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Aliases for RAVER2 Gene

Aliases for RAVER2 Gene

  • Ribonucleoprotein, PTB Binding 2 2 3
  • Ribonucleoprotein, PTB-Binding 2 2 5
  • Protein Raver-2 4
  • KIAA1579 4

External Ids for RAVER2 Gene

Previous GeneCards Identifiers for RAVER2 Gene

  • GC01P064916
  • GC01P065210
  • GC01P063319

Summaries for RAVER2 Gene

GeneCards Summary for RAVER2 Gene

RAVER2 (Ribonucleoprotein, PTB Binding 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RAVER1.

UniProtKB/Swiss-Prot for RAVER2 Gene

  • May bind single-stranded nucleic acids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAVER2 Gene

Genomics for RAVER2 Gene

Regulatory Elements for RAVER2 Gene

Promoters for RAVER2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAVER2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAVER2 Gene

Chromosome:
1
Start:
64,744,964 bp from pter
End:
64,833,232 bp from pter
Size:
88,269 bases
Orientation:
Plus strand

Genomic View for RAVER2 Gene

Genes around RAVER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAVER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAVER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAVER2 Gene

Proteins for RAVER2 Gene

  • Protein details for RAVER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCJ3-RAVR2_HUMAN
    Recommended name:
    Ribonucleoprotein PTB-binding 2
    Protein Accession:
    Q9HCJ3
    Secondary Accessions:
    • Q6P141
    • Q9NPV7

    Protein attributes for RAVER2 Gene

    Size:
    691 amino acids
    Molecular mass:
    74339 Da
    Quaternary structure:
    • Interacts with PTBP1 and RAVER1.
    SequenceCaution:
    • Sequence=BAB13405.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAVER2 Gene

    Alternative splice isoforms for RAVER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAVER2 Gene

Proteomics data for RAVER2 Gene at MOPED

Post-translational modifications for RAVER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAVER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAVER2 Gene

Domains & Families for RAVER2 Gene

Gene Families for RAVER2 Gene

Suggested Antigen Peptide Sequences for RAVER2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCJ3

UniProtKB/Swiss-Prot:

RAVR2_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RAVER2: view

Function for RAVER2 Gene

Molecular function for RAVER2 Gene

UniProtKB/Swiss-Prot Function:
May bind single-stranded nucleic acids.

Gene Ontology (GO) - Molecular Function for RAVER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA,IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RAVER2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAVER2 Gene

Localization for RAVER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAVER2 Gene

Nucleus. Cytoplasm. Note=May shuttle between the nucleus and the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAVER2 Gene COMPARTMENTS Subcellular localization image for RAVER2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RAVER2 Gene

Pathways & Interactions for RAVER2 Gene

SuperPathways for RAVER2 Gene

No Data Available

Interacting Proteins for RAVER2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360112%0d%0a9606.ENSP00000349428%0d%0a9606.ENSP00000376076%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000360112 Q9HCJ3-RAVR2_HUMAN for RAVER2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for RAVER2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RAVER2 Gene

Drugs & Compounds for RAVER2 Gene

No Compound Related Data Available

Transcripts for RAVER2 Gene

Unigene Clusters for RAVER2 Gene

Ribonucleoprotein, PTB-binding 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAVER2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for RAVER2 Gene

GeneLoc Exon Structure for
RAVER2
ECgene alternative splicing isoforms for
RAVER2

Expression for RAVER2 Gene

mRNA expression in normal human tissues for RAVER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAVER2 Gene

This gene is overexpressed in Adipocyte (24.0), Pancreas (14.9), Placenta (14.2), and Islet of Langerhans (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAVER2 Gene



SOURCE GeneReport for Unigene cluster for RAVER2 Gene Hs.591443

genes like me logo Genes that share expression patterns with RAVER2: view

Protein tissue co-expression partners for RAVER2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAVER2 Gene

Orthologs for RAVER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAVER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAVER2 35
  • 99.51 (n)
  • 99.12 (a)
RAVER2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAVER2 36
  • 85 (a)
OneToOne
RAVER2 35
  • 91.32 (n)
  • 90.91 (a)
dog
(Canis familiaris)
Mammalia RAVER2 35
  • 91.36 (n)
  • 92.59 (a)
RAVER2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Raver2 16
Raver2 35
  • 81.25 (n)
  • 82.66 (a)
Raver2 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAVER2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAVER2 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Raver2 35
  • 81.25 (n)
  • 82.03 (a)
chicken
(Gallus gallus)
Aves RAVER2 35
  • 71.76 (n)
  • 69.47 (a)
RAVER2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAVER2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia raver2 35
  • 64.88 (n)
  • 59.88 (a)
zebrafish
(Danio rerio)
Actinopterygii raver2 36
  • 37 (a)
OneToOne
raver2 35
  • 57.13 (n)
  • 55.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2565 36
  • 32 (a)
OneToMany
Species with no ortholog for RAVER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAVER2 Gene

ENSEMBL:
Gene Tree for RAVER2 (if available)
TreeFam:
Gene Tree for RAVER2 (if available)

Paralogs for RAVER2 Gene

Paralogs for RAVER2 Gene

(1) SIMAP similar genes for RAVER2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RAVER2: view

Variants for RAVER2 Gene

Sequence variations from dbSNP and Humsavar for RAVER2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs310237 -- 64,820,745(+) agctc(A/G)ttctt intron-variant
rs310238 -- 64,818,191(-) caata(A/C)tggaa intron-variant
rs883824 -- 64,830,174(-) CTGCT(C/T)AGCTT intron-variant
rs928509 -- 64,816,206(+) GATTT(A/C)TTGTA intron-variant
rs928510 -- 64,816,225(+) TCCAT(A/G)GAAAG intron-variant

Variation tolerance for RAVER2 Gene

Residual Variation Intolerance Score: 9.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAVER2 Gene

HapMap Linkage Disequilibrium report
RAVER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAVER2 Gene

Disorders for RAVER2 Gene

Relevant External Links for RAVER2

Human Genome Epidemiology (HuGE) Navigator
RAVER2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAVER2

No disorders were found for RAVER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAVER2 Gene

Publications for RAVER2 Gene

  1. Raver2, a new member of the hnRNP family. (PMID: 16051233) Kleinhenz B. … Illenberger S. (FEBS Lett. 2005) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Transcriptional regulation of the human Raver2 ribonucleoprotein gene. (PMID: 22146317) Romanelli M.G. … Morandi C. (Gene 2012) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3

Products for RAVER2 Gene

Sources for RAVER2 Gene

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