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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASSF10 Gene

protein-coding   GIFtS: 38
GCID: GC11P012990

Ras Association (RalGDS/AF-6) Domain Family (N-Terminal)...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 101 2
Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal
Interactor-Like1
Ras Association Domain-Containing Protein 102

External Ids:    HGNC: 339841   Entrez Gene: 6449432   Ensembl: ENSG000001894317   OMIM: 6147135   UniProtKB: A6NK893   

Export aliases for RASSF10 gene to outside databases

Previous GC identifer: GC11P012710


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RASSF10 Gene: 
RASSF10 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 10) is a protein-coding gene. Diseases associated with RASSF10 include astrocytoma, and glioblastoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASSF10 gene promoter:
         Spz1   POU3F1   CUTL1   RelA   S8   c-Rel   POU2F1   POU2F1a   HSF2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RASSF10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASSF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

RASSF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P012990:  view genomic region     (about GC identifiers)

Start:
13,030,696 bp from pter      End:
13,033,653 bp from pter
Size:
2,958 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASFA_HUMAN, A6NK89 (See protein sequence)
Recommended Name: Ras association domain-containing protein 10  
Size: 507 amino acids; 56900 Da
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear
staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent
localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles
particularly during metaphase and anaphase before relocating back to the cytoplasm

Explore the universe of human proteins at neXtProt for RASSF10: NX_A6NK89

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NK89

  • RASSF10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001073990.2  
    Human Recombinant Protein Products for RASSF10: 
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol IEA--

    RASSF10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry A6NK89

    ProtoNet protein and cluster: A6NK89

    UniProtKB/Swiss-Prot: RASFA_HUMAN, A6NK89
    Similarity: Contains 1 Ras-associating domain


    RASSF10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASSF10

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--

    RASSF10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RASSF10 (RASFA)

    Search CenterWatch for drugs/clinical trials and news about RASSF10 / RASFA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for RASSF10 gene: 
    NM_001080521.2  

    Unigene Cluster for RASSF10:

    Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
    Hs.134650  [show with all ESTs]
    Unigene Representative Sequence: NM_001080521
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529419(uc021qdz.1) ENST00000340901
    miRNA
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    1 DOTS entry:

    DT.40125990 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASSF10 expression in normal human tissues (normalized intensities)      RASSF10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGAATCCC
    RASSF10 Expression
    About this image


    RASSF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme

    Genevestigator expression for RASSF10

    SOURCE GeneReport for Unigene cluster: Hs.134650

    UniProtKB/Swiss-Prot: RASFA_HUMAN, A6NK89
    Tissue specificity: Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter
    methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma
    grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I
    astrocytomas

        SABiosciences Custom PCR Arrays for RASSF10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASSF10 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rassf101 , 5 Ras association (RalGDS/AF-6) domain family (N-terminal) more1, 5 85.21(n)1
    86.59(a)1
      7 (59.13 cM)5
    787481  NM_175279.31  NP_780488.21 
     1129539625 
    chicken
    (Gallus gallus)
    Aves LOC1008590081 ras association domain-containing protein 10-like 76.19(n)
    74.64(a)
      100859008  XM_003641315.1  XP_003641363.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rassf10a1 Ras association (RalGDS/AF-6) domain family (N-terminal) more 64.66(n)
    64.9(a)
      559430  XM_682769.4  XP_687861.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138751 CG13875 39.51(n)
    24.87(a)
      38024  NM_138161.1  NP_612005.1 


    ENSEMBL Gene Tree for RASSF10 (if available)
    TreeFam Gene Tree for RASSF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/17 SNPs in RASSF10 are shown (see all 17)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0429994
    ----see VAR_0429992 Q H mis40--------
    rs1881033371,2
    --13032724(+) GGCTCC/GCGGAC 1 -- ut310--------
    rs1144472921,2
    C--13032905(+) CTATAC/TTGGAA 1 -- ut310--------
    rs1165325031,2
    C--13032919(+) AAACAA/CCCCAA 1 -- ut310--------
    rs353076661,2
    C--13032945(+) GAGCCC/-ATTTT 1 -- ut311Minor allele frequency- -:0.50NA 2
    rs11410901,2
    C,F,A,H--13033155(-) AAAGAG/TGTAAG 1 -- ut3122Minor allele frequency- T:0.34MN NS EA NA WA CSA 2530
    rs1140855311,2
    C,F--13033297(+) CCTCCT/GAGTAA 1 -- ut311Minor allele frequency- G:0.05WA 118
    rs1862267581,2
    --13033408(+) ATCGTC/GGTTAA 1 -- ut310--------
    rs1903876191,2
    --13033463(+) GAGTTA/GCCCTT 1 -- ut310--------
    rs1816565001,2
    --13033478(+) TCGTAC/TTGCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RASSF10 (13030696 - 13033653 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RASSF10: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RASSF10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614713    OMIM disorders: --

    4 diseases for RASSF10:    About MalaCards
    astrocytoma    glioblastoma    melanoma    prostatitis


    RASSF10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASSF10

    Export disorders for RASSF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASSF10 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with RASSF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RASSF7 Is a Member of a New Family of RAS Association Domain-containing Proteins and Is Required for Completing Mitosis. (PubMed id 18272789)1, 2, 3 Sherwood V....Chalmers A.D. (2008)
    2. Epigenetic inactivation of the RASSF10 candidate tumo r suppressor gene is a frequent and an early event in gliomagenesis. (PubMed id 20956940)1, 2 Hill V.K....Latif F. (2011)
    3. RASSF10 is epigenetically silenced and functions as a tumor suppressor in gastric cancer. (PubMed id 23428420)1 Wei Z....Cai Q. (2013)
    4. RASSF10 promoter hypermethylation is frequent in malig nant melanoma of the skin but uncommon in nevus cell nevi. (PubMed id 22113481)1 Helmbold P....Dammann R.H. (2012)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    6. Epigenetic down regulation of RASSF10 and its possible clinical implication in prostate carcinoma. (PubMed id 22415519)1 Dansranjavin T....Schagdarsurengin U. (2012)
    7. Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)4 Elks C.E....Murray A. (2010)
    8. Frequent epigenetic inactivation of RASSF10 in thyroi d cancer. (PubMed id 19934646)1 Schagdarsurengin U....Dammann R.H. (2009)
    9. The novel RASSF6 and RASSF10 candidate tumour suppres sor genes are frequently epigenetically inactivated in childhood leukaemias. (PubMed id 19570220)1 Hesson L.B....Latif F. (2009)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644943 HGNC: 33984 Ensembl:ENSG00000189431 euGenes: HUgn644943 ECgene: RASSF10
    H-InvDB: RASSF10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASSF10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASSF10 gene:
    Search GeneIP for patents involving RASSF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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