RASSF2 Gene

Aliases
for RASSF2 gene

Previous GC identifers: GC20M004748 GC20M004755 GC20M004708

Summaries
for RASSF2 gene

Genomic Views
for RASSF2 gene

RefSeq DNA sequence:

NC_000020.10  NC_018931.1  NT_011387.8  

SwitchGear Promoter luciferase reporter plasmid: RASSF2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASSF2

RASSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M004760:  view genomic region     (about GC identifiers)

Proteins
for RASSF2 gene

Explore the universe of human proteins at neXtProt for RASSF2: NX_P50749

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): RASSF2 OriGene Protein Over-expression Lysate (see all 3): RASSF2 OriGene Custom Protein Services for RASSF2
	GenScript Custom Purified and Recombinant Proteins Services for RASSF2
	Novus Biologicals RASSF2 Protein Novus Biologicals RASSF2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RASSF2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for RASSF2
	OriGene Antibodies (see all 2): RASSF2 OriGene Custom Antibody Services for RASSF2
	GenScript Custom Superior Antibodies Services for RASSF2
	Novus Biologicals RASSF2 Antibodies
	Abcam antibodies for RASSF2
	Uscn Antibodies for RASSF2
	ThermoFisher Antibody for RASSF2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RASSF2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RASSF2

Protein Domains /
Families
for RASSF2 gene

ProtoNet protein and cluster: P50749

Function
for RASSF2 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RASSF2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASSF2
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate RASSF2 (see all 65):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-218
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASSF2 (see all 7) OriGene shRNA RFP: RASSF2 OriGene siRNA: RASSF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASSF2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RASSF2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASSF2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASSF2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RASSF2 (NM_170774)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASSF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RASSF2
		Search LifeMap BioReagents cell lines for RASSF2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Rassf2)

Pathways & Interactions
for RASSF2 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for RASSF2 gene

Transcripts
for RASSF2 gene

Expression
for RASSF2 gene

RASSF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGATTCA

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierPostnatal Endothelial Cells			Blood Brain Barrier, Endothelium
	KidneyMetanephros			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 4 LifeMap Cells
	Name			Category
	PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)			Blood, Endothelium
	PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)			Blood, Endothelium
	PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)			Endothelium
	PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)			Endothelium

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASSF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASSF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASSF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASSF2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF2

Orthologs
for RASSF2 gene

Paralogs
for RASSF2 gene

Paralogs for RASSF2 gene

RASSF4²  RASSF6²  

2 SIMAP similar genes for RASSF2 using alignment to 2 protein entries:     RASF2_HUMAN (see all proteins):

RASSF4    RASSF6

RASSF2 for paralogs           About GeneDecksing

Genomic Variants
for RASSF2 gene

10/1071 NCBI SNPs in RASSF2 are shown (see all 1071)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1833307291,2		--	4760186(+)	TCCCCA/GTACCA	2	--	ds5001		0	--	--	--	--
rs1856002981,2		--	4760292(+)	CAGGGA/GGGCTT	2	--	ds5001		0	--	--	--	--
rs130423031,2	C,H	--	4760364(+)	tccaaG/Aaggaa	2	--	ds5001		6		NS EA NA	600
rs605539741,2		--	4760656(+)	ACCCAG/TCCACG	2	--	ds5001		0	--	--	--	--
rs786491701,2	F,	--	4760660(+)	ATCCAC/TGGGGC	2	--	ds5001		1		WA	118
rs1824245601,2		--	4760819(+)	CCAAAA/CGTTGA	2	--	ut31		0	--	--	--	--
rs1866732431,2		--	4760899(+)	GAAAAA/CCCTTC	2	--	ut31		0	--	--	--	--
rs412794281,2	C,F,	--	4761049(+)	AGGGGC/TGCTTC	2	--	ut31		2		WA NA	238
rs787766991,2	C,F,	--	4761059(+)	CAACAC/TCCCCC	2	--	ut31		1		EA	120
rs1921796821,2		--	4761062(+)	CACCCC/TCCTTG	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for RASSF2 (4760669 - 4804291 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RASSF2
     1 Indel: 73461

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASSF2

DNA2.0 Custom Variant and Variant Library Synthesis for RASSF2

Disorders / Diseases
for RASSF2 gene

Publications
for RASSF2 gene

PubMed articles for RASSF2 gene, integrated from 9 sources (see all 39): (articles sorted by number of sources associating them with RASSF2)

Utopia: connect your pdf to the dynamic world of online information

1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)^{1, 2, 3} Nagase T.... Nomura N. (1996)
2. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. (PubMed id 16012945)^{1, 2, 9} Akino K.... Tokino T. (2005)
3. RASSF2 associates with and stabilizes the proapoptoti c kinase MST2. (PubMed id 19525978)^{1, 2} Cooper W.N....Latif F. (2009)
4. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. (PubMed id 15569673)^{1, 2} Fujita H.... Mochizuki N. (2005)
5. CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. (PubMed id 15806169)^{1, 3} Hesson L.B....Latif F. (2005)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor. (PubMed id 12732644)^{1, 2} Vos M.D.... Clark G.J. (2003)
8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
9. Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers. (PubMed id 17549418)^{1, 9} Kaira K....Mori M. (2007)
10. Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene. (PubMed id 11210185)^{1, 9} Comincini S....Ferretti L. (2001)

External Searches for RASSF2 gene

Genome Databases showing RASSF2 gene

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Products
for RASSF2 gene