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Aliases for RASSF4 Gene

Aliases for RASSF4 Gene

  • Ras Association (RalGDS/AF-6) Domain Family Member 4 2 3
  • AD037 3 6
  • Ras Association (RalGDS/AF-6) Domain Family 4 3
  • Ras Association Domain-Containing Protein 4 3
  • RAS Association Domain Family 4 3
  • Tumor Suppressor RASSF4 3

External Ids for RASSF4 Gene

Previous GeneCards Identifiers for RASSF4 Gene

  • GC10P045230
  • GC10P044739
  • GC10P044775
  • GC10P045454
  • GC10P041979

Summaries for RASSF4 Gene

Entrez Gene Summary for RASSF4 Gene

  • The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF4 Gene

RASSF4 (Ras Association (RalGDS/AF-6) Domain Family Member 4) is a Protein Coding gene. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot for RASSF4 Gene

  • Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF4 Gene

Genomics for RASSF4 Gene

Regulatory Elements for RASSF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASSF4 Gene

Start:
44,959,407 bp from pter
End:
44,995,891 bp from pter
Size:
36,485 bases
Orientation:
Plus strand

Genomic View for RASSF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF4 Gene

Proteins for RASSF4 Gene

  • Protein details for RASSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2L5-RASF4_HUMAN
    Recommended name:
    Ras association domain-containing protein 4
    Protein Accession:
    Q9H2L5
    Secondary Accessions:
    • Q86WH5
    • Q86WH6
    • Q86WH7
    • Q8N5A9
    • Q8TCK6

    Protein attributes for RASSF4 Gene

    Size:
    321 amino acids
    Molecular mass:
    36748 Da
    Quaternary structure:
    • Interacts directly with activated KRAS in a GTP-dependent manner.

    Alternative splice isoforms for RASSF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF4 Gene

Proteomics data for RASSF4 Gene at MOPED

Post-translational modifications for RASSF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF4 Gene

Antibody Products

No data available for DME Specific Peptides for RASSF4 Gene

Domains for RASSF4 Gene

Protein Domains for RASSF4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RASSF4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2L5

UniProtKB/Swiss-Prot:

RASF4_HUMAN :
  • Q9H2L5
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF4: view

No data available for Gene Families for RASSF4 Gene

Function for RASSF4 Gene

Molecular function for RASSF4 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.

Gene Ontology (GO) - Molecular Function for RASSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with RASSF4: view

Phenotypes for RASSF4 Gene

GenomeRNAi human phenotypes for RASSF4:
genes like me logo Genes that share phenotypes with RASSF4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RASSF4 Gene

Localization for RASSF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF4 Gene COMPARTMENTS Subcellular localization image for RASSF4 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF4 Gene

Pathways for RASSF4 Gene

SuperPathways for RASSF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF4: view

No data available for Pathways by source for RASSF4 Gene

Compounds for RASSF4 Gene

(1) HMDB Compounds for RASSF4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RASSF4: view

Transcripts for RASSF4 Gene

Unigene Clusters for RASSF4 Gene

Ras association (RalGDS/AF-6) domain family member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - - - -
SP15:
SP16: - -
SP17: -
SP18: - - -
SP19:

ExUns: 12c ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -
SP16: -
SP17:
SP18: -
SP19: -

Relevant External Links for RASSF4 Gene

GeneLoc Exon Structure for
RASSF4
ECgene alternative splicing isoforms for
RASSF4

Expression for RASSF4 Gene

mRNA expression in normal human tissues for RASSF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF4 Gene

This gene is overexpressed in Kidney - Cortex (4.4).

Protein differential expression in normal tissues for RASSF4 Gene

This gene is overexpressed in Fetal Brain (35.3), Spleen (18.7), and NK cells (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASSF4 Gene

SOURCE GeneReport for Unigene cluster for RASSF4 Gene Hs.522895

mRNA Expression by UniProt/SwissProt for RASSF4 Gene

Q9H2L5-RASF4_HUMAN
Tissue specificity: Widely expressed. Frequently down-regulated in tumor cell lines.
genes like me logo Genes that share expressions with RASSF4: view

Expression partners for RASSF4 Gene

In Situ Assay Products

Orthologs for RASSF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASSF4 35
  • 83.77 (n)
  • 81.41 (a)
RASSF4 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF4 35
  • 87.12 (n)
  • 87.85 (a)
RASSF4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf4 35
  • 82.97 (n)
  • 84.74 (a)
Rassf4 16
Rassf4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RASSF4 35
  • 98.96 (n)
  • 98.13 (a)
RASSF4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf4 35
  • 82.87 (n)
  • 85.67 (a)
oppossum
(Monodelphis domestica)
Mammalia RASSF4 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf4 35
  • 63.38 (n)
  • 64.8 (a)
zebrafish
(Danio rerio)
Actinopterygii rassf4 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000149 35
  • 56.12 (n)
  • 45.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rassf 35
  • 51.53 (n)
  • 40 (a)
Rassf 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for RASSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF4 Gene

ENSEMBL:
Gene Tree for RASSF4 (if available)
TreeFam:
Gene Tree for RASSF4 (if available)

Paralogs for RASSF4 Gene

Paralogs for RASSF4 Gene

Selected SIMAP similar genes for RASSF4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RASSF4: view

Variants for RASSF4 Gene

Sequence variations from dbSNP and Humsavar for RASSF4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs869156 -- 44,983,604(-) TCTTG(G/T)CAGGA intron-variant
rs870204 -- 44,963,037(-) TCCCC(A/G)CTGCG intron-variant
rs870957 - 44,982,644(+) TGCCC(A/G)GACGG reference, missense, synonymous-codon
rs871043 -- 44,983,986(+) CTGCC(A/G)GCAGC intron-variant, synonymous-codon, reference
rs882845 -- 44,971,999(+) ATCAC(A/G/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF4 Gene

Variant ID Type Subtype PubMed ID
nsv831845 CNV Gain 17160897
nsv831846 CNV Loss 17160897
nsv526734 CNV Loss 19592680

Relevant External Links for RASSF4 Gene

HapMap Linkage Disequilibrium report
RASSF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF4 Gene

Disorders for RASSF4 Gene

Relevant External Links for RASSF4

Genetic Association Database (GAD)
RASSF4
Human Genome Epidemiology (HuGE) Navigator
RASSF4

No disorders were found for RASSF4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RASSF4 Gene

Publications for RASSF4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family. (PMID: 15574778) Eckfeld K. … Clark G.J. (Cancer Res. 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan A.R. … Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 48
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for RASSF4 Gene

Sources for RASSF4 Gene

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