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Aliases for RASSF5 Gene

Aliases for RASSF5 Gene

  • Ras Association Domain Family Member 5 2 3
  • Ras Association (RalGDS/AF-6) Domain Family Member 5 2 3 5
  • Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues 2 4
  • Novel Ras Effector 1 2 3
  • New Ras Effector 1 3 4
  • NORE1 3 4
  • RAPL 3 4
  • Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue 3
  • Ras Association (RalGDS/AF-6) Domain Family 5 3
  • Ras Effector-Like Protein 3
  • Tumor Suppressor RASSF3 3
  • Rap1-Binding Protein 3
  • NORE1A 3
  • NORE1B 3
  • RASSF3 3
  • Maxp1 3

External Ids for RASSF5 Gene

Previous GeneCards Identifiers for RASSF5 Gene

  • GC01P202391
  • GC01P203324
  • GC01P203764
  • GC01P203069
  • GC01P204747
  • GC01P206680
  • GC01P177379

Summaries for RASSF5 Gene

Entrez Gene Summary for RASSF5 Gene

  • This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF5 Gene

RASSF5 (Ras Association Domain Family Member 5) is a Protein Coding gene. Diseases associated with RASSF5 include gastric cardia adenocarcinoma and gastric cardia carcinoma. Among its related pathways are Ras signaling pathway and Pathways in cancer. An important paralog of this gene is RASSF3.

UniProtKB/Swiss-Prot for RASSF5 Gene

  • Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Gene Wiki entry for RASSF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF5 Gene

Genomics for RASSF5 Gene

Regulatory Elements for RASSF5 Gene

Promoters for RASSF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASSF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF5 Gene

Chromosome:
1
Start:
206,507,530 bp from pter
End:
206,589,284 bp from pter
Size:
81,755 bases
Orientation:
Plus strand

Genomic View for RASSF5 Gene

Genes around RASSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF5 Gene

Proteins for RASSF5 Gene

  • Protein details for RASSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWW0-RASF5_HUMAN
    Recommended name:
    Ras association domain-containing protein 5
    Protein Accession:
    Q8WWW0
    Secondary Accessions:
    • A8K1E6
    • Q5SY32
    • Q8WWV9
    • Q8WXF4
    • Q9BT99

    Protein attributes for RASSF5 Gene

    Size:
    418 amino acids
    Molecular mass:
    47090 Da
    Quaternary structure:
    • Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation.
    SequenceCaution:
    • Sequence=AAH04270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH04270.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RASSF5 Gene

    Alternative splice isoforms for RASSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF5 Gene

Proteomics data for RASSF5 Gene at MOPED

Post-translational modifications for RASSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF5 Gene

Antibody Products

No data available for DME Specific Peptides for RASSF5 Gene

Domains & Families for RASSF5 Gene

Gene Families for RASSF5 Gene

Protein Domains for RASSF5 Gene

Suggested Antigen Peptide Sequences for RASSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWW0

UniProtKB/Swiss-Prot:

RASF5_HUMAN :
  • Contains 1 Ras-associating domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASSF5: view

Function for RASSF5 Gene

Molecular function for RASSF5 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
genes like me logo Genes that share phenotypes with RASSF5: view

Animal Models for RASSF5 Gene

MGI Knock Outs for RASSF5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASSF5 Gene

Localization for RASSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF5 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF5 Gene COMPARTMENTS Subcellular localization image for RASSF5 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for RASSF5 Gene

Pathways & Interactions for RASSF5 Gene

genes like me logo Genes that share pathways with RASSF5: view

Gene Ontology (GO) - Biological Process for RASSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RASSF5: view

No data available for SIGNOR curated interactions for RASSF5 Gene

Drugs & Compounds for RASSF5 Gene

(1) Drugs for RASSF5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Salirasib Pharma Inhibitor of active Ras protein 0

(3) Additional Compounds for RASSF5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(1) ApexBio Compounds for RASSF5 Gene

Compound Action Cas Number
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with RASSF5: view

Transcripts for RASSF5 Gene

Unigene Clusters for RASSF5 Gene

Ras association (RalGDS/AF-6) domain family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF5 Gene

No ASD Table

Relevant External Links for RASSF5 Gene

GeneLoc Exon Structure for
RASSF5
ECgene alternative splicing isoforms for
RASSF5

Expression for RASSF5 Gene

mRNA expression in normal human tissues for RASSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF5 Gene

This gene is overexpressed in Whole Blood (x13.3).

Protein differential expression in normal tissues from HIPED for RASSF5 Gene

This gene is overexpressed in Lymph node (12.9), Tlymphocyte (9.3), Monocytes (9.1), Bone marrow stromal cell (8.1), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RASSF5 Gene



SOURCE GeneReport for Unigene cluster for RASSF5 Gene Hs.497579

mRNA Expression by UniProt/SwissProt for RASSF5 Gene

Q8WWW0-RASF5_HUMAN
Tissue specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
genes like me logo Genes that share expression patterns with RASSF5: view

Protein tissue co-expression partners for RASSF5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RASSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASSF5 35
  • 87.96 (n)
  • 87.8 (a)
mouse
(Mus musculus)
Mammalia Rassf5 35
  • 84.99 (n)
  • 85.71 (a)
Rassf5 16
rat
(Rattus norvegicus)
Mammalia Rassf5 35
  • 86.28 (n)
  • 87.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150414 35
  • 62.25 (n)
  • 60.93 (a)
wufj66h02 35
Species with no ortholog for RASSF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF5 Gene

ENSEMBL:
Gene Tree for RASSF5 (if available)
TreeFam:
Gene Tree for RASSF5 (if available)

Paralogs for RASSF5 Gene

Paralogs for RASSF5 Gene

(3) SIMAP similar genes for RASSF5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASSF5: view

Variants for RASSF5 Gene

Sequence variations from dbSNP and Humsavar for RASSF5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs868937 -- 206,509,762(+) CGTTT(G/T)TGTGT intron-variant
rs871782 -- 206,512,396(-) GCTCT(A/G)ATGAA intron-variant
rs874717 -- 206,511,645(-) GTTAG(A/T)TGGCC intron-variant
rs874718 -- 206,511,644(-) TTAGT(G/T)GGCCT intron-variant
rs1007802 -- 206,562,363(+) AATTT(C/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF5 Gene

Variant ID Type Subtype PubMed ID
esv2672106 CNV Deletion 23128226
nsv160541 CNV Loss 16902084

Variation tolerance for RASSF5 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASSF5 Gene

HapMap Linkage Disequilibrium report
RASSF5
Human Gene Mutation Database (HGMD)
RASSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF5 Gene

Disorders for RASSF5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RASSF5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
gastric cardia carcinoma
  • carcinoma of cardia of stomach
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RASSF5

Genetic Association Database (GAD)
RASSF5
Human Genome Epidemiology (HuGE) Navigator
RASSF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASSF5
genes like me logo Genes that share disorders with RASSF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF5 Gene

Publications for RASSF5 Gene

  1. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PMID: 11965544) Tommasi S. … Pfeifer G.P. (Oncogene 2002) 2 3 4 23 67
  2. Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. (PMID: 23972470) Ni L. … Luo X. (Structure 2013) 2 3
  3. NORE1A tumor suppressor candidate modulates p21CIP1 via p53. (PMID: 19435914) Calvisi D.F. … Clark G.J. (Cancer Res. 2009) 3 23
  4. Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma. (PMID: 18452173) Geli J. … Larsson C. (Int. J. Cancer 2008) 3 23
  5. Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. (PMID: 18596699) Stieglitz B. … Herrmann C. (EMBO J. 2008) 3 23

Products for RASSF5 Gene

Sources for RASSF5 Gene

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