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Aliases for RASSF2 Gene

Aliases for RASSF2 Gene

  • Ras Association (RalGDS/AF-6) Domain Family Member 2 2 3
  • Centromere Protein 34 2 3
  • Ras Association (RalGDS/AF-6) Domain Family 2 3
  • Ras Association Domain-Containing Protein 2 3
  • RASFADIN 3
  • KIAA0168 4
  • CENP-34 3

External Ids for RASSF2 Gene

Previous GeneCards Identifiers for RASSF2 Gene

  • GC20M004748
  • GC20M004755
  • GC20M004708

Summaries for RASSF2 Gene

Entrez Gene Summary for RASSF2 Gene

  • This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF2 Gene

RASSF2 (Ras Association (RalGDS/AF-6) Domain Family Member 2) is a Protein Coding gene. An important paralog of this gene is RASSF4.

UniProtKB/Swiss-Prot for RASSF2 Gene

  • Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Gene Wiki entry for RASSF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF2 Gene

Genomics for RASSF2 Gene

Regulatory Elements for RASSF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASSF2 Gene

Start:
4,780,023 bp from pter
End:
4,823,645 bp from pter
Size:
43,623 bases
Orientation:
Minus strand

Genomic View for RASSF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF2 Gene

Proteins for RASSF2 Gene

  • Protein details for RASSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50749-RASF2_HUMAN
    Recommended name:
    Ras association domain-containing protein 2
    Protein Accession:
    P50749
    Secondary Accessions:
    • A6NIX9
    • A8K5Z3
    • Q17S06
    • Q53HD0
    • Q6AHZ2
    • Q8IZA5

    Protein attributes for RASSF2 Gene

    Size:
    326 amino acids
    Molecular mass:
    37790 Da
    Quaternary structure:
    • Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.
    SequenceCaution:
    • Sequence=BAA11485.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF2 Gene

Proteomics data for RASSF2 Gene at MOPED

Post-translational modifications for RASSF2 Gene

Other Protein References for RASSF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASSF2 Gene

Domains for RASSF2 Gene

Protein Domains for RASSF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RASSF2 Gene

Graphical View of Domain Structure for InterPro Entry

P50749

UniProtKB/Swiss-Prot:

RASF2_HUMAN :
  • P50749
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF2: view

No data available for Gene Families for RASSF2 Gene

Function for RASSF2 Gene

Molecular function for RASSF2 Gene

UniProtKB/Swiss-Prot Function: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Gene Ontology (GO) - Molecular Function for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12732644
genes like me logo Genes that share ontologies with RASSF2: view
genes like me logo Genes that share phenotypes with RASSF2: view

Animal Models for RASSF2 Gene

MGI Knock Outs for RASSF2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASSF2 Gene

Localization for RASSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF2 Gene

Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF2 Gene COMPARTMENTS Subcellular localization image for RASSF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RASSF2: view

Pathways for RASSF2 Gene

SuperPathways for RASSF2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction --
GO:0038168 epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade IEA --
genes like me logo Genes that share ontologies with RASSF2: view

No data available for Pathways by source for RASSF2 Gene

Compounds for RASSF2 Gene

(1) HMDB Compounds for RASSF2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RASSF2: view

Transcripts for RASSF2 Gene

Unigene Clusters for RASSF2 Gene

Ras association (RalGDS/AF-6) domain family member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7:
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for RASSF2 Gene

GeneLoc Exon Structure for
RASSF2
ECgene alternative splicing isoforms for
RASSF2

Expression for RASSF2 Gene

mRNA expression in normal human tissues for RASSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF2 Gene

This gene is overexpressed in Whole Blood (11.0), Brain - Spinal cord (cervical c-1) (9.6), and Brain - Substantia nigra (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASSF2 Gene

SOURCE GeneReport for Unigene cluster for RASSF2 Gene Hs.631504

mRNA Expression by UniProt/SwissProt for RASSF2 Gene

P50749-RASF2_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
genes like me logo Genes that share expressions with RASSF2: view

In Situ Assay Products

Orthologs for RASSF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF2 35
  • 99.28 (n)
  • 99.69 (a)
RASSF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASSF2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF2 35
  • 91 (n)
  • 95.71 (a)
RASSF2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf2 35
  • 87.32 (n)
  • 92.64 (a)
Rassf2 16
Rassf2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASSF2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf2 35
  • 87.63 (n)
  • 93.25 (a)
chicken
(Gallus gallus)
Aves RASSF2 35
  • 78.19 (n)
  • 82.72 (a)
RASSF2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASSF2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf2 35
  • 69.9 (n)
  • 79.37 (a)
Str.8222 35
zebrafish
(Danio rerio)
Actinopterygii rassf2a 35
  • 66.78 (n)
  • 69 (a)
rassf2a 36
  • 63 (a)
OneToMany
rassf2b 36
  • 52 (a)
OneToMany
wufa04h12 35
fruit fly
(Drosophila melanogaster)
Insecta Rassf 36
  • 9 (a)
OneToMany
CG4656 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for RASSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF2 Gene

ENSEMBL:
Gene Tree for RASSF2 (if available)
TreeFam:
Gene Tree for RASSF2 (if available)

Paralogs for RASSF2 Gene

Paralogs for RASSF2 Gene

Selected SIMAP similar genes for RASSF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASSF2: view

Variants for RASSF2 Gene

Sequence variations from dbSNP and Humsavar for RASSF2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs723559 -- 4,796,902(+) TTTTG(A/G)AGCCA intron-variant
rs723560 -- 4,796,982(+) AAAAT(A/G)ACATC intron-variant
rs723561 -- 4,797,094(+) TTAGG(C/T)GTCTC intron-variant
rs747748 -- 4,815,079(+) GGAGC(C/G)GTGGG intron-variant
rs753409 -- 4,822,099(-) TCCAC(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF2 Gene

Variant ID Type Subtype PubMed ID
nsv912628 CNV Gain 21882294
nsv912629 CNV Gain 21882294
esv274965 CNV Loss 21479260
esv29645 CNV Loss 19812545
esv1413742 CNV Insertion 17803354
nsv526507 CNV Loss 19592680

Relevant External Links for RASSF2 Gene

HapMap Linkage Disequilibrium report
RASSF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF2 Gene

Disorders for RASSF2 Gene

Relevant External Links for RASSF2

Genetic Association Database (GAD)
RASSF2
Human Genome Epidemiology (HuGE) Navigator
RASSF2
genes like me logo Genes that share disorders with RASSF2: view

No data available for UniProtKB/Swiss-Prot for RASSF2 Gene

Publications for RASSF2 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. (PMID: 16012945) Akino K. … Tokino T. (Gastroenterology 2005) 3 4 23
  3. Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers. (PMID: 17549418) Kaira K. … Mori M. (Int. J. Oncol. 2007) 3 23
  4. Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene. (PMID: 11210185) Comincini S. … Ferretti L. (Mamm. Genome 2001) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for RASSF2 Gene

Sources for RASSF2 Gene

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