Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RASSF4 Gene

Aliases for RASSF4 Gene

  • Ras Association Domain Family Member 4 2 3
  • Ras Association (RalGDS/AF-6) Domain Family Member 4 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family 4 3
  • Ras Association Domain Family 4 3
  • Tumor Suppressor RASSF4 3
  • AD037 3

External Ids for RASSF4 Gene

Previous GeneCards Identifiers for RASSF4 Gene

  • GC10P045230
  • GC10P044739
  • GC10P044775
  • GC10P045454
  • GC10P041979

Summaries for RASSF4 Gene

Entrez Gene Summary for RASSF4 Gene

  • The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF4 Gene

RASSF4 (Ras Association Domain Family Member 4) is a Protein Coding gene. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot for RASSF4 Gene

  • Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF4 Gene

Genomics for RASSF4 Gene

Regulatory Elements for RASSF4 Gene

Enhancers for RASSF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASSF4 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASSF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF4 Gene

Chromosome:
10
Start:
44,959,407 bp from pter
End:
44,995,891 bp from pter
Size:
36,485 bases
Orientation:
Plus strand

Genomic View for RASSF4 Gene

Genes around RASSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF4 Gene

Proteins for RASSF4 Gene

  • Protein details for RASSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2L5-RASF4_HUMAN
    Recommended name:
    Ras association domain-containing protein 4
    Protein Accession:
    Q9H2L5
    Secondary Accessions:
    • Q86WH5
    • Q86WH6
    • Q86WH7
    • Q8N5A9
    • Q8TCK6

    Protein attributes for RASSF4 Gene

    Size:
    321 amino acids
    Molecular mass:
    36748 Da
    Quaternary structure:
    • Interacts directly with activated KRAS in a GTP-dependent manner.

    Alternative splice isoforms for RASSF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF4 Gene

Proteomics data for RASSF4 Gene at MOPED

Post-translational modifications for RASSF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF4 Gene

Antibody Products

No data available for DME Specific Peptides for RASSF4 Gene

Domains & Families for RASSF4 Gene

Gene Families for RASSF4 Gene

Protein Domains for RASSF4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RASSF4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2L5

UniProtKB/Swiss-Prot:

RASF4_HUMAN :
  • Contains 1 Ras-associating domain.
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF4: view

Function for RASSF4 Gene

Molecular function for RASSF4 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
genes like me logo Genes that share phenotypes with RASSF4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RASSF4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF4 Gene

Localization for RASSF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF4 Gene COMPARTMENTS Subcellular localization image for RASSF4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF4 Gene

Pathways & Interactions for RASSF4 Gene

SuperPathways for RASSF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RASSF4 Gene

Drugs & Compounds for RASSF4 Gene

(1) Drugs for RASSF4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASSF4: view

Transcripts for RASSF4 Gene

Unigene Clusters for RASSF4 Gene

Ras association (RalGDS/AF-6) domain family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - - - -
SP15:
SP16: - -
SP17: -
SP18: - - -
SP19:

ExUns: 12c ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -
SP16: -
SP17:
SP18: -
SP19: -

Relevant External Links for RASSF4 Gene

GeneLoc Exon Structure for
RASSF4
ECgene alternative splicing isoforms for
RASSF4

Expression for RASSF4 Gene

mRNA expression in normal human tissues for RASSF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF4 Gene

This gene is overexpressed in Kidney - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for RASSF4 Gene

This gene is overexpressed in Fetal Brain (35.3), Spleen (18.7), and NK cells (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASSF4 Gene



SOURCE GeneReport for Unigene cluster for RASSF4 Gene Hs.522895

mRNA Expression by UniProt/SwissProt for RASSF4 Gene

Q9H2L5-RASF4_HUMAN
Tissue specificity: Widely expressed. Frequently down-regulated in tumor cell lines.
genes like me logo Genes that share expression patterns with RASSF4: view

Protein tissue co-expression partners for RASSF4 Gene

Primer Products

Orthologs for RASSF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASSF4 35
  • 83.77 (n)
  • 81.41 (a)
RASSF4 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF4 35
  • 87.12 (n)
  • 87.85 (a)
RASSF4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf4 35
  • 82.97 (n)
  • 84.74 (a)
Rassf4 16
Rassf4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RASSF4 35
  • 98.96 (n)
  • 98.13 (a)
RASSF4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf4 35
  • 82.87 (n)
  • 85.67 (a)
oppossum
(Monodelphis domestica)
Mammalia RASSF4 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf4 35
  • 63.38 (n)
  • 64.8 (a)
zebrafish
(Danio rerio)
Actinopterygii rassf4 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000149 35
  • 56.12 (n)
  • 45.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rassf 35
  • 51.53 (n)
  • 40 (a)
Rassf 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for RASSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF4 Gene

ENSEMBL:
Gene Tree for RASSF4 (if available)
TreeFam:
Gene Tree for RASSF4 (if available)

Paralogs for RASSF4 Gene

Paralogs for RASSF4 Gene

(2) SIMAP similar genes for RASSF4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RASSF4: view

Variants for RASSF4 Gene

Sequence variations from dbSNP and Humsavar for RASSF4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_034438 -
rs870957 - 44,982,644(+) TGCCC(A/G)GACGG intron-variant, reference, synonymous-codon, missense
rs1888983 -- 44,966,771(+) cacca(C/T)gttgg intron-variant
rs3758398 -- 44,981,632(-) ACCTC(A/G)GCTGC intron-variant
rs3814566 -- 44,968,587(+) AGCAC(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF4 Gene

Variant ID Type Subtype PubMed ID
nsv831845 CNV Gain 17160897
nsv831846 CNV Loss 17160897
nsv526734 CNV Loss 19592680

Variation tolerance for RASSF4 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASSF4 Gene

HapMap Linkage Disequilibrium report
RASSF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF4 Gene

Disorders for RASSF4 Gene

Relevant External Links for RASSF4

Genetic Association Database (GAD)
RASSF4
Human Genome Epidemiology (HuGE) Navigator
RASSF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASSF4

No disorders were found for RASSF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF4 Gene

Publications for RASSF4 Gene

  1. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan A.R. … Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 48 67
  2. RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT. (PMID: 25701784) Zhang F. … Liu W. (Biochem. Biophys. Res. Commun. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  5. Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal. (PMID: 23954638) Michifuri Y. … Sato N. (Biochem. Biophys. Res. Commun. 2013) 3

Products for RASSF4 Gene

Sources for RASSF4 Gene

Content