702291
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RBAK: view

Animal Model Products

CRISPR Products

miRNA for RBAK Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBAK

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBAK Gene

Localization for RBAK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBAK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBAK Gene COMPARTMENTS Subcellular localization image for RBAK gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus TAS 10702291
genes like me logo Genes that share ontologies with RBAK: view

Pathways for RBAK Gene

SuperPathways for RBAK Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10702291
GO:0045892 negative regulation of transcription, DNA-templated TAS 10702291
genes like me logo Genes that share ontologies with RBAK: view

No data available for Pathways by source for RBAK Gene

Transcripts for RBAK Gene

Unigene Clusters for RBAK Gene

RB-associated KRAB zinc finger:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBAK

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RBAK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBAK Gene

No ASD Table

Relevant External Links for RBAK Gene

GeneLoc Exon Structure for
RBAK
ECgene alternative splicing isoforms for
RBAK

Expression for RBAK Gene

mRNA expression in normal human tissues for RBAK Gene

mRNA differential expression in normal tissues according to GTEx for RBAK Gene

This gene is overexpressed in Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBAK Gene

SOURCE GeneReport for Unigene cluster for RBAK Gene Hs.396178

mRNA Expression by UniProt/SwissProt for RBAK Gene

Q9NYW8-RBAK_HUMAN
Tissue specificity: Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.
genes like me logo Genes that share expressions with RBAK: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RBAK Gene

Orthologs for RBAK Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBAK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBAK 35
  • 99.02 (n)
  • 99.58 (a)
RBAK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBAK 35
  • 85.26 (n)
  • 87.18 (a)
RBAK 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBAK 35
  • 88.61 (n)
  • 89.36 (a)
RBAK 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbak 35
  • 79.31 (n)
  • 79.69 (a)
Rbak 16
Rbak 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7427 36
  • 40 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rbak 35
  • 79.3 (n)
  • 79.01 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX324142.2 36
  • 40 (a)
ManyToMany
BX465848.2 36
  • 40 (a)
ManyToMany
BX465848.3 36
  • 38 (a)
ManyToMany
BX572103.5 36
  • 45 (a)
ManyToMany
BX936350.2 36
  • 41 (a)
ManyToMany
CABZ01000592.1 36
  • 41 (a)
ManyToMany
CR388095.2 36
  • 43 (a)
ManyToMany
CR388132.1 36
  • 42 (a)
ManyToMany
si:ch211-271g18.3 36
  • 38 (a)
ManyToMany
si:dkey-149m13.2 36
  • 41 (a)
ManyToMany
si:dkey-16p19.10 36
  • 36 (a)
ManyToMany
si:dkey-202n8.1 36
  • 36 (a)
ManyToMany
si:dkey-257e4.5 36
  • 41 (a)
ManyToMany
si:dkey-261j4.5 36
  • 32 (a)
ManyToMany
si:dkey-47k16.3 36
  • 43 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
Species with no ortholog for RBAK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBAK Gene

ENSEMBL:
Gene Tree for RBAK (if available)
TreeFam:
Gene Tree for RBAK (if available)

Paralogs for RBAK Gene

Selected SIMAP similar genes for RBAK Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RBAK Gene

genes like me logo Genes that share paralogs with RBAK: view

Variants for RBAK Gene

Sequence variations from dbSNP and Humsavar for RBAK Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_038438 -

Structural Variations from Database of Genomic Variants (DGV) for RBAK Gene

Variant ID Type Subtype PubMed ID
nsv8033 CNV Loss 18304495
nsv436904 CNV Insertion 17901297

Relevant External Links for RBAK Gene

HapMap Linkage Disequilibrium report
RBAK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBAK Gene

Disorders for RBAK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RBAK Gene including...

Search for RBAK Gene in MalaCards »

Relevant External Links for RBAK

Genetic Association Database (GAD)
RBAK
Human Genome Epidemiology (HuGE) Navigator
RBAK
genes like me logo Genes that share disorders with RBAK: view

No data available for UniProtKB/Swiss-Prot for RBAK Gene

Publications for RBAK Gene

  1. Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. (PMID: 10702291) Skapek S.X. … Lee E.Y.-H.P. (J. Biol. Chem. 2000) 3 4 23
  2. The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity. (PMID: 14664718) Hofman K. … Heyns W. (J. Mol. Endocrinol. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  5. Identification of candidate genes for human pituitary development by EST analysis. (PMID: 19284880) Ma Y. … Hao X. (BMC Genomics 2009) 3

Products for RBAK Gene

Sources for RBAK Gene

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