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RASSF6 Gene

protein-coding   GIFtS: 54
GCID: GC04M074437

Ras Association (RalGDS/AF-6) Domain Family Member 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Association (RalGDS/AF-6) Domain Family Member 61 2
Putative RAS Binding Protein2
Ras Association (RalGDS/AF-6) Domain Family 62
Ras Association Domain-Containing Protein 62

External Ids:    HGNC: 207961   Entrez Gene: 1668242   Ensembl: ENSG000001694357   OMIM: 6126205   UniProtKB: Q6ZTQ33   

Export aliases for RASSF6 gene to outside databases

Previous GC identifers: GC04M074680 GC04M074842 GC04M074907 GC04M074905 GC04M074803 GC04M070250


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASSF6 Gene:
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a
highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this
gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to
susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein
isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for RASSF6 Gene:
RASSF6 (Ras association (RalGDS/AF-6) domain family member 6) is a protein-coding gene. Diseases associated with RASSF6 include bronchiolitis, and cystic fibrosis. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot: RASF6_HUMAN, Q6ZTQ3
Function: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways.
May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASSF6 gene promoter:
         HFH-3   FOXI1   Nkx6-1   HTF   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASSF6 promoter sequence
   Search Chromatin IP Primers for RASSF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASSF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q21.1

RASSF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074437:  view genomic region     (about GC identifiers)

Start:
74,437,267 bp from pter      End:
74,486,348 bp from pter
Size:
49,082 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASF6_HUMAN, Q6ZTQ3 (See protein sequence)
Recommended Name: Ras association domain-containing protein 6  
Size: 369 amino acids; 43384 Da
Subunit: Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate:
interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of
interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779)
Sequence caution: Sequence=AAH58835.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH18138.1; Type=Erroneous termination; Positions=148; Note=Translated as Gln;
Secondary accessions: Q68DT2 Q6PDA6 Q86WG9 Q86WH0
Alternative splicing: 4 isoforms:  Q6ZTQ3-1   Q6ZTQ3-2   Q6ZTQ3-3   Q6ZTQ3-4   

Explore the universe of human proteins at neXtProt for RASSF6: NX_Q6ZTQ3

Explore proteomics data for RASSF6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASSF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257320.1  NP_001257321.1  NP_803876.1  NP_958834.1  

    ENSEMBL proteins: 
     ENSP00000303877   ENSP00000340578   ENSP00000379123   ENSP00000335582  

    RASSF6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011524 SARAH_dom
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry Q6ZTQ3

    ProtoNet protein and cluster: Q6ZTQ3

    UniProtKB/Swiss-Prot: RASF6_HUMAN, Q6ZTQ3
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SARAH domain


    RASSF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASF6_HUMAN, Q6ZTQ3
    Function: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways.
    May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    RASSF6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASSF6
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASSF6

    miRNA
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    miRTarBase miRNAs that target RASSF6:
    hsa-mir-128-3p (MIRT021964), hsa-mir-335-5p (MIRT017788), hsa-mir-181a-5p (MIRT025042), hsa-mir-148b-3p (MIRT019339)

    Block miRNA regulation of human, mouse, rat RASSF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASSF6 (see all 9):
    hsa-miR-3942-5p hsa-miR-935 hsa-miR-2117 hsa-miR-143 hsa-miR-3915 hsa-miR-205* hsa-miR-590-3p hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidRASSF6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RASSF6

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    Sino Biological Human cDNA Clone for RASSF6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASSF6 About    
    See pathways by source

    SuperPathContained pathways About
    1Hippo signaling pathway
    Hippo signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RASSF6):
        Hippo signaling pathway


    RASSF6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASSF6
    Interactions:

        Search GeneGlobe Interaction Network for RASSF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for RASSF6 (Q6ZTQ31, 3 ENSP000003405784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK4Q130431, 3, ENSP000003618924EBI-2933412,EBI-367376 I2D: score=1 STRING: ENSP00000361892
    STK3Q131883, ENSP000003905004I2D: score=1 STRING: ENSP00000390500
    MOAP1ENSP000002988944STRING: ENSP00000298894
    SAV1ENSP000003247294STRING: ENSP00000324729
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0042981regulation of apoptotic process ----
    GO:0043065positive regulation of apoptotic process IEA--

    RASSF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASSF6 (RASF6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RASSF6 gene (4 alternative transcripts): 
    NM_001270391.1  NM_001270392.1  NM_177532.4  NM_201431.2  

    Unigene Cluster for RASSF6:

    Ras association (RalGDS/AF-6) domain family member 6
    Hs.529677  [show with all ESTs]
    Unigene Representative Sequence: NM_177532
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307439(uc003hhc.1 uc010iik.1) ENST00000342081(uc003hhd.1 uc010iil.1)
    ENST00000395777 ENST00000335049 ENST00000512591
    miRNA
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    Block miRNA regulation of human, mouse, rat RASSF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASSF6 (see all 9):
    hsa-miR-3942-5p hsa-miR-935 hsa-miR-2117 hsa-miR-143 hsa-miR-3915 hsa-miR-205* hsa-miR-590-3p hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidRASSF6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RASSF6 (NM_177532)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF6
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RASSF6
      QuantiFast Probe-based Assays in human, mouse, rat RASSF6

    Additional mRNA sequence: 

    AK126346.1 AY217664.1 AY217665.1 BC058835.1 CR749283.1 

    6 DOTS entries:

    DT.109242  DT.102826639  DT.443166  DT.101972393  DT.121252212  DT.75186696 

    Selected AceView cDNA sequences (see all 57):

    AI016998 AA806780 AA280132 NM_201431 AA921679 AU137808 NM_177532 AK002032 
    AY217665 AA280131 AY217664 BX437347 AI167789 AW137911 BX450616 BX496993 
    BX103114 BU941996 AI769016 BU930079 N41418 BG291982 AW151616 BX100520 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RASSF6    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:              -     -     -                                                                           
    SP2:                          -                                                                           
    SP3:              -     -           -     -                                                               
    SP4:                          -                                   -                                       


    ECgene alternative splicing isoforms for RASSF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASSF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCGAGATG
    RASSF6 Expression
    About this image


    RASSF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    RASSF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASSF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529677

    UniProtKB/Swiss-Prot: RASF6_HUMAN, Q6ZTQ3
    Tissue specificity: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and
    lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas,
    stomach and the thyroid gland compared to the normal counterpart

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASSF6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rassf61 , 5 Ras association (RalGDS/AF-6) domain family member more1, 5 81.05(n)1
    77.98(a)1
      5 (44.78 cM)5
    732461  NM_028478.21  NP_082754.21 
     906030765 
    chicken
    (Gallus gallus)
    Aves RASSF61 Ras association (RalGDS/AF-6) domain family member more 66.37(n)
    59.4(a)
      422653  XM_004941188.1  XP_004941245.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC529382 hypothetical protein MGC52938 74.11(n)    BC043762.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rassf61 Ras association (RalGDS/AF-6) domain family 6 59.19(n)
    50(a)
      751594  NM_001045339.1  NP_001038804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rassf6
    Ras association family member
    10(a)
    1 → many
    3R(18939736-18943673)


    ENSEMBL Gene Tree for RASSF6 (if available)
    TreeFam Gene Tree for RASSF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASSF6 gene
    RASSF22  RASSF42  
    2 SIMAP similar genes for RASSF6 using alignment to 1 protein entry:     RASF6_HUMAN:
    RASSF2    RASSF4

    RASSF6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASSF6 (see all 1154)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911314201,2
    --74436779(+) TAAAAA/GCCTTG 4 -- ds50010--------
    rs1150269491,2
    F--74436879(+) TAAACG/ATAGTG 4 -- ds50011Minor allele frequency- A:0.03WA 118
    rs131491721,2
    C,F,H--74436926(+) AAATCC/ATTGCC 4 -- ds500113Minor allele frequency- A:0.43NS EA WA NA 790
    rs1420817821,2
    --74437011(+) ATGAAG/TGTCAT 4 -- ds50010--------
    rs1461773871,2
    --74437050(+) CCTATG/TTCTTG 4 -- ds50010--------
    rs119309461,2
    C,F,A,H--74437054(+) TTTCTT/CGTTCT 4 -- ds500117Minor allele frequency- C:0.19NS EA NA CSA WA 1454
    rs1837688651,2
    --74437215(+) ATTTCA/GTAGTA 4 -- ds50010--------
    rs1893234851,2
    --74437247(+) TACCAC/TTATAT 4 -- ds50010--------
    rs1379923221,2
    C--74437264(+) AAAAC-/ATATATA 4 -- ds50010--------
    rs1926281661,2
    --74437435(+) CCTACA/GCACAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for RASSF6 (74437267 - 74486348 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RASSF6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676507CNV Deletion23128226
    nsv292546CNV Loss16902084
    nsv822617CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASSF6
    DNA2.0 Custom Variant and Variant Library Synthesis for RASSF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612620    OMIM disorders: --

    9 diseases for RASSF6:    
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    bronchiolitis    cystic fibrosis    chronic lymphocytic leukemia    neuroblastoma
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    RASSF6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASSF6
    Human Genome Epidemiology (HuGE) Navigator: RASSF6 (1 document)

    Export disorders for RASSF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASSF6 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RASSF6)
        Utopia: connect your pdf to the dynamic
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    1. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1, 4 Hillian A.D....Drumm M.L. (Genes Immun. 2008)
    2. RASSF6 is a novel member of the RASSF family of tumor suppressors. (PubMed id 17404571)1, 2 Allen N.P.... Clark G.J. (Oncogene 2007)
    3. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. (PubMed id 17367779)1, 2 Ikeda M.... Hata Y. (Exp. Cell Res. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. (PubMed id 24003224)1 Iwasa H....Hata Y. (J. Biol. Chem. 2013)
    8. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    9. KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia. (PubMed id 22430796)1 Shinawi T....Latif F. (Epigenetics 2012)
    10. Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells. (PubMed id 22577168)1 Withanage K....Hata Y. (J. Biochem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 166824 HGNC: 20796 AceView: RASSF6 Ensembl:ENSG00000169435 euGenes: HUgn166824
    ECgene: RASSF6 Kegg: 166824 H-InvDB: RASSF6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASSF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASSF6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASSF6 gene:
    Search GeneIP for patents involving RASSF6

    GeneCards and IP:
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