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Aliases for RAVER1 Gene

Aliases for RAVER1 Gene

  • Ribonucleoprotein, PTB-Binding 1 2 3
  • KIAA1978 4 6
  • Protein Raver-1 4

External Ids for RAVER1 Gene

Previous GeneCards Identifiers for RAVER1 Gene

  • GC19U990309
  • GC19M010649
  • GC19M010272
  • GC19M010287
  • GC19M010426
  • GC19M010007

Summaries for RAVER1 Gene

GeneCards Summary for RAVER1 Gene

RAVER1 (Ribonucleoprotein, PTB-Binding 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RAVER2.

UniProtKB/Swiss-Prot for RAVER1 Gene

  • Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

Gene Wiki entry for RAVER1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAVER1 Gene

Genomics for RAVER1 Gene

Regulatory Elements for RAVER1 Gene

Transcription factor binding sites by QIAGEN in the RAVER1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAVER1 Gene

10,316,212 bp from pter
10,333,640 bp from pter
17,429 bases
Minus strand

Genomic View for RAVER1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAVER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAVER1 Gene

Proteins for RAVER1 Gene

  • Protein details for RAVER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonucleoprotein PTB-binding 1
    Protein Accession:
    Secondary Accessions:
    • A6NMU4
    • Q8IY60
    • Q8TF24

    Protein attributes for RAVER1 Gene

    606 amino acids
    Molecular mass:
    63877 Da
    Quaternary structure:
    • Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1 (By similarity).
    • Sequence=AAH37565.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB85564.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAVER1 Gene

    Alternative splice isoforms for RAVER1 Gene


neXtProt entry for RAVER1 Gene

Proteomics data for RAVER1 Gene at MOPED

Post-translational modifications for RAVER1 Gene

No Post-translational modifications

Other Protein References for RAVER1 Gene

Antibody Products

No data available for DME Specific Peptides for RAVER1 Gene

Domains for RAVER1 Gene

Gene Families for RAVER1 Gene

  • RBM :RNA binding motif (RRM) containing

Protein Domains for RAVER1 Gene

Suggested Antigen Peptide Sequences for RAVER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IY67
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with RAVER1: view

Function for RAVER1 Gene

Molecular function for RAVER1 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

Gene Ontology (GO) - Molecular Function for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RAVER1: view

Phenotypes for RAVER1 Gene

MGI mutant phenotypes for RAVER1:
inferred from 1 alleles
GenomeRNAi human phenotypes for RAVER1:
genes like me logo Genes that share phenotypes with RAVER1: view

Animal Model Products

miRNA for RAVER1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAVER1 Gene

Localization for RAVER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAVER1 Gene

Nucleus. Cytoplasm. Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RAVER1 Gene COMPARTMENTS Subcellular localization image for RAVER1 gene
Compartment Confidence
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RAVER1: view

Pathways for RAVER1 Gene

SuperPathways for RAVER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAVER1 Gene


No data available for Pathways by source for RAVER1 Gene

Transcripts for RAVER1 Gene

Unigene Clusters for RAVER1 Gene

Ribonucleoprotein, PTB-binding 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAVER1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAVER1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: -
SP5: -

Relevant External Links for RAVER1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAVER1 Gene

mRNA expression in normal human tissues for RAVER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RAVER1 Gene

This gene is overexpressed in Liver (29.9), Peripheral blood mononuclear cells (8.9), Nasal epithelium (8.3), and Lymph node (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAVER1 Gene

SOURCE GeneReport for Unigene cluster for RAVER1 Gene Hs.744952

genes like me logo Genes that share expressions with RAVER1: view

Expression partners for RAVER1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAVER1 Gene

Orthologs for RAVER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAVER1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAVER1 35
  • 89.53 (n)
  • 92.74 (a)
  • 92 (a)
(Canis familiaris)
Mammalia RAVER1 35
  • 89.14 (n)
  • 92.85 (a)
  • 92 (a)
(Mus musculus)
Mammalia Raver1 35
  • 84.44 (n)
  • 89.04 (a)
Raver1 16
Raver1 36
  • 88 (a)
(Pan troglodytes)
Mammalia RAVER1 35
  • 96.76 (n)
  • 96.31 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Raver1 35
  • 85.12 (n)
  • 89.04 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia raver1 35
  • 62.61 (n)
  • 64.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30898 35
(Danio rerio)
Actinopterygii raver1 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2565 36
  • 33 (a)
Species with no ortholog for RAVER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAVER1 Gene

Gene Tree for RAVER1 (if available)
Gene Tree for RAVER1 (if available)

Paralogs for RAVER1 Gene

Paralogs for RAVER1 Gene

Selected SIMAP similar genes for RAVER1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RAVER1: view

Variants for RAVER1 Gene

Sequence variations from dbSNP and Humsavar for RAVER1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs176002 -- 10,331,384(+) aaaaa(C/T)aacaa intron-variant
rs281412 -- 10,330,798(+) gtggc(C/T)cacgc intron-variant
rs281420 -- 10,327,278(+) gagat(A/G)agggt intron-variant
rs281421 -- 10,326,818(+) ctgga(A/G)tacag intron-variant
rs281422 -- 10,325,679(+) ggtga(C/T)gcatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAVER1 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195
nsv911040 CNV Loss 21882294

Relevant External Links for RAVER1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAVER1 Gene

Disorders for RAVER1 Gene

Relevant External Links for RAVER1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RAVER1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RAVER1 Gene

Publications for RAVER1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. (PMID: 11724819) HA1ttelmaier S. … Jockusch B.M. (J. Cell Biol. 2001) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for RAVER1 Gene

Sources for RAVER1 Gene

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