Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASSF1 Gene

protein-coding   GIFtS: 64
GCID: GC03M050369

Ras Association (RalGDS/AF-6) Domain Family Member 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Association (RalGDS/AF-6) Domain Family Member 11 2     WUGSC:H_LUCA12.52
RDA322 3     Cardiac-Specific Ras Association Domain Family 1 Protein2
123F22     Pancreas-Specific Ras Association Domain Family 1 Protein2
NORE2A2     Ras Association Domain-Containing Protein 12
RASSF1A2     Tumor Suppressor Protein RDA322
REH3P212     

External Ids:    HGNC: 98821   Entrez Gene: 111862   Ensembl: ENSG000000680287   OMIM: 6050825   UniProtKB: Q9NS233   

Export aliases for RASSF1 gene to outside databases

Previous GC identifers: GC03P049608 GC03P049778 GC03M050221 GC03M050326 GC03M050342


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASSF1 Gene:
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been
associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this
gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island
promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also
shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced
transcript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, May 2011)

GeneCards Summary for RASSF1 Gene: 
RASSF1 (Ras association (RalGDS/AF-6) domain family member 1) is a protein-coding gene. Diseases associated with RASSF1 include intracranial primitive neuroectodermal tumor, and monophasic synovial sarcoma, and among its related super-pathways are Glioma and Cell cycle Role of APC in cell cycle regulation. GO annotations related to this gene include protein N-terminus binding and identical protein binding. An important paralog of this gene is RASSF5.

UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23
Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of
STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with
MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and
TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC,
resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively
regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1
protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform.
Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53
by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage

Gene Wiki entry for RASSF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASSF1 gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RASSF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASSF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASSF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

RASSF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASSF1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050369:  view genomic region     (about GC identifiers)

Start:
50,367,217 bp from pter      End:
50,378,411 bp from pter
Size:
11,195 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23 (See protein sequence)
Recommended Name: Ras association domain-containing protein 1  
Size: 344 amino acids; 39219 Da
Subunit: Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2
and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in
response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with
RSSF5 and probably associates with HRAS1 via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2,
DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is
independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts
(via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53
Subcellular location: Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center,
centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to
cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase,
to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the
midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus
Subcellular location: Isoform C: Nucleus. Note=Predominantly nuclear
Sequence caution: Sequence=AAB67312.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for RASSF1:
2KZU (3D)    
Secondary accessions: B7ZLL1 O14571 O60539 O60710 Q0VGC6 Q5TZT2 Q9HB04 Q9HB18 Q9NS22 Q9UND4
Q9UND5
Alternative promoter usage, Alternative splicing: 8 isoforms:  Q9NS23-1   Q9NS23-2   Q9NS23-3   Q9NS23-4   Q9NS23-5   Q9NS23-6   Q9NS23-7   Q9NS23-9   
(Produced by alternative splicing of isoform C)

Explore the universe of human proteins at neXtProt for RASSF1: NX_Q9NS23

Explore proteomics data for RASSF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NS23

  • RASSF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASSF1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001193886.1  NP_009113.3  NP_733830.1  NP_733831.1  NP_733832.1  

    ENSEMBL proteins: 
     ENSP00000333327   ENSP00000378558   ENSP00000349547   ENSP00000378549   ENSP00000352323  
     ENSP00000433000  

    Human Recombinant Protein Products for RASSF1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RASSF1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RASSF1
    GenScript Custom Purified and Recombinant Proteins Services for RASSF1
    Novus Biologicals RASSF1 Proteins
    Novus Biologicals RASSF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASSF1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IDA14743218
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005874microtubule IEA--

    RASSF1 for ontologies           About GeneDecksing



    RASSF1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RASSF1
    OriGene Custom Antibody Services for RASSF1
    GenScript Custom Superior Antibodies Services for RASSF1
    Novus Biologicals RASSF1 Antibodies
    Abcam antibodies for RASSF1
    Cloud-Clone Corp. Antibodies for RASSF1 
    ThermoFisher Antibodies for RASSF1
    LSBio Antibodies in human, mouse, rat for RASSF1 

    Assay Products for RASSF1: 
    EMD Millipore Kits and Assays for the Analysis of RASSF1
    OriGene Custom Assay Services for RASSF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RASSF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RASSF1 
    Cloud-Clone Corp. CLIAs for RASSF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011524 SARAH_dom
     IPR000159 Ras-assoc
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry Q9NS23

    ProtoNet protein and cluster: Q9NS23

    UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SARAH domain


    RASSF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASF1_HUMAN, Q9NS23
    Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of
    STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with
    MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and
    TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC,
    resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively
    regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1
    protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform.
    Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53
    by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11857081
    GO:0008270zinc ion binding TAS11333291
    GO:0042802identical protein binding IPI11857081
    GO:0047485protein N-terminus binding IPI18566590
         
    RASSF1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rassf1):
     cardiovascular system  cellular  homeostasis/metabolism  immune system  mortality/aging 
     normal  tumorigenesis 

    RASSF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RASSF1: Rassf1tm1.2Brd Rassf1tm1Gpp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RASSF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RASSF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASSF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASSF1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASSF1
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RASSF1 (see all 19):
    hsa-miR-323-3p hsa-miR-181c hsa-miR-330-5p hsa-miR-3138 hsa-miR-650 hsa-miR-342-3p hsa-miR-326 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidRASSF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RASSF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASSF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RASSF1
    Sirion Biotech Customized adenovirus for overexpression of RASSF1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RASSF1 (see all 25)
    OriGene ORF clones in mouse, rat for RASSF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RASSF1 (NM_170712)
    Sino Biological Human cDNA Clone for RASSF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASSF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF1
    Sirion Biotech Customized lentivirus for stable overexpression of RASSF1 
                         Customized lentivirus expression plasmids for stable overexpression of RASSF1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RASSF1
    Search LifeMap BioReagents cell lines for RASSF1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RASSF1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glioma
    Non-small cell lung cancer0.51
    Bladder cancer0.31
    2Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98
    3G-protein signaling K-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway0.96
    4p53 pathway
    p53 pathway
    5Pathways in cancer
    Pathways in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for RASSF1
        G-protein signaling K-RAS regulation pathway
    Cell cycle Role of APC in cell cycle regulation


    2 GeneGo (Thomson Reuters) Pathways for RASSF1
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling K-RAS regulation pathway

    1 BioSystems Pathway for RASSF1
        p53 pathway



    5         Kegg Pathways  (Kegg details for RASSF1):
        Hippo signaling pathway
    Pathways in cancer
    MicroRNAs in cancer
    Bladder cancer
    Non-small cell lung cancer


    RASSF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASSF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for RASSF1 (Q9NS231, 2, 3 ENSP000003495474) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206206Q9UER72, 3MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D: score=3 
    ENSG00000206279Q9UER72, 3MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D: score=3 
    ENSG00000227046Q9UER72, 3MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D: score=3 
    ENSG00000231617Q9UER72, 3MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D: score=3 
    DAXXQ9UER72, 3, ENSP000003968764MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D: score=3 STRING: ENSP00000396876 STRING: ENSP00000266000
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006974response to DNA damage stimulus IMP18566590
    GO:0007050cell cycle arrest IMP12024041
    GO:0007165signal transduction ----
    GO:0007265Ras protein signal transduction IDA15109305
    GO:0031398positive regulation of protein ubiquitination IDA18566590

    RASSF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RASSF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASSF1 (RASF1)

    10/843 HMDB Compounds for RASSF1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    10/19 Novoseek inferred chemical compound relationships for RASSF1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 83.6 41 14506151 (2), 17938735 (1), 11306494 (1), 12670917 (1) (see all 29)
    sodium bisulfite 59.4 1 17898258 (1)
    p00031 55.9 3 11709729 (1), 12629521 (1)
    crcs 51.1 3 16007118 (2), 12973852 (1)
    o6-methylguanine 50 6 16258509 (2), 16374457 (1), 15197802 (1), 16361635 (1) (see all 5)
    retinoic acid 43.9 23 12839965 (1), 15289848 (1), 17285579 (1), 17696735 (1) (see all 21)
    5-methylcytosine 18.6 1 12154064 (1)
    threonine 12.3 2 14961576 (1), 19559616 (1)
    estrogen 6.51 6 15041725 (1), 17584191 (1), 15788661 (1), 16720314 (1) (see all 5)
    oligonucleotide 0 1 16116475 (1)

    Search CenterWatch for drugs/clinical trials and news about RASSF1 / RASF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASSF1 gene (8 alternative transcripts): 
    NM_001206957.1  NM_007182.4  NM_170712.2  NM_170713.2  NM_170714.1  NM_170715.1  NM_170716.1  NM_170717.1  

    Unigene Cluster for RASSF1:

    Ras association (RalGDS/AF-6) domain family member 1
    Hs.476270  [show with all ESTs]
    Unigene Representative Sequence: NM_170714
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327761(uc003dab.1) ENST00000395126(uc003daa.1 uc003dac.2)
    ENST00000357043 ENST00000395117 ENST00000359365(uc003dad.1 uc003dae.1 uc003daf.1)
    ENST00000482447(uc010hlk.1) ENST00000478619(uc011bdq.1) ENST00000488024
    ENST00000494145
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASSF1
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RASSF1 (see all 19):
    hsa-miR-323-3p hsa-miR-181c hsa-miR-330-5p hsa-miR-3138 hsa-miR-650 hsa-miR-342-3p hsa-miR-326 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidRASSF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RASSF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASSF1
    Clone
    Products:
         
    OriGene clones in human, mouse for RASSF1 (see all 25)
    OriGene ORF clones in mouse, rat for RASSF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RASSF1 (NM_170712)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASSF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF1
    Sirion Biotech Customized lentivirus for stable overexpression of RASSF1 
                         Customized lentivirus expression plasmids for stable overexpression of RASSF1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RASSF1
    OriGene qSTAR qPCR primer pairs in human, mouse for RASSF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RASSF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASSF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASSF1

    Additional mRNA sequence: 

    AF040703.2 AF061836.1 AF102770.2 AF102771.2 AF102772.2 AF132675.1 AF132676.1 AF132677.1 
    AF286217.1 AK292638.1 AK300994.1 AK310032.1 BC110412.1 BC117153.1 BC143879.1 BT020047.1 
    BT020048.1 

    14 DOTS entries:

    DT.95232294  DT.91745194  DT.97814194  DT.95232300  DT.70103096  DT.86837702  DT.91745195  DT.95232295 
    DT.120854530  DT.100785977  DT.100785982  DT.101969178  DT.120854527  DT.95232296 

    24/200 AceView cDNA sequences (see all 200):

    AW848748 BX484118 BI042844 AW848804 AI590726 BM680220 BI869331 BM932273 
    BI962846 AF132677 BQ045340 BM917709 NM_170715 CR603388 BU553836 CR621674 
    AI879702 BM542113 CR604275 AL559408 BM763945 BM725006 BX102498 BQ438298 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RASSF1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
    SP1:        -     -     -     -           -     -     -     -                                 
    SP2:        -     -     -                 -     -     -     -                                 
    SP3:                          -           -     -     -     -                                 
    SP4:        -     -     -     -           -     -     -                                       
    SP5:        -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for RASSF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASSF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTTAATG
    RASSF1 Expression
    About this image


    See RASSF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASSF1

    SOURCE GeneReport for Unigene cluster: Hs.476270

    UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23
    Tissue specificity: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is
    absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including RASSF1 (see all 8): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RASSF1
    OriGene qSTAR qPCR primer pairs in human, mouse for RASSF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RASSF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASSF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASSF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASSF1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rassf11 , 5 Ras association (RalGDS/AF-6) domain family member more1, 5 85.39(n)1
    90.88(a)1
      9 (58.12 cM)5
    562891  NM_001243748.11  NP_001230677.11 
     1075515555 
    lizard
    (Anolis carolinensis)
    Reptilia RASSF16
    Ras association (RalGDS/AF-6) domain family member...
    66(a)
    1 ↔ 1
    2(149999901-150023240)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144332 Xenopus laevis transcribed sequence with weak similarity more 76.87(n)    BJ062943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17f022 wufc17f02 74.7(n)   324049  CK027942.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T24F1.31 , 3 DAG binding domain3
    Protein T24F1.31
    38(a)3
    49.94(n)1
    42.12(a)1
      II(11306322-11311709)3
    1747281  NM_001027191.21  NP_001022362.11 


    ENSEMBL Gene Tree for RASSF1 (if available)
    TreeFam Gene Tree for RASSF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASSF1 gene
    RASSF52  RASSF32  
    4 SIMAP similar genes for RASSF1 using alignment to 3 protein entries:     RASF1_HUMAN (see all proteins):
    PRKCH    FLJ00186    RASSF3    RASSF5

    RASSF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/350 SNPs in RASSF1 are shown (see all 350)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0195454
    ----see VAR_0195452 S F mis40--------
    VAR_0195474
    ----see VAR_0195472 Y C mis40--------
    rs1407564341,2
    --50299611(+) TCACCC/TTTGGC 5 -- ds50010--------
    rs757471421,2
    C,F--50300047(+) TATGAA/GGCATT 5 -- ut311Minor allele frequency- G:0.04WA 118
    rs1430940141,2
    --50300072(+) ACTGTA/GAGCCA 5 -- ut310--------
    rs1907755561,2
    --50300167(+) CACCCA/GCCCTT 5 -- ut310--------
    rs754000951,2
    C,F--50300384(+) AGGCCC/GAGTAA 5 -- ut311Minor allele frequency- G:0.08WA 118
    rs20734971,2
    C,F,A,H--50300453(+) AAGCTA/CCTTCG 5 -- ut3111Minor allele frequency- C:0.46EA NA WA CSA 1160
    rs1115285931,2
    C,F--50300491(+) CAGGAG/TGGCCT 5 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1997812261,2
    C--50300584(+) CACCTA/GGGGGT 5 -- ut310--------

    HapMap Linkage Disequilibrium report for RASSF1 (50367217 - 50378411 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for RASSF1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5132n71CNV Loss21882294
    nsv523662CNV Loss19592680
    dgv5133n71CNV Loss21882294
    nsv876770CNV Loss21882294
    nsv3813CNV Loss18451855
    dgv5131n71CNV Loss21882294
    nsv876769CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv470561CNV Loss18288195
    nsv834693CNV Loss17160897


    Human Gene Mutation Database (HGMD): RASSF1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RASSF1
    DNA2.0 Custom Variant and Variant Library Synthesis for RASSF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605082   
    OMIM disorders: 211980  
    20/100 diseases for RASSF1 (see all 100):    About MalaCards
    intracranial primitive neuroectodermal tumor    monophasic synovial sarcoma    progesterone-receptor negative breast cancer    nasopharynx carcinoma
    choroid plexus papilloma    cervical squamous cell carcinoma    atypical teratoid rhabdoid tumor    gastric cardia adenocarcinoma
    clear cell renal cell carcinoma    cervical adenocarcinoma    supratentorial primitive neuroectodermal tumor    primitive neuroectodermal tumor
    thyroid cancer    adenoiditis    papilloma    ganglioneuroma
    von hippel-lindau disease    rhabdoid tumor    renal clear cell carcinoma    refractory anemia

    6 diseases from the University of Copenhagen DISEASES database for RASSF1:
    Lung cancer     Carcinoma     Breast cancer     Nasopharynx carcinoma
    Urinary bladder cancer     Hepatocellular carcinoma

    RASSF1 for disorders           About GeneDecksing

    10/96 Novoseek inferred disease relationships for RASSF1 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 73.2 653 15375503 (8), 16315018 (6), 15378022 (5), 14871978 (5) (see all 99)
    cancer 67.7 152 17325427 (5), 17608924 (3), 15948711 (3), 12647816 (2) (see all 96)
    nsclc 65 126 14500366 (5), 14559805 (4), 17606310 (4), 15700308 (4) (see all 38)
    primary tumor 64.9 45 14506151 (3), 12684417 (3), 12839965 (2), 17121881 (2) (see all 32)
    cancer lung 63.5 88 12887746 (4), 17267069 (4), 16444703 (3), 18313166 (3) (see all 41)
    allelic loss 58.6 15 12142046 (2), 15761971 (1), 19548529 (1), 11313894 (1) (see all 8)
    adenocarcinoma lung 58.3 10 15898433 (2), 14511407 (1), 14742312 (1), 15700308 (1) (see all 9)
    nasopharyngeal carcinoma 56.9 15 20042089 (3), 12865217 (2), 11358799 (2), 17720308 (2) (see all 10)
    multiple tumors 53.7 2 15467712 (1), 15129426 (1)
    follicular thyroid cancer 52 2 16946009 (1), 14996725 (1)

    Genetic Association Database (GAD): RASSF1
    Human Genome Epidemiology (HuGE) Navigator: RASSF1 (11 documents)

    Export disorders for RASSF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASSF1 gene, integrated from 9 sources (see all 662):
    (articles sorted by number of sources associating them with RASSF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. (PubMed id 11333291)1, 2, 9 Burbee D.G.... Minna J.D. (2001)
    2. Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (PubMed id 14729613)1, 2, 9 Fenton S.L....Latif F. (2004)
    3. RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. (PubMed id 15205320)1, 2, 9 Dallol A.... Latif F. (2004)
    4. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. (PubMed id 16510573)1, 2, 9 Oh H.J.... Lim D.-S. (2006)
    5. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. (PubMed id 12024041)1, 2, 9 Shivakumar L.... White M.A. (2002)
    6. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. (PubMed id 14743218)1, 2, 9 Song M.S....Lim D.-S. (2004)
    7. Putative association of the single nucleotide polymorphisms in RASSF1A promoter with Korean lung cancer. (PubMed id 18313166)1, 4, 9 Sung J.S....Kim Y.H. (2008)
    8. RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers. (PubMed id 18172292)1, 4, 9 Gao B....Minna J.D. (2008)
    9. Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5. (PubMed id 15753381)1, 2, 9 Liu L.... McKeehan W.L. (2005)
    10. RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication. (PubMed id 12794755)1, 4, 9 Endoh H....Mitsudomi T. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11186 HGNC: 9882 AceView: RASSF1 Ensembl:ENSG00000068028 euGenes: HUgn11186
    ECgene: RASSF1 Kegg: 11186 H-InvDB: RASSF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASSF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASSF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASSF1 gene:
    Search GeneIP for patents involving RASSF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Kits and Assays for the Analysis of RASSF1
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RASSF1   OriGene RNAi products in human, mouse, rat for RASSF1  
     OriGene qPCR primer pairs and template standards for RASSF1   OriGene Protein Over-expression Lysate for RASSF1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RASSF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RASSF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RASSF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RASSF1   OriGene Custom Protein Services for RASSF1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RASSF1
     QIAGEN SeqTarget long-range PCR primers for resequencing RASSF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASSF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASSF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASSF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASSF1
     GenScript Custom Purified and Recombinant Proteins Services for RASSF1 GenScript cDNA clones with any tag delivered in your preferred vector for RASSF1
     GenScript Custom Assay Services for RASSF1 GenScript Custom Superior Antibodies Services for RASSF1
     GenScript Custom overexpressing Cell Line Services for RASSF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RASSF1 promoter
     Search Chromatin IP Primers for RASSF1
     RT2 qPCR Primer Assay in human, mouse / rat RASSF1
     GNC Network for RASSF1
     SABiosciences PCR Arrays including human, mouse / rat RASSF1
     Search Tocris compounds for RASSF1 (RASF1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RASSF1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RASSF1 antibodies
     RASSF1 proteins
     RASSF1 lysates
     Antibodies for RASSF1
     See all of Abcam's Antibodies, Kits and Proteins for RASSF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RASSF1
     Antibodies for RASSF1
     ELISAs for RASSF1
     CLIAs for RASSF1
     Search LifeMap BioReagents cell lines for RASSF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF1
     SwitchGear 3'UTR luciferase reporter plasmids for RASSF1
     SwitchGear Promoter luciferase reporter plasmids for RASSF1
     ThermoFisher Antibodies for RASSF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RASSF1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RASSF1
    Customized:
     lentivirus for stable overexpression of RASSF1
     lentivirus expression plasmids for stable overexpression of RASSF1
     adenovirus for overexpression of RASSF1
     LSBio Antibodies in human, mouse, rat for RASSF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RASSF1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4