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Aliases for RASSF7 Gene

Aliases for RASSF7 Gene

  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 7 2 3
  • C11orf13 3 4 6
  • HRC1 3 4 6
  • HRAS1-Related Cluster Protein 1 3 4
  • Ras Association (RalGDS/AF-6) Domain Family 7 3
  • Ras Association Domain-Containing Protein 7 3
  • Chromosome 11 Open Reading Frame 13 2
  • HRAS1-Related Cluster-1 3
  • HRAS1 3

External Ids for RASSF7 Gene

Previous HGNC Symbols for RASSF7 Gene

  • C11orf13

Previous GeneCards Identifiers for RASSF7 Gene

  • GC11P000552
  • GC11P000375

Summaries for RASSF7 Gene

GeneCards Summary for RASSF7 Gene

RASSF7 (Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 7) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton. An important paralog of this gene is RASSF8.

UniProtKB/Swiss-Prot for RASSF7 Gene

  • Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF7 Gene

Genomics for RASSF7 Gene

Regulatory Elements for RASSF7 Gene

Transcription factor binding sites by QIAGEN in the RASSF7 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASSF7 Gene

Start:
559,470 bp from pter
End:
564,025 bp from pter
Size:
4,556 bases
Orientation:
Plus strand

Genomic View for RASSF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF7 Gene

Proteins for RASSF7 Gene

  • Protein details for RASSF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02833-RASF7_HUMAN
    Recommended name:
    Ras association domain-containing protein 7
    Protein Accession:
    Q02833
    Secondary Accessions:
    • G5E9N9
    • Q3KP41
    • Q3KP42

    Protein attributes for RASSF7 Gene

    Size:
    373 amino acids
    Molecular mass:
    39945 Da
    Quaternary structure:
    • Interacts with MAP2K7 and GTP-bound NRAS.

    Alternative splice isoforms for RASSF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF7 Gene

Proteomics data for RASSF7 Gene at MOPED

Post-translational modifications for RASSF7 Gene

  • Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF7 Gene

Domains for RASSF7 Gene

Protein Domains for RASSF7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RASSF7 Gene

Graphical View of Domain Structure for InterPro Entry

Q02833

UniProtKB/Swiss-Prot:

RASF7_HUMAN :
  • Q02833
Domain:
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASSF7: view

No data available for Gene Families for RASSF7 Gene

Function for RASSF7 Gene

Molecular function for RASSF7 Gene

UniProtKB/Swiss-Prot Function: Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

Gene Ontology (GO) - Molecular Function for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RASSF7: view

Phenotypes for RASSF7 Gene

genes like me logo Genes that share phenotypes with RASSF7: view

Animal Model Products

CRISPR Products

miRNA for RASSF7 Gene

miRTarBase miRNAs that target RASSF7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASSF7 Gene

Localization for RASSF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF7 Gene COMPARTMENTS Subcellular localization image for RASSF7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with RASSF7: view

Pathways for RASSF7 Gene

genes like me logo Genes that share pathways with RASSF7: view

Pathways by source for RASSF7 Gene

1 BioSystems pathway for RASSF7 Gene

Interacting Proteins for RASSF7 Gene

Selected Interacting proteins: Q02833-RASF7_HUMAN for RASSF7 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF7: view

Transcripts for RASSF7 Gene

Unigene Clusters for RASSF7 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RASSF7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for RASSF7 Gene

GeneLoc Exon Structure for
RASSF7
ECgene alternative splicing isoforms for
RASSF7

Expression for RASSF7 Gene

mRNA expression in normal human tissues for RASSF7 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RASSF7 Gene

SOURCE GeneReport for Unigene cluster for RASSF7 Gene Hs.72925

genes like me logo Genes that share expressions with RASSF7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RASSF7 Gene

Orthologs for RASSF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF7 35
  • 99.11 (n)
  • 99.2 (a)
RASSF7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASSF7 35
  • 81.93 (n)
  • 85.84 (a)
RASSF7 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF7 35
  • 83.29 (n)
  • 84.7 (a)
RASSF7 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf7 35
  • 83.5 (n)
  • 84.82 (a)
Rassf7 16
Rassf7 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASSF7 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf7 35
  • 81.68 (n)
  • 81.08 (a)
chicken
(Gallus gallus)
Aves RASSF7 35
  • 61.42 (n)
  • 55.48 (a)
RASSF7 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASSF7 36
  • 38 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14379 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf7 35
  • 57.08 (n)
  • 52.5 (a)
Str.13483 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7475 35
zebrafish
(Danio rerio)
Actinopterygii RASSF7 (3 of 3) 36
  • 31 (a)
OneToMany
rassf7a 36
  • 31 (a)
OneToMany
rassf7b 36
  • 31 (a)
OneToMany
sbcb262 35
fruit fly
(Drosophila melanogaster)
Insecta RASSF8 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K05B2.2 36
  • 17 (a)
OneToMany
Species with no ortholog for RASSF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASSF7 Gene

ENSEMBL:
Gene Tree for RASSF7 (if available)
TreeFam:
Gene Tree for RASSF7 (if available)

Paralogs for RASSF7 Gene

Paralogs for RASSF7 Gene

Selected SIMAP similar genes for RASSF7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASSF7: view

Variants for RASSF7 Gene

Sequence variations from dbSNP and Humsavar for RASSF7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1016474 -- 564,268(+) TGCTG(A/G)TTCAG downstream-variant-500B
rs1599726 -- 564,295(-) ACAAA(C/T)GCCTG downstream-variant-500B
rs1599727 -- 564,045(-) TGCCC(A/G)GCGCA downstream-variant-500B
rs3168185 -- 563,823(+) TGGGG(C/G)GTAGC utr-variant-3-prime
rs7109278 -- 563,649(-) ACTAG(A/G)CTGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RASSF7 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv931n71 CNV Loss 21882294
nsv896532 CNV Gain 21882294
essv23843 CNV CNV 17122850
dgv933n71 CNV Loss 21882294
nsv467634 CNV Loss 19166990
nsv896544 CNV Loss 21882294
nsv896545 CNV Loss 21882294
dgv934n71 CNV Loss 21882294
dgv935n71 CNV Loss 21882294
nsv469924 CNV Gain 18288195
dgv936n71 CNV Loss 21882294
dgv937n71 CNV Loss 21882294
dgv938n71 CNV Loss 21882294
dgv939n71 CNV Loss 21882294
nsv467635 CNV Loss 19166990
nsv528415 CNV Loss 19592680
nsv896559 CNV Loss 21882294

Relevant External Links for RASSF7 Gene

HapMap Linkage Disequilibrium report
RASSF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF7 Gene

Disorders for RASSF7 Gene

(1) Novoseek inferred disease relationships for RASSF7 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for RASSF7

Genetic Association Database (GAD)
RASSF7
Human Genome Epidemiology (HuGE) Navigator
RASSF7
genes like me logo Genes that share disorders with RASSF7: view

No data available for UniProtKB/Swiss-Prot for RASSF7 Gene

Publications for RASSF7 Gene

  1. The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain. (PMID: 1339391) Weitzel J.N. … Krontiris T.G. (Genomics 1992) 2 3 4 23
  2. Human longevity and 11p15.5: a study in 1321 centenarians. (PMID: 19367319) Lescai F. … Franceschi C. (Eur. J. Hum. Genet. 2009) 3 48
  3. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. (PMID: 20629633) Recino A. … Chalmers A.D. (Biochem. J. 2010) 3 4
  4. RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. (PMID: 21278800) Takahashi S. … Katada T. (Cell Death Differ. 2011) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RASSF7 Gene

Sources for RASSF7 Gene

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