RB1CC1 Gene
protein-coding GIFtS: 56
GCID: GC08M053584
|
|
RB1-inducible coiled-coil 1
| |
Aliases
for RB1CC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RB1-Inducible Coiled-Coil 11 2 | | Cc11 | | FIP2001 2 3 | | DRAGOU141 | | KIAA02031 3 5 | | 200 KDa FAK Family Kinase-Interacting Protein2 | | FAK Family Kinase-Interacting Protein Of 200 KDa2 3 | | RB1-Inducible Coiled-Coil Protein 12 | | CC12 5 | | RBICC3 |
Export aliases for RB1CC1 gene to outside databasesPrevious GC identifers: GC08M052817 GC08M053540 GC08M053258 GC08M053697 GC08M049002 |
Summaries
for RB1CC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RB1CC1:
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cellproliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 geneexpression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.(provided by RefSeq, Nov 2009)
UniProtKB/Swiss-Prot: RBCC1_HUMAN, Q8TDY2Function: Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potentregulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is,thus, a prerequisite for myogenic differentiation. Involved in autophagy. Required for autophagosome formation (Bysimilarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways
Gene Wiki entry for RB1CC1
|
Genomic Views
for RB1CC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RB1CC1 gene promoter:
C/EBPbeta Elk-1 AML1a AP-1 ATF-2 Evi-1 c-Jun ZID MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RB1CC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RB1CC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q11 Ensembl cytogenetic band: 8q11.23 HGNC cytogenetic band: 8q11RB1CC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M053584: view genomic region
(about GC identifiers)
Start:
|
53,535,016 bp from pter |
End:
|
53,658,403 bp from pter |
Size:
|
123,388 bases |
Orientation:
|
minus strand |
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Proteins
for RB1CC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBCC1_HUMAN, Q8TDY2 (See
protein sequence)Recommended Name: RB1-inducible coiled-coil protein 1 Size: 1594 amino acids; 183091 Da
Subunit: Part of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1. This complex associates with ATG101.Interacts with PTK2/FAK1 and PTK2B/PYK2
Subcellular location: Nucleus. Cytoplasm, cytosol. Preautophagosomal structure (By similarity). Note=Under starvationconditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portionof the cytoplasm resulting in the formation of an autophagosome (By similarity)
Developmental stage: Expression was difficult to detect in immature proliferating chondroblasts or myogenic cells inembryos, but became obvious and prominent concomitantly with the maturation of osteocytes, chondrocytes, and skeletalmuscle cells. Expression in these musculoskeletal cells increased with RB1 expression, which is linked to the terminaldifferentiation of many tissues and cells. The introduction of the wild-type protein decreased the formation ofmacroscopic colonies in a cell growth assay
Miscellaneous: Probably involved in the tumorigenesis of breast cancer. RB1CC1 is frequently mutated in breast cancerand shows characteristics of a classical tumor suppressor gene
Sequence caution: Sequence=BAA13194.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q86YR4 Q8WVU9 Q92601Alternative splicing: 2 isoforms: Q8TDY2-1 Q8TDY2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RB1CC1: NX_Q8TDY2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TDY2
RB1CC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001077086.1 NP_055596.3
ENSEMBL proteins: ENSP00000025008 ENSP00000396067 ENSP00000430809 ENSP00000430792 ENSP00000429879 ENSP00000429918 ENSP00000429115 ENSP00000429611 ENSP00000445960
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RB1CC1 for ontologies About GeneDecksing
RB1CC1 Antibody Products:
Assay Products for RB1CC1: |
Protein
Domains /
Families
for RB1CC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RB1CC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TDY2ProtoNet protein and cluster: Q8TDY2 1 Blocks protein family: IPB000626 Ubiquitin domain
|
Function
for RB1CC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RBCC1_HUMAN, Q8TDY2Function: Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potentregulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is,thus, a prerequisite for myogenic differentiation. Involved in autophagy. Required for autophagosome formation (Bysimilarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RB1CC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RB1CC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RB1CC1 (NM_014781) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RB1CC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RB1CC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RB1CC1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0019901 | protein kinase binding |
IEA | -- |
RB1CC1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RB1CC1:
Animal Models:
Mouse knock-outs for RB1CC1: Rb1cc1tm1.3Guan Rb1cc1tm1.2Guan
11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rb1cc1):
RB1CC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RB1CC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Integrated Pancreatic Cancer Pathway | | | 2 | Senescence and Autophagy | | | 3 | mTOR signaling pathway | | | 4 | GPCR Pathway | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RB1CC1
4  BioSystems Pathways for RB1CC1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RB1CC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/258 Interacting proteins for RB1CC1 (Q8TDY21, 3 ENSP000000250084) via UniProtKB, MINT, STRING, and/or I2D (see all 258)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ATG13 | O751431, 3, ENSP000003103214 | EBI-1047793,EBI-2798775 I2D:
score=6 STRING: ENSP00000310321 | | TBKBP1 | A7MCY61, 3, ENSP000003547774 | STRING: ENSP00000354777 EBI-1047793,EBI-359969 I2D:
score=2 | | ULK1 | O753851, 3, ENSP000003245604 | EBI-1047793,EBI-908831 I2D:
score=6 STRING: ENSP00000324560 | | ATG16L1 | Q676U53, ENSP000003758724 | I2D:
score=3 STRING: ENSP00000375872 | | PRKAB2 | O437413, ENSP000002541014 | I2D:
score=3 STRING: ENSP00000254101 |
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000045 | autophagic vacuole assembly |
IEA | -- | | GO:0001889 | liver development |
IEA | -- | | GO:0001934 | positive regulation of protein phosphorylation |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
RB1CC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RB1CC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RB1CC1
Search CenterWatch for drugs/clinical trials and news about RB1CC1 / RBCC1
|
Transcripts
for RB1CC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RB1CC1 gene (2 alternative transcripts): NM_001083617.1 NM_014781.4 Unigene Cluster for RB1CC1: RB1-inducible coiled-coil 1 Hs.196102 [show with all ESTs]Unigene Representative Sequence: NM_01478111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000025008(uc003xre.4 uc003xrf.4) ENST00000435644 ENST00000521611
ENST00000519912 ENST00000522957 ENST00000523594 ENST00000518710 ENST00000517963
ENST00000518211 ENST00000518468 ENST00000539297
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RB1CC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RB1CC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RB1CC1 (NM_014781) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RB1CC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RB1CC1 |
Additional cDNA sequence: AB059622.1 AK095971.1 AK291699.1 AK294579.1 AK307436.1 AY173931.1 BC017556.1 BC032074.1 D86958.1 Z35085.1 16 DOTS entries: DT.456236 DT.100683921 DT.75166221 DT.91834114 DT.95293439 DT.426729 DT.92011885 DT.95293447 DT.95293450 DT.102842939 DT.120649475 DT.91745872 DT.92454309 DT.95293414 DT.95293416 DT.91738016 24/289 AceView cDNA sequences (see all 289): CB991758 R22753 AI093402 BU181360 AA825362 Z40222 AA338296 BM675289 BC032074 F11154 AA131779 BU902094 AI339976 AL044138 BI089085 AA063364 T39659 D86958 N77304 AU138642 BG390116 BU507512 W38750 AL043663
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RB1CC1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24 | ^ | 25a | · | 25b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RB1CC1
|
Expression
for RB1CC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RB1CC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGAGTTTC
About this image
See RB1CC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RB1CC1
SOURCE GeneReport for Unigene cluster: Hs.196102
UniProtKB/Swiss-Prot: RBCC1_HUMAN, Q8TDY2Tissue specificity: Expression levels correlated closely with those of RB1 in cancer cell lines as well as in variousnormal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells
SABiosciences Custom PCR Arrays for RB1CC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RB1CC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RB1CC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RB1CC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RB1CC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RB1CC1 |
Orthologs
for RB1CC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RB1CC1 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for RB1CC1 (if available)
TreeFam Gene Tree for RB1CC1 (if available) |
Paralogs
for RB1CC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RB1CC1 gene
RB1CC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RB1CC1
PGOHUM00000235705
|
Genomic Variants
for RB1CC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RB1CC1 (53535016 - 53658403 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RB1CC1: --
Human Gene Mutation Database (HGMD): RB1CC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RB1CC1 |
|
Disorders
/ Diseases
for RB1CC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RB1CC1 for disorders About GeneDecksing
OMIM gene information: 606837
OMIM disorders: 114480
13  diseases for RB1CC1: About MalaCardsretinoblastoma breast cancer, somatic breast cancer pulmonary disease
alzheimer's disease breast carcinoma osteosarcoma esophagitis
schizophrenia adenocarcinoma carcinoma neuronitis
ovarian cancer
1 Novoseek disease relationship for RB1CC1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoblastoma |
55.6 |
3 |
15375585 (1), 19437535 (1), 12163359 (1) |
Human Genome Epidemiology (HuGE) Navigator: RB1CC1 (5 documents)
Export disorders for RB1CC1 gene to outside databases
|
Publications
for RB1CC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RB1CC1 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with RB1CC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells. (PubMed id 11850849)1, 2, 3 Chano T.... Saeki Y. (2002)
- Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells. (PubMed id 12163359)1, 2, 9 Chano T.... Okabe H. (2002)
- Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PubMed id 19211835)1, 2 Hosokawa N....Mizushima N. (2009)
- FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. (PubMed id 18443221)1, 3 Hara T....Mizushima N. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells. (PubMed id 14533007)1, 2 Kontani K.... Okabe H. (2003)
- Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. (PubMed id 12221124)1, 2 Abbi S....Guan J.L. (2002)
- Isolation, characterization and mapping of the mouse and human RB1CC1 genes. (PubMed id 12095676)1, 2 Chano T.... Okabe H. (2002)
- Truncating mutations of RB1CC1 in human breast cancer. (PubMed id 12068296)1, 2 Chano T.... Ikegawa S. (2002)
|
External Searches for RB1CC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RB1CC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RB1CC1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RB1CC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RB1CC1 gene:
Search GeneIP for patents involving RB1CC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RB1CC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RB1CC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RB1CC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RB1CC1 | | | OriGene Protein Over-expression Lysate for RB1CC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RB1CC1 | | OriGene 3'-UTR Clone for RB1CC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RB1CC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RB1CC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RB1CC1 | | OriGene Custom Protein Services for RB1CC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RB1CC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RB1CC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RB1CC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RB1CC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RB1CC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RB1CC1 |
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| | Antibodies & Assays for RB1CC1 |
| | | | Search Tocris compounds for RB1CC1 |
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 | | | RB1CC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RB1CC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for RB1CC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RB1CC1 |
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