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Aliases for RASSF10 Gene

Aliases for RASSF10 Gene

  • Ras Association Domain Family Member 10 2 3
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 10 2 5
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor-Like 2

External Ids for RASSF10 Gene

Previous GeneCards Identifiers for RASSF10 Gene

  • GC11P012710

Summaries for RASSF10 Gene

GeneCards Summary for RASSF10 Gene

RASSF10 (Ras Association Domain Family Member 10) is a Protein Coding gene. An important paralog of this gene is RASSF9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF10 Gene

Genomics for RASSF10 Gene

Regulatory Elements for RASSF10 Gene

Enhancers for RASSF10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASSF10 on UCSC Golden Path with GeneCards custom track

Promoters for RASSF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASSF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASSF10 Gene

13,009,423 bp from pter
13,012,106 bp from pter
2,684 bases
Plus strand

Genomic View for RASSF10 Gene

Genes around RASSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF10 Gene

Proteins for RASSF10 Gene

  • Protein details for RASSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 10
    Protein Accession:

    Protein attributes for RASSF10 Gene

    507 amino acids
    Molecular mass:
    56900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASSF10 Gene

Proteomics data for RASSF10 Gene at MOPED

Post-translational modifications for RASSF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASSF10 Gene

Domains & Families for RASSF10 Gene

Gene Families for RASSF10 Gene

Protein Domains for RASSF10 Gene


Suggested Antigen Peptide Sequences for RASSF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASSF10: view

Function for RASSF10 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF10 Gene

Localization for RASSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF10 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.

Gene Ontology (GO) - Cellular Components for RASSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
genes like me logo Genes that share ontologies with RASSF10: view

No data available for Subcellular locations from COMPARTMENTS for RASSF10 Gene

Pathways & Interactions for RASSF10 Gene

SuperPathways for RASSF10 Gene

No Data Available

Interacting Proteins for RASSF10 Gene

Gene Ontology (GO) - Biological Process for RASSF10 Gene


No data available for Pathways by source and SIGNOR curated interactions for RASSF10 Gene

Drugs & Compounds for RASSF10 Gene

No Compound Related Data Available

Transcripts for RASSF10 Gene

mRNA/cDNA for RASSF10 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASSF10 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF10 Gene

No ASD Table

Relevant External Links for RASSF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF10 Gene

mRNA expression in normal human tissues for RASSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF10 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.8), Skin - Sun Exposed (Lower leg) (x8.1), Skin - Not Sun Exposed (Suprapubic) (x7.2), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for RASSF10 Gene

This gene is overexpressed in CD4 Tcells (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF10 Gene

SOURCE GeneReport for Unigene cluster for RASSF10 Gene Hs.134650

mRNA Expression by UniProt/SwissProt for RASSF10 Gene

Tissue specificity: Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.
genes like me logo Genes that share expression patterns with RASSF10: view

Protein tissue co-expression partners for RASSF10 Gene

Primer Products

Orthologs for RASSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASSF10 35
  • 86.85 (n)
  • 89.55 (a)
(Canis familiaris)
Mammalia RASSF10 35
  • 88.36 (n)
  • 87.99 (a)
(Mus musculus)
Mammalia Rassf10 35
  • 85.21 (n)
  • 86.59 (a)
Rassf10 16
(Pan troglodytes)
Mammalia RASSF10 35
  • 99.8 (n)
  • 99.41 (a)
(Rattus norvegicus)
Mammalia RGD1309847 35
  • 84.32 (n)
  • 86.17 (a)
(Gallus gallus)
Aves LOC100859008 35
  • 73.46 (n)
  • 71.54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492205 35
  • 64.11 (n)
  • 66.13 (a)
(Danio rerio)
Actinopterygii rassf10a 35
  • 64.66 (n)
  • 64.9 (a)
Species with no ortholog for RASSF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF10 Gene

Gene Tree for RASSF10 (if available)
Gene Tree for RASSF10 (if available)

Paralogs for RASSF10 Gene

Paralogs for RASSF10 Gene

genes like me logo Genes that share paralogs with RASSF10: view

Variants for RASSF10 Gene

Sequence variations from dbSNP and Humsavar for RASSF10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_042999 -
rs1141090 -- 13,011,608(-) AAAGA(G/T)GTAAG utr-variant-3-prime
rs11822061 -- 13,012,420(+) CCATG(C/T)AATTG downstream-variant-500B
rs114085531 -- 13,011,750(+) CCTCC(G/T)AGTAA utr-variant-3-prime
rs114447292 -- 13,011,358(+) CTATA(C/T)TGGAA utr-variant-3-prime

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for RASSF10 Gene

Disorders for RASSF10 Gene

Relevant External Links for RASSF10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASSF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF10 Gene

Publications for RASSF10 Gene

  1. RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis. (PMID: 18272789) Sherwood V. … Chalmers A.D. (Mol. Biol. Cell 2008) 2 3 4 67
  2. RASSF10 is an epigenetically silenced tumor suppressor in gastric cancer. (PMID: 24573726) Li Z. … Sun Q. (Oncol. Rep. 2014) 3
  3. Epigenetic silencing of RASSF10 promotes tumor growth in esophageal squamous cell carcinoma. (PMID: 24759621) Lu D. … Guo M. (Discov Med 2014) 3
  4. RASSF10 is epigenetically silenced and functions as a tumor suppressor in gastric cancer. (PMID: 23428420) Wei Z. … Cai Q. (Biochem. Biophys. Res. Commun. 2013) 3
  5. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3

Products for RASSF10 Gene

Sources for RASSF10 Gene