Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RASSF2 Gene

protein-coding   GIFtS: 61
GCID: GC20M004760

Ras Association (RalGDS/AF-6) Domain Family Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ras Association (RalGDS/AF-6) Domain Family Member 21 2     Ras Association (RalGDS/AF-6) Domain Family 22
Centromere Protein 341 2     Ras Association Domain-Containing Protein 22
CENP-342     KIAA01683
RASFADIN2     

External Ids:    HGNC: 98831   Entrez Gene: 97702   Ensembl: ENSG000001012657   OMIM: 6094925   UniProtKB: P507493   

Export aliases for RASSF2 gene to outside databases

Previous GC identifers: GC20M004748 GC20M004755 GC20M004708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RASSF2 Gene:
This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts,
this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have
been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RASSF2 Gene:
RASSF2 (Ras association (RalGDS/AF-6) domain family member 2) is a protein-coding gene. Diseases associated with RASSF2 include oral squamous cell carcinoma, and thyroid cancer. An important paralog of this gene is RASSF4.

UniProtKB/Swiss-Prot: RASF2_HUMAN, P50749
Function: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell
cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation

Gene Wiki entry for RASSF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASSF2 gene promoter:
         NF-AT4   SRY   NF-AT2   IRF-1   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASSF2 promoter sequence
   Search Chromatin IP Primers for RASSF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASSF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

RASSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M004760:  view genomic region     (about GC identifiers)

Start:
4,760,669 bp from pter      End:
4,804,291 bp from pter
Size:
43,623 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RASF2_HUMAN, P50749 (See protein sequence)
Recommended Name: Ras association domain-containing protein 2  
Size: 326 amino acids; 37790 Da
Subunit: Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with
STK3/MST2 AND STK4/MST1
Sequence caution: Sequence=BAA11485.2; Type=Erroneous initiation;
Secondary accessions: A6NIX9 A8K5Z3 Q17S06 Q53HD0 Q6AHZ2

Explore the universe of human proteins at neXtProt for RASSF2: NX_P50749

Explore proteomics data for RASSF2 at MOPED

Post-translational modifications: 

  • Phosphorylated by STK3/MST2 and STK4/MST11
  • Ubiquitination2 at Lys206
  • Modification sites at PhosphoSitePlus

  • See RASSF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055552.1  NP_739580.1  

    ENSEMBL proteins: 
     ENSP00000368710   ENSP00000368684  

    RASSF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RASSF2
    OriGene Protein Over-expression Lysate for RASSF2
    OriGene MassSpec for RASSF2
    OriGene Custom Protein Services for RASSF2
    GenScript Custom Purified and Recombinant Proteins Services for RASSF2
    Novus Biologicals RASSF2 Protein
    Novus Biologicals RASSF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASSF2

    RASSF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RASSF2
    OriGene Antibodies for RASSF2
    OriGene Custom Antibody Services for RASSF2
    Novus Biologicals RASSF2 Antibodies
    Abcam antibodies for RASSF2
    Cloud-Clone Corp. Antibodies for RASSF2
    ThermoFisher Antibody for RASSF2
    LSBio Antibodies in human, mouse, rat for RASSF2

    RASSF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RASSF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RASSF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RASSF2
    Cloud-Clone Corp. CLIAs for RASSF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011524 SARAH_dom
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry P50749

    ProtoNet protein and cluster: P50749

    1 Blocks protein domain: IPB000159 RA domain

    UniProtKB/Swiss-Prot: RASF2_HUMAN, P50749
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SARAH domain


    RASSF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASF2_HUMAN, P50749
    Function: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell
    cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12732644
         
    RASSF2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rassf2):
     cellular  growth/size/body  hematopoietic system  immune system  liver/biliary system 
     mortality/aging  skeleton 

    RASSF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rassf2tm1Dlim for RASSF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASSF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASSF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASSF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASSF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RASSF2:
    hsa-mir-200b-3p (MIRT024131), hsa-mir-141-3p (MIRT021654), hsa-mir-200c-3p (MIRT021074), hsa-mir-124-3p (MIRT022828), hsa-mir-200a-3p (MIRT020352), hsa-mir-429 (MIRT016642), hsa-mir-19b-3p (MIRT031279)

    Block miRNA regulation of human, mouse, rat RASSF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASSF2 (see all 65):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-218
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RASSF2
    Predesigned siRNA for gene silencing in human, mouse, rat RASSF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RASSF2

    Clone
    Products:
         
    OriGene clones in human, mouse for RASSF2 (see all 12)
    OriGene ORF clones in mouse, rat for RASSF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RASSF2 (NM_170774)
    Sino Biological Human cDNA Clone for RASSF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RASSF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RASSF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RASF2_HUMAN, P50749: Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND
    STK4/MST1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    RASSF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Array including RASSF2: 
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RASSF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for RASSF2 (P507491, 3 ENSP000003686844) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK3Q131881, 3, ENSP000003905004EBI-960081,EBI-992580 I2D: score=3 STRING: ENSP00000390500
    STK4Q130431, 3, ENSP000003618924EBI-960081,EBI-367376 I2D: score=3 STRING: ENSP00000361892
    KRASP011161, 3, ENSP000002560784EBI-960081,EBI-367415 I2D: score=5 STRING: ENSP00000256078
    HRASP011123, ENSP000003098454I2D: score=3 STRING: ENSP00000309845
    RASSF5Q8WWW03, ENSP000003474434I2D: score=1 STRING: ENSP00000347443
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction IEA--

    RASSF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASSF2 (RASF2)

    1 HMDB Compound for RASSF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RASSF2 gene (2 alternative transcripts): 
    NM_014737.2  NM_170774.1  

    Unigene Cluster for RASSF2:

    Ras association (RalGDS/AF-6) domain family member 2
    Hs.631504  [show with all ESTs]
    Unigene Representative Sequence: AY154470
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478553(uc002wlc.3) ENST00000379400(uc002wlf.3) ENST00000379376(uc002wld.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RASSF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASSF2 (see all 65):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-218
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RASSF2
    Predesigned siRNA for gene silencing in human, mouse, rat RASSF2
    Clone
    Products:
         
    OriGene clones in human, mouse for RASSF2 (see all 12)
    OriGene ORF clones in mouse, rat for RASSF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RASSF2 (NM_170774)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RASSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for RASSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASSF2
      QuantiTect SYBR Green Assays in human, mouse, rat RASSF2
      QuantiFast Probe-based Assays in human, mouse, rat RASSF2

    Additional mRNA sequence: 

    AK222650.1 AK291458.1 AK307232.1 AK309635.1 AY154470.1 AY154471.1 AY154472.1 BC110385.1 
    BC117118.1 BC117120.1 D79990.1 

    19 DOTS entries:

    DT.115905  DT.99995990  DT.91755691  DT.100787784  DT.100829463  DT.91875070  DT.120809450  DT.120809420 
    DT.95084873  DT.120809667  DT.120809927  DT.120809421  DT.100787791  DT.95255079  DT.300279  DT.100787785 
    DT.100787792  DT.120809664  DT.120809885 

    Selected AceView cDNA sequences (see all 233):

    AI948613 AW575914 AA703168 AA927714 BQ059714 NM_014737 AW504586 BF432383 
    D79990 AA935550 BU730128 NM_170774 AA339455 AI355582 AI161346 AY154472 
    AY154471 BF057886 BM672748 BF939935 CF121954 AA432161 W60625 CB153320 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RASSF2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:        -           -     -                 -           -     -     -     -     -                                                               
    SP2:                    -     -                 -           -     -     -     -     -                                                               
    SP3:                                                                                                                          -                     
    SP4:                                                                          -                                               -                     
    SP5:        -     -     -     -                 -           -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for RASSF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RASSF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTGATTCA
    RASSF2 Expression
    About this image


    RASSF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    RASSF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASSF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631504

    UniProtKB/Swiss-Prot: RASF2_HUMAN, P50749
    Tissue specificity: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently
    down-regulated in lung tumor cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including RASSF2: 
              Lung Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RASSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for RASSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASSF2
    QuantiTect SYBR Green Assays in human, mouse, rat RASSF2
    QuantiFast Probe-based Assays in human, mouse, rat RASSF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RASSF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rassf21 , 5 Ras association (RalGDS/AF-6) domain family member more1, 5 87.32(n)1
    92.64(a)1
      2 (64.14 cM)5
    2156531  NM_175445.41  NP_780654.11 
     1319894155 
    chicken
    (Gallus gallus)
    Aves RASSF21 Ras association (RalGDS/AF-6) domain family member more 78.19(n)
    82.72(a)
      419521  NM_001030884.1  NP_001026055.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASSF26
    Ras association (RalGDS/AF-6) domain family member...
    70(a)
    1 ↔ 1
    GL343968.1(68107-77450)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.82222 Transcribed sequence with moderate similarity to protein more 77.05(n)    CF523814.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04h122 wufa04h12 75.54(n)   334841  CD596037.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46563   -- 35(a)     --


    ENSEMBL Gene Tree for RASSF2 (if available)
    TreeFam Gene Tree for RASSF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RASSF2 gene
    RASSF42  RASSF62  
    2 SIMAP similar genes for RASSF2 using alignment to 2 protein entries:     RASF2_HUMAN (see all proteins):
    RASSF4    RASSF6

    RASSF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RASSF2 (see all 1241)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358254
    A colorectal cancer sample4--see VAR_0358252 R H mis40--------
    rs38309741,2
    C--4732322(+) CCCTC-/TTTCTCT 2 -- int11Minor allele frequency- TT:0.00NA 2
    rs1833307291,2
    --4760186(+) TCCCCA/GTACCA 2 -- ds50010--------
    rs1856002981,2
    --4760292(+) CAGGGA/GGGCTT 2 -- ds50010--------
    rs130423031,2
    C,H--4760364(+) tccaaG/Aaggaa 2 -- ds50016Minor allele frequency- A:0.00NS EA NA 600
    rs605539741,2
    F--4760656(+) ACCCAG/TCCACG 2 -- ds50010--------
    rs786491701,2
    F--4760660(+) ATCCAC/TGGGGC 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1824245601,2
    --4760819(+) CCAAAA/CGTTGA 2 -- ut310--------
    rs1866732431,2
    --4760899(+) GAAAAA/CCCTTC 2 -- ut310--------
    rs412794281,2
    C,F--4761049(+) AGGGGC/TGCTTC 2 -- ut312Minor allele frequency- T:0.05WA NA 238

    HapMap Linkage Disequilibrium report for RASSF2 (4760669 - 4804291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RASSF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1413742CNV Insertion17803354
    esv29645CNV Loss19812545
    esv274965CNV Loss21479260
    nsv526507CNV Loss19592680
    nsv912629CNV Gain21882294
    nsv912628CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASSF2
    DNA2.0 Custom Variant and Variant Library Synthesis for RASSF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609492    OMIM disorders: --

    15 diseases for RASSF2:    
    About MalaCards
    oral squamous cell carcinoma    thyroid cancer    peritonitis    pancreatic ductal adenocarcinoma
    nasopharyngitis    breast and colorectal cancer    endotheliitis    squamous cell carcinoma
    thyroiditis    hepatitis b    colorectal cancer    lung cancer
    hepatitis    adenocarcinoma    pancreatitis


    RASSF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASSF2
    Human Genome Epidemiology (HuGE) Navigator: RASSF2 (1 document)

    Export disorders for RASSF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RASSF2 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with RASSF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    2. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. (PubMed id 16012945)1, 2, 9 Akino K.... Tokino T. (Gastroenterology 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. (PubMed id 19525978)1, 2 Cooper W.N.... Latif F. (Oncogene 2009)
    5. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. (PubMed id 15569673)1, 2 Fujita H.... Mochizuki N. (J. Biol. Chem. 2005)
    6. CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. (PubMed id 15806169)1, 3 Hesson L.B....Latif F. (Oncogene 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor. (PubMed id 12732644)1, 2 Vos M.D.... Clark G.J. (J. Biol. Chem. 2003)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers. (PubMed id 17549418)1, 9 Kaira K....Mori M. (Int. J. Oncol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9770 HGNC: 9883 AceView: RASSF2 Ensembl:ENSG00000101265 euGenes: HUgn9770
    ECgene: RASSF2 H-InvDB: RASSF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0168

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RASSF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASSF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RASSF2 gene:
    Search GeneIP for patents involving RASSF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for RASSF2 (RASSF2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RASSF2   OriGene RNAi products in human, mouse, rat for RASSF2  
     OriGene qPCR primer pairs and template standards for RASSF2   OriGene Protein Over-expression Lysate for RASSF2  
     OriGene MassSpec something-or-other for RASSF2   OriGene clones in human, mouse for RASSF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RASSF2   OriGene Purified Protein for RASSF2  
     OriGene ORF clones in mouse, rat for RASSF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RASSF2   OriGene Custom Protein Services for RASSF2  

     
     
     Block miRNA regulation of human, mouse, rat RASSF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RASSF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASSF2 Predesigned siRNA for gene silencing in human, mouse, rat RASSF2
     QuantiFast Probe-based Assays in human, mouse, rat RASSF2 QuantiTect SYBR Green Assays in human, mouse, rat RASSF2
     PCR Arrays including human, mouse, rat RASSF2 Search Chromatin IP Primers for RASSF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASSF2  GeneGlobe Interaction Network for RASSF2
     Regulatory tfbs in RASSF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RASSF2 GenScript cDNA clones with any tag delivered in your preferred vector for RASSF2
     GenScript Custom Assay Services for RASSF2 GenScript Custom overexpressing Cell Line Services for RASSF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RASSF2 (RASF2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RASSF2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RASSF2 antibodies
     RASSF2 proteins
     RASSF2 lysates
     Antibodies for RASSF2
     See all of Abcam's Antibodies, Kits and Proteins for RASSF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RASSF2
     Antibodies for RASSF2
     ELISAs for RASSF2
     CLIAs for RASSF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for RASSF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RASSF2
     SwitchGear Promoter luciferase reporter plasmids for RASSF2
     ThermoFisher Antibody for RASSF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASSF2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASSF2
     LSBio Antibodies in human, mouse, rat for RASSF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RASSF2 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4