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Aliases for RASSF9 Gene

Aliases for RASSF9 Gene

  • Ras Association Domain Family Member 9 2 3
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 9 2 3 5
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor 2 4
  • PAM COOH-Terminal Interactor Protein 1 3 4
  • P-CIP1 3 4
  • PAMCI 3 4
  • PCIP1 3 4
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor Protein-1 3

External Ids for RASSF9 Gene

Previous HGNC Symbols for RASSF9 Gene


Previous GeneCards Identifiers for RASSF9 Gene

  • GC12M084722
  • GC12M086198
  • GC12M083254

Summaries for RASSF9 Gene

Entrez Gene Summary for RASSF9 Gene

  • The protein encoded by this gene localizes to perinuclear endosomes. This protein associates with peptidylglycine alpha-amidating monooxygenase, and may be involved with the trafficking of this enzyme through secretory or endosomal pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF9 Gene

RASSF9 (Ras Association Domain Family Member 9) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is RASSF10.

UniProtKB/Swiss-Prot for RASSF9 Gene

  • May play a role in regulating vesicuar trafficking in cells.

Gene Wiki entry for RASSF9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF9 Gene

Genomics for RASSF9 Gene

Regulatory Elements for RASSF9 Gene

Enhancers for RASSF9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASSF9 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASSF9 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF9 Gene

85,800,697 bp from pter
85,836,570 bp from pter
35,874 bases
Minus strand

Genomic View for RASSF9 Gene

Genes around RASSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF9 Gene

Proteins for RASSF9 Gene

  • Protein details for RASSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • B3KMQ4
    • Q8N5U8

    Protein attributes for RASSF9 Gene

    435 amino acids
    Molecular mass:
    50021 Da
    Quaternary structure:
    • Interacts with PAM.

neXtProt entry for RASSF9 Gene

Proteomics data for RASSF9 Gene at MOPED

Post-translational modifications for RASSF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASSF9 Gene

Domains & Families for RASSF9 Gene

Gene Families for RASSF9 Gene

Protein Domains for RASSF9 Gene


Suggested Antigen Peptide Sequences for RASSF9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASSF9: view

Function for RASSF9 Gene

Molecular function for RASSF9 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating vesicuar trafficking in cells.
genes like me logo Genes that share phenotypes with RASSF9: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF9 Gene

Localization for RASSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF9 Gene

Endosome. Note=Accumulates on perinuclear endosomes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RASSF9 Gene COMPARTMENTS Subcellular localization image for RASSF9 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
golgi apparatus 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with RASSF9: view

Pathways & Interactions for RASSF9 Gene

SuperPathways for RASSF9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting NAS 9837933
genes like me logo Genes that share ontologies with RASSF9: view

No data available for Pathways by source and SIGNOR curated interactions for RASSF9 Gene

Drugs & Compounds for RASSF9 Gene

No Compound Related Data Available

Transcripts for RASSF9 Gene

mRNA/cDNA for RASSF9 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASSF9 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF9 Gene

No ASD Table

Relevant External Links for RASSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF9 Gene

mRNA expression in normal human tissues for RASSF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RASSF9 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASSF9 Gene

SOURCE GeneReport for Unigene cluster for RASSF9 Gene Hs.527881

genes like me logo Genes that share expression patterns with RASSF9: view

Protein tissue co-expression partners for RASSF9 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RASSF9 Gene

Orthologs for RASSF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASSF9 35
  • 91.8 (n)
  • 92.18 (a)
  • 92 (a)
(Canis familiaris)
Mammalia RASSF9 35
  • 91.53 (n)
  • 91.21 (a)
  • 91 (a)
(Mus musculus)
Mammalia Rassf9 35
  • 82.76 (n)
  • 85.29 (a)
Rassf9 16
Rassf9 36
  • 85 (a)
(Pan troglodytes)
Mammalia RASSF9 35
  • 99.92 (n)
  • 99.77 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rassf9 35
  • 82.84 (n)
  • 85.29 (a)
(Monodelphis domestica)
Mammalia RASSF9 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia RASSF9 36
  • 77 (a)
(Gallus gallus)
Aves RASSF9 35
  • 72.26 (n)
  • 69.89 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia RASSF9 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf9 35
  • 59.29 (n)
  • 50.25 (a)
(Danio rerio)
Actinopterygii LOC100150148 35
  • 55.7 (n)
  • 46.48 (a)
rassf9 36
  • 41 (a)
Species with no ortholog for RASSF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF9 Gene

Gene Tree for RASSF9 (if available)
Gene Tree for RASSF9 (if available)

Paralogs for RASSF9 Gene

Paralogs for RASSF9 Gene Pseudogenes for RASSF9 Gene

genes like me logo Genes that share paralogs with RASSF9: view

Variants for RASSF9 Gene

Sequence variations from dbSNP and Humsavar for RASSF9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7397266 - 85,805,157(+) TTCAG(C/T)AGAGA reference, missense
rs7298536 -- 85,826,496(+) aggct(A/G)gagtg intron-variant
rs12815343 -- 85,814,500(+) ATTTT(A/C)ATCAT intron-variant
rs12817020 -- 85,800,618(+) aaaaa(A/G)GGATA downstream-variant-500B
rs7303344 -- 85,831,285(+) CCAAC(A/C/G)AACAC intron-variant

Variation tolerance for RASSF9 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RASSF9 Gene

Disorders for RASSF9 Gene

Relevant External Links for RASSF9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASSF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF9 Gene

Publications for RASSF9 Gene

  1. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. (PMID: 9837933) Chen L. … Milgram S.L. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis. (PMID: 18272789) Sherwood V. … Chalmers A.D. (Mol. Biol. Cell 2008) 2 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  5. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3

Products for RASSF9 Gene

Sources for RASSF9 Gene