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Aliases for RASSF6 Gene

Aliases for RASSF6 Gene

  • Ras Association (RalGDS/AF-6) Domain Family Member 6 2 3

External Ids for RASSF6 Gene

Summaries for RASSF6 Gene

Entrez Gene Summary for RASSF6 Gene

  • This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for RASSF6 Gene

RASSF6 (Ras Association (RalGDS/AF-6) Domain Family Member 6) is a Protein Coding gene. Diseases associated with RASSF6 include bronchiolitis. Among its related pathways are Hippo signaling pathway. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot for RASSF6 Gene

  • Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF6 Gene

Genomics for RASSF6 Gene

Genomic Location for RASSF6 Gene

73,571,550 bp from pter
73,620,631 bp from pter
49,082 bases
Minus strand

Genomic View for RASSF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF6 Gene

Regulatory Elements for RASSF6 Gene

Proteins for RASSF6 Gene

  • Protein details for RASSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q68DT2
    • Q6PDA6
    • Q86WG9
    • Q86WH0

    Protein attributes for RASSF6 Gene

    369 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    • Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779).
    • Sequence=AAH58835.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18138.1; Type=Erroneous termination; Positions=148; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF6 Gene


neXtProt entry for RASSF6 Gene

Proteomics data for RASSF6 Gene at MOPED

Post-translational modifications for RASSF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF6 Gene

No data available for DME Specific Peptides for RASSF6 Gene

Domains for RASSF6 Gene

Protein Domains for RASSF6 Gene

Suggested Antigen Peptide Sequences for RASSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.:
    • Q6ZTQ3
  • Contains 1 SARAH domain.:
    • Q6ZTQ3
genes like me logo Genes that share domains with RASSF6: view

No data available for Gene Families for RASSF6 Gene

Function for RASSF6 Gene

Molecular function for RASSF6 Gene

UniProtKB/Swiss-Prot Function: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Gene Ontology (GO) - Molecular Function for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20920251
genes like me logo Genes that share ontologies with RASSF6: view

miRNA for RASSF6 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASSF6 Gene

Localization for RASSF6 Gene

Subcellular locations from

Jensen Localization Image for RASSF6 Gene COMPARTMENTS Subcellular localization image for RASSF6 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF6 Gene

Pathways for RASSF6 Gene

SuperPathways for RASSF6 Gene

Superpath Contained pathways
1 Hippo signaling pathway
genes like me logo Genes that share pathways with RASSF6: view

Pathways by source for RASSF6 Gene

1 KEGG pathway for RASSF6 Gene

Gene Ontology (GO) - Biological Process for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0042981 regulation of apoptotic process --
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with RASSF6: view

Transcripts for RASSF6 Gene

Unigene Clusters for RASSF6 Gene

Ras association (RalGDS/AF-6) domain family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -

Relevant External Links for RASSF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF6 Gene

mRNA expression in normal human tissues for RASSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF6 Gene

This gene is overexpressed in Stomach (7.1), Colon - Transverse (5.3), Bladder (5.0), Small Intestine - Terminal Ileum (4.1), and Pancreas (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASSF6 Gene

SOURCE GeneReport for Unigene cluster for RASSF6 Gene Hs.529677

mRNA Expression by UniProt/SwissProt for RASSF6 Gene

Tissue specificity: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.
genes like me logo Genes that share expressions with RASSF6: view

Orthologs for RASSF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASSF6 35
  • 99.91 (n)
  • 99.73 (a)
  • 100 (a)
(Bos Taurus)
Mammalia RASSF6 35
  • 87.06 (n)
  • 83.28 (a)
  • 77 (a)
(Canis familiaris)
Mammalia RASSF6 35
  • 86.67 (n)
  • 80.9 (a)
  • 81 (a)
(Mus musculus)
Mammalia Rassf6 35
  • 81.05 (n)
  • 77.98 (a)
Rassf6 16
Rassf6 36
  • 76 (a)
(Monodelphis domestica)
Mammalia RASSF6 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia RASSF6 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Rassf6 35
  • 80.16 (n)
  • 76.19 (a)
(Gallus gallus)
Aves RASSF6 35
  • 66.37 (n)
  • 59.4 (a)
  • 53 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52938 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf6 35
  • 63.86 (n)
  • 60.96 (a)
Str.15569 35
(Danio rerio)
Actinopterygii rassf6 35
  • 59.19 (n)
  • 50 (a)
rassf6 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rassf 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for RASSF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF6 Gene

Gene Tree for RASSF6 (if available)
Gene Tree for RASSF6 (if available)

Paralogs for RASSF6 Gene

Paralogs for RASSF6 Gene

Selected SIMAP similar genes for RASSF6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASSF6: view

Variants for RASSF6 Gene

Sequence variations from dbSNP and Humsavar for RASSF6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs765596 -- 73,619,380(-) AAGCA(C/G)GTGAC intron-variant
rs997478 -- 73,590,057(+) AAGCA(A/T)ACACA intron-variant
rs1247585 -- 73,622,375(+) GTAAA(C/G)TTAGA upstream-variant-2KB
rs1247586 -- 73,622,222(+) TTTTA(C/T)CTGCA upstream-variant-2KB
rs1247587 -- 73,621,772(-) aagtg(A/T)tcctc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASSF6 Gene

Variant ID Type Subtype PubMed ID
nsv822617 CNV Loss 20364138
esv2676507 CNV Deletion 23128226
nsv292546 CNV Loss 16902084

Relevant External Links for RASSF6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF6 Gene

Disorders for RASSF6 Gene

(1) MalaCards Diseases for RASSF6 Gene

Search for RASSF6 Gene in MalaCards »

Relevant External Links for RASSF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RASSF6: view

No data available for UniProtKB/Swiss-Prot for RASSF6 Gene

Publications for RASSF6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. (PMID: 17367779) Ikeda M. … Hata Y. (Exp. Cell Res. 2007) 3 4
  4. RASSF6 is a novel member of the RASSF family of tumor suppressors. (PMID: 17404571) Allen N.P. … Clark G.J. (Oncogene 2007) 3 4
  5. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian A.D. … Drumm M.L. (Genes Immun. 2008) 3 48

Products for RASSF6 Gene

Sources for RASSF6 Gene

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