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Aliases for RASSF3 Gene

Aliases for RASSF3 Gene

  • Ras Association Domain Family Member 3 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family Member 3 2 3
  • Ras Association (RalGDS/AF-6) Domain Family 3 3
  • Ras Association Domain-Containing Protein 3 3
  • RASSF5 3

External Ids for RASSF3 Gene

Previous GeneCards Identifiers for RASSF3 Gene

  • GC12U990170
  • GC12P064721
  • GC12P063290
  • GC12P065004
  • GC12P062056
  • GC12P064610

Summaries for RASSF3 Gene

Entrez Gene Summary for RASSF3 Gene

  • The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]

GeneCards Summary for RASSF3 Gene

RASSF3 (Ras Association Domain Family Member 3) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is RASSF5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF3 Gene

Genomics for RASSF3 Gene

Regulatory Elements for RASSF3 Gene

Enhancers for RASSF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F064649 1.8 FANTOM5 Ensembl ENCODE 33.7 +160.9 160942 36.5 HDGF PKNOX1 ARNT MLX ZFP64 SIN3A ARID4B FEZF1 ZNF2 YY1 RASSF3 MSRB3 LOC105369804 MIR548C ENSG00000223294 LOC100507065 LEMD3 GNS C12orf66 TBK1
GH12F064632 1.2 Ensembl ENCODE 16.4 +126.9 126930 3.8 ARID4B ZNF48 FOS ZNF263 TBX21 PPARG KAT8 MIER3 SMARCA4 GLIS1 RASSF3 GNS LOC105369804 ENSG00000215159 ENSG00000223294 ENSG00000225195 ENSG00000256314
GH12F064594 1.4 FANTOM5 Ensembl ENCODE 13.8 +90.3 90300 5.4 HDAC1 LEF1 PKNOX1 CEBPG ZNF316 FOXK2 GATA2 NFE2 FOS SMARCE1 RASSF3 MIR548C TBK1 GC12P064587 LOC105369804
GH12F064607 1.5 FANTOM5 ENCODE 12.1 +103.9 103902 5.9 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TBK1 RASSF3 LEMD3 ATP6V1E1P3 C12orf66 GNS LOC105369804 GC12P064623
GH12F064618 1.5 FANTOM5 ENCODE 9.3 +116.6 116625 10.1 HDGF ARID4B SIN3A DMAP1 YY1 CBX5 ZNF207 FOS JUNB REST TBK1 RASSF3 ATP6V1E1P3 GNS ENSG00000225195 MIR548Z
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASSF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF3 Gene

Chromosome:
12
Start:
64,507,001 bp from pter
End:
64,697,567 bp from pter
Size:
190,567 bases
Orientation:
Plus strand

Genomic View for RASSF3 Gene

Genes around RASSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF3 Gene

Proteins for RASSF3 Gene

  • Protein details for RASSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WH2-RASF3_HUMAN
    Recommended name:
    Ras association domain-containing protein 3
    Protein Accession:
    Q86WH2
    Secondary Accessions:
    • Q86WH1

    Protein attributes for RASSF3 Gene

    Size:
    238 amino acids
    Molecular mass:
    27562 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF3 Gene

Post-translational modifications for RASSF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF3 Gene

No data available for DME Specific Peptides for RASSF3 Gene

Domains & Families for RASSF3 Gene

Gene Families for RASSF3 Gene

Protein Domains for RASSF3 Gene

Suggested Antigen Peptide Sequences for RASSF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WH2

UniProtKB/Swiss-Prot:

RASF3_HUMAN :
  • Contains 1 Ras-associating domain.
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF3: view

Function for RASSF3 Gene

Gene Ontology (GO) - Molecular Function for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20920251
GO:0042802 identical protein binding IPI 20920251
genes like me logo Genes that share ontologies with RASSF3: view
genes like me logo Genes that share phenotypes with RASSF3: view

Animal Model Products

miRNA for RASSF3 Gene

miRTarBase miRNAs that target RASSF3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF3 Gene

Localization for RASSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Localized to microtubules in vascular endothelial cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RASSF3: view

Pathways & Interactions for RASSF3 Gene

SuperPathways for RASSF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with RASSF3: view

No data available for Pathways by source and SIGNOR curated interactions for RASSF3 Gene

Transcripts for RASSF3 Gene

mRNA/cDNA for RASSF3 Gene

Unigene Clusters for RASSF3 Gene

Ras association (RalGDS/AF-6) domain family member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for RASSF3 Gene

GeneLoc Exon Structure for
RASSF3
ECgene alternative splicing isoforms for
RASSF3

Expression for RASSF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF3 Gene

This gene is overexpressed in Artery - Tibial (x6.7) and Colon - Sigmoid (x4.5).

Protein differential expression in normal tissues from HIPED for RASSF3 Gene

This gene is overexpressed in CD4 Tcells (31.5), CD8 Tcells (26.1), and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RASSF3 Gene



Protein tissue co-expression partners for RASSF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASSF3 Gene:

RASSF3

SOURCE GeneReport for Unigene cluster for RASSF3 Gene:

Hs.643605

mRNA Expression by UniProt/SwissProt for RASSF3 Gene:

Q86WH2-RASF3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RASSF3: view

Primer Products

Orthologs for RASSF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF3 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia RASSF3 34 35
  • 92.74 (n)
dog
(Canis familiaris)
Mammalia RASSF3 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf3 34
  • 88.49 (n)
mouse
(Mus musculus)
Mammalia Rassf3 34 16 35
  • 88.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASSF3 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASSF3 34 35
  • 79.66 (n)
lizard
(Anolis carolinensis)
Reptilia RASSF3 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf3 34
  • 71.19 (n)
zebrafish
(Danio rerio)
Actinopterygii rassf3 35
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsf-1 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for RASSF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASSF3 Gene

ENSEMBL:
Gene Tree for RASSF3 (if available)
TreeFam:
Gene Tree for RASSF3 (if available)

Paralogs for RASSF3 Gene

Paralogs for RASSF3 Gene

(3) SIMAP similar genes for RASSF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASSF3: view

Variants for RASSF3 Gene

Sequence variations from dbSNP and Humsavar for RASSF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1008159 -- 64,674,906(+) TGCAC(C/T)CTTTC intron-variant
rs1008160 -- 64,675,055(+) CCCCC(C/T)CCCCG intron-variant
rs10128936 -- 64,620,825(+) TTTAA(A/G)TTTCA intron-variant, upstream-variant-2KB
rs10161254 -- 64,690,129(+) TTTTA(A/G)AACTC intron-variant
rs10506535 -- 64,662,997(-) TATAT(A/G)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF3 Gene

Variant ID Type Subtype PubMed ID
nsv832444 CNV loss 17160897
nsv832443 CNV loss 17160897
nsv818921 CNV loss 17921354
nsv524627 CNV loss 19592680
nsv515833 CNV loss 19592680
nsv476769 CNV novel sequence insertion 20440878
nsv438218 CNV loss 16468122
nsv1133186 CNV tandem duplication 24896259
nsv1110895 OTHER inversion 24896259
esv3629777 CNV loss 21293372
esv3629776 CNV loss 21293372
esv3629775 CNV loss 21293372
esv2446886 CNV deletion 19546169
esv2387704 CNV deletion 18987734
dgv298e199 CNV deletion 23128226
dgv2682n54 CNV gain 21841781

Variation tolerance for RASSF3 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASSF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF3 Gene

Disorders for RASSF3 Gene

Relevant External Links for RASSF3

Genetic Association Database (GAD)
RASSF3
Human Genome Epidemiology (HuGE) Navigator
RASSF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASSF3

No disorders were found for RASSF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF3 Gene

Publications for RASSF3 Gene

  1. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. (PMID: 15569673) Fujita H. … Mochizuki N. (J. Biol. Chem. 2005) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PMID: 11965544) Tommasi S. … Pfeifer G.P. (Oncogene 2002) 3 4 64
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64

Products for RASSF3 Gene

Sources for RASSF3 Gene

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