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Aliases for RASSF7 Gene

Aliases for RASSF7 Gene

  • Ras Association Domain Family Member 7 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 7 2 3
  • HRAS1-Related Cluster Protein 1 3 4
  • C11orf13 3 4
  • HRC1 3 4
  • Ras Association (RalGDS/AF-6) Domain Family 7 3
  • Ras Association Domain-Containing Protein 7 3
  • Chromosome 11 Open Reading Frame 13 2
  • HRAS1-Related Cluster-1 3
  • HRAS1 3

External Ids for RASSF7 Gene

Previous HGNC Symbols for RASSF7 Gene

  • C11orf13

Previous GeneCards Identifiers for RASSF7 Gene

  • GC11P000552
  • GC11P000375

Summaries for RASSF7 Gene

GeneCards Summary for RASSF7 Gene

RASSF7 (Ras Association Domain Family Member 7) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton. An important paralog of this gene is RASSF8.

UniProtKB/Swiss-Prot for RASSF7 Gene

  • Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF7 Gene

Genomics for RASSF7 Gene

Regulatory Elements for RASSF7 Gene

Enhancers for RASSF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F000514 0.2 ENCODE 12.8 -44.6 -44553 1.8 CEBPB RNH1 HRAS RASSF7 ENSG00000254815 LMNTD2 PTDSS2 SLC25A22 CEND1 PIDD1 RPLP2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RASSF7 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001601182 1324 1801 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 FOS

Genomic Location for RASSF7 Gene

Chromosome:
11
Start:
559,776 bp from pter
End:
564,025 bp from pter
Size:
4,250 bases
Orientation:
Plus strand

Genomic View for RASSF7 Gene

Genes around RASSF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF7 Gene

Proteins for RASSF7 Gene

  • Protein details for RASSF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02833-RASF7_HUMAN
    Recommended name:
    Ras association domain-containing protein 7
    Protein Accession:
    Q02833
    Secondary Accessions:
    • G5E9N9
    • Q3KP41
    • Q3KP42

    Protein attributes for RASSF7 Gene

    Size:
    373 amino acids
    Molecular mass:
    39945 Da
    Quaternary structure:
    • Interacts with MAP2K7 and GTP-bound NRAS.

    Alternative splice isoforms for RASSF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF7 Gene

Post-translational modifications for RASSF7 Gene

  • Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF7 Gene

Domains & Families for RASSF7 Gene

Gene Families for RASSF7 Gene

Protein Domains for RASSF7 Gene

Suggested Antigen Peptide Sequences for RASSF7 Gene

Graphical View of Domain Structure for InterPro Entry

Q02833

UniProtKB/Swiss-Prot:

RASF7_HUMAN :
  • Contains 1 Ras-associating domain.
Domain:
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASSF7: view

Function for RASSF7 Gene

Molecular function for RASSF7 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

Gene Ontology (GO) - Molecular Function for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RASSF7: view
genes like me logo Genes that share phenotypes with RASSF7: view

Animal Model Products

miRNA for RASSF7 Gene

miRTarBase miRNAs that target RASSF7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF7 Gene

Localization for RASSF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF7 Gene COMPARTMENTS Subcellular localization image for RASSF7 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with RASSF7: view

Pathways & Interactions for RASSF7 Gene

SuperPathways for RASSF7 Gene

genes like me logo Genes that share pathways with RASSF7: view

Pathways by source for RASSF7 Gene

1 BioSystems pathway for RASSF7 Gene

Interacting Proteins for RASSF7 Gene

Gene Ontology (GO) - Biological Process for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0070507 regulation of microtubule cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with RASSF7: view

No data available for SIGNOR curated interactions for RASSF7 Gene

Transcripts for RASSF7 Gene

Unigene Clusters for RASSF7 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for RASSF7 Gene

GeneLoc Exon Structure for
RASSF7
ECgene alternative splicing isoforms for
RASSF7

Expression for RASSF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF7 Gene

Protein differential expression in normal tissues from HIPED for RASSF7 Gene

This gene is overexpressed in Pancreas (30.9), Placenta (30.8), and Islet of Langerhans (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF7 Gene



Protein tissue co-expression partners for RASSF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASSF7 Gene:

RASSF7

SOURCE GeneReport for Unigene cluster for RASSF7 Gene:

Hs.72925
genes like me logo Genes that share expression patterns with RASSF7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RASSF7 Gene

Orthologs for RASSF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF7 34 35
  • 99.11 (n)
mouse
(Mus musculus)
Mammalia Rassf7 34 16 35
  • 83.5 (n)
dog
(Canis familiaris)
Mammalia RASSF7 34 35
  • 83.29 (n)
cow
(Bos Taurus)
Mammalia RASSF7 34 35
  • 81.93 (n)
rat
(Rattus norvegicus)
Mammalia Rassf7 34
  • 81.68 (n)
oppossum
(Monodelphis domestica)
Mammalia RASSF7 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASSF7 34 35
  • 61.42 (n)
lizard
(Anolis carolinensis)
Reptilia RASSF7 35
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf7 34
  • 57.08 (n)
Str.13483 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14379 34
zebrafish
(Danio rerio)
Actinopterygii RASSF7 (3 of 3) 35
  • 31 (a)
OneToMany
rassf7a 35
  • 31 (a)
OneToMany
rassf7b 35
  • 31 (a)
OneToMany
sbcb262 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7475 34
fruit fly
(Drosophila melanogaster)
Insecta RASSF8 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K05B2.2 35
  • 17 (a)
OneToMany
Species where no ortholog for RASSF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASSF7 Gene

ENSEMBL:
Gene Tree for RASSF7 (if available)
TreeFam:
Gene Tree for RASSF7 (if available)

Paralogs for RASSF7 Gene

Paralogs for RASSF7 Gene

(2) SIMAP similar genes for RASSF7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASSF7: view

Variants for RASSF7 Gene

Sequence variations from dbSNP and Humsavar for RASSF7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1016474 -- 564,268(+) TGCTG(A/G)TTCAG downstream-variant-500B
rs111486594 -- 564,087(+) GGGTG(-/C)CACTG downstream-variant-500B
rs111565913 -- 558,173(+) GCTCG(A/C)TCCTT upstream-variant-2KB, reference, missense
rs111784302 -- 559,579(+) GGCCC(C/T)AGCAT intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs111838516 -- 562,820(+) CCTGA(C/T)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF7 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for RASSF7 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.26; 81.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASSF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF7 Gene

Disorders for RASSF7 Gene

Relevant External Links for RASSF7

Genetic Association Database (GAD)
RASSF7
Human Genome Epidemiology (HuGE) Navigator
RASSF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASSF7

No disorders were found for RASSF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF7 Gene

Publications for RASSF7 Gene

  1. The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain. (PMID: 1339391) Weitzel J.N. … Krontiris T.G. (Genomics 1992) 2 3 4 22 64
  2. RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. (PMID: 21278800) Takahashi S. … Katada T. (Cell Death Differ. 2011) 3 4 64
  3. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. (PMID: 20629633) Recino A. … Chalmers A.D. (Biochem. J. 2010) 3 4 64
  4. Human longevity and 11p15.5: a study in 1321 centenarians. (PMID: 19367319) Lescai F. … Franceschi C. (Eur. J. Hum. Genet. 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RASSF7 Gene

Sources for RASSF7 Gene

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