RASSF3 Gene
protein-coding GIFtS : 52
GCID: GC12 P065004
Ras association (RalGDS/AF-6) domain family member 3
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Aliasesfor RASSF3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Ras Association (RalGDS/AF-6) Domain Family Member 3 1 2 RASSF52 Ras Association (RalGDS/AF-6) Domain Family 32 Ras Association Domain-Containing Protein 32
External Ids: HGNC: 14271 1 Entrez Gene: 283349 2 Ensembl: ENSG00000153179 7 OMIM: 607019 5 UniProtKB: Q86WH2 3 ORGUL members: NONCODE:n411693
Export aliases for RASSF3 gene to outside databases Previous GC identifers: GC12U990170 GC12P064721 GC12P063290 GC12P062056
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Summariesfor RASSF3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RASSF3 : The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.(supplied by OMIM, Jul 2003)
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Genomic Viewsfor RASSF3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RASSF3 gene promoter: FOXI1 HFH-3 Sox5 POU2F1a MyoD Hand1 Msx-1 Tal-1beta E47 Other transcription factors Search SABiosciences Chromatin IP Primers for RASSF3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RASSF3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q14.2 Ensembl cytogenetic band: 12q14.2 HGNC cytogenetic band: 12q14.2 RASSF3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P065004: view genomic region
(about GC identifiers )
Start:
65,004,293 bp from pter
End:
65,091,347 bp from pter
Size:
87,055 bases
Orientation:
plus strand
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Proteinsfor RASSF3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RASF3_HUMAN, Q86WH2 (See
protein sequence )Recommended Name: Ras association domain-containing protein 3 Size : 238 amino acids; 27562 Da
Subcellular location : Cytoplasm. Cytoplasm, cytoskeleton. Note=Localized to microtubules in vascular endothelial cells
Caution : Was termed (Ref.1) RASSF5
Secondary accessions : Q86WH1Alternative splicing : 2 isoforms : Q86WH2-1 Q86WH2-2 Explore the universe of human proteins at neXtProt for RASSF3: NX_Q86WH2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86WH2 RASSF3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_835463.1 ENSEMBL proteins: ENSP00000283172 ENSP00000443021 ENSP00000336616 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
RASSF3 for ontologies About GeneDecksing RASSF3 Antibody Products: Assay Products for RASSF3:
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Protein
Domains / Familiesfor RASSF3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RASSF3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q86WH2 ProtoNet protein and cluster: Q86WH2
UniProtKB/Swiss-Prot: RASF3_HUMAN, Q86WH2 Similarity : Contains 1 Ras-associating domainSimilarity : Contains 1 SARAH domain
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Functionfor RASSF3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RASSF3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RASSF3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RASSF3 (NM_178169 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASSF3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RASSF3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF3
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IPI -- GO:0042802 identical protein binding
IPI --
RASSF3 for ontologies About GeneDecksing
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Pathways & Interactionsfor RASSF3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASSF3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)5/19 Interacting proteins for RASSF3 (Q86WH2 1 , 3 ENSP00000336616 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 19 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007165 signal transduction
IEA --
RASSF3 for ontologies About GeneDecksing
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Drugs & Compoundsfor RASSF3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RASSF3 Search CenterWatch for drugs/clinical trials and news about RASSF3 / RASF3
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Transcriptsfor RASSF3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RASSF3 gene: NM_178169.3 Unigene Cluster for RASSF3:
Ras association (RalGDS/AF-6) domain family member 3 Hs.643605 [show with all ESTs ] Unigene Representative Sequence: NM_178169 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000283172 ENST00000542104 (uc001ssd.3 uc009zqn.3 uc001sse.3 )ENST00000540088 ENST00000336061 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RASSF3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RASSF3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RASSF3 (NM_178169 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASSF3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RASSF3
Additional cDNA sequence: AY217662.1 BC100949.2 BC100950.1 BC100951.1 BC100952.1 NR_040718.1
6 DOTS entries : DT.412610 DT.95354287
DT.121114211 DT.40302273 DT.91872275 DT.92052103 12 AceView cDNA sequences :
AY217662 NM_178169 AY217663 BU556605 BU182700 BQ050672 BF896651 BM562361 AA573427 AA401810 BF737560 BU940690 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for RASSF3 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 SP1 :           SP2 :     -      
ECgene alternative splicing isoforms for RASSF3
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Expression for RASSF3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RASSF3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGAATCGAAA
About this image RASSF3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See RASSF3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RASSF3 SOURCE GeneReport for Unigene cluster: Hs.643605 UniProtKB/Swiss-Prot: RASF3_HUMAN, Q86WH2 Tissue specificity : Widely expressed SABiosciences Custom PCR Arrays for RASSF3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RASSF3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RASSF3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RASSF3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RASSF3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF3
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Orthologsfor RASSF3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for RASSF3 gene from 6/16 species (see all 16 ) About this table
ENSEMBL Gene Tree for RASSF3 (if available)TreeFam Gene Tree for RASSF3 (if available)
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Paralogsfor RASSF3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RASSF3 gene RASSF5 2 RASSF1 2 3 SIMAP similar genes for RASSF3 using alignment to 2 protein entries: RASF3_HUMAN (see all proteins ):RASSF5 RASSF1 FLJ00186
RASSF3 for paralogs About GeneDecksing
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Genomic Variantsfor RASSF3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RASSF3 (65004293 - 65091347 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for RASSF3 3 CNVs : 43862 101543 1918 3 Indels : 49121 22413 22414
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RASSF3
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Disorders
/ Diseasesfor RASSF3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RASSF3 for disorders About GeneDecksing
OMIM gene information: 607019
OMIM disorders : --4 diseases for RASSF3 : About MalaCards low tension glaucoma glaucoma hepatitis b hepatitis Human Genome Epidemiology (HuGE) Navigator: RASSF3 (4 documents) Export disorders for RASSF3 gene to outside databases
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Publicationsfor RASSF3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RASSF3 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with RASSF3) Utopia : connect your pdf to the dynamic world of online information
Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. (PubMed id 15569673) 1 , 2 Fujita H.... Mochizuki N. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PubMed id 11965544) 1 , 2 Tommasi S....Pfeifer G.P. (2002) The RASSF3 candidate tumor suppressor induces apoptosi s and G1-S cell-cycle arrest via p53. (PubMed id 22593196) 1 Kudo T....Hata Y. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496) 1 Davila S....Seielstad M. (2010) Large-scale proteomics analysis of the human kinome. (PubMed id 19369195) 2 Oppermann F.S.... Daub H. (2009) Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice. (PubMed id 19148488) 1 Jacquemart I.C....Chen W.Y. (2009) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for RASSF3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RASSF3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RASSF3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RASSF3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for RASSF3 gene: Search GeneIP for patents involving RASSF3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RASSF3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for RASSF3 OriGene shRNA RFP for RASSF3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RASSF3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RASSF3 OriGene Protein Over-expression Lysate for RASSF3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RASSF3 OriGene 3'-UTR Clone for RASSF3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RASSF3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RASSF3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RASSF3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RASSF3 OriGene Custom Protein Services for RASSF3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RASSF3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RASSF3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RASSF3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RASSF3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RASSF3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RASSF3
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RASSF3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF3
ThermoFisher Antibodies for RASSF3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RASSF3
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