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Aliases for RASSF6 Gene

Aliases for RASSF6 Gene

  • Ras Association Domain Family Member 6 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family Member 6 2

External Ids for RASSF6 Gene

Previous GeneCards Identifiers for RASSF6 Gene

  • GC04M074680
  • GC04M074842
  • GC04M074907
  • GC04M074905
  • GC04M074803
  • GC04M074437
  • GC04M070250

Summaries for RASSF6 Gene

Entrez Gene Summary for RASSF6 Gene

  • This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for RASSF6 Gene

RASSF6 (Ras Association Domain Family Member 6) is a Protein Coding gene. Diseases associated with RASSF6 include Bronchiolitis. Among its related pathways are Hippo signaling pathway and Hippo signaling pathway -multiple species. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot for RASSF6 Gene

  • Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF6 Gene

Genomics for RASSF6 Gene

Regulatory Elements for RASSF6 Gene

Enhancers for RASSF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F073598 1.5 FANTOM5 Ensembl ENCODE 15.1 +20.4 20439 3.5 MLX ARID4B SIN3A ZNF48 GATA2 SP5 MIER2 PPARG KAT8 MIER3 RASSF6 MTHFD2L PF4V1 ENSG00000249970
GH04F073660 1.4 FANTOM5 Ensembl ENCODE 15.5 -41.8 -41766 3.3 CTCF ATF1 JUN RAD21 YY1 ZNF664 SMC3 FOS MAFK ZNF654 CXCL3 CXCL2 CXCL8 RASSF6 MTHFD2L PF4V1 LOC105377272
GH04F073588 1.2 Ensembl ENCODE 16.8 +30.7 30651 2.6 HDGF HDAC1 TBP PKNOX1 TBL1XR1 BMI1 FEZF1 ZNF2 YY1 CBX5 RASSF6 MTHFD2L ANKRD17 ENSG00000250220 ENSG00000221639 ENSG00000249970
GH04F073605 1.4 FANTOM5 Ensembl ENCODE 9.9 +12.3 12309 5.9 SOX13 TBP WRNIP1 ZNF384 EBF1 RELA RARA ZNF143 RCOR1 FOS RASSF6 MTHFD2L ENSG00000249970
GH04F073615 1.2 Ensembl ENCODE 7.4 +1.8 1840 7.2 HDAC1 PKNOX1 ZNF133 ZNF76 SIN3A FEZF1 ZNF48 RARA GLIS2 GATA2 RASSF6 ENSG00000249970
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASSF6 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001432014 630 1600 HDAC1 PKNOX1 ZNF76 FEZF1 ZNF48 RARA GLIS2 SCRT2 ZNF143 SP3

Genomic Location for RASSF6 Gene

Chromosome:
4
Start:
73,571,550 bp from pter
End:
73,620,631 bp from pter
Size:
49,082 bases
Orientation:
Minus strand

Genomic View for RASSF6 Gene

Genes around RASSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF6 Gene

Proteins for RASSF6 Gene

  • Protein details for RASSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTQ3-RASF6_HUMAN
    Recommended name:
    Ras association domain-containing protein 6
    Protein Accession:
    Q6ZTQ3
    Secondary Accessions:
    • Q68DT2
    • Q6PDA6
    • Q86WG9
    • Q86WH0

    Protein attributes for RASSF6 Gene

    Size:
    369 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    • Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779).
    SequenceCaution:
    • Sequence=AAH58835.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18138.1; Type=Erroneous termination; Positions=148; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF6 Gene

Post-translational modifications for RASSF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF6 Gene

Domains & Families for RASSF6 Gene

Gene Families for RASSF6 Gene

Protein Domains for RASSF6 Gene

Suggested Antigen Peptide Sequences for RASSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZTQ3

UniProtKB/Swiss-Prot:

RASF6_HUMAN :
  • Contains 1 Ras-associating domain.
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF6: view

Function for RASSF6 Gene

Molecular function for RASSF6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Gene Ontology (GO) - Molecular Function for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20920251
genes like me logo Genes that share ontologies with RASSF6: view
genes like me logo Genes that share phenotypes with RASSF6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF6 Gene

Localization for RASSF6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF6 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF6 Gene

Pathways & Interactions for RASSF6 Gene

genes like me logo Genes that share pathways with RASSF6: view

Pathways by source for RASSF6 Gene

SIGNOR curated interactions for RASSF6 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with RASSF6: view

Transcripts for RASSF6 Gene

Unigene Clusters for RASSF6 Gene

Ras association (RalGDS/AF-6) domain family member 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -

Relevant External Links for RASSF6 Gene

GeneLoc Exon Structure for
RASSF6
ECgene alternative splicing isoforms for
RASSF6

Expression for RASSF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF6 Gene

This gene is overexpressed in Stomach (x7.1), Colon - Transverse (x5.3), Bladder (x5.0), Small Intestine - Terminal Ileum (x4.1), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for RASSF6 Gene

This gene is overexpressed in Liver (47.7), Thyroid (12.2), and Cardia (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASSF6 Gene



NURSA nuclear receptor signaling pathways regulating expression of RASSF6 Gene:

RASSF6

SOURCE GeneReport for Unigene cluster for RASSF6 Gene:

Hs.529677

mRNA Expression by UniProt/SwissProt for RASSF6 Gene:

Q6ZTQ3-RASF6_HUMAN
Tissue specificity: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.
genes like me logo Genes that share expression patterns with RASSF6: view

Primer Products

No data available for Protein tissue co-expression partners for RASSF6 Gene

Orthologs for RASSF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF6 34 35
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia RASSF6 34 35
  • 87.06 (n)
dog
(Canis familiaris)
Mammalia RASSF6 34 35
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Rassf6 34 16 35
  • 81.05 (n)
rat
(Rattus norvegicus)
Mammalia Rassf6 34
  • 80.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASSF6 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASSF6 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASSF6 34 35
  • 66.37 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf6 34
  • 63.86 (n)
Str.15569 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52938 34
zebrafish
(Danio rerio)
Actinopterygii rassf6 34 35
  • 59.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rassf 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for RASSF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF6 Gene

ENSEMBL:
Gene Tree for RASSF6 (if available)
TreeFam:
Gene Tree for RASSF6 (if available)

Paralogs for RASSF6 Gene

Paralogs for RASSF6 Gene

(2) SIMAP similar genes for RASSF6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASSF6: view

Variants for RASSF6 Gene

Sequence variations from dbSNP and Humsavar for RASSF6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10003721 -- 73,575,067(+) AGTAA(C/T)GCCTT utr-variant-3-prime
rs10004505 -- 73,572,281(+) aagtg(A/G)tccaa utr-variant-3-prime
rs10009048 -- 73,588,065(+) TTATA(A/G)CAATT intron-variant
rs10009599 -- 73,612,685(+) TCTTT(A/G)TAGCA intron-variant, upstream-variant-2KB
rs10011419 -- 73,587,974(+) CCATT(C/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF6 Gene

Variant ID Type Subtype PubMed ID
esv2676507 CNV deletion 23128226
esv3600997 CNV gain 21293372
esv3600998 CNV loss 21293372
nsv1001725 CNV gain 25217958
nsv1117100 CNV deletion 24896259
nsv292546 CNV deletion 16902084
nsv822617 CNV loss 20364138

Variation tolerance for RASSF6 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASSF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF6 Gene

Disorders for RASSF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASSF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bronchiolitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RASSF6

Genetic Association Database (GAD)
RASSF6
Human Genome Epidemiology (HuGE) Navigator
RASSF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASSF6
genes like me logo Genes that share disorders with RASSF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF6 Gene

Publications for RASSF6 Gene

  1. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian A.D. … Drumm M.L. (Genes Immun. 2008) 3 46 64
  2. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. (PMID: 17367779) Ikeda M. … Hata Y. (Exp. Cell Res. 2007) 3 4 64
  3. RASSF6 is a novel member of the RASSF family of tumor suppressors. (PMID: 17404571) Allen N.P. … Clark G.J. (Oncogene 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RASSF6 Gene

Sources for RASSF6 Gene

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