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Aliases for RASSF3 Gene

Aliases for RASSF3 Gene

  • Ras Association (RalGDS/AF-6) Domain Family Member 3 2 3
  • Ras Association (RalGDS/AF-6) Domain Family 3 3
  • RASSF5 3

External Ids for RASSF3 Gene

Previous GeneCards Identifiers for RASSF3 Gene

  • GC12U990170
  • GC12P064721
  • GC12P063290
  • GC12P065004
  • GC12P062056

Summaries for RASSF3 Gene

Entrez Gene Summary for RASSF3 Gene

  • The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]

GeneCards Summary for RASSF3 Gene

RASSF3 (Ras Association (RalGDS/AF-6) Domain Family Member 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Pathways in cancer. GO annotations related to this gene include identical protein binding. An important paralog of this gene is RASSF1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF3 Gene

Genomics for RASSF3 Gene

Regulatory Elements for RASSF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASSF3 Gene

Chromosome:
12
Start:
64,610,513 bp from pter
End:
64,697,567 bp from pter
Size:
87,055 bases
Orientation:
Plus strand

Genomic View for RASSF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF3 Gene

Proteins for RASSF3 Gene

  • Protein details for RASSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WH2-RASF3_HUMAN
    Recommended name:
    Ras association domain-containing protein 3
    Protein Accession:
    Q86WH2
    Secondary Accessions:
    • Q86WH1

    Protein attributes for RASSF3 Gene

    Size:
    238 amino acids
    Molecular mass:
    27562 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF3 Gene

Proteomics data for RASSF3 Gene at MOPED

Post-translational modifications for RASSF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASSF3 Gene

Domains & Families for RASSF3 Gene

Protein Domains for RASSF3 Gene

Suggested Antigen Peptide Sequences for RASSF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WH2

UniProtKB/Swiss-Prot:

RASF3_HUMAN :
  • Contains 1 Ras-associating domain.
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF3: view

No data available for Gene Families for RASSF3 Gene

Function for RASSF3 Gene

Gene Ontology (GO) - Molecular Function for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20920251
GO:0042802 identical protein binding IPI 20920251
genes like me logo Genes that share ontologies with RASSF3: view

Phenotypes for RASSF3 Gene

GenomeRNAi human phenotypes for RASSF3:
genes like me logo Genes that share phenotypes with RASSF3: view

Animal Model Products

miRNA for RASSF3 Gene

miRTarBase miRNAs that target RASSF3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF3 Gene

Localization for RASSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Localized to microtubules in vascular endothelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF3 Gene COMPARTMENTS Subcellular localization image for RASSF3 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RASSF3: view

Pathways & Interactions for RASSF3 Gene

genes like me logo Genes that share pathways with RASSF3: view

Gene Ontology (GO) - Biological Process for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF3: view

No data available for SIGNOR curated interactions for RASSF3 Gene

Drugs & Compounds for RASSF3 Gene

No Compound Related Data Available

Transcripts for RASSF3 Gene

mRNA/cDNA for RASSF3 Gene

Unigene Clusters for RASSF3 Gene

Ras association (RalGDS/AF-6) domain family member 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for RASSF3 Gene

GeneLoc Exon Structure for
RASSF3
ECgene alternative splicing isoforms for
RASSF3

Expression for RASSF3 Gene

mRNA expression in normal human tissues for RASSF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF3 Gene

This gene is overexpressed in Artery - Tibial (x6.7) and Colon - Sigmoid (x4.5).

Protein differential expression in normal tissues from HIPED for RASSF3 Gene

This gene is overexpressed in CD4 Tcells (31.5), CD8 Tcells (26.1), and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASSF3 Gene



SOURCE GeneReport for Unigene cluster for RASSF3 Gene Hs.643605

mRNA Expression by UniProt/SwissProt for RASSF3 Gene

Q86WH2-RASF3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RASSF3: view

Protein tissue co-expression partners for RASSF3 Gene

Primer Products

In Situ Assay Products

Orthologs for RASSF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASSF3 35
  • 92.74 (n)
  • 93.16 (a)
RASSF3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf3 35
  • 88.46 (n)
  • 94.37 (a)
Rassf3 16
Rassf3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RASSF3 35
  • 99.55 (n)
  • 100 (a)
RASSF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf3 35
  • 88.49 (n)
  • 93.72 (a)
dog
(Canis familiaris)
Mammalia RASSF3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASSF3 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASSF3 35
  • 79.66 (n)
  • 80.08 (a)
RASSF3 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASSF3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf3 35
  • 71.19 (n)
  • 73.31 (a)
zebrafish
(Danio rerio)
Actinopterygii rassf3 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsf-1 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for RASSF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASSF3 Gene

ENSEMBL:
Gene Tree for RASSF3 (if available)
TreeFam:
Gene Tree for RASSF3 (if available)

Paralogs for RASSF3 Gene

Paralogs for RASSF3 Gene

(3) SIMAP similar genes for RASSF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASSF3: view

Variants for RASSF3 Gene

Sequence variations from dbSNP and Humsavar for RASSF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8648 -- 64,697,251(+) CAGCA(A/G)CATTT utr-variant-3-prime, nc-transcript-variant
rs15958 -- 64,697,534(+) CAAAA(G/T)TGTTT utr-variant-3-prime, nc-transcript-variant
rs508792 -- 64,688,550(-) CACAA(C/T)TGACA intron-variant
rs572046 -- 64,661,755(+) tggcc(C/T)actgc intron-variant
rs577303 -- 64,685,774(+) GGGGA(C/T)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF3 Gene

Variant ID Type Subtype PubMed ID
nsv832443 CNV Loss 17160897
nsv832444 CNV Loss 17160897
esv2446886 CNV Deletion 19546169
esv2387704 CNV Deletion 18987734
dgv298e199 CNV Deletion 23128226
nsv515833 CNV Loss 19592680
nsv818921 CNV Loss 17921354
nsv438218 CNV Loss 16468122
dgv1443n71 CNV Loss 21882294
nsv524627 CNV Loss 19592680

Variation tolerance for RASSF3 Gene

Residual Variation Intolerance Score: 63.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASSF3 Gene

HapMap Linkage Disequilibrium report
RASSF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF3 Gene

Disorders for RASSF3 Gene

Relevant External Links for RASSF3

Genetic Association Database (GAD)
RASSF3
Human Genome Epidemiology (HuGE) Navigator
RASSF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASSF3
genes like me logo Genes that share disorders with RASSF3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF3 Gene

Publications for RASSF3 Gene

  1. DNA Damage Regulates Translation through I^-TRCP Targeting of CReP. (PMID: 26091241) Loveless T.B. … Toczyski D.P. (PLoS Genet. 2015) 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 67
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 67
  4. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. (PMID: 24246507) Fukatsu A. … Sekido Y. (Lung Cancer 2014) 67
  5. Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck. (PMID: 24295637) Guo H. … Liu Z. (Eur. J. Cancer 2013) 67

Products for RASSF3 Gene

Sources for RASSF3 Gene

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