RASSF1 Gene
protein-coding GIFtS: 64
GCID: GC03M050369
|
|
Ras association (RalGDS/AF-6) domain family member 1
| |
Aliases
for RASSF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ras Association (RalGDS/AF-6) Domain Family Member 11 2 | | WUGSC:H_LUCA12.52 | | RDA321 2 3 | | Cardiac-Specific Ras Association Domain Family 1 Protein2 | | 123F21 2 | | Pancreas-Specific Ras Association Domain Family 1 Protein2 | | NORE2A1 2 | | Ras Association Domain-Containing Protein 12 | | REH3P211 2 | | Tumor Suppressor Protein RDA322 | | RASSF1A2 | | |
Export aliases for RASSF1 gene to outside databasesPrevious GC identifers: GC03P049608 GC03P049778 GC03M050221 GC03M050326 GC03M050342 |
Summaries
for RASSF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RASSF1:
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has beenassociated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene.The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region.The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit theaccumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants ofthis gene encoding distinct isoforms have been reported. (provided by RefSeq, May 2011)
UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotesBAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition ofAPC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at thelevel of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not toperform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2,DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination incell-cycle checkpoint control in response to DNA damage
Gene Wiki entry for RASSF1
|
Genomic Views
for RASSF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RASSF1 gene promoter:
AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RASSF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASSF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3RASSF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M050369: view genomic region
(about GC identifiers)
Start:
|
50,367,217 bp from pter |
End:
|
50,378,411 bp from pter |
Size:
|
11,195 bases |
Orientation:
|
minus strand |
|
Proteins
for RASSF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23 (See
protein sequence)Recommended Name: Ras association domain-containing protein 1 Size: 344 amino acids; 39219 Da
Subunit: Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 andSTK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response totheir respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 andprobably associates with HRAS1 via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 andUSP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 andTP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (viaC-terminus); the interaction is independent of TP53
Subcellular location: Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton,spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase,to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphaseand anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes withMDM2 in the nucleus
Subcellular location: Isoform C: Nucleus. Note=Predominantly nuclear
Sequence caution: Sequence=AAB67312.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from  and Proteopedia  for RASSF1:2KZU (3D)
Secondary accessions: B7ZLL1 O14571 O60539 O60710 Q0VGC6 Q5TZT2 Q9HB04 Q9HB18 Q9NS22 Q9UND4 Q9UND5Alternative promoter usage, Alternative splicing: 8 isoforms: Q9NS23-1 Q9NS23-2 Q9NS23-3 Q9NS23-4 Q9NS23-5 Q9NS23-6 Q9NS23-7 Q9NS23-9 (Produced by alternative splicing of isoform C)Explore the universe of human proteins at neXtProt for RASSF1: NX_Q9NS23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS23
RASSF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001193886.1 NP_009113.3 NP_733830.1 NP_733831.1 NP_733832.1
ENSEMBL proteins: ENSP00000333327 ENSP00000378558 ENSP00000349547 ENSP00000378549 ENSP00000352323 ENSP00000433000
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
RASSF1 for ontologies About GeneDecksing
RASSF1 Antibody Products:
Assay Products for RASSF1: |
Protein
Domains /
Families
for RASSF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RASSF1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NS23ProtoNet protein and cluster: Q9NS23 UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23Similarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 Ras-associating domainSimilarity: Contains 1 SARAH domain |
Function
for RASSF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotesBAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition ofAPC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at thelevel of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not toperform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2,DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination incell-cycle checkpoint control in response to DNA damage
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASSF1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASSF1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): RASSF1 (NM_170712) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASSF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RASSF1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for RASSF1: Rassf1tm1.2Brd Rassf1tm1Gpp
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rassf1):
RASSF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RASSF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling K-RAS regulation pathway | | | 2 | Cell cycle Role of APC in cell cycle regulation | | | 3 | p53 pathway | | | 4 | Bladder cancer | | | 5 | Pathways in cancer | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for RASSF1
2  GeneGo (Thomson Reuters) Pathways for RASSF1
1  BioSystems Pathway for RASSF1
3 
Kegg Pathways (Kegg details for RASSF1):
RASSF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASSF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/65 Interacting proteins for RASSF1 (Q9NS231, 2, 3 ENSP000003495474) via UniProtKB, MINT, STRING, and/or I2D (see all 65)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| DAXX | Q9UER72, 3, ENSP000003968764 | MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D:
score=3 STRING: ENSP00000396876 STRING: ENSP00000266000 | | HRAS | P011121, 2, 3, ENSP000003098454 | EBI-438698,EBI-350145 MINT-6949036 I2D:
score=4 STRING: ENSP00000309845 | | MDM2 | Q009872, 3, ENSP000004172814 | MINT-6801526 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801662 MINT-6801730 MINT-6801508 I2D:
score=3 STRING: ENSP00000417281 | | STK4 | Q130431, 3, ENSP000003618924 | EBI-438698,EBI-367376 I2D:
score=5 STRING: ENSP00000361892 | | CNKSR1 | Q969H42, 3, ENSP000003546094 | MINT-56515 I2D:
score=4 STRING: ENSP00000354609 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
RASSF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RASSF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RASSF1 for compounds About GeneDecksing
 Browse Tocris compounds for RASSF1
10/843 HMDB Compounds for RASSF1 (see all 843) About this table
10/19 Novoseek chemical compound relationships for RASSF1 gene (see all 19) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 5-aza-2'deoxycytidine |
83.6 |
41 |
14506151 (2), 17938735 (1), 11306494 (1), 12670917 (1) (see all 29) |
| sodium bisulfite |
59.4 |
1 |
17898258 (1) |
| p00031 |
55.9 |
3 |
11709729 (1), 12629521 (1) |
| crcs |
51.1 |
3 |
16007118 (2), 12973852 (1) |
| o6-methylguanine |
50 |
6 |
16258509 (2), 16374457 (1), 15197802 (1), 16361635 (1) (see all 5) |
| retinoic acid |
43.9 |
23 |
12839965 (1), 15289848 (1), 17285579 (1), 17696735 (1) (see all 21) |
| 5-methylcytosine |
18.6 |
1 |
12154064 (1) |
| threonine |
12.3 |
2 |
14961576 (1), 19559616 (1) |
| estrogen |
6.51 |
6 |
15041725 (1), 17584191 (1), 15788661 (1), 16720314 (1) (see all 5) |
| oligonucleotide |
0 |
1 |
16116475 (1) |
Search CenterWatch for drugs/clinical trials and news about RASSF1 / RASF1
|
Transcripts
for RASSF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RASSF1 gene (8 alternative transcripts): NM_001206957.1 NM_007182.4 NM_170712.2 NM_170713.2 NM_170714.1 NM_170715.1 NM_170716.1 NM_170717.1 Unigene Cluster for RASSF1: Ras association (RalGDS/AF-6) domain family member 1 Hs.476270 [show with all ESTs]Unigene Representative Sequence: NM_1707149 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000327761(uc003dab.1) ENST00000395126(uc003daa.1 uc003dac.2)
ENST00000357043 ENST00000395117 ENST00000359365(uc003dad.1 uc003dae.1 uc003daf.1)
ENST00000482447(uc010hlk.1) ENST00000478619(uc011bdq.1) ENST00000488024
ENST00000494145
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASSF1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASSF1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): RASSF1 (NM_170712) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASSF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASSF1 |
Additional cDNA sequence: AF040703.2 AF061836.1 AF102770.2 AF102771.2 AF102772.2 AF132675.1 AF132676.1 AF132677.1 AF286217.1 AK292638.1 AK300994.1 AK310032.1 BC110412.1 BC117153.1 BC143879.1 BT020047.1 BT020048.1 14 DOTS entries: DT.95232294 DT.91745194 DT.97814194 DT.95232300 DT.70103096 DT.86837702 DT.91745195 DT.95232295 DT.120854530 DT.100785977 DT.100785982 DT.101969178 DT.120854527 DT.95232296 24/200 AceView cDNA sequences (see all 200): AA371117 BI869331 AW162276 CR604275 BM932273 BI915594 CR603388 CR620030 BU187947 BM680220 AA340880 NM_170714 BU553836 AI879702 BM542113 CR612949 AF132676 BI042844 AL559408 CA503126 BQ072763 BI753305 AW848804 BM464204
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RASSF1 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for RASSF1
|
Expression
for RASSF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RASSF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTTAATG
About this image
See RASSF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASSF1
SOURCE GeneReport for Unigene cluster: Hs.476270
UniProtKB/Swiss-Prot: RASF1_HUMAN, Q9NS23Tissue specificity: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A isabsent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells
SABiosciences Expression via Pathway-Focused PCR Arrays including RASSF1 (see all 8):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASSF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RASSF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASSF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASSF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASSF1 |
Orthologs
for RASSF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RASSF1 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RASSF16 |
-- |
67(a) |
1 ↔ 1 |
2(150000607-150039613) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.144332 |
Xenopus laevis transcribed sequence with weak similarity more |
76.87(n) |
|
BJ062943.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc17f022 |
wufc17f02 |
74.7(n) |
|
324049 CK027942.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
T24F1.31 , 3 |
DAG binding domain3
Protein T24F1.31 |
38(a)3
49.94(n)1
42.12(a)1 |
|
II(11306322-11311709)3
1747281 NM_001027191.21 NP_001022362.11 |
ENSEMBL Gene Tree for RASSF1 (if available)
TreeFam Gene Tree for RASSF1 (if available) |
Paralogs
for RASSF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RASSF1 gene
- RASSF52 RASSF32
4 SIMAP similar genes for RASSF1 using alignment to 3 protein entries: RASF1_HUMAN (see all proteins):PRKCH FLJ00186 RASSF3 RASSF5
RASSF1 for paralogs About GeneDecksing
|
Genomic Variants
for RASSF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RASSF1 (50367217 - 50378411 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RASSF1
4 CNVs: 30176 4335 3429 4336
Human Gene Mutation Database (HGMD): RASSF1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASSF1 |
|
Disorders
/ Diseases
for RASSF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RASSF1 for disorders About GeneDecksing
OMIM gene information: 605082
OMIM disorders: 211980
20/115  diseases for RASSF1 (see all 115): About MalaCardsvon hippel-lindau disease progesterone-receptor negative breast cancer monoclonal gammopathy of undetermined significance atypical teratoid rhabdoid tumor
primitive neuroectodermal tumor supratentorial primitive neuroectodermal tumor monophasic synovial sarcoma intracranial primitive neuroectodermal tumor
familial adenomatous polyposis choroid plexus papilloma renal clear cell carcinoma non-small cell lung carcinoma
neuroectodermal tumors pre-eclampsia male germ cell tumor cervical squamous cell carcinoma
clear cell renal cell carcinoma squamous cell carcinoma soft tissue sarcoma carcinoma
5 diseases from the University of Copenhagen DISEASES database for RASSF1:Lung cancer Carcinoma Breast cancer Nasopharynx carcinoma
Hepatocellular carcinoma 10/96 Novoseek disease relationships for RASSF1 gene (see all 96) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
73.2 |
653 |
15375503 (8), 16315018 (6), 15378022 (5), 14871978 (5) (see all 99) |
| cancer |
67.7 |
152 |
17325427 (5), 17608924 (3), 15948711 (3), 12647816 (2) (see all 96) |
| nsclc |
65 |
126 |
14500366 (5), 14559805 (4), 17606310 (4), 15700308 (4) (see all 38) |
| primary tumor |
64.9 |
45 |
14506151 (3), 12684417 (3), 12839965 (2), 17121881 (2) (see all 32) |
| cancer lung |
63.5 |
88 |
12887746 (4), 17267069 (4), 16444703 (3), 18313166 (3) (see all 41) |
| allelic loss |
58.6 |
15 |
12142046 (2), 15761971 (1), 19548529 (1), 11313894 (1) (see all 8) |
| adenocarcinoma lung |
58.3 |
10 |
15898433 (2), 14511407 (1), 14742312 (1), 15700308 (1) (see all 9) |
| nasopharyngeal carcinoma |
56.9 |
15 |
20042089 (3), 12865217 (2), 11358799 (2), 17720308 (2) (see all 10) |
| multiple tumors |
53.7 |
2 |
15467712 (1), 15129426 (1) |
| follicular thyroid cancer |
52 |
2 |
16946009 (1), 14996725 (1) |
Genetic Association Database (GAD): RASSF1
Human Genome Epidemiology (HuGE) Navigator: RASSF1 (11 documents)
Export disorders for RASSF1 gene to outside databases
|
Publications
for RASSF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RASSF1 gene, integrated from 9 sources (see all 650):
(articles sorted by number of sources associating them with RASSF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. (PubMed id 11333291)1, 2, 9 Burbee D.G.... Minna J.D. (2001)
- Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. (PubMed id 14729613)1, 2, 9 Fenton S.L....Latif F. (2004)
- RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. (PubMed id 15205320)1, 2, 9 Dallol A.... Latif F. (2004)
- Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. (PubMed id 16510573)1, 2, 9 Oh H.J.... Lim D.-S. (2006)
- The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. (PubMed id 12024041)1, 2, 9 Shivakumar L.... White M.A. (2002)
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. (PubMed id 14743218)1, 2, 9 Song M.S....Lim D.-S. (2004)
- Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5. (PubMed id 15753381)1, 2, 9 Liu L.... McKeehan W.L. (2005)
- RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication. (PubMed id 12794755)1, 4, 9 Endoh H....Mitsudomi T. (2003)
- Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk. (PubMed id 16125301)1, 4, 9 Kanzaki H....Shimizu K. (2006)
- A polymorphism at codon 133 of the tumor suppressor RASSF1A is associated with tumorous alteration of the breast. (PubMed id 15942659)1, 4, 9 Schagdarsurengin U....Dammann R. (2005)
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External Searches for RASSF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RASSF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RASSF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RASSF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for RASSF1 gene:
Search GeneIP for patents involving RASSF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RASSF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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