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Aliases for RASSF6 Gene

Aliases for RASSF6 Gene

  • Ras Association Domain Family Member 6 2 3
  • Ras Association (RalGDS/AF-6) Domain Family Member 6 2 5

External Ids for RASSF6 Gene

Previous GeneCards Identifiers for RASSF6 Gene

  • GC04M074680
  • GC04M074842
  • GC04M074907
  • GC04M074905
  • GC04M074803
  • GC04M074437
  • GC04M070250

Summaries for RASSF6 Gene

Entrez Gene Summary for RASSF6 Gene

  • This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for RASSF6 Gene

RASSF6 (Ras Association Domain Family Member 6) is a Protein Coding gene. Diseases associated with RASSF6 include Bronchiolitis. Among its related pathways are Hippo signaling pathway. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot for RASSF6 Gene

  • Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF6 Gene

Genomics for RASSF6 Gene

Regulatory Elements for RASSF6 Gene

Enhancers for RASSF6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASSF6 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASSF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF6 Gene

73,571,550 bp from pter
73,620,631 bp from pter
49,082 bases
Minus strand

Genomic View for RASSF6 Gene

Genes around RASSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF6 Gene

Proteins for RASSF6 Gene

  • Protein details for RASSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q68DT2
    • Q6PDA6
    • Q86WG9
    • Q86WH0

    Protein attributes for RASSF6 Gene

    369 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    • Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779).
    • Sequence=AAH58835.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18138.1; Type=Erroneous termination; Positions=148; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF6 Gene


neXtProt entry for RASSF6 Gene

Proteomics data for RASSF6 Gene at MOPED

Post-translational modifications for RASSF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF6 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RASSF6

No data available for DME Specific Peptides for RASSF6 Gene

Domains & Families for RASSF6 Gene

Gene Families for RASSF6 Gene

Protein Domains for RASSF6 Gene

Suggested Antigen Peptide Sequences for RASSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF6: view

Function for RASSF6 Gene

Molecular function for RASSF6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Phenotypes for RASSF6 Gene

genes like me logo Genes that share phenotypes with RASSF6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF6 Gene

Localization for RASSF6 Gene

Subcellular locations from

Jensen Localization Image for RASSF6 Gene COMPARTMENTS Subcellular localization image for RASSF6 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF6 Gene

Pathways & Interactions for RASSF6 Gene

SuperPathways for RASSF6 Gene

Superpath Contained pathways
1 Hippo signaling pathway
genes like me logo Genes that share pathways with RASSF6: view

Pathways by source for RASSF6 Gene

1 KEGG pathway for RASSF6 Gene

SIGNOR curated interactions for RASSF6 Gene


Gene Ontology (GO) - Biological Process for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF6: view

Drugs & Compounds for RASSF6 Gene

No Compound Related Data Available

Transcripts for RASSF6 Gene

Unigene Clusters for RASSF6 Gene

Ras association (RalGDS/AF-6) domain family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -

Relevant External Links for RASSF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF6 Gene

mRNA expression in normal human tissues for RASSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF6 Gene

This gene is overexpressed in Stomach (x7.1), Colon - Transverse (x5.3), Bladder (x5.0), Small Intestine - Terminal Ileum (x4.1), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for RASSF6 Gene

This gene is overexpressed in Liver (47.7), Thyroid (12.2), and Cardia (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASSF6 Gene

SOURCE GeneReport for Unigene cluster for RASSF6 Gene Hs.529677

mRNA Expression by UniProt/SwissProt for RASSF6 Gene

Tissue specificity: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.
genes like me logo Genes that share expression patterns with RASSF6: view

Primer Products

No data available for Protein tissue co-expression partners for RASSF6 Gene

Orthologs for RASSF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASSF6 35
  • 87.06 (n)
  • 83.28 (a)
  • 77 (a)
(Canis familiaris)
Mammalia RASSF6 35
  • 86.67 (n)
  • 80.9 (a)
  • 81 (a)
(Mus musculus)
Mammalia Rassf6 35
  • 81.05 (n)
  • 77.98 (a)
Rassf6 16
Rassf6 36
  • 76 (a)
(Pan troglodytes)
Mammalia RASSF6 35
  • 99.91 (n)
  • 99.73 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rassf6 35
  • 80.16 (n)
  • 76.19 (a)
(Monodelphis domestica)
Mammalia RASSF6 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia RASSF6 36
  • 58 (a)
(Gallus gallus)
Aves RASSF6 35
  • 66.37 (n)
  • 59.4 (a)
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf6 35
  • 63.86 (n)
  • 60.96 (a)
Str.15569 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52938 35
(Danio rerio)
Actinopterygii rassf6 35
  • 59.19 (n)
  • 50 (a)
rassf6 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rassf 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for RASSF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF6 Gene

Gene Tree for RASSF6 (if available)
Gene Tree for RASSF6 (if available)

Paralogs for RASSF6 Gene

Paralogs for RASSF6 Gene

(2) SIMAP similar genes for RASSF6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASSF6: view

Variants for RASSF6 Gene

Sequence variations from dbSNP and Humsavar for RASSF6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs12507775 - 73,585,356(+) ATAAG(A/G)TAAAT nc-transcript-variant, reference, missense
rs17804499 - 73,576,632(+) CTTCT(C/G)CATCT reference, missense
rs997478 -- 73,590,057(+) AAGCA(A/T)ACACA intron-variant
rs765596 -- 73,619,380(-) AAGCA(C/G)GTGAC intron-variant
rs1247585 -- 73,622,375(+) GTAAA(C/G)TTAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASSF6 Gene

Variant ID Type Subtype PubMed ID
nsv822617 CNV Loss 20364138
esv2676507 CNV Deletion 23128226
nsv292546 CNV Loss 16902084

Variation tolerance for RASSF6 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RASSF6 Gene

Disorders for RASSF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASSF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RASSF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RASSF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF6 Gene

Publications for RASSF6 Gene

  1. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian A.D. … Drumm M.L. (Genes Immun. 2008) 3 48 67
  2. Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival. (PMID: 26074700) Ye H.L. … Chen R.F. (World J. Gastroenterol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Downregulation of Ras association domain family member 6 (RASSF6) underlies the treatment resistance of highly metastatic nasopharyngeal carcinoma cells. (PMID: 25028967) Liang Y.Y. … Qian C.N. (PLoS ONE 2014) 3
  5. RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells. (PMID: 25482183) Mezzanotte J.J. … Clark G.J. (Epigenetics 2014) 3

Products for RASSF6 Gene

Sources for RASSF6 Gene