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Aliases for RASSF10 Gene

Aliases for RASSF10 Gene

  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 10 2 3
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor-Like 2

External Ids for RASSF10 Gene

Previous GeneCards Identifiers for RASSF10 Gene

  • GC11P012710

Summaries for RASSF10 Gene

GeneCards Summary for RASSF10 Gene

RASSF10 (Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 10) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF10 Gene

Genomics for RASSF10 Gene

Regulatory Elements for RASSF10 Gene

Genomic Location for RASSF10 Gene

13,009,423 bp from pter
13,012,106 bp from pter
2,684 bases
Plus strand

Genomic View for RASSF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF10 Gene

Proteins for RASSF10 Gene

  • Protein details for RASSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 10
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RASSF10 Gene

    507 amino acids
    Molecular mass:
    56900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASSF10 Gene

Proteomics data for RASSF10 Gene at MOPED

Post-translational modifications for RASSF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASSF10 Gene

Domains for RASSF10 Gene

Protein Domains for RASSF10 Gene


Suggested Antigen Peptide Sequences for RASSF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A6NK89
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASSF10: view

No data available for Gene Families for RASSF10 Gene

Function for RASSF10 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RASSF10 Gene

Localization for RASSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF10 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.

Subcellular locations from

Jensen Localization Image for RASSF10 Gene COMPARTMENTS Subcellular localization image for RASSF10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with RASSF10: view

Pathways for RASSF10 Gene

SuperPathways for RASSF10 Gene

No Data Available

Interacting Proteins for RASSF10 Gene

Gene Ontology (GO) - Biological Process for RASSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF10: view

No data available for Pathways by source for RASSF10 Gene

Transcripts for RASSF10 Gene

mRNA/cDNA for RASSF10 Gene

(0) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASSF10 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 10:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF10 Gene

No ASD Table

Relevant External Links for RASSF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF10 Gene

mRNA expression in normal human tissues for RASSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF10 Gene

This gene is overexpressed in Esophagus - Mucosa (9.8), Skin - Sun Exposed (Lower leg) (8.1), Skin - Not Sun Exposed (Suprapubic) (7.2), and Stomach (4.3).

Protein differential expression in normal tissues for RASSF10 Gene

This gene is overexpressed in CD4 Tcells (66.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RASSF10 Gene

SOURCE GeneReport for Unigene cluster for RASSF10 Gene Hs.134650

mRNA Expression by UniProt/SwissProt for RASSF10 Gene

Tissue specificity: Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.
genes like me logo Genes that share expressions with RASSF10: view

Expression partners for RASSF10 Gene

In Situ Assay Products

Orthologs for RASSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASSF10 35
  • 86.85 (n)
  • 89.55 (a)
(Canis familiaris)
Mammalia RASSF10 35
  • 88.36 (n)
  • 87.99 (a)
(Mus musculus)
Mammalia Rassf10 35
  • 85.21 (n)
  • 86.59 (a)
Rassf10 16
(Pan troglodytes)
Mammalia RASSF10 35
  • 99.8 (n)
  • 99.41 (a)
(Rattus norvegicus)
Mammalia RGD1309847 35
  • 84.32 (n)
  • 86.17 (a)
(Gallus gallus)
Aves LOC100859008 35
  • 73.46 (n)
  • 71.54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492205 35
  • 64.11 (n)
  • 66.13 (a)
(Danio rerio)
Actinopterygii rassf10a 35
  • 64.66 (n)
  • 64.9 (a)
Species with no ortholog for RASSF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF10 Gene

Gene Tree for RASSF10 (if available)
Gene Tree for RASSF10 (if available)

Paralogs for RASSF10 Gene

No data available for Paralogs for RASSF10 Gene

Variants for RASSF10 Gene

Sequence variations from dbSNP and Humsavar for RASSF10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1141090 -- 13,011,608(-) AAAGA(G/T)GTAAG utr-variant-3-prime
rs4323847 - 13,010,158(+) CAGCA(C/G)ACACC missense, reference
rs4756741 -- 13,008,131(+) AACTC(C/T)TTGCA upstream-variant-2KB
rs7105342 -- 13,008,176(+) CTAGC(A/G)TAGGA upstream-variant-2KB
rs7932060 -- 13,009,184(+) GGCGC(A/G)GCAAG upstream-variant-2KB

Relevant External Links for RASSF10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RASSF10 Gene

Disorders for RASSF10 Gene

Relevant External Links for RASSF10

Genetic Association Database (GAD)

No disorders were found for RASSF10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RASSF10 Gene

Publications for RASSF10 Gene

  1. RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis. (PMID: 18272789) Sherwood V. … Chalmers A.D. (Mol. Biol. Cell 2008) 2 3 4
  2. Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. (PMID: 20956940) Hill V.K. … Latif F. (Oncogene 2011) 3 4
  3. RASSF10 promoter hypermethylation is frequent in malignant melanoma of the skin but uncommon in nevus cell nevi. (PMID: 22113481) Helmbold P. … Dammann R.H. (J. Invest. Dermatol. 2012) 3
  4. Epigenetic down regulation of RASSF10 and its possible clinical implication in prostate carcinoma. (PMID: 22415519) Dansranjavin T. … Schagdarsurengin U. (Prostate 2012) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for RASSF10 Gene

Sources for RASSF10 Gene

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