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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASSF5 Gene

protein-coding   GIFtS: 62
GCID: GC01P206680

Ras Association (RalGDS/AF-6) Domain Family Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Association (RalGDS/AF-6) Domain Family Member 51 2     Novel Ras Effector 12
NORE12 3 5     Rap1-Binding Protein2
New Ras Effector 12 3     Ras Association (RalGDS/AF-6) Domain Family 52
RAPL2 3     Ras Association Domain-Containing Protein 52
Maxp12     Ras Effector-Like Protein2
NORE1A2     Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue2
NORE1B2     Tumor Suppressor RASSF32
RASSF32     Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues3

External Ids:    HGNC: 176091   Entrez Gene: 835932   Ensembl: ENSG000001366537   OMIM: 6070205   UniProtKB: Q8WWW03   

Export aliases for RASSF5 gene to outside databases

Previous GC identifers: GC01P202391 GC01P203324 GC01P203764 GC01P203069 GC01P204747 GC01P177379


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASSF5 Gene:
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated
in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the
GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte
adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RASSF5 Gene: 
RASSF5 (Ras association (RalGDS/AF-6) domain family member 5) is a protein-coding gene. Diseases associated with RASSF5 include follicular thyroid carcinoma, and clear cell renal cell carcinoma, and among its related super-pathways are TCR signaling in naive CD8+ T cells and Glioma. GO annotations related to this gene include protein binding and metal ion binding. An important paralog of this gene is RASSF1.

UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0
Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon
T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and
the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may
participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required
for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras
apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis

Gene Wiki entry for RASSF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASSF5 gene promoter:
         Ik-2   p53   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASSF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASSF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASSF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

RASSF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206680:  view genomic region     (about GC identifiers)

Start:
206,680,879 bp from pter      End:
206,762,616 bp from pter
Size:
81,738 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0 (See protein sequence)
Recommended Name: Ras association domain-containing protein 5  
Size: 418 amino acids; 47090 Da
Subunit: Interacts directly with activated HRAS1; a RASSF5-STK4/MST1 complex probably associates with activated
HRAS1. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA.
Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the
association of RSSF1 with HRAS1 (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds
STK4/MST1, inhibiting STK4/MST1 autoactivation
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear
region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with
ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules
in vascular endothelial cells and is dissociated from microtubules by activated RAP1A
Caution: Was termed (Ref.3) RASSF3
Sequence caution: Sequence=AAH04270.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH04270.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=AAH07203.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAH07203.1; Type=Miscellaneous discrepancy;
Note=Aberrant splicing;
Secondary accessions: A8K1E6 Q5SY32 Q8WWV9 Q8WXF4 Q9BT99
Alternative splicing: 3 isoforms:  Q8WWW0-1   Q8WWW0-2   Q8WWW0-3   (Initiator Met-1 is removed. Contains a N-acetylthreonine at position 2)

Explore the universe of human proteins at neXtProt for RASSF5: NX_Q8WWW0

Explore proteomics data for RASSF5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWW0

  • RASSF5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASSF5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_872604.1  NP_872605.1  NP_872606.1  

    ENSEMBL proteins: 
     ENSP00000347443   ENSP00000356084   ENSP00000342620   ENSP00000306091  

    Human Recombinant Protein Products for RASSF5: 
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    Novus Biologicals RASSF5 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASSF5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--

    RASSF5 for ontologies           About GeneDecksing



    RASSF5 Antibody Products: 
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    ThermoFisher Antibodies for RASSF5
    LSBio Antibodies in human, mouse, rat for RASSF5 

    Assay Products for RASSF5: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RASSF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RASSF5 
    Cloud-Clone Corp. CLIAs for RASSF5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011524 SARAH_dom
     IPR000159 Ras-assoc
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry Q8WWW0

    ProtoNet protein and cluster: Q8WWW0

    1 Blocks protein domain: IPB000159 RA domain

    UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SARAH domain


    RASSF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASF5_HUMAN, Q8WWW0
    Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon
    T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and
    the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may
    participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required
    for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras
    apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12845325
    GO:0046872metal ion binding IEA--
         
    RASSF5 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rassf5):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system  tumorigenesis 

    RASSF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RASSF5: Rassf5tm1Sblee Rassf5tm1Kina

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RASSF5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RASSF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASSF5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASSF5 

    miRNA
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    miRTarBase miRNAs that target RASSF5:
    hsa-mir-124 (MIRT002619)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASSF5
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate RASSF5 (see all 44):
    hsa-miR-4291 hsa-miR-1321 hsa-miR-15a hsa-miR-513a-5p hsa-miR-218 hsa-miR-371-5p hsa-miR-570 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRASSF5 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASSF5

    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of RASSF5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RASSF5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    TCR signaling in naive CD8+ T cells0.64
    2Glioma
    Non-small cell lung cancer0.51
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Pathways in cancer
    Pathways in cancer
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RASSF5
        Transendothelial Migration of Leukocytes

    2 BioSystems Pathways for RASSF5
        TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells



    3         Kegg Pathways  (Kegg details for RASSF5):
        Leukocyte transendothelial migration
    Pathways in cancer
    Non-small cell lung cancer


    RASSF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASSF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/330 Interacting proteins for RASSF5 (Q8WWW01, 2, 3 ENSP000003474434) via UniProtKB, MINT, STRING, and/or I2D (see all 330)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction ----
    GO:0031398positive regulation of protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    RASSF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASSF5 (RASF5)

    10/843 HMDB Compounds for RASSF5 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Search CenterWatch for drugs/clinical trials and news about RASSF5 / RASF5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASSF5 gene (4 alternative transcripts): 
    NM_182663.2  NM_182664.2  NM_182665.2  NM_031437.1  

    Unigene Cluster for RASSF5:

    Ras association (RalGDS/AF-6) domain family member 5
    Hs.497579  [show with all ESTs]
    Unigene Representative Sequence: NM_182663
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355294 ENST00000367117 ENST00000338603(uc001hed.3 uc001hee.3)
    ENST00000304534(uc001hef.3) ENST00000491368(uc001heg.1 uc001hec.1)
    ENST00000481486
    miRNA
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    hsa-miR-4291 hsa-miR-1321 hsa-miR-15a hsa-miR-513a-5p hsa-miR-218 hsa-miR-371-5p hsa-miR-570 hsa-miR-424
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF445801.1 AK289861.1 AK291268.1 AK292039.1 AL832784.1 AY062002.1 AY062003.1 AY216268.1 
    AY261332.1 BC004270.1 BC007203.1 BC042651.1 

    13 DOTS entries:

    DT.95166051  DT.116216  DT.91873153  DT.100774962  DT.102826282  DT.95360289  DT.95166048  DT.121422162 
    DT.91705236  DT.121422117  DT.121422141  DT.91705234  DT.95166055 

    24/181 AceView cDNA sequences (see all 181):

    AI675526 N74659 AI283532 AW953689 AA767555 AY261332 AW338689 AA360601 
    CA313923 CA310872 AA648293 AA287053 CA944923 BF111127 BQ285945 AI696540 
    AW572103 AI377761 BQ777975 BQ269302 NM_182663 CD633166 CR610514 CA448504 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RASSF5 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                    -                                                   
    SP2:                    -                       -                           
    SP3:                                                                        
    SP4:                    -                                                   
    SP5:                                                                        


    ECgene alternative splicing isoforms for RASSF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASSF5 expression in normal human tissues (normalized intensities)      RASSF5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATATACA
    RASSF5 Expression
    About this image


    RASSF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             heart muscle ; myocytes   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; squamous epithelial cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex

    See RASSF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASSF5

    SOURCE GeneReport for Unigene cluster: Hs.497579

    UniProtKB/Swiss-Prot: RASF5_HUMAN, Q8WWW0
    Tissue specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASSF5 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rassf51 , 5 Ras association (RalGDS/AF-6) domain family member more1, 5 85.47(n)1
    86.2(a)1
      1 (56.91 cM)5
    543541  NM_018750.31  NP_061220.21 
     1311764105 
    chicken
    (Gallus gallus)
    Aves RASSF56
    Ras association (RalGDS/AF-6) domain family member...
    70(a)
    1 ↔ 1
    26(2438015-2447837)
    lizard
    (Anolis carolinensis)
    Reptilia RASSF56
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343228.1(1459532-1577763)
    zebrafish
    (Danio rerio)
    Actinopterygii wufj66h022 Transcribed sequence with weak similarity to protein more 80.13(n)    CD603570.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsf-16
    Protein T24F1.3, isoform a
    15(a)
    1 → many
    II(11306399-11311940)


    ENSEMBL Gene Tree for RASSF5 (if available)
    TreeFam Gene Tree for RASSF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASSF5 gene
    RASSF12  RASSF32  
    3 SIMAP similar genes for RASSF5 using alignment to 1 protein entry:     RASF5_HUMAN:
    FLJ00186    RASSF3    RASSF1

    RASSF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1671 SNPs in RASSF5 are shown (see all 1671)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422229481,2
    C--177407370(+) GTGTC-/TGTGTGT 2 -- int10--------
    rs723247111,2
    C--177407371(+) TGTCT-/TG    
       
    /TGTG
    GTGTG
    2 -- int10--------
    rs75359391,2
    C,A--177417009(+) tgtgtG/Tttttt 2 -- int1 trp30--------
    rs666441631,2
    C--177427159(+) GAAAC-/TCCCCC 3 -- us2k1 int10--------
    rs96605381,2
    C,F,A,H--206702455(+) ACAAGC/TGGCTG 2 -- int15Minor allele frequency- T:0.17NS EA WA 538
    rs120829071,2
    A--206702627(+) CCCCAC/GTAAGA 2 -- int10--------
    rs1128752601,2
    F--206702757(+) GCCCTG/TTGTCA 2 -- int12Minor allele frequency- T:0.12CSA WA 120
    rs741480051,2
    C,F--206702877(+) AAGGGC/TGCTTT 2 -- int14Minor allele frequency- T:0.17WA CSA 124
    rs347694851,2
    C--206703098(+) AAAAA-/ATTAAC 2 -- int11Minor allele frequency- A:0.50NA 2
    rs113788631,2
    C--206705391(+) AAAAAA/-TCTTT 2 -- int12Minor allele frequency- -:0.00NA CSA 4

    HapMap Linkage Disequilibrium report for RASSF5 (206680879 - 206762616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RASSF5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672106CNV Deletion23128226
    nsv160541CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607020    OMIM disorders: --

    11 diseases for RASSF5:    About MalaCards
    follicular thyroid carcinoma    clear cell renal cell carcinoma    renal cell carcinoma    thyroiditis
    neuroblastoma    hepatitis b    lung cancer    endotheliitis
    hepatocellular carcinoma    hepatitis    breast cancer


    RASSF5 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RASSF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    primary tumor 41.3 1 11965544 (1)
    tumors 18.8 8 15007383 (3), 11965544 (1), 18452173 (1), 19435914 (1) (see all 5)

    Genetic Association Database (GAD): RASSF5
    Human Genome Epidemiology (HuGE) Navigator: RASSF5 (5 documents)

    Export disorders for RASSF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASSF5 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with RASSF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PubMed id 11965544)1, 2, 3, 9 Tommasi S....Pfeifer G.P. (2002)
    2. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. (PubMed id 15109305)1, 2, 9 Praskova M.... Avruch J. (2004)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. (PubMed id 15569673)1, 2 Fujita H.... Mochizuki N. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. (PubMed id 12845325)1, 2 Katagiri K.... Kinashi T. (2003)
    10. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. (PubMed id 12676952)1, 2 Vos M.D.... Clark G.J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83593 HGNC: 17609 AceView: RASSF5 Ensembl:ENSG00000136653 euGenes: HUgn83593
    ECgene: RASSF5 Kegg: 83593 H-InvDB: RASSF5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASSF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASSF5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASSF5 gene:
    Search GeneIP for patents involving RASSF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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