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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASSF5 Gene

protein-coding   GIFtS: 60
GCID: GC01P206680

Ras association (RalGDS/AF-6) domain family member 5
 Explore 15 diseases affiliated with
RASSF5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RASSF5    

Aliases
for RASSF5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras Association (RalGDS/AF-6) Domain Family Member 51 2     Novel Ras Effector 12
NORE11 2 3 5     Rap1-Binding Protein2
RAPL1 2 3     Ras Association (RalGDS/AF-6) Domain Family 52
Maxp11 2     Ras Association Domain-Containing Protein 52
New Ras Effector 12 3     Ras Effector-Like Protein2
NORE1A2     Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue2
NORE1B2     Tumor Suppressor RASSF32
RASSF32     Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues3

External Ids:    HGNC: 176091   Entrez Gene: 835932   Ensembl: ENSG000001366537   OMIM: 6070205   UniProtKB: Q8WWW03   

Export aliases for RASSF5 gene to outside databases

Previous GC identifers: GC01P202391 GC01P203324 GC01P203764 GC01P203069 GC01P204747 GC01P177379


Summaries
for RASSF5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RASSF5:
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a
variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the
GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion
and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0
Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon
T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the
patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may
participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for
directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic
function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis

Gene Wiki entry for RASSF5


Genomic Views
for RASSF5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASSF5 gene promoter:
         Ik-2   p53   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASSF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASSF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASSF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

RASSF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206680:  view genomic region     (about GC identifiers)

Start:
 206,680,879 bp from pter      End:
 206,762,616 bp from pter
Size:
 81,738 bases      Orientation:
 plus strand

Proteins
for RASSF5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0 (See protein sequence)
Recommended Name: Ras association domain-containing protein 5  
Size: 418 amino acids; 47090 Da
Subunit: Interacts directly with activated HRAS1; a RASSF5-STK4/MST1 complex probably associates with activated HRAS1.
Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can
self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the
association of RSSF1 with HRAS1 (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds
STK4/MST1, inhibiting STK4/MST1 autoactivation
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of
unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in
the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular
endothelial cells and is dissociated from microtubules by activated RAP1A
Caution: Was termed (Ref.3) RASSF3
Sequence caution: Sequence=AAH04270.1; Type=Erroneous initiation; Sequence=AAH07203.1; Type=Erroneous initiation;
Secondary accessions: A8K1E6 Q5SY32 Q8WWV9 Q8WXF4 Q9BT99
Alternative splicing: 4 isoforms:  Q8WWW0-1   Q8WWW0-2   Q8WWW0-3   Q8WWW0-4   (Initiator Met-1 is removed. Contains a N-acetylthreonine at position 2)

Explore the universe of human proteins at neXtProt for RASSF5: NX_Q8WWW0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WWW0

    • RASSF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_872604.1  NP_872605.1  NP_872606.1  

    ENSEMBL proteins: 
     ENSP00000347443   ENSP00000356084   ENSP00000342620   ENSP00000306091  

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    Novus Biologicals RASSF5 Proteins
    Novus Biologicals RASSF5 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RASSF5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--


    RASSF5 for ontologies           About GeneDecksing



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    Uscn Antibodies for RASSF5
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    Uscn ELISAs and CLIAs for RASSF5

    Protein Domains /
    Families
    for RASSF5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RASSF5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011524 SARAH
     IPR000159 Ras-assoc
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry Q8WWW0

    ProtoNet protein and cluster: Q8WWW0

    1 Blocks protein family: IPB000159 RA domain

    UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SARAH domain


    Function
    for RASSF5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0
    Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon
    T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the
    patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may
    participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for
    directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic
    function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis

    miRNA
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    hsa-mir-124 (MIRT002619)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASSF5
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate RASSF5 (see all 44):
    hsa-miR-4291 hsa-miR-1321 hsa-miR-15a hsa-miR-513a-5p hsa-miR-218 hsa-miR-371-5p hsa-miR-570 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: RASSF5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--


    RASSF5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for RASSF5: Rassf5tm1Sblee Rassf5tm1Kina
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rassf5):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system  tumorigenesis 

    RASSF5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RASSF5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TCR signaling in naive CD4+ T cells
    		TCR signaling in naive CD4+ T cells1.00
    		TCR signaling in naive CD8+ T cells0.64
    2Pathways in cancer
    		Pathways in cancer1.00
    3Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00
    4Glioma
    		Non-small cell lung cancer0.53
    5Integrin Pathway
    		Transendothelial Migration of Leukocytes0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RASSF5
        Transendothelial Migration of Leukocytes

    2 BioSystems Pathways for RASSF5 
        TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells


    3         Kegg Pathways  (Kegg details for RASSF5):
        Leukocyte transendothelial migration
    Pathways in cancer
    Non-small cell lung cancer


    RASSF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASSF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/308 Interacting proteins for RASSF5 (Q8WWW01, 2, 3 ENSP000003474434) via UniProtKB, MINT, STRING, and/or I2D (see all 308)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0035556intracellular signal transduction IEA--


    RASSF5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RASSF5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASSF5

    10/843 HMDB Compounds for RASSF5 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----
    Search CenterWatch for drugs/clinical trials and news about RASSF5 / RASF5 

    Transcripts
    for RASSF5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RASSF5 gene (4 alternative transcripts): 
    NM_182663.2  NM_182664.2  NM_182665.2  NM_031437.1  

    Unigene Cluster for RASSF5:

    Ras association (RalGDS/AF-6) domain family member 5
    Hs.497579  [show with all ESTs]
    Unigene Representative Sequence: NM_182663
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355294 ENST00000367117 ENST00000338603(uc001hed.3 uc001hee.3)
    ENST00000304534(uc001hef.3) ENST00000491368(uc001heg.1 uc001hec.1)
    ENST00000481486

    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate RASSF5 (see all 44):
    hsa-miR-4291 hsa-miR-1321 hsa-miR-15a hsa-miR-513a-5p hsa-miR-218 hsa-miR-371-5p hsa-miR-570 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: RASSF5 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF445801.1 AK289861.1 AK291268.1 AK292039.1 AL832784.1 AY062002.1 AY062003.1 AY216268.1 
    AY261332.1 BC004270.1 BC007203.1 BC042651.1 

    13 DOTS entries:

    DT.95166051  DT.116216  DT.91873153  DT.100774962  DT.102826282  DT.95360289  DT.95166048  DT.121422162 
    DT.91705236  DT.121422117  DT.121422141  DT.91705234  DT.95166055 

    24/181 AceView cDNA sequences (see all 181):

    AW339664 AA360601 NM_182663 CR610514 AY062002 AI093871 CA313923 CA448892 
    CA448504 AA648293 BQ285945 CA310872 W00997 BG055351 AW338689 AI675526 
    AI696540 AA767555 AY261332 AA287053 AI283532 AA233074 BQ777975 AW572103 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RASSF5 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                    -                                                   
    SP2:                    -                       -                           
    SP3:                                                                        
    SP4:                    -                                                   
    SP5:                                                                        


    ECgene alternative splicing isoforms for RASSF5

    Expression
    for RASSF5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASSF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATATATACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RASSF5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RASSF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASSF5

    SOURCE GeneReport for Unigene cluster: Hs.497579

    UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0
    Tissue specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors

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    In Situ
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    Orthologs
    for RASSF5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RASSF5 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Q5ZHZ1_CHICK6
    		 Ras association (RalGDS/AF-6) domain family 5
    		 70(a)
    		 1 ↔ 1
    		 26(2305309-2315131)
    lizard
    (Anolis carolinensis)    		 Reptilia RASSF56
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343228.1(1569713-1577763)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj66h022 Transcribed sequence with weak similarity to protein more 80.13(n)    CD603570.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea T24F1.36
    		 Protein T24F1.3, isoform a
    		 19(a)
    		 1 → many
    		 II(11306335-11311876)


    ENSEMBL Gene Tree for RASSF5 (if available)
    TreeFam Gene Tree for RASSF5 (if available) 

    Paralogs
    for RASSF5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASSF5 gene
    RASSF12  RASSF32  
    3 SIMAP similar genes for RASSF5 using alignment to 1 protein entry:     RASF5_HUMAN:
    FLJ00186    RASSF3    RASSF1

    RASSF5 for paralogs           About GeneDecksing



    Genomic Variants
    for RASSF5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1398 NCBI SNPs in RASSF5 are shown (see all 1398)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs756108421,2
    		C,F,--177377315(+) AGCCAT/ACTCAA 2 -- us2k11Minor allele frequency- A:0.09WA 118
    rs608837831,2
    		C,F,--177377438(+) CAAAAG/ACAAGG 2 -- us2k14Minor allele frequency- A:0.18WA CSA 124
    rs774664431,2
    		--177377665(+) GACTAT/CGATTA 2 -- us2k12Minor allele frequency- C:0.15CSA WA 120
    rs776995671,2
    		C,F,--177378148(+) TTTGTG/AGGAAC 2 -- us2k11Minor allele frequency- A:0.09WA 118
    rs38139751,2
    		C,--177378756(-) CACTCA/TCCCGC 2 -- us2k10--------
    rs1121995801,2
    		--177378930(+) GCCTAG/CGGCCC 2 -- us2k12Minor allele frequency- C:0.08CSA WA 120
    rs120663691,2
    		F,--177378979(+) GCGCTC/GCTCTG 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs583781141,2
    		C,--177379174(+) GTGGGC/GCGGCC 2 -- us2k10--------
    rs762677571,2
    		--177380350(+) GGACTC/GTGCTC 2 -- int12Minor allele frequency- G:0.15CSA WA 120
    rs1115180651,2
    		C,--177380568(+) TCCTTG/-GGGGT 2 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for RASSF5 (206680879 - 206762616 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RASSF5
         1 CNV: 5545

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    Disorders / Diseases
    for RASSF5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RASSF5 for disorders           About GeneDecksing

    OMIM gene information: 607020    OMIM disorders: --

    15 diseases for RASSF5:    About MalaCards
    clear cell renal cell carcinoma    renal cell carcinoma    follicular thyroid carcinoma    thyroid carcinoma
    hepatitis b    carcinoma    thyroiditis    polyposis
    hepatocellular carcinoma    lung carcinoma    lung cancer    breast cancer
    ataxia    hepatitis    neuroblastoma

    2 Novoseek disease relationships for RASSF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    primary tumor 41.3 1 11965544 (1)
    tumors 18.8 8 15007383 (3), 11965544 (1), 18452173 (1), 19435914 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: RASSF5 (5 documents)

    Export disorders for RASSF5 gene to outside databases

    Publications
    for RASSF5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASSF5 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with RASSF5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PubMed id 11965544)1, 2, 3, 9 Tommasi S....Pfeifer G.P. (2002)
    2. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. (PubMed id 15109305)1, 2, 9 Praskova M.... Avruch J. (2004)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. (PubMed id 15569673)1, 2 Fujita H.... Mochizuki N. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. (PubMed id 12845325)1, 2 Katagiri K.... Kinashi T. (2003)
    8. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. (PubMed id 12676952)1, 2 Vos M.D.... Clark G.J. (2003)
    9. Chromosome mapping and sequence variation of the murine Ras effector gene Nore1. (PubMed id 11978988)1, 3 Yao R....You M. (2001)
    10. The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. (PubMed id 14667507)1, 9 Chen J....Teh B.T. (2003)

    External Searches for RASSF5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing RASSF5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83593 HGNC: 17609 AceView: RASSF5 Ensembl:ENSG00000136653 euGenes: HUgn83593
    ECgene: RASSF5 Kegg: 83593 H-InvDB: RASSF5

    Other Databases showing RASSF5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RASSF5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASSF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASSF5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RASSF5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RASSF5 gene:
    Search GeneIP for patents involving RASSF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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