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Aliases for RASSF8 Gene

Aliases for RASSF8 Gene

  • Ras Association Domain Family Member 8 2 3
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 8 2 3 5
  • Carcinoma-Associated Protein HOJ-1 3 4
  • C12orf2 3 4
  • Chromosome 12 Open Reading Frame 2 2
  • HOJ1 3

External Ids for RASSF8 Gene

Previous HGNC Symbols for RASSF8 Gene

  • C12orf2

Previous GeneCards Identifiers for RASSF8 Gene

  • GC12P026004
  • GC12P026111
  • GC12P025896

Summaries for RASSF8 Gene

Entrez Gene Summary for RASSF8 Gene

  • This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for RASSF8 Gene

RASSF8 (Ras Association Domain Family Member 8) is a Protein Coding gene. Diseases associated with RASSF8 include Synpolydactyly. An important paralog of this gene is RASSF7.

Gene Wiki entry for RASSF8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF8 Gene

Genomics for RASSF8 Gene

Regulatory Elements for RASSF8 Gene

Enhancers for RASSF8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASSF8 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASSF8 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF8 Gene

25,959,029 bp from pter
26,079,892 bp from pter
120,864 bases
Plus strand

Genomic View for RASSF8 Gene

Genes around RASSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF8 Gene

Proteins for RASSF8 Gene

  • Protein details for RASSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • A8K1Z0
    • O95647
    • Q5SCI2
    • Q76KB6

    Protein attributes for RASSF8 Gene

    419 amino acids
    Molecular mass:
    48327 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC95425.1; Type=Frameshift; Positions=108; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RASSF8 Gene

    Alternative splice isoforms for RASSF8 Gene


neXtProt entry for RASSF8 Gene

Proteomics data for RASSF8 Gene at MOPED

Post-translational modifications for RASSF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF8 Gene

Domains & Families for RASSF8 Gene

Gene Families for RASSF8 Gene

Protein Domains for RASSF8 Gene


Suggested Antigen Peptide Sequences for RASSF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASSF8: view

Function for RASSF8 Gene

Phenotypes for RASSF8 Gene

genes like me logo Genes that share phenotypes with RASSF8: view

Animal Models for RASSF8 Gene

MGI Knock Outs for RASSF8:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASSF8 Gene

Localization for RASSF8 Gene

Subcellular locations from

Jensen Localization Image for RASSF8 Gene COMPARTMENTS Subcellular localization image for RASSF8 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF8 Gene

Pathways & Interactions for RASSF8 Gene

SuperPathways for RASSF8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF8 Gene


No data available for Pathways by source and SIGNOR curated interactions for RASSF8 Gene

Drugs & Compounds for RASSF8 Gene

No Compound Related Data Available

Transcripts for RASSF8 Gene

Unigene Clusters for RASSF8 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h · 8i ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: -
SP9: - -
SP11: -

Relevant External Links for RASSF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF8 Gene

mRNA expression in normal human tissues for RASSF8 Gene

Protein differential expression in normal tissues from HIPED for RASSF8 Gene

This gene is overexpressed in Adrenal (32.2), Plasma (19.7), and Fetal ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASSF8 Gene

SOURCE GeneReport for Unigene cluster for RASSF8 Gene Hs.696433

mRNA Expression by UniProt/SwissProt for RASSF8 Gene

Tissue specificity: Widely expressed as a 6.2 kb transcript. A 2.2 kb alternatively spliced transcript is expressed exclusively in testis.
genes like me logo Genes that share expression patterns with RASSF8: view

Protein tissue co-expression partners for RASSF8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RASSF8 Gene

Orthologs for RASSF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASSF8 35
  • 92.36 (n)
  • 98.09 (a)
C12ORF2 36
  • 98 (a)
(Canis familiaris)
Mammalia RASSF8 35
  • 93.72 (n)
  • 98.81 (a)
  • 99 (a)
(Mus musculus)
Mammalia Rassf8 35
  • 82.98 (n)
  • 91.65 (a)
Rassf8 16
Rassf8 36
  • 92 (a)
(Pan troglodytes)
Mammalia RASSF8 35
  • 99.52 (n)
  • 99.76 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rassf8 35
  • 82.5 (n)
  • 90.45 (a)
(Monodelphis domestica)
Mammalia RASSF8 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RASSF8 36
  • 65 (a)
(Gallus gallus)
Aves RASSF8 35
  • 76.21 (n)
  • 90.45 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia RASSF8 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf8 35
  • 69.65 (n)
  • 76.73 (a)
(Danio rerio)
Actinopterygii rassf8b 35
  • 64.48 (n)
  • 68.37 (a)
zgc64017 35
CABZ01003826.1 36
  • 51 (a)
RASSF8 (3 of 3) 36
  • 26 (a)
rassf8b 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001370 35
  • 49.2 (n)
  • 41.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta RASSF8 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea K05B2.2 36
  • 20 (a)
Species with no ortholog for RASSF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASSF8 Gene

Gene Tree for RASSF8 (if available)
Gene Tree for RASSF8 (if available)

Paralogs for RASSF8 Gene

Paralogs for RASSF8 Gene

(2) SIMAP similar genes for RASSF8 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RASSF8: view

Variants for RASSF8 Gene

Sequence variations from dbSNP and Humsavar for RASSF8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1979748 -- 26,066,106(+) aggca(A/G)ttaaa intron-variant
rs1986802 -- 26,050,074(-) TGGGC(G/T)TGGTG intron-variant
rs1986803 -- 26,050,056(-) CCTGT(A/G)ATTCC intron-variant
rs1994995 -- 25,996,770(-) CTCAA(C/T)GCTAG intron-variant
rs1994996 -- 25,996,581(-) AGCAA(A/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF8 Gene

Variant ID Type Subtype PubMed ID
dgv485e1 CNV Complex 17122850
esv26656 CNV Gain+Loss 19812545
nsv898931 CNV Gain 21882294
nsv433521 CNV Loss 18776910
nsv517117 CNV Loss 19592680
nsv522351 CNV Loss 19592680
esv1625213 CNV Insertion 17803354

Variation tolerance for RASSF8 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RASSF8 Gene

Disorders for RASSF8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASSF8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • syndactyly type 2
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving RASSF8 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with FBLN1. {ECO:0000269 PubMed:11836357}.

Relevant External Links for RASSF8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RASSF8: view

No data available for Genatlas for RASSF8 Gene

Publications for RASSF8 Gene

  1. The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly. (PMID: 11836357) Debeer P. … Van De Ven W.J.M. (J. Med. Genet. 2002) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for RASSF8 Gene

Sources for RASSF8 Gene