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Aliases for RASSF10 Gene

Aliases for RASSF10 Gene

  • Ras Association Domain Family Member 10 2 3 5
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor-Like 2
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 10 2

External Ids for RASSF10 Gene

Previous GeneCards Identifiers for RASSF10 Gene

  • GC11P012710

Summaries for RASSF10 Gene

GeneCards Summary for RASSF10 Gene

RASSF10 (Ras Association Domain Family Member 10) is a Protein Coding gene. An important paralog of this gene is RASSF9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF10 Gene

Genomics for RASSF10 Gene

Regulatory Elements for RASSF10 Gene

Enhancers for RASSF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F013138 1.5 FANTOM5 Ensembl ENCODE 10.8 +132.1 132067 5.1 MLX ARID4B DMAP1 YY1 SP5 NFYC MXD4 MIER2 PPARG KAT8 RASSF10 ENSG00000255558 ENSG00000255018
GH11F013117 1.5 FANTOM5 Ensembl ENCODE 9.7 +109.9 109878 4.3 ATF1 MLX SIN3A ARID4B DMAP1 YY1 FOS PAF1 SP5 NFYC RASSF10 LINC00958 LOC105376558 ENSG00000255558
GH11F013125 0.9 Ensembl ENCODE 10.7 +117.3 117288 1.5 BHLHE40 CEBPB USF2 JUND ZSCAN29 FOS MAFK NFE2L2 RASSF10 ENSG00000255558 LOC105376558
GH11F013114 1.2 Ensembl ENCODE 4.9 +105.5 105474 1.4 TBP CBX3 ARID4B RAD21 RFX5 SCRT2 ZNF143 RCOR1 CREM ZNF654 RASSF10 LOC105376558 ENSG00000255558
GH11F013134 1.1 Ensembl ENCODE 4.8 +126.1 126146 2.8 TBP ATF1 ARID4B SCRT2 CREM NFYC CEBPB KAT8 SREBF1 KLF16 LINC00958 RASSF10 ENSG00000255558 ENSG00000255018
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASSF10 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001766640 -23 801 MAZ RFX1 SP3 RNF2 NFIA SP2 ZBTB8A NR3C1 ZNF843 GLIS2
ENSR00000558831 1677 201 MAX

Genomic Location for RASSF10 Gene

Chromosome:
11
Start:
13,009,423 bp from pter
End:
13,012,106 bp from pter
Size:
2,684 bases
Orientation:
Plus strand

Genomic View for RASSF10 Gene

Genes around RASSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF10 Gene

Proteins for RASSF10 Gene

  • Protein details for RASSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK89-RASFA_HUMAN
    Recommended name:
    Ras association domain-containing protein 10
    Protein Accession:
    A6NK89

    Protein attributes for RASSF10 Gene

    Size:
    507 amino acids
    Molecular mass:
    56900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASSF10 Gene

Post-translational modifications for RASSF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASSF10 Gene

Domains & Families for RASSF10 Gene

Gene Families for RASSF10 Gene

Protein Domains for RASSF10 Gene

Suggested Antigen Peptide Sequences for RASSF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NK89

UniProtKB/Swiss-Prot:

RASFA_HUMAN :
  • Contains 1 Ras-associating domain.
Domain:
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASSF10: view

Function for RASSF10 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF10 Gene

Localization for RASSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF10 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.

Gene Ontology (GO) - Cellular Components for RASSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with RASSF10: view

No data available for Subcellular locations from COMPARTMENTS for RASSF10 Gene

Pathways & Interactions for RASSF10 Gene

SuperPathways for RASSF10 Gene

No Data Available

Interacting Proteins for RASSF10 Gene

Selected Interacting proteins: A6NK89-RASFA_HUMAN for RASSF10 Gene via IID

Gene Ontology (GO) - Biological Process for RASSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF10: view

No data available for Pathways by source and SIGNOR curated interactions for RASSF10 Gene

Transcripts for RASSF10 Gene

mRNA/cDNA for RASSF10 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASSF10 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF10 Gene

No ASD Table

Relevant External Links for RASSF10 Gene

GeneLoc Exon Structure for
RASSF10
ECgene alternative splicing isoforms for
RASSF10

Expression for RASSF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF10 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.8), Skin - Sun Exposed (Lower leg) (x8.1), Skin - Not Sun Exposed (Suprapubic) (x7.2), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for RASSF10 Gene

This gene is overexpressed in CD4 Tcells (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF10 Gene



Protein tissue co-expression partners for RASSF10 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASSF10 Gene:

RASSF10

SOURCE GeneReport for Unigene cluster for RASSF10 Gene:

Hs.134650

mRNA Expression by UniProt/SwissProt for RASSF10 Gene:

A6NK89-RASFA_HUMAN
Tissue specificity: Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.
genes like me logo Genes that share expression patterns with RASSF10: view

Primer Products

Orthologs for RASSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF10 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia RASSF10 34
  • 88.36 (n)
cow
(Bos Taurus)
Mammalia RASSF10 34
  • 86.85 (n)
mouse
(Mus musculus)
Mammalia Rassf10 34 16
  • 85.21 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309847 34
  • 84.32 (n)
chicken
(Gallus gallus)
Aves LOC100859008 34
  • 73.46 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492205 34
  • 64.11 (n)
zebrafish
(Danio rerio)
Actinopterygii rassf10a 34
  • 64.66 (n)
Species where no ortholog for RASSF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF10 Gene

ENSEMBL:
Gene Tree for RASSF10 (if available)
TreeFam:
Gene Tree for RASSF10 (if available)

Paralogs for RASSF10 Gene

Paralogs for RASSF10 Gene

genes like me logo Genes that share paralogs with RASSF10: view

Variants for RASSF10 Gene

Sequence variations from dbSNP and Humsavar for RASSF10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10603579 -- 13,011,136(+) CAGGG(-/GG)ATTCT upstream-variant-2KB, utr-variant-3-prime
rs112708803 -- 13,009,246(+) TCTGG(A/G)CCTTG upstream-variant-2KB
rs11399899 -- 13,011,139(+) GGGAT(-/C)TCTTT upstream-variant-2KB, utr-variant-3-prime
rs114085531 -- 13,011,750(+) CCTCC(G/T)AGTAA utr-variant-3-prime
rs1141090 -- 13,011,608(-) AAAGA(G/T)GTAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RASSF10 Gene

Variant ID Type Subtype PubMed ID
esv3625395 CNV gain 21293372
esv3625402 CNV gain 21293372
nsv951309 CNV deletion 24416366

Relevant External Links for RASSF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RASSF10 Gene

Disorders for RASSF10 Gene

Relevant External Links for RASSF10

Genetic Association Database (GAD)
RASSF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASSF10

No disorders were found for RASSF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF10 Gene

Publications for RASSF10 Gene

  1. RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis. (PMID: 18272789) Sherwood V. … Chalmers A.D. (Mol. Biol. Cell 2008) 2 3 4 64
  2. Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. (PMID: 20956940) Hill V.K. … Latif F. (Oncogene 2011) 3 4 64
  3. RASSF10 is an epigenetically inactivated tumor suppressor and independent prognostic factor in hepatocellular carcinoma. (PMID: 26701853) Wang F. … Xue W.J. (Oncotarget 2016) 3 64
  4. Methylation of RASSF10 promotes cell proliferation and serves as a docetaxel resistant marker in human breast cancer. (PMID: 26645898) Dong T. … Guo M. (Discov Med 2015) 3 64
  5. RASSF10 is an epigenetically silenced tumor suppressor in gastric cancer. (PMID: 24573726) Li Z. … Sun Q. (Oncol. Rep. 2014) 3 64

Products for RASSF10 Gene

Sources for RASSF10 Gene

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