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Aliases for RASSF5 Gene

Aliases for RASSF5 Gene

  • Ras Association (RalGDS/AF-6) Domain Family Member 5 2 3
  • NORE1 3 4 6
  • New Ras Effector 1 3 4
  • RAPL 3 4
  • Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues 4
  • Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue 3
  • Ras Association (RalGDS/AF-6) Domain Family 5 3
  • Ras Association Domain-Containing Protein 5 3
  • Ras Effector-Like Protein 3
  • Tumor Suppressor RASSF3 3
  • Rap1-Binding Protein 3
  • Novel Ras Effector 1 3
  • NORE1A 3
  • NORE1B 3
  • RASSF3 3
  • Maxp1 3

External Ids for RASSF5 Gene

Previous GeneCards Identifiers for RASSF5 Gene

  • GC01P202391
  • GC01P203324
  • GC01P203764
  • GC01P203069
  • GC01P204747
  • GC01P206680
  • GC01P177379

Summaries for RASSF5 Gene

Entrez Gene Summary for RASSF5 Gene

  • This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF5 Gene

RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Ras signaling pathway.

UniProtKB/Swiss-Prot for RASSF5 Gene

  • Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Gene Wiki entry for RASSF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF5 Gene

Genomics for RASSF5 Gene

Regulatory Elements for RASSF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASSF5 Gene

Start:
206,507,530 bp from pter
End:
206,589,284 bp from pter
Size:
81,755 bases
Orientation:
Plus strand

Genomic View for RASSF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF5 Gene

Proteins for RASSF5 Gene

  • Protein details for RASSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWW0-RASF5_HUMAN
    Recommended name:
    Ras association domain-containing protein 5
    Protein Accession:
    Q8WWW0
    Secondary Accessions:
    • A8K1E6
    • Q5SY32
    • Q8WWV9
    • Q8WXF4
    • Q9BT99

    Protein attributes for RASSF5 Gene

    Size:
    418 amino acids
    Molecular mass:
    47090 Da
    Quaternary structure:
    • Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation.
    SequenceCaution:
    • Sequence=AAH04270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH04270.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RASSF5 Gene

    Alternative splice isoforms for RASSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF5 Gene

Proteomics data for RASSF5 Gene at MOPED

Post-translational modifications for RASSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF5 Gene

Antibody Products

No data available for DME Specific Peptides for RASSF5 Gene

Domains for RASSF5 Gene

Protein Domains for RASSF5 Gene

Suggested Antigen Peptide Sequences for RASSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWW0

UniProtKB/Swiss-Prot:

RASF5_HUMAN :
  • Q8WWW0
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASSF5: view

No data available for Gene Families for RASSF5 Gene

Function for RASSF5 Gene

Molecular function for RASSF5 Gene

UniProtKB/Swiss-Prot Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Gene Ontology (GO) - Molecular Function for RASSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12845325
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASSF5: view
genes like me logo Genes that share phenotypes with RASSF5: view

Animal Models for RASSF5 Gene

MGI Knock Outs for RASSF5:

Animal Model Products

CRISPR Products

miRNA for RASSF5 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASSF5 Gene

Localization for RASSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF5 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF5 Gene COMPARTMENTS Subcellular localization image for RASSF5 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with RASSF5: view

Pathways for RASSF5 Gene

genes like me logo Genes that share pathways with RASSF5: view

Gene Ontology (GO) - Biological Process for RASSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF5: view

Compounds for RASSF5 Gene

(843) HMDB Compounds for RASSF5 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with RASSF5: view

Transcripts for RASSF5 Gene

Unigene Clusters for RASSF5 Gene

Ras association (RalGDS/AF-6) domain family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RASSF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF5 Gene

No ASD Table

Relevant External Links for RASSF5 Gene

GeneLoc Exon Structure for
RASSF5
ECgene alternative splicing isoforms for
RASSF5

Expression for RASSF5 Gene

mRNA expression in normal human tissues for RASSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF5 Gene

This gene is overexpressed in Whole Blood (13.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RASSF5 Gene

SOURCE GeneReport for Unigene cluster for RASSF5 Gene Hs.497579

mRNA Expression by UniProt/SwissProt for RASSF5 Gene

Q8WWW0-RASF5_HUMAN
Tissue specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
genes like me logo Genes that share expressions with RASSF5: view

In Situ Assay Products

Orthologs for RASSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASSF5 35
  • 87.96 (n)
  • 87.8 (a)
mouse
(Mus musculus)
Mammalia Rassf5 35
  • 84.99 (n)
  • 85.71 (a)
Rassf5 16
rat
(Rattus norvegicus)
Mammalia Rassf5 35
  • 86.28 (n)
  • 87.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150414 35
  • 62.25 (n)
  • 60.93 (a)
wufj66h02 35
Species with no ortholog for RASSF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF5 Gene

ENSEMBL:
Gene Tree for RASSF5 (if available)
TreeFam:
Gene Tree for RASSF5 (if available)

Paralogs for RASSF5 Gene

Selected SIMAP similar genes for RASSF5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASSF5: view

No data available for Paralogs for RASSF5 Gene

Variants for RASSF5 Gene

Sequence variations from dbSNP and Humsavar for RASSF5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11589 -- 206,588,606(-) GGGTC(A/G)GAGAG utr-variant-3-prime
rs868937 -- 206,509,762(+) CGTTT(G/T)TGTGT intron-variant
rs871782 -- 206,512,396(-) GCTCT(A/G)ATGAA intron-variant
rs874717 -- 206,511,645(-) GTTAG(A/T)TGGCC intron-variant
rs874718 -- 206,511,644(-) TTAGT(G/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF5 Gene

Variant ID Type Subtype PubMed ID
esv2672106 CNV Deletion 23128226
nsv160541 CNV Loss 16902084

Relevant External Links for RASSF5 Gene

HapMap Linkage Disequilibrium report
RASSF5
Human Gene Mutation Database (HGMD)
RASSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF5 Gene

Disorders for RASSF5 Gene

(2) Novoseek inferred disease relationships for RASSF5 Gene

Disease -log(P) Hits PubMed IDs
primary tumor 41.3 1
tumors 18.8 7

Relevant External Links for RASSF5

Genetic Association Database (GAD)
RASSF5
Human Genome Epidemiology (HuGE) Navigator
RASSF5
genes like me logo Genes that share disorders with RASSF5: view

No data available for UniProtKB/Swiss-Prot for RASSF5 Gene

Publications for RASSF5 Gene

  1. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PMID: 11965544) Tommasi S. … Pfeifer G.P. (Oncogene 2002) 2 3 4 23
  2. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. (PMID: 15109305) Praskova M. … Avruch J. (Biochem. J. 2004) 3 4 23
  3. Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma. (PMID: 18452173) Geli J. … Larsson C. (Int. J. Cancer 2008) 3 23
  4. Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. (PMID: 18596699) Stieglitz B. … Herrmann C. (EMBO J. 2008) 3 23
  5. The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. (PMID: 14667507) Chen J. … Teh B.T. (Cancer Cell 2003) 3 23

Products for RASSF5 Gene

Sources for RASSF5 Gene

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