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RASSF8 Gene

protein-coding   GIFtS: 50
GCID: GC12P026111

Ras Association (RalGDS/AF-6) Domain Family (N-Terminal)...

(Previous name: chromosome 12 open reading frame 2)
(Previous symbol: C12orf2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 81 2
C12orf21 2 3 5
Carcinoma-Associated Protein HOJ-12 3
Chromosome 12 Open Reading Frame 21
HOJ12
Ras Association Domain-Containing Protein 82

External Ids:    HGNC: 132321   Entrez Gene: 112282   Ensembl: ENSG000001230947   OMIM: 6082315   UniProtKB: Q8NHQ83   

Export aliases for RASSF8 gene to outside databases

Previous GC identifers: GC12P026004 GC12P025896


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASSF8 Gene:
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is
essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell
migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3)
leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple
alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, May 2011)

GeneCards Summary for RASSF8 Gene:
RASSF8 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 8) is a protein-coding gene. Diseases associated with RASSF8 include vaccinia, and lung adenocarcinoma. An important paralog of this gene is RASSF7.

Gene Wiki entry for RASSF8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RASSF8 gene promoter:
         TBP   RP58   AML1a   Tal-1beta   E47   CREB   RORalpha1   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASSF8 promoter sequence
   Search Chromatin IP Primers for RASSF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12.3

RASSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P026111:  view genomic region     (about GC identifiers)

Start:
26,111,962 bp from pter      End:
26,232,825 bp from pter
Size:
120,864 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RASF8_HUMAN, Q8NHQ8 (See protein sequence)
Recommended Name: Ras association domain-containing protein 8  
Size: 419 amino acids; 48327 Da
Sequence caution: Sequence=AAC95425.1; Type=Frameshift; Positions=108;
1 PDB 3D structure from and Proteopedia for RASSF8:
2CS4 (3D)    
Secondary accessions: A8K1Z0 O95647 Q5SCI2 Q76KB6
Alternative splicing: 2 isoforms:  Q8NHQ8-1   Q8NHQ8-2   

Explore the universe of human proteins at neXtProt for RASSF8: NX_Q8NHQ8

Explore proteomics data for RASSF8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASSF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001158218.1  NP_001158219.1  NP_001158220.1  NP_009142.2  

    ENSEMBL proteins: 
     ENSP00000370756   ENSP00000442036   ENSP00000384491   ENSP00000439839   ENSP00000442485  
     ENSP00000441294   ENSP00000445434   ENSP00000445970   ENSP00000282884   ENSP00000443696  
     ENSP00000442191   ENSP00000443096  

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    Novus Biologicals RASSF8 Proteins
    Novus Biologicals RASSF8 Lysates
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    Cloud-Clone Corp. Proteins for RASSF8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry Q8NHQ8

    ProtoNet protein and cluster: Q8NHQ8

    UniProtKB/Swiss-Prot: RASF8_HUMAN, Q8NHQ8
    Similarity: Contains 1 Ras-associating domain


    RASSF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASSF8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASSF8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASSF8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASSF8

    miRNA
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    miRTarBase miRNAs that target RASSF8:
    hsa-mir-335-5p (MIRT017153), hsa-mir-375 (MIRT019781), hsa-mir-192-5p (MIRT026276), hsa-mir-9-5p (MIRT021333), hsa-mir-148a-3p (MIRT026013), hsa-mir-130b-3p (MIRT020197)

    Block miRNA regulation of human, mouse, rat RASSF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASSF8 (see all 150):
    hsa-miR-3921 hsa-miR-149 hsa-miR-200b hsa-miR-4273 hsa-miR-30b* hsa-miR-374b* hsa-miR-186* hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidRASSF8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RASSF8

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASSF8
    Interactions:

        Search GeneGlobe Interaction Network for RASSF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RASSF8 (Q8NHQ82, 3 ENSP000002828844) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMD4P550362, 3, ENSP000003578794MINT-67927 I2D: score=5 STRING: ENSP00000357879
    FRMD6Q96NE92, 3, ENSP000003485504MINT-66192 I2D: score=4 STRING: ENSP00000348550
    YWHAGP619812, 3, ENSP000003063304MINT-50871 I2D: score=4 STRING: ENSP00000306330
    PARD3Q8TEW03, ENSP000003639214I2D: score=2 STRING: ENSP00000363921
    YWHAHQ049173, ENSP000002489754I2D: score=2 STRING: ENSP00000248975
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--

    RASSF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASSF8 (RASF8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RASSF8 gene (4 alternative transcripts): 
    NM_001164746.1  NM_001164747.1  NM_001164748.1  NM_007211.4  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381352(uc001rgw.2 uc001rgz.3) ENST00000538081 ENST00000535907
    ENST00000405154 ENST00000542865 ENST00000542004 ENST00000538365 ENST00000542315
    ENST00000537946 ENST00000541218 ENST00000282884 ENST00000545413 ENST00000539545
    ENST00000541490(uc001rgx.3 uc001rgy.3 uc009zjd.2 uc009zje.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RASSF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASSF8 (see all 150):
    hsa-miR-3921 hsa-miR-149 hsa-miR-200b hsa-miR-4273 hsa-miR-30b* hsa-miR-374b* hsa-miR-186* hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidRASSF8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RASSF8
    Predesigned siRNA for gene silencing in human, mouse, rat RASSF8
    Clone
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    OriGene clones in human, mouse for RASSF8 (see all 23)
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    GenScript: all cDNA clones in your preferred vector (see all 4): RASSF8 (NM_007211)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RASSF8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASSF8
      QuantiTect SYBR Green Assays in human, mouse, rat RASSF8
      QuantiFast Probe-based Assays in human, mouse, rat RASSF8

    Selected AceView cDNA sequences (see all 151):

    AA917994 BI826442 BP371608 AW274884 AA902704 AU118062 AI656321 AI280007 
    BE440096 BI828806 AI219256 BP369416 BE179634 AL598061 CF528690 BX111606 
    AA952905 AI611262 AW082291 BQ023827 AU118999 BQ432847 AI188063 BC030021 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RASSF8 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h · 8i ^ 9 ^ 10
    SP1:                          -     -     -     -     -     -     -                                                                                       
    SP2:                          -     -     -     -     -     -     -     -                                                                                 
    SP3:                                      -     -     -     -     -     -                                                                                 
    SP4:                          -           -     -     -     -     -                                                                                       
    SP5:                          -           -     -     -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for RASSF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACTAATT
    RASSF8 Expression
    About this image

    RASSF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASSF8 Protein Expression

    UniProtKB/Swiss-Prot: RASF8_HUMAN, Q8NHQ8
    Tissue specificity: Widely expressed as a 6.2 kb transcript. A 2.2 kb alternatively spliced transcript is
    expressed exclusively in testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASSF8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rassf81 , 5 Ras association (RalGDS/AF-6) domain family (N-terminal) more1, 5 82.98(n)1
    91.65(a)1
      6 (77.68 cM)5
    713231  NM_027760.21  NP_082036.11 
     1457467485 
    chicken
    (Gallus gallus)
    Aves RASSF81 Ras association (RalGDS/AF-6) domain family (N-terminal) more 76.21(n)
    90.45(a)
      418210  XM_416437.4  XP_416437.2 
    lizard
    (Anolis carolinensis)
    Reptilia RASSF86
    Ras association (RalGDS/AF-6) domain family (N-ter...
    88(a)
    1 ↔ 1
    GL343349.1(1012293-1118225)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rassf81 Ras association (RalGDS/AF-6) domain family (N-terminal) more 69.65(n)
    76.73(a)
      100495279  XM_002940725.2  XP_002940771.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640172 hypothetical protein MGC64017 73(n)   393334  BC053201.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RASSF86
    --
    21(a)
    1 → many
    3R(21487522-21491366)
    worm
    (Caenorhabditis elegans)
    Secernentea K05B2.26
    Protein K05B2.2, isoform a
    20(a)
    1 → many
    X(4907290-4912323) WBGene00019403


    ENSEMBL Gene Tree for RASSF8 (if available)
    TreeFam Gene Tree for RASSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASSF8 gene
    RASSF72  
    2 SIMAP similar genes for RASSF8 using alignment to 8 protein entries:     RASF8_HUMAN (see all proteins):
    C12orf2    RASSF7

    RASSF8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASSF8 (see all 2563)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863490121,2
    --25880797(+) TCAGGC/GTGGTC 2 -- us2k10--------
    rs1476555731,2
    --25880798(+) CAGGCG/TGGTCT 2 -- us2k10--------
    rs1893809891,2
    --25880804(+) GGTCTC/TGAACT 2 -- us2k10--------
    rs1810204751,2
    --25880816(+) CCAACC/TTCAGG 2 -- us2k10--------
    rs1407370661,2
    --25880840(+) TTGGCC/TTCCCA 2 -- us2k10--------
    rs1448921651,2
    --25880932(+) ATGCCA/GCAAAG 2 -- us2k10--------
    rs1860498601,2
    --25880937(+) ACAAAA/GGGCAC 2 -- us2k10--------
    rs1173470811,2
    C,F--25880969(+) CATTAG/AATTTG 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1913655751,2
    --25881004(+) TTCAGC/TGGAGT 2 -- us2k10--------
    rs1469776521,2
    C--25881165(+) GTGAA-/CTTT  
            
    CTTTC
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RASSF8 (26111962 - 26232825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RASSF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1625213CNV Insertion17803354
    nsv522351CNV Loss19592680
    nsv433521CNV Loss18776910
    nsv517117CNV Loss19592680
    nsv898931CNV Gain21882294
    esv26656CNV Gain+Loss19812545
    dgv485e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASSF8
    DNA2.0 Custom Variant and Variant Library Synthesis for RASSF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608231    OMIM disorders: --

    UniProtKB/Swiss-Prot: RASF8_HUMAN, Q8NHQ8
  • Note=A chromosomal aberration involving RASSF8 is found in a complex type of synpolydactyly referred to
    as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation
    t(12;22)(p11.2;q13.3) with FBLN1

  • 7 diseases for RASSF8:    About MalaCards
    vaccinia    lung adenocarcinoma    adenocarcinoma    multiple myeloma
    myeloma    malaria    endotheliitis


    RASSF8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASSF8
    Human Genome Epidemiology (HuGE) Navigator: RASSF8 (2 documents)

    Export disorders for RASSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASSF8 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with RASSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly. (PubMed id 11836357)1, 2, 9 Debeer P.... Van De Ven W.J.M. (J. Med. Genet. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Common polymorphisms in D12S1034 flanking genes RASSF8 and BHLHB3 are not associated with lung adenocarcinoma risk. (PubMed id 17194498)1, 4 Falvella F.S....Dragani T.A. (Lung Cancer 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Physical map of a 1.5 mb region on 12p11.2 harbouring a synpolydactyly associated chromosomal breakpoint. (PubMed id 10951517)1, 2 Debeer P.... Van de Ven W.J.M. (Eur. J. Hum. Genet. 2000)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. (PubMed id 21915095)1 Dodding M.P....Way M. (EMBO J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11228 HGNC: 13232 AceView: C12orf2 Ensembl:ENSG00000123094 euGenes: HUgn11228
    ECgene: RASSF8 H-InvDB: RASSF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASSF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASSF8 gene:
    Search GeneIP for patents involving RASSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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