Aliases for RB1CC1 Gene
External Ids for RB1CC1 Gene
Previous GeneCards Identifiers for RB1CC1 Gene
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
GeneCards Summary for RB1CC1 Gene
RB1CC1 (RB1-Inducible Coiled-Coil 1) is a Protein Coding gene. Diseases associated with RB1CC1 include breast cancer. Among its related pathways are GPCR Pathway and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include protein kinase binding.
UniProtKB/Swiss-Prot for RB1CC1 Gene
Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.