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Aliases for RASSF2 Gene

Aliases for RASSF2 Gene

  • Ras Association Domain Family Member 2 2 3
  • Ras Association (RalGDS/AF-6) Domain Family Member 2 2 3 5
  • Centromere Protein 34 2 3
  • Ras Association (RalGDS/AF-6) Domain Family 2 3
  • KIAA0168 4
  • CENP-34 3

External Ids for RASSF2 Gene

Previous GeneCards Identifiers for RASSF2 Gene

  • GC20M004748
  • GC20M004755
  • GC20M004708

Summaries for RASSF2 Gene

Entrez Gene Summary for RASSF2 Gene

  • This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF2 Gene

RASSF2 (Ras Association Domain Family Member 2) is a Protein Coding gene. An important paralog of this gene is RASSF4.

UniProtKB/Swiss-Prot for RASSF2 Gene

  • Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Gene Wiki entry for RASSF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF2 Gene

Genomics for RASSF2 Gene

Regulatory Elements for RASSF2 Gene

Enhancers for RASSF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASSF2 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASSF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF2 Gene

4,780,023 bp from pter
4,823,645 bp from pter
43,623 bases
Minus strand

Genomic View for RASSF2 Gene

Genes around RASSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF2 Gene

Proteins for RASSF2 Gene

  • Protein details for RASSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NIX9
    • A8K5Z3
    • Q17S06
    • Q53HD0
    • Q6AHZ2
    • Q8IZA5

    Protein attributes for RASSF2 Gene

    326 amino acids
    Molecular mass:
    37790 Da
    Quaternary structure:
    • Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.
    • Sequence=BAA11485.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF2 Gene


neXtProt entry for RASSF2 Gene

Proteomics data for RASSF2 Gene at MOPED

Post-translational modifications for RASSF2 Gene

Other Protein References for RASSF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASSF2 Gene

Domains & Families for RASSF2 Gene

Gene Families for RASSF2 Gene

Protein Domains for RASSF2 Gene


Suggested Antigen Peptide Sequences for RASSF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
genes like me logo Genes that share domains with RASSF2: view

Function for RASSF2 Gene

Molecular function for RASSF2 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.
genes like me logo Genes that share phenotypes with RASSF2: view

Animal Models for RASSF2 Gene

MGI Knock Outs for RASSF2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASSF2 Gene

Localization for RASSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF2 Gene

Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

Subcellular locations from

Jensen Localization Image for RASSF2 Gene COMPARTMENTS Subcellular localization image for RASSF2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RASSF2 Gene

Pathways & Interactions for RASSF2 Gene

SuperPathways for RASSF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0006468 protein phosphorylation IGI 19962960
GO:0007165 signal transduction IEA --
GO:0031954 positive regulation of protein autophosphorylation IDA 19962960
genes like me logo Genes that share ontologies with RASSF2: view

No data available for Pathways by source and SIGNOR curated interactions for RASSF2 Gene

Drugs & Compounds for RASSF2 Gene

(1) Drugs for RASSF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASSF2: view

Transcripts for RASSF2 Gene

Unigene Clusters for RASSF2 Gene

Ras association (RalGDS/AF-6) domain family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for RASSF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF2 Gene

mRNA expression in normal human tissues for RASSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF2 Gene

This gene is overexpressed in Whole Blood (x11.0), Brain - Spinal cord (cervical c-1) (x9.6), and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for RASSF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.6), Lymph node (10.7), Monocytes (10.1), CD8 Tcells (6.9), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASSF2 Gene

SOURCE GeneReport for Unigene cluster for RASSF2 Gene Hs.631504

mRNA Expression by UniProt/SwissProt for RASSF2 Gene

Tissue specificity: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
genes like me logo Genes that share expression patterns with RASSF2: view

Protein tissue co-expression partners for RASSF2 Gene

- Elite partner

Primer Products

Orthologs for RASSF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RASSF2 35
  • 91 (n)
  • 95.71 (a)
  • 96 (a)
(Mus musculus)
Mammalia Rassf2 35
  • 87.32 (n)
  • 92.64 (a)
Rassf2 16
Rassf2 36
  • 93 (a)
(Pan troglodytes)
Mammalia RASSF2 35
  • 99.28 (n)
  • 99.69 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rassf2 35
  • 87.63 (n)
  • 93.25 (a)
(Bos Taurus)
Mammalia RASSF2 36
  • 95 (a)
(Monodelphis domestica)
Mammalia RASSF2 36
  • 87 (a)
(Gallus gallus)
Aves RASSF2 35
  • 78.19 (n)
  • 82.72 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia RASSF2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf2 35
  • 69.9 (n)
  • 79.37 (a)
Str.8222 35
(Danio rerio)
Actinopterygii rassf2a 35
  • 66.78 (n)
  • 69 (a)
wufa04h12 35
rassf2a 36
  • 63 (a)
rassf2b 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4656 37
  • 35 (a)
Rassf 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for RASSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF2 Gene

Gene Tree for RASSF2 (if available)
Gene Tree for RASSF2 (if available)

Paralogs for RASSF2 Gene

Paralogs for RASSF2 Gene

(2) SIMAP similar genes for RASSF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASSF2: view

Variants for RASSF2 Gene

Sequence variations from dbSNP and Humsavar for RASSF2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_035825 A colorectal cancer sample
rs723559 -- 4,796,902(+) TTTTG(A/G)AGCCA intron-variant
rs723560 -- 4,796,982(+) AAAAT(A/G)ACATC intron-variant
rs723561 -- 4,797,094(+) TTAGG(C/T)GTCTC intron-variant
rs1076056 -- 4,823,256(-) ATGCC(C/G)GGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF2 Gene

Variant ID Type Subtype PubMed ID
nsv912628 CNV Gain 21882294
nsv912629 CNV Gain 21882294
esv274965 CNV Loss 21479260
esv29645 CNV Loss 19812545
esv1413742 CNV Insertion 17803354
nsv526507 CNV Loss 19592680

Variation tolerance for RASSF2 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RASSF2 Gene

Disorders for RASSF2 Gene

Relevant External Links for RASSF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASSF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF2 Gene

Publications for RASSF2 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers. (PMID: 17549418) Kaira K. … Mori M. (Int. J. Oncol. 2007) 3 23
  3. CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. (PMID: 15806169) Hesson L.B. … Latif F. (Oncogene 2005) 2 3
  4. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. (PMID: 16012945) Akino K. … Tokino T. (Gastroenterology 2005) 3 23
  5. Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene. (PMID: 11210185) Comincini S. … Ferretti L. (Mamm. Genome 2001) 3 23

Products for RASSF2 Gene

Sources for RASSF2 Gene