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Aliases for RASSF1 Gene

Aliases for RASSF1 Gene

  • Ras Association (RalGDS/AF-6) Domain Family Member 1 2 3
  • RDA32 3 4
  • Pancreas-Specific Ras Association Domain Family 1 Protein 3
  • Cardiac-Specific Ras Association Domain Family 1 Protein 3
  • Ras Association Domain-Containing Protein 1 3
  • Tumor Suppressor Protein RDA32 3
  • WUGSC:H_LUCA12.5 3
  • RASSF1A 3
  • REH3P21 3
  • NORE2A 3
  • 123F2 3

External Ids for RASSF1 Gene

Previous GeneCards Identifiers for RASSF1 Gene

  • GC03P049608
  • GC03P049778
  • GC03M050221
  • GC03M050326
  • GC03M050342

Summaries for RASSF1 Gene

Entrez Gene Summary for RASSF1 Gene

  • This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

GeneCards Summary for RASSF1 Gene

RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1) is a Protein Coding gene. Diseases associated with RASSF1 include intracranial primitive neuroectodermal tumor and monophasic synovial sarcoma. Among its related pathways are Ras signaling pathway and Pathways in cancer. GO annotations related to this gene include identical protein binding and protein N-terminus binding. An important paralog of this gene is RASSF3.

UniProtKB/Swiss-Prot for RASSF1 Gene

  • Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Gene Wiki entry for RASSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF1 Gene

Genomics for RASSF1 Gene

Regulatory Elements for RASSF1 Gene

Transcription factor binding sites by QIAGEN in the RASSF1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASSF1 Gene

Start:
50,329,782 bp from pter
End:
50,340,980 bp from pter
Size:
11,199 bases
Orientation:
Minus strand

Genomic View for RASSF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF1 Gene

Proteins for RASSF1 Gene

  • Protein details for RASSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS23-RASF1_HUMAN
    Recommended name:
    Ras association domain-containing protein 1
    Protein Accession:
    Q9NS23
    Secondary Accessions:
    • B7ZLL1
    • O14571
    • O60539
    • O60710
    • Q0VGC6
    • Q5TZT2
    • Q9HB04
    • Q9HB18
    • Q9NS22
    • Q9UND4
    • Q9UND5

    Protein attributes for RASSF1 Gene

    Size:
    344 amino acids
    Molecular mass:
    39219 Da
    Quaternary structure:
    • Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 and probably associates with HRAS via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53.
    SequenceCaution:
    • Sequence=AAB67312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RASSF1 Gene

    Alternative splice isoforms for RASSF1 Gene

neXtProt entry for RASSF1 Gene

Proteomics data for RASSF1 Gene at MOPED

Post-translational modifications for RASSF1 Gene

  • Ubiquitination at Lys236
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RASSF1 Gene

Domains for RASSF1 Gene

Protein Domains for RASSF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NS23

UniProtKB/Swiss-Prot:

RASF1_HUMAN :
  • Q9NS23
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SARAH domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASSF1: view

No data available for Gene Families for RASSF1 Gene

Function for RASSF1 Gene

Molecular function for RASSF1 Gene

UniProtKB/Swiss-Prot Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Gene Ontology (GO) - Molecular Function for RASSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11857081
GO:0008270 zinc ion binding TAS 11333291
GO:0042802 identical protein binding IPI 11857081
GO:0047485 protein N-terminus binding IPI 18566590
genes like me logo Genes that share ontologies with RASSF1: view
genes like me logo Genes that share phenotypes with RASSF1: view

Animal Models for RASSF1 Gene

MGI Knock Outs for RASSF1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASSF1 Gene

Localization for RASSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF1 Gene

Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.
Isoform C: Nucleus. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASSF1 Gene COMPARTMENTS Subcellular localization image for RASSF1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IDA 14743218
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with RASSF1: view

Pathways for RASSF1 Gene

genes like me logo Genes that share pathways with RASSF1: view

Pathways by source for RASSF1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RASSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 18566590
GO:0007050 cell cycle arrest IMP 12024041
GO:0007165 signal transduction --
GO:0007265 Ras protein signal transduction IDA 15109305
GO:0031398 positive regulation of protein ubiquitination IDA 18566590
genes like me logo Genes that share ontologies with RASSF1: view

Compounds for RASSF1 Gene

(843) HMDB Compounds for RASSF1 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available

(19) Novoseek inferred chemical compound relationships for RASSF1 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 83.6 30
sodium bisulfite 59.4 1
p00031 55.9 2
crcs 51.1 3
o6-methylguanine 50 6
genes like me logo Genes that share compounds with RASSF1: view

Transcripts for RASSF1 Gene

Unigene Clusters for RASSF1 Gene

Ras association (RalGDS/AF-6) domain family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASSF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: -

Relevant External Links for RASSF1 Gene

GeneLoc Exon Structure for
RASSF1
ECgene alternative splicing isoforms for
RASSF1

Expression for RASSF1 Gene

mRNA expression in normal human tissues for RASSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF1 Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASSF1 Gene

SOURCE GeneReport for Unigene cluster for RASSF1 Gene Hs.476270

mRNA Expression by UniProt/SwissProt for RASSF1 Gene

Q9NS23-RASF1_HUMAN
Tissue specificity: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
genes like me logo Genes that share expressions with RASSF1: view

In Situ Assay Products

Orthologs for RASSF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF1 35
  • 99.61 (n)
  • 99.71 (a)
RASSF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASSF1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF1 35
  • 89.41 (n)
  • 93.82 (a)
RASSF1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf1 35
  • 85.39 (n)
  • 91.18 (a)
Rassf1 16
Rassf1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASSF1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASSF1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf1 35
  • 85.29 (n)
  • 90.59 (a)
chicken
(Gallus gallus)
Aves RASSF1 35
  • 71.99 (n)
  • 72.87 (a)
lizard
(Anolis carolinensis)
Reptilia RASSF1 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14433 35
zebrafish
(Danio rerio)
Actinopterygii rassf1 35
  • 61.7 (n)
  • 57.45 (a)
rassf1 36
  • 50 (a)
OneToOne
wufc17f02 35
worm
(Caenorhabditis elegans)
Secernentea rsf-1 36
  • 19 (a)
OneToMany
T24F1.3 35
  • 49.88 (n)
  • 42.14 (a)
T24F1.3 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for RASSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RASSF1 Gene

ENSEMBL:
Gene Tree for RASSF1 (if available)
TreeFam:
Gene Tree for RASSF1 (if available)

Paralogs for RASSF1 Gene

Paralogs for RASSF1 Gene

Selected SIMAP similar genes for RASSF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RASSF1: view

Variants for RASSF1 Gene

Sequence variations from dbSNP and Humsavar for RASSF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1046468 -- 50,330,413(-) CACCT(A/G)TGGGT utr-variant-3-prime
rs1143432 -- 50,335,438(-) tgggg(A/G)ggctg intron-variant
rs1143433 -- 50,335,428(-) gaggc(A/G)ggagt intron-variant
rs1143434 -- 50,335,419(-) gtatc(A/G)cttga intron-variant
rs1143436 -- 50,335,409(-) aaccc(A/G)gaaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF1 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
nsv3813 CNV Loss 18451855
dgv5133n71 CNV Loss 21882294

Relevant External Links for RASSF1 Gene

HapMap Linkage Disequilibrium report
RASSF1
Human Gene Mutation Database (HGMD)
RASSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF1 Gene

Disorders for RASSF1 Gene

(1) OMIM Diseases for RASSF1 Gene (605082)

(96) Novoseek inferred disease relationships for RASSF1 Gene

Disease -log(P) Hits PubMed IDs
tumors 73.2 291
cancer 67.7 121
nsclc 65 83
primary tumor 64.9 41
cancer lung 63.5 64

Relevant External Links for RASSF1

Genetic Association Database (GAD)
RASSF1
Human Genome Epidemiology (HuGE) Navigator
RASSF1
genes like me logo Genes that share disorders with RASSF1: view

No data available for UniProtKB/Swiss-Prot for RASSF1 Gene

Publications for RASSF1 Gene

  1. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. (PMID: 11333291) Burbee D.G. … Minna J.D. (J. Natl. Cancer Inst. 2001) 3 4 23
  2. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. (PMID: 12024041) Shivakumar L. … White M.A. (Mol. Cell. Biol. 2002) 3 4 23
  3. RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication. (PMID: 12794755) Endoh H. … Mitsudomi T. (Int. J. Cancer 2003) 3 23 48
  4. Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (PMID: 14729613) Fenton S.L. … Latif F. (Cancer Res. 2004) 3 4 23
  5. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. (PMID: 14743218) Song M.S. … Lim D.-S. (Nat. Cell Biol. 2004) 3 4 23

Products for RASSF1 Gene

Sources for RASSF1 Gene

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