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Aliases for RAVER1 Gene

Aliases for RAVER1 Gene

  • Ribonucleoprotein, PTB Binding 1 2 3 5
  • Ribonucleoprotein, PTB-Binding 1 2
  • Protein Raver-1 4
  • KIAA1978 4

External Ids for RAVER1 Gene

Previous GeneCards Identifiers for RAVER1 Gene

  • GC19U990309
  • GC19M010649
  • GC19M010272
  • GC19M010287
  • GC19M010426
  • GC19M010007

Summaries for RAVER1 Gene

GeneCards Summary for RAVER1 Gene

RAVER1 (Ribonucleoprotein, PTB Binding 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RAVER2.

UniProtKB/Swiss-Prot for RAVER1 Gene

  • Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

Gene Wiki entry for RAVER1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAVER1 Gene

Genomics for RAVER1 Gene

Regulatory Elements for RAVER1 Gene

Enhancers for RAVER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010757 1.6 Ensembl ENCODE dbSUPER 30.8 -429.1 -429069 9.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 RAVER1 FBXL12 ZNF627 EIF3G TIMM29 PRKCSH MIR199A1 SLC44A2 DNM2 MIR638
GH19G010379 1.1 ENCODE 43 -46.9 -46887 1.9 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 FBXL12 ZNF561 TIMM29 RAVER1 EIF3G LOC100419831 ZNF562 ZNF846 CDC37 ZNF121
GH19G010100 1.8 FANTOM5 ENCODE dbSUPER 25.4 +229.3 229253 8.3 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 TBX21 ZNF699 ZNF561 FBXL12 LOC100419831 ZNF562 ZNF559 TIMM29 EIF3G RAVER1 ZNF846
GH19G010267 1.4 ENCODE dbSUPER 30.1 +63.3 63303 5.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ZNF699 FBXL12 LOC100419831 ZNF559 ZNF561 ZNF846 RAVER1 ZNF562 TIMM29 EIF3G
GH19G010285 1.7 Ensembl ENCODE dbSUPER 23.6 +43.9 43949 7.6 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF559 RAVER1 LOC100419831 ZNF699 FBXL12 ZNF561 ICAM5 EIF3G ZNF177 ILF3-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAVER1 on UCSC Golden Path with GeneCards custom track

Promoters for RAVER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106993 -360 2801 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610

Transcription factor binding sites by QIAGEN in the RAVER1 gene promoter:

Genomic Location for RAVER1 Gene

Chromosome:
19
Start:
10,316,212 bp from pter
End:
10,333,640 bp from pter
Size:
17,429 bases
Orientation:
Minus strand

Genomic View for RAVER1 Gene

Genes around RAVER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAVER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAVER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAVER1 Gene

Proteins for RAVER1 Gene

  • Protein details for RAVER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY67-RAVR1_HUMAN
    Recommended name:
    Ribonucleoprotein PTB-binding 1
    Protein Accession:
    Q8IY67
    Secondary Accessions:
    • A6NMU4
    • Q8IY60
    • Q8TF24

    Protein attributes for RAVER1 Gene

    Size:
    606 amino acids
    Molecular mass:
    63877 Da
    Quaternary structure:
    • Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1 (By similarity).
    SequenceCaution:
    • Sequence=AAH37565.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB85564.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAVER1 Gene

    Alternative splice isoforms for RAVER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAVER1 Gene

Post-translational modifications for RAVER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAVER1 Gene

No data available for DME Specific Peptides for RAVER1 Gene

Domains & Families for RAVER1 Gene

Gene Families for RAVER1 Gene

Suggested Antigen Peptide Sequences for RAVER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAVER1: view

No data available for UniProtKB/Swiss-Prot for RAVER1 Gene

Function for RAVER1 Gene

Molecular function for RAVER1 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

Gene Ontology (GO) - Molecular Function for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA --
GO:0003723 RNA binding IEA,IDA 22681889
genes like me logo Genes that share ontologies with RAVER1: view
genes like me logo Genes that share phenotypes with RAVER1: view

Animal Models for RAVER1 Gene

MGI Knock Outs for RAVER1:

Animal Model Products

CRISPR Products

miRNA for RAVER1 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAVER1 Gene

Localization for RAVER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAVER1 Gene

Nucleus. Cytoplasm. Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAVER1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RAVER1: view

Pathways & Interactions for RAVER1 Gene

SuperPathways for RAVER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
genes like me logo Genes that share ontologies with RAVER1: view

No data available for Pathways by source and SIGNOR curated interactions for RAVER1 Gene

Drugs & Compounds for RAVER1 Gene

No Compound Related Data Available

Transcripts for RAVER1 Gene

Unigene Clusters for RAVER1 Gene

Ribonucleoprotein, PTB-binding 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAVER1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: -
SP4:
SP5: -

Relevant External Links for RAVER1 Gene

GeneLoc Exon Structure for
RAVER1
ECgene alternative splicing isoforms for
RAVER1

Expression for RAVER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAVER1 Gene

Protein differential expression in normal tissues from HIPED for RAVER1 Gene

This gene is overexpressed in Liver (29.9), Peripheral blood mononuclear cells (8.9), Nasal epithelium (8.3), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAVER1 Gene



Protein tissue co-expression partners for RAVER1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAVER1 Gene:

RAVER1

SOURCE GeneReport for Unigene cluster for RAVER1 Gene:

Hs.744952

Evidence on tissue expression from TISSUES for RAVER1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RAVER1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAVER1 Gene

Orthologs for RAVER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAVER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAVER1 34 35
  • 96.76 (n)
cow
(Bos Taurus)
Mammalia RAVER1 34 35
  • 89.53 (n)
dog
(Canis familiaris)
Mammalia RAVER1 34 35
  • 89.14 (n)
rat
(Rattus norvegicus)
Mammalia Raver1 34
  • 85.12 (n)
mouse
(Mus musculus)
Mammalia Raver1 34 16 35
  • 84.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia raver1 34
  • 62.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30898 34
zebrafish
(Danio rerio)
Actinopterygii raver1 35
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2565 35
  • 33 (a)
OneToMany
Species where no ortholog for RAVER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAVER1 Gene

ENSEMBL:
Gene Tree for RAVER1 (if available)
TreeFam:
Gene Tree for RAVER1 (if available)

Paralogs for RAVER1 Gene

Paralogs for RAVER1 Gene

(1) SIMAP similar genes for RAVER1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RAVER1: view

Variants for RAVER1 Gene

Sequence variations from dbSNP and Humsavar for RAVER1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs587777600 Uncertain significance 10,315,996(+) GGCCA(A/T)GACAT downstream-variant-500B, reference, missense
rs1000176100 -- 10,332,020(+) GATAG(C/T)GTCTT intron-variant
rs1000406097 -- 10,325,905(+) GAAAC(A/G)GGCTA intron-variant
rs1000544895 -- 10,333,036(+) GCCCG(C/T)TTCCA intron-variant
rs1000639468 -- 10,333,738(+) TGGGT(-/G)GGAGA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAVER1 Gene

Variant ID Type Subtype PubMed ID
nsv470124 CNV gain 18288195

Variation tolerance for RAVER1 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAVER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAVER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAVER1 Gene

Disorders for RAVER1 Gene

Relevant External Links for RAVER1

Genetic Association Database (GAD)
RAVER1
Human Genome Epidemiology (HuGE) Navigator
RAVER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAVER1

No disorders were found for RAVER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAVER1 Gene

Publications for RAVER1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for RAVER1 Gene

Sources for RAVER1 Gene

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