RB1 Gene

Aliases &
Descriptions
for RB1

Previous GC identifers: GC13P046877 GC13P042865 GC13P047814 GC13P046675

Summaries
for RB1

Gene Wiki entry for RB1 (Retinoblastoma_protein)

Genomic Location
for RB1

Proteins
for RB1

PDB structures from and Proteopedia :

1AD6 (3D)    1GH6 (3D)    1GUX (3D)    1H25 (3D)    1N4M (3D)    1O9K (3D)    1PJM (3D)    2AZE (3D)    

2QDJ (3D)    2R7G (3D)    

Post-translational modifications:

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant RB1 Protein
	Sigma-Aldrich CompoZr ZFN for RB1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (cleaved RB, Rb)
	Human Recombinant Proteins from Abnova (RB1)

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

	Invitrogen Antibodies for RB1
	Millipore Mono- and Polyclonal Antibodies for the study of RB1
	Sigma-Aldrich Antibody Arrays and Antibodies for RB1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RB1  (Rb)
	Antibodies from Abcam (cleaved RB, Rb), each with their AbpromiseSM
	Monoclonal and Polyclonal Antibodies from Abnova (RB1)
	Novus Biologicals Antibodies for RB1

	Invitrogen Assays for RB1
	Millipore Kits and Assays for the Analysis of RB1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for RB1

5/6 InterPro domains/families (see all 6 ):

IPR015030 Rb_C  IPR002719 RB_B  IPR015652 Rb_associated  IPR013763 Cyclin_related  IPR002720 RB_A    GeneDecks  RB1 for the domains selected above   About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P06400

ProtoNet protein and cluster: P06400

Gene Function
for RB1

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RB1)
		Millipore RNAi Products for the Analysis of RB1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (RB1)

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

15/27 MGI mutant phenotypes (inferred from 17 alleles) (MGI details for Rb1) (see all 27 ):

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

Pathways & Interactions
for RB1

5/6 Invitrogen iPath™ Online BioAtlas - Pathways for RB1 (see all 6 ) (Maps provided by GeneGo):

Opioid and somatostatin systems in negative cell growth regulation via MAP kinase pathways  Caspases cascade activation by granzyme and other signaling proteins  Regulatory cascade of cyclin gene expression  Regulation of G1-S transition  P53 signaling pathway    GeneDecks  RB1 for the pathways selected above   About GeneDecksing

4 Millipore Pathways for RB1

Cell cycle Regulation of G1/S transition (part 2)  Cell cycle ESR1 regulation of G1/S transition  Transcription P53 signaling pathway  Cell cycle Cell cycle (generic schema)    GeneDecks  RB1 for the pathways selected above   About GeneDecksing

5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for  RB1  (Your Favorite Gene powered by Ingenuity)

Molecular Mechanisms of Cancer  Cell Cycle: G1/S Checkpoint Regulation  Bladder Cancer Signaling  Melanoma Signaling  Role of BRCA1 in DNA Damage Response    GeneDecks  RB1 for the pathways selected above   About GeneDecksing

1 Cell Signaling Technology (CST) Pathway for RB1: 

Cell Cycle Control: G1/S Checkpoint    GeneDecks  RB1 for the pathways selected above   About GeneDecksing

5/10 Kegg Pathways  (Kegg details for RB1) (see all 10 ):

hsa04110 Cell cycle  hsa05200 Pathways in cancer  hsa05212 Pancreatic cancer  hsa05214 Glioma  hsa05215 Prostate cancer    GeneDecks  RB1 for the pathways selected above   About GeneDecksing

5/20 Gene Ontology (GO) biological process terms (links to tree view) (see all 20 ):

Drugs & Compounds
for RB1

Transcripts
for RB1

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RB1)
		Millipore RNAi Products for the Analysis of RB1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (RB1)

Applied Biosystems Silencer® siRNAs: 

REFSEQ mRNAs for RB1 gene: 

Applied Biosystems TaqMan ® Gene Expression Assays: 

Expression
for RB1

RB1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RB1

¹ / ² / ³

10 probe-sets matching RB1 gene

	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
			# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	1905_s_at2, 3	U95-A	1	1.00	1.00	0.68	0.55	HG2441-HT2537	0.20	1.00	0.72	1
	2044_s_at2, 3	U95-A	1	1.00	1.00	0.73	1.59	M15400	1.00	0.90	0.95	1
	1672_f_at2, 3	U95-A	1	1.00	1.00	0.65	0.17	L41913	0.20	1.00	0.72	1
	1900_at2, 3	U95-A	1	1.00	1.00	0.53	0.96	L41870	1.00	0.90	0.95	1
	1571_f_at2, 3	U95-A	1	0.94	1.00	0.76	0.95	L49229	0.20	1.00	0.72	1
	1570_f_at2, 3	U95-A	2	0.81	0.92	0.09	0.22	L49219	0.20	1.00	0.72	1
	203132_at2, 3	U133-A	1	1.00	1.00	--	--	NM_000321	0.60	1.00	0.82	1
	211540_s_at2, 3	U133-A	1	1.00	1.00	--	--	M19701	0.60	1.00	0.82	1
	203132_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	211540_s_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AATATCATAC

SOURCE GeneReport for Unigene cluster: Hs.408528

Expression variation in blood from EXPOLDB for RB1

UniProtKB/Swiss-Prot: RB_HUMAN, P06400

Tissue specificity: Expressed in the retina

Orthologs
for RB1

Paralogs
for RB1

Paralogs for RB1 gene

RBL2²  RBL1²  

SNPs/Variants
for RB1

Disorders & Mutations
for RB1

UniProtKB/Swiss-Prot: RB_HUMAN, P06400

10/96 Novoseek disease relationships for RB1 gene (see all 96 )

Medical News
for RB1

Publications
for RB1

• Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. (PubMed id 7935440)^{1, 3, 4} Kim Y.W.... Kaye F.J. (1994)
• Comprehensive screening for constitutional RB1 mutations by DHPLC and QMPSF. (PubMed id 14722923)^{1, 3, 6} Houdayer C....Stoppa-Lyonnet D. (2004)
• Age at diagnosis of isolated unilateral retinoblastoma does not distinguish patients with and without a constitutional RB1 gene mutation but is influenced by a parent-of-origin effect. (PubMed id 15763650)^{1, 3, 6} Schuler A....Lohmann D.R. (2005)
• Spectrum of germline mutations in the RB1 gene: a study of 232 patients with hereditary and non hereditary retinoblastoma. (PubMed id 7795591)^{1, 3, 4} Blanquet V.... Besmond C. (1995)
• Genotype phenotype correlations in Israeli colorectal cancer patients. (PubMed id 15523694)^{1, 3, 6} Starinsky S....Friedman E. (2005)
• Twelve novel RB1 gene mutations in patients with hereditary retinoblastoma. (PubMed id 10671068)^{1, 3, 4} Yilmaz S.... Lohmann D.R. (1998)
• Germline mutations in the RB1 gene in patients with hereditary retinoblastoma. (PubMed id 8605116)^{1, 3, 4} Liu Z.... Cowell J.K. (1995)
• Distinct RB1 gene mutations with low penetrance in hereditary retinoblastoma. (PubMed id 7927327)^{1, 3, 4} Lohmann D.R.... Horsthemke B. (1994)
• Frequent constitutional C to T mutations in CGA-arginine codons in the RB1 gene produce premature stop codons in patients with bilateral (hereditary) retinoblastoma. (PubMed id 7704558)^{1, 3, 4} Cowell J.K.... Bia B. (1994)
• Detection of heterozygous mutations in the RB1 gene in retinoblastoma patients using single-strand conformation polymorphism analysis and polymerase chain reaction sequencing. (PubMed id 1352398)^{1, 3, 4} Hogg A.... Cowell J.K. (1992)
• Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. (PubMed id 17974914)^{3, 4} Liu X. and Marmorstein R. (2007)
• Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. (PubMed id 15803180)^{3, 4} Roesch A....Vogt T. (2005)
• Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)^{3, 4} Gray S.G.... Dangond F. (2005)
• Outpatient clinic for genetic counseling and gene testing of retinoblastoma. (PubMed id 15162822)^{3, 6} Sugano K....Kaneko A. (2004)
• Ethnic variations of a retinoblastoma susceptibility gene (RB1) polymorphism in eight Asian populations. (PubMed id 14631100)^{3, 6} Kadam-Pai P....Lai P.S. (2003)
• Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. (PubMed id 12682072)^{3, 4} Balasenthil S. and Vadlamudi R.K. (2003)
• Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein. (PubMed id 12475961)^{3, 4} Markiewicz E.... Hutchison C.J. (2002)
• A parent-of-origin effect in two families with retinoblastoma is associated with a distinct splice mutation in the RB1 gene. (PubMed id 12016586)^{3, 6} Klutz M....Lohmann D.R. (2002)
• Identification of four novel RB1 germline mutations in Korean retinoblastoma patients. (PubMed id 11524739)^{3, 4} Yu Y.S.... Park J.-G. (2001)
• Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p. (PubMed id 10779342)^{3, 4} Zheng L.... Lee W.-H. (2000)
• RB1 gene mutations in peripheral blood DNA of patients with isolated unilateral retinoblastoma. (PubMed id 9973307)^{3, 4} Klutz M.... Lohmann D.R. (1999)
• Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product. (PubMed id 10446990)^{3, 4} Numata S.... Croce C.M. (1999)
• Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. (PubMed id 9495340)^{3, 4} Lee J.O.... Pavletich N.P. (1998)
• Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma. (PubMed id 9311732)^{3, 4} Lohmann D.R.... Horsthemke B. (1997)
• Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. (PubMed id 9145110)^{3, 4} Kim H.Y. and Cho Y. (1997)
• Genetics of retinoblastoma: a study. (PubMed id 9140452)^{3, 4} Mateu E.... Prieto F. (1997)
• The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. (PubMed id 7525595)^{3, 4} Durfee T.... Lee W.H. (1994)
• Complete genomic sequence of the human retinoblastoma susceptibility gene. (PubMed id 7902321)^{3, 4} Toguchida J.... Dryja T.P. (1993)
• Molecular mechanisms of oncogenic mutations in tumors from patients with bilateral and unilateral retinoblastoma. (PubMed id 8346255)^{3, 4} Hogg A.... Cowell J.K. (1993)
• Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype. (PubMed id 1352883)^{3, 4} Onadim Z.... Cowell J.K. (1992)
• Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PubMed id 1857421)^{2, 3} Defeo-Jones D.... Oliff A. (1991)
• The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. (PubMed id 1756735)^{3, 4} Lees J.A.... Harlow E. (1991)
• Genomic organization of the human retinoblastoma gene. (PubMed id 2717184)^{3, 4} T'Ang A.... Fung Y.K.T. (1989)
• Structure and partial genomic sequence of the human retinoblastoma susceptibility gene. (PubMed id 2701949)^{3, 4} McGee T.L.... Dryja T.P. (1989)
• Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. (PubMed id 2594029)^{3, 4} Yandell D.W.... Dryja T.P. (1989)
• Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79. (PubMed id 3413073)^{3, 4} Lee E.Y.-H.P....Lee W.-H. (1988)
• SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. (PubMed id 2839300)^{3, 4} Decaprio J.A.... Livingston D.M. (1988)
• The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. (PubMed id 3657987)^{3, 4} Lee W.-H.... Lee E.Y.-H.P. (1987)
• Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. (PubMed id 3480530)^{3, 4} Friend S.H.... Weinberg R.A. (1987)
• Human retinoblastoma susceptibility gene: cloning, identification, and sequence. (PubMed id 3823889)^{3, 4} Lee W.-H....Lee E.Y.-H.P. (1987)
• Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. (PubMed id 15655836)^{1, 3} Ma H.B....Li Y. (2005)
• Interaction of the retinoblastoma gene product, RB, with cyclophilin A negatively affects cyclosporin-inhibited NFAT signaling. (PubMed id 12210730)^{1, 3} Cui Y....Chiu R. (2002)
• Retinoblastoma protein is frequently absent or phosphorylated in anaplastic large-cell lymphoma. (PubMed id 15161658)^{1, 3} Rassidakis G.Z....Medeiros L.J. (2004)
• Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity. (PubMed id 11126356)^{1, 3} Siegert J.L....Robbins P.D. (2000)
• Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells. (PubMed id 17616676)^{1, 3} Sharma A....Knudsen K.E. (2007)
• Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells. (PubMed id 17163992)^{1, 3} Cobrinik D....Lee T.C. (2006)
• Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation. (PubMed id 14585976)^{1, 3} Angus S.P....Knudsen E.S. (2003)
• Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis. (PubMed id 11420704)^{1, 3} Fattman C.L....Johnson D.E. (2001)
• Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase. (PubMed id 16352731)^{1, 3} Knight J.S....Robertson E.S. (2005)
• Spectrum of gross deletions and insertions in the RB1 gene in patients with retinoblastoma and association with phenotypic expression. (PubMed id 16127685)^{1, 3} Albrecht P....Lohmann D.R. (2005)
• RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein. (PubMed id 10734134)^{1, 3} Nicolas E.... Trouche D. (2000)
• Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. (PubMed id 7828850)^{1, 3} Welch P.J. and Wang J.Y. (1995)
• Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. (PubMed id 18332869)^{1, 3} Qiu W....Xiao Z.X. (2008)
• Spectrum of RB1 gene mutations and loss of heterozygosity in Mexican patients with retinoblastoma: identification of six novel mutations. (PubMed id 18503160)^{1, 3} Macias M....Orozco L. (2008)
• ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2. (PubMed id 17297463)^{1, 3} Chang D.L....Xiao Z.X. (2007)
• Sensitive multistep clinical molecular screening of 180 unrelated individuals with retinoblastoma detects 36 novel mutations in the RB1 gene. (PubMed id 15884040)^{1, 3} Nichols K.E....Ganguly A. (2005)
• [RB1 and CDKN2A functional defects resulting in retinoblastoma] (PubMed id 12391839)^{1, 3} Babenko O.V....Nemtsova M.V. (2002)
• Patterns of missplicing caused by RB1 gene mutations in patients with retinoblastoma and association with phenotypic expression. (PubMed id 18181215)^{1, 3} Zhang K....Lohmann D.R. (2008)
• Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure. (PubMed id 18381962)^{1, 3} Derenzini M....Trere D. (2008)
• Pathogenic validation of unique germline intronic variants of RB1 in retinoblastoma patients using minigenes. (PubMed id 18000883)^{1, 3} Gamez-Pozo A....Alonso J. (2007)
• Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer. (PubMed id 17671693)^{1, 3} Schoenlein P.V....Barrett J.T. (2007)
• Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb). (PubMed id 16464825)^{1, 3} Xu Y. and Sugiyama H. (2006)
• [Genomic retinoblastoma perspectives: implications of tumor supressor gene RB1] (PubMed id 16315642)^{1, 3} Rodriguez-Cruz M....Salcedo M. (2005)
• The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. (PubMed id 12845674)^{1, 3} Arhel N.J....Williams A.C. (2003)
• [Low-penetrance retinoblastoma due to exons 24 and 25 deletions in the Rb1 gene] (PubMed id 12362308)^{1, 3} Du C....Gallie B.L. (2002)
• [Spectrum and frequencies of RB1 gene structural defects in retinoblastoma] (PubMed id 12173465)^{1, 3} Babenko O.V....Nemtsova M.V. (2002)
• Novel RB1 gene constitutional mutations found in Polish patients with familial and/or bilateral retinoblastoma. (PubMed id 11668642)^{1, 3} Jakubowska A....Lubinski J. (2001)
• Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. (PubMed id 9632788)^{1, 3} Whitaker L.L....Wang J.Y. (1998)
• Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element. (PubMed id 7592647)^{1, 3} Johnson E.M....Lee W.H. (1995)
• A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. (PubMed id 8242749)^{1, 3} Welch P.J. and Wang J.Y. (1993)
• An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma. (PubMed id 8217129)^{1, 6} Issing W.J....Nerlich A. (1993)
• The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas. (PubMed id 18782450)^{1, 3} Herschkowitz J.I....Perou C.M. (2008)
• Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes. (PubMed id 18321963)^{1, 3} Prichard M.N....Kern E.R. (2008)
• Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein. (PubMed id 17977825)^{1, 3} Darnell G.A....Suhrbier A. (2007)
• Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. (PubMed id 17996702)^{1, 3} Hassler M....Mittnacht S. (2007)
• Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation. (PubMed id 16698799)^{1, 3} Grinstein E....Wernet P. (2006)
• Membrane depolarization stimulates the proliferation of SH-SY5Y human neuroblastoma cells by increasing retinoblastoma protein (RB) phosphorylation through the activation of cyclin-dependent kinase 2 (Cdk2). (PubMed id 16824683)^{1, 3} Seo M....Juhnn Y.S. (2006)
• Selective ablation of retinoblastoma protein function by the RET finger protein. (PubMed id 15837424)^{1, 3} Krutzfeldt M.... Mittnacht S. (2005)
• The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. (PubMed id 16042572)^{1, 3} Clemo N.K....Williams A.C. (2005)
• Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. (PubMed id 15763542)^{1, 3} Wagner S. and Roemer K. (2005)
• Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein. (PubMed id 15811853)^{1, 3} Boyer Arnold N. and Korc M. (2005)
• Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase. (PubMed id 16332962)^{1, 3} Munakata T....Lemon S.M. (2005)
• Retinoblastoma: revisiting the model prototype of inherited cancer. (PubMed id 15264269)^{1, 3} Lohmann D.R. and Gallie B.L. (2004)
• Retinoblastoma tumor suppressor and genome stability. (PubMed id 12374284)^{1, 3} Zheng L. and Lee W.H. (2002)
• Identification of novel mutations in the RB1 gene in Mexican patients with retinoblastoma. (PubMed id 12419581)^{1, 3} Rodriguez M....Arenas D. (2002)
• Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription. (PubMed id 11358960)^{1, 3} Chan S.W. and Hong W. (2001)
• Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. (PubMed id 10702291)^{1, 3} Skapek S.X....Lee E.Y. (2000)
• Functional interaction between human topoisomerase IIalpha and retinoblastoma protein. (PubMed id 10393912)^{1, 3} Bhat U.G....Beck W.T. (1999)
• Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other. (PubMed id 9343168)^{1, 3} Fortunato E.A....Spector D.H. (1997)
• Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. (PubMed id 1316611)^{1, 4} Chellappan S.... Nevins J.R. (1992)
• AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D. (PubMed id 19144636)³ Zang Y....Li J. (2009)
• Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein. (PubMed id 19212661)³ Hoppe-Seyler K....Sauer P. (2009)
• TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. (PubMed id 18305152)³ Ayala Y.M....Baralle F.E. (2008)
• The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F. (PubMed id 18768921)³ Gorges L.L....Baldassare J.J. (2008)
• Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation. (PubMed id 18071317)³ Jiao W....Rane S.G. (2008)
• Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB). (PubMed id 18697743)³ Popowski M....Van Den Berg C.L. (2008)
• Familial retinoblastoma with unilateral and unifocal involvement in 2 families. (PubMed id 18779498)³ Sarafzadeh S....Augsburger J.J. (2008)
• Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A. (PubMed id 18755268)³ Kiss A....Erdodi F. (2008)
• Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. (PubMed id 18216119)³ Chau C.M....Lieberman P.M. (2008)
• The impact of trisomy 12, retinoblastoma gene and P53 in prognosis of B-cell chronic lymphocytic leukemia. (PubMed id 18702872)³ AbdelSalam M....Gadallah F. (2008)

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