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RASSF7 Gene

protein-coding   GIFtS: 55
GCID: GC11P000560

Ras Association (RalGDS/AF-6) Domain Family (N-Terminal)...

(Previous name: chromosome 11 open reading frame 13)
(Previous symbol: C11orf13)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 71 2     HRAS12
C11orf131 2 3 5     HRAS1-Related Cluster-12
HRC12 3 5     Ras Association (RalGDS/AF-6) Domain Family 72
HRAS1-Related Cluster Protein 12 3     Ras Association Domain-Containing Protein 72
Chromosome 11 Open Reading Frame 131     

External Ids:    HGNC: 11661   Entrez Gene: 80452   Ensembl: ENSG000000998497   OMIM: 1430235   UniProtKB: Q028333   
ORGUL members:         

Export aliases for RASSF7 gene to outside databases

Previous GC identifers: GC11P000552 GC11P000375


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RASSF7 Gene:
RASSF7 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 7) is a protein-coding gene. An important paralog of this gene is RASSF8.

UniProtKB/Swiss-Prot: RASF7_HUMAN, Q02833
Function: Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and
inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of
degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and
chromosomal congression during mitosis where it stimulates microtubule polymerization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NT_187586.1  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASSF7 gene promoter:
         NF-1/L   NF-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASSF7 promoter sequence
   Search Chromatin IP Primers for RASSF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASSF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

RASSF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000560:  view genomic region     (about GC identifiers)

Start:
560,404 bp from pter      End:
564,025 bp from pter
Size:
3,622 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASF7_HUMAN, Q02833 (See protein sequence)
Recommended Name: Ras association domain-containing protein 7  
Size: 373 amino acids; 39945 Da
Subunit: Interacts with MAP2K7 and GTP-bound NRAS
Secondary accessions: G5E9N9 Q3KP41 Q3KP42
Alternative splicing: 3 isoforms:  Q02833-1   Q02833-2   Q02833-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASSF7: NX_Q02833

Explore proteomics data for RASSF7 at MOPED

Post-translational modifications: 

  • Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli1
  • Modification sites at neXtProt

  • See RASSF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137465.1  NP_001137466.1  NP_003466.1  

    ENSEMBL proteins: 
     ENSP00000403068   ENSP00000380712   ENSP00000413484   ENSP00000380713   ENSP00000405606  
     ENSP00000433165   ENSP00000435885   ENSP00000344226  

    RASSF7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RASSF7

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry Q02833

    ProtoNet protein and cluster: Q02833

    1 Blocks protein domain: IPB000159 RA domain

    UniProtKB/Swiss-Prot: RASF7_HUMAN, Q02833
    Similarity: Contains 1 Ras-associating domain


    Find genes that share domains with RASSF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASF7_HUMAN, Q02833
    Function: Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and
    inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of
    degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and
    chromosomal congression during mitosis where it stimulates microtubule polymerization

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
         
    Find genes that share ontologies with RASSF7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RASSF7:
     Decreased viability with carbo  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASSF7
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    miRTarBase miRNAs that target RASSF7:
    hsa-mir-196a-5p (MIRT048225)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RASF7_HUMAN, Q02833: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with
    gamma-tubulin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    extracellular2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--

    Find genes that share ontologies with RASSF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASSF7 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of Actin Cytoskeleton0.57


    1 BioSystems Pathway for RASSF7
        Regulation of Actin Cytoskeleton



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASSF7
    Interactions:

        Search GeneGlobe Interaction Network for RASSF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RASSF7 (Q028333 ENSP000003442264) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI53, ENSP000003555964I2D: score=3 STRING: ENSP00000355596
    TSC1Q925743, ENSP000002985524I2D: score=2 STRING: ENSP00000298552
    CHMP1BQ7LBR13I2D: score=1 
    ABL2ENSP000003565954STRING: ENSP00000356595
    BRAPENSP000003308134STRING: ENSP00000330813
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--

    Find genes that share ontologies with RASSF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASSF7 (RASF7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASSF7 gene (3 alternative transcripts): 
    NM_001143993.1  NM_001143994.1  NM_003475.3  

    Unigene Cluster for RASSF7:

    Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
    Hs.72925  [show with all ESTs]
    Unigene Representative Sequence: NM_001143993
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431809 ENST00000397582(uc001lqb.3) ENST00000414138 ENST00000524468
    ENST00000397583(uc001lqc.3) ENST00000454668(uc001lqd.3) ENST00000528736
    ENST00000531112 ENST00000344375
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat RASSF7

    Additional mRNA sequence: 

    BC106921.1 BC106922.1 M91083.1 

    8 DOTS entries:

    DT.75102780  DT.100750109  DT.95276785  DT.100023384  DT.97814901  DT.100750108  DT.95344802  DT.91883537 

    Selected AceView cDNA sequences (see all 145):

    BM769566 BM769192 AI148716 BM741368 BM854646 BQ084472 BM825465 CR613045 
    BI766050 BI523944 BQ773922 CB048774 BU187732 CA454507 BM808267 CR595567 
    BF438314 CR604720 CR623626 CR611851 CR612580 BM726453 BM547304 CR591016 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RASSF7 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
    SP1:                                                  -                     
    SP2:        -                                                               
    SP3:        -                                                               
    SP4:                                                  -     -               
    SP5:                                                                        


    ECgene alternative splicing isoforms for RASSF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASSF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGCCAC
    RASSF7 Expression
    About this image

    RASSF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASSF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72925
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASSF7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rassf71 , 5 Ras association (RalGDS/AF-6) domain family (N-terminal) more1, 5 83.5(n)1
    84.82(a)1
      7 (86.51 cM)5
    669851  NM_025886.31  NP_080162.31 
     1412158605 
    chicken
    (Gallus gallus)
    Aves RASSF71 Ras association (RalGDS/AF-6) domain family (N-terminal) more 61.42(n)
    55.48(a)
      423107  XM_004941471.1  XP_004941528.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASSF76
    Ras association (RalGDS/AF-6) domain family (N-ter...
    38(a)
    1 ↔ 1
    1(74529013-74597090)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143792 Xenopus laevis transcribed sequence with weak similarity more 75.97(n)    BJ034347.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb2622 sbcb262 74.78(n)   368288  BC044177.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RASSF86
    --
    13(a)
    1 → many
    3R(21487522-21491366)
    worm
    (Caenorhabditis elegans)
    Secernentea K05B2.26
    Protein K05B2.2, isoform a
    17(a)
    1 → many
    X(4907290-4912323) WBGene00019403


    ENSEMBL Gene Tree for RASSF7 (if available)
    TreeFam Gene Tree for RASSF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASSF7 gene
    RASSF82  
    2 SIMAP similar genes for RASSF7 using alignment to 4 protein entries:     RASF7_HUMAN (see all proteins):
    C12orf2    RASSF8

    Find genes that share paralogs with RASSF7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for RASSF7    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22421821,2,4
    ----see VAR_0218602 mis40--------
    rs22421831,2,4
    ----see VAR_0218592 mis40--------

    HapMap Linkage Disequilibrium report for RASSF7 (560404 - 564025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RASSF7 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    dgv937n71CNV Loss21882294
    nsv896545CNV Loss21882294
    dgv938n71CNV Loss21882294
    dgv931n71CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv933n71CNV Loss21882294
    dgv935n71CNV Loss21882294
    dgv918n71CNV Loss21882294
    nsv467635CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 143023    OMIM disorders: --


    Find genes that share disorders with RASSF7           About GenesLikeMe

    1 Novoseek inferred disease relationship for RASSF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 11753967 (1)

    Genetic Association Database (GAD): RASSF7
    Human Genome Epidemiology (HuGE) Navigator: RASSF7 (1 document)

    Export disorders for RASSF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASSF7 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RASSF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain. (PubMed id 1339391)1, 2, 3, 9 Weitzel J.N.... Krontiris T.G. (Genomics 1992)
    2. RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. (PubMed id 21278800)1, 2 Takahashi S....Katada T. (Cell Death Differ. 2011)
    3. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. (PubMed id 20629633)1, 2 Recino A....Chalmers A.D. (Biochem. J. 2010)
    4. Human longevity and 11p15.5: a study in 1321 centenarians. (PubMed id 19367319)1, 4 Lescai F....Franceschi C. (Eur. J. Hum. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. (PubMed id 22695170)1 Djos A....CarAcn H. (Mol. Cancer 2012)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis. (PubMed id 18272789)1 Sherwood V.... Chalmers A.D. (Mol. Biol. Cell 2008)
    10. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8045 HGNC: 1166 AceView: C11orf13 Ensembl:ENSG00000099849 euGenes: HUgn8045
    ECgene: RASSF7 H-InvDB: RASSF7

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASSF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASSF7 Genetics and Cytogenetics in Oncology and Haematology

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